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How Metacognition May Damage the Interpretation of Clinical Outcomes in AD Trials 5 10 11
![How metacognition may damage the interpretation of clinical outcomes in AD trials Jonathan Rubright, MS 1,2 , Mark Cary, PhD 6 , Elizabeth Sullo, BA 3,4 , Jennifer Bronstein, BA 3,4 , Jason Karlawish, MD 3-9 University of Delaware School of Education 1 , Education Research and Development Center 2 , University of Pennsylvania, Department of Medicine 3 , Alzheimer’s Disease Center 4 , Department of Medical Ethics 5 , Center for Clinical Epidemiology and Biostatistics 6 , Center for Bioethics 7 , Institute on Aging 8 , Leonard Davis Institute of Health Economics 9 The research reported on this poster is supported by The Marian S. Ware Alzheimer Program and NIA P30-AG01024. Table 1: Demographic and clinical characteristics of the sample. ,[object Object],Figure 1: Z-scores of QOL, mood, and perceived cognitive difficulties * p <. 05, ** p<.01 Table 2: Spearman rank order correlations of cognition, mood, and QOL. *p values based on χ 2 or one way ANOVA. Normal MCI AD Mean (SD) or % Healthy Controls ( n= 41) MCI ( n= 27) AD ( n= 32) p* Age 80.0 (6.8) 77.1 (5.7) 78.6 (6.3) .14 Female 65.9 44.4 62.5 .19 African American 7.3 18.5 6.2 .22 ≥ 16 years of education 68.3 77.8 59.4 .32 MMSE 29.2 (1.0) 26.5 (2.4) 24.9 (2.8) <.01 ,[object Object],[object Object],[object Object],[object Object],Methods ,[object Object],[object Object],[object Object],[object Object],Results ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Conclusions ,[object Object],[object Object],[object Object],[object Object],Background ,[object Object],[object Object],[object Object],[object Object],Objectives MOCA Biber delayed learning Cognitive Difficulty Cognitive Distress Geriatric Depression Scale - 30 .04 -.03 .38** .35** Beck Anxiety Scale -.03 .02 .40** .39** Perceived Stress Scale -.15 -.01 .56** .61** QOL AD .07 .02 -.36** -.36** Euro QOL -.06 -.18 -.18 -.2*](https://image.slidesharecdn.com/karlawishjasonhowmetacognitionmaydamagetheinterpretationofclinicaloutcomesinadtrials51011-110513090214-phpapp02/85/how-metacognition-may-damage-the-interpretation-of-clinical-outcomes-in-ad-trials-5-10-11-1-320.jpg)
