The document describes TAPBOOST, a breakthrough protein production platform that enhances protein folding and secretion. It works by controlling the protein folding system and cellular quality control mechanisms in the host cell. The platform can increase yields of various target proteins including antibodies, enzymes, and difficult-to-express proteins. It has been shown to boost production levels by over 2000% for some proteins while also reducing aggregation. The platform works in mammalian, bacterial, and yeast expression systems and provides advantages such as increased productivity for any target protein and easy implementation into existing bioprocesses.