1. “ Strength does not come from winning. Struggles & Hardship develop your strength. When you go through hardship and decide not to surrender, that is strength” Arnold Schwarzenegger Bodybuilder and Actor

2. Pathology of Breast Cancer Dr. Venkatesh M. Shashidhar Senior Lecturer in Pathology Fiji School of Medicine

4. Normal Breast

5. Myoepithelial Cells (ipx)

11. Etiology of Breast Carcinoma:

14. Histological Types Histologic Type Freq. (UK) Infiltrating Duct Ca 63.6 (75) Lobular Carcinoma 5.9 (10) Infiltrating Ductal & Lobular Ca 1.6 Medullary Carcinoma 2.8 (3) Mucinous (colloid) Carcinoma 2.1 (3) Comedocarcinoma 1.4 Carcinoma-In-Situ 5%

15. Breast Carcinoma

16. Breast Carcinoma

17. Breast Carcinoma - Schirrous

18. Infiltrating Duct Carcinoma: small hard

19. Medullary Carcinoma: Large soft

20. Infiltrating Duct Carcinoma

21. Infiltrating Duct Carcinoma

22. Medullary Carcinoma: Inflammation.

23. Infiltrating Duct Carcinoma: Fibrosis

24. Schirrous Carcinoma

25. Medullary Carcinoma Soft, inflammatory cells

26. Intraductal in-situ Carcinoma

27. Lobular Carcinoma

28. Intraduct Carcinoma-in-situ

29. Intraduct Carcinoma

30. Lymphatic spread – Peu-de Orange..

31. Spread of Breast Carcinoma:

32. Pagets Disease

33. Pagets Disease (Epidermal invasion)

36. Estrogen receptor (ER) in nuclei

37. Immunoperoxidase Positivity Neg 1+ 2+ 3+

38. Stag Definition 5-year Surv (%) 7-year Surv (%) I Tumor 2 cm or less without spread 96 92 II Tumor 2-5cm with regional lymph node involvement but without distant metastases, OR > 5 cm in diameter without spread 81 71 III Any size with skin/chest wall fixation, & axillary or internal mammary nodal involvement, without distant metastases 52 39 IV Tumor of any size with or without regional spread but with evidence of distant metastases 18 11