The document provides an overview of the EVICEL fibrin sealant product, including its performance and market share growth. It discusses EVICEL's new general hemostasis indication, which expands its promotional opportunities in plastic surgery procedures. Guidelines for sales representatives to follow regarding on-label and off-label promotion are also presented.

1. EVICEL Fibrin Sealant (Human) Product Information EVICEL TM Fibrin Sealant (Human) PSR Sales Training Module

3. Biosurgicals Products EVICEL* FIBRIN SEALANT (HUMAN) ORC (Oxidized Regenerated Cellulose) GELATIN FLOWABLE GELATIN COLLAGEN FIBRIN SEALANT SURGICEL* Hemostats SURGICEL FIBRILLAR* Hemostats SURGICEL NU-KNIT* Hemostats SURGIFOAM* GELATIN SPONGE & POWDER Hemostats INSTAT* MICROFIBRILLARCOLLAGEN Hemostats SURGIFOAM* POWDER Kit SURGIFLO* Hemostatic Matrix THROMBIN EVITHROM* Thrombin, Topical (Human)

4. Fibrin Sealant Market Overview

5. U.S. Fibrin Market *IMS Data, 2007 Vitagel EVICEL Tisseel 2006 Fibrin Market ($92 MM) 2007 Fibrin Market ($103 MM est.) Total fibrin market grew by 12% in 2007 Source: IMS 2007

6. EVICEL Performance 2005 $183,364 $847,628 $1.2MM $1.9MM $2.2MM $2.2MM $3.1MM $3.6MM $4.2MM $5.3MM Launched EVICEL Launched CROSSEAL Launched EVICEL Vascular 2006 2007 $6.1MM $8.4 MM $7.1 MM Launched EVICEL General Hemostasis $8.8MM 2008 $10.4MM YTD in 2007 vs $17.7MM YTD in 2008 70% growth over 2007!!!

7. 122% -15% 37% The Fibrin Sealants segment increased 18% over previous quarter and 14% over 4Q ’06 to $27.3M this quarter. Evicel leads the growth, with almost $5M growth in the past year and $0.7M in the past quarter. Although Tisseel is down over the past year, it rebounded in 4Q ’07 after its drop in 3Q ’07. Tisseel is cannibalizing its VH (nonfrozen) business with the newer frozen formulations which now account for 22% of its total dollar volume US Biosurgicals Market: Fibrin Sealants Detailed Segment, Short-term Dollar Performance 3 Month Quarters, $ Volume, in Millions Growth over Pr. Yr. Segment Volume (MM) $3.9 $5.8 $8.2 $8.3 $8.8 $17.0 $17.5 $14.3 $11.4 $12.0 $3.5 $3.4 $2.9 $3.5 $4.0 $- $5 $10 $15 $20 $25 $30 4Q '06 1Q '07 2Q '07 3Q '07 4Q '07 $, Millions Evicel Tisseel Vitagel Source: IMS HIS Data Compiled by: Pinky Shaw, BIWW

8. Plastic/Burn Surgery Market Overview **NOTE: As always, promotion only for on-label surgeries for hemostasis $764MM 1,038,000 TOTAL $338MM 735,000 Breast (Reconstruction, Lift, Reduction and augmentation) (5 mL) $100MM 100,000 Burn Surgery (10 mL) $240MM 160,000 Abdominoplasty (15 mL) $86MM 43,000 Massive Weight Loss Body Contouring (20 mL) Potential Market (100% Penetration) Volume Procedure

10. Background & New Indication

15. New Indication for EVICEL TM EVICEL TM Fibrin Sealant (Human) is indicated as an adjunct to hemostasis for patients undergoing surgery when control of bleeding by standard surgical techniques is ineffective or impractical * Pending final labeling from FDA

16. EVICEL ™ Fibrin Sealant (Human) Original Promotional Road Map Does the surgeon operate on the liver? Sales rep can also respond to a training request Sales rep or Medical Affairs * can respond to request for clinical info. Yes Yes You and the customer can initiate questions on EVICEL Fibrin Sealant (Human) for the approved indication Can you (sales rep) initiate conversation on EVICEL Fibrin Sealant (Human) for the approved indication? Can you (sales rep) respond to clinical questions on EVICEL Fibrin Sealant (Human) for the approved indication? Yes Only customers can initiate questions on EVICEL Fibrin Sealant (Human) No Only Medical Affairs * can respond to request for off-label clinical information on fibrin glue Sales rep could provide proper usage instructions upon request (including indications & safety information) to customers who decide to use the product Can you (sales rep) respond to off-label clinical questions on EVICEL Fibrin Sealant (Human)? Can you (Sales rep) initiate conversation on EVICEL Fibrin Sealant (Human)? No Training should include Indications, Contraindications, Precautions, Warnings, and the technical aspects of the product. * Pending final labeling from FDA No

17. EVICEL ™ Fibrin Sealant (Human) Vascular Promotional Road Map Does the surgeon operate on the liver or perform vascular surgery? Sales rep can also respond to a training request Sales rep or Medical Affairs * can respond to request for clinical info. Yes Yes You and the customer can initiate questions on EVICEL Fibrin Sealant (Human) for the approved indication Can you (sales rep) initiate conversation on EVICEL Fibrin Sealant (Human) for the approved indication? Can you (sales rep) respond to clinical questions on EVICEL Fibrin Sealant (Human) for the approved indication? Yes Only customers can initiate questions on EVICEL Fibrin Sealant (Human) No Only Medical Affairs * can respond to request for off-label clinical information on fibrin glue Sales rep could provide proper usage instructions upon request (including indications & safety information) to customers who decide to use the product Can you (sales rep) respond to off-label clinical questions on EVICEL Fibrin Sealant (Human)? Can you (Sales rep) initiate conversation on EVICEL Fibrin Sealant (Human)? No Training should include Indications, Contraindications, Precautions, Warnings, and the technical aspects of the product. * Pending final labeling from FDA No

18. EVICEL ™ Fibrin Sealant (Human) General Hemostasis Promotional Road Map Sales rep or Medical Affairs can respond to request for clinical info. Yes Yes You and the customer can initiate questions on EVICEL for the approved indication Can you (sales rep) initiate conversation on EVICEL for the approved indication? Can you (sales rep) respond to clinical questions on EVICEL for the approved indication? Only customers can initiate questions on EVICEL for off-label uses No, cannot promote for off-label uses, such as sealing and fixation Only Medical Affairs can respond to request for off-label clinical information on fibrin glues Can you (sales rep) respond to off-label clinical questions on EVICEL Fibrin Sealant (Human)? Can you (Sales rep) initiate conversation on off-label uses? No Training should include Indications, Contraindications, Precautions, Warnings, and the technical aspects of the product. Promote On-label for Hemostasis? Does the surgeon perform surgery? Yes * Pending final labeling from FDA No

20. Leverage our Broad GH Indication Retroperitoneal Bleeding/Soft Tissue (3) Peripheral Vascular Surgery (2) Liver Resection Surgery (1) General Hemostasis Indication Studied in 3 different tissue types

22. Competitive Overview

26. Clot Longevity Comparison* Longevity of the EVICEL TM Fibrin Sealant (Human) clot in vivo is comparable to that of CROSSEAL* Fibrin Sealant, and other marketed fibrin sealants such as Tisseel *Johnson & Johnson Wound Management Data on File, Data from in vitro animal model

27. EVICEL TM Product Training

28. Think EVICEL TM for your Plastic Surgery Procedures EVICEL TM is the first and only fibrin sealant approved for general hemostasis in surgery 1 TRAM Flap Abdominoplasty Think 1. Full Prescribing Information.

34. Device Overview 2 luer locks for easy removal and attachment of accessory tips Triple lumen 7cm clog resistant applicator tip Optional 35cm Rigid Tip Can be sprayed or dripped from the same device

35. 35 cm Rigid Tip Overview EVICEL 35 cm Rigid Tip Packaging (3 per box) Ready to spray or drip One-Handed delivery Atraumatic & clog-resistant tip (triple lumen runs throughout tip) Attaches easily to the device

36. Pressure Regulator EVICEL TM Fibrin Sealant (Human) should be sprayed using an air pressure of 20–25 psi measured by air flow* * EVICEL TM Fibrin Sealant (Human) Pressure Regulator Instructions for Use

37. Preparation Video

39. Plastic Surgery Sales Tools

40. Updated Main Sales Aid NOW the only fibrin sealant approved for general hemostasis in surgery New Effective Bullet: Proven Rapid Hemostasis in vascular, urologic, gynecologic and general surgery New Soft Tissue Study data in general, gynecologic and urologic surgery * Pending final labeling from FDA; Draft Piece-Subject to change

41. New Plastics Slim Jim Plastics Images (Breast Reconstruction) Hemostatic Efficacy (New Soft Tissue Study Data) in general, gynecologic and urologic surgery Experience the clear choice for your plastic surgery procedures Spray or drip EVICEL™ to achieve hemostasis during reconstructive procedures, including: breast reconstruction, abdominoplasty, facial reconstruction and vascular anastomoses * Subject to FDA Review * Pending final labeling from FDA; Draft Piece-Subject to change

43. Product Preparation Poster New Cling-zee OR Wall Poster Easy preparation: No mixing required New easy-to-see images Preparation instructions for the 35 cm Rigid Tip

44. EVICEL Product Codes

45. New Customer In-service Deck (Updated with new indication & modular device) New Updated Website (New specialty tabs in Ortho, Burns & Plastics) New Blackberry Videos (3 new videos in Ortho, Burns & Plastics)

46. EVICEL in Plastic Surgery Overview

47. Plastic & Burn Specialty Overview

57. Scar Revision

58. Surgery Videos

59. Breast Reconstruction

60. Q&A