Prescription drug monitoring programs (PDMPs) are statewide electronic databases that track controlled substance prescriptions. Checking a state's PDMP regularly, such as every 3 months or before each opioid prescription, allows clinicians to identify patients receiving opioids from multiple providers, calculate total daily opioid doses, and identify potential drug interactions. This helps improve patient safety and informs safer opioid prescribing practices. The document provides guidance on checking PDMPs, considering risks when prescribing opioids, addressing concerning patient information found in PDMPs, and registering for a state's PDMP.