The study evaluated 1,349 knee radiographs from 1,192 patients to determine the incidence and distribution of dorsal defects of the patella. The key findings were:
1. Dorsal defects of the patella were present in about 1% of the population studied (13 cases out of 1,349 knees).
2. Females were more commonly affected than males (10 females, 4 males).
3. The lesions ranged in age from 17-56 years old and could persist into adulthood.
4. When both knees were available, the defect was bilateral in only one of three affected individuals.
PCMT identifies a large-scale deletion in mitochondrial DNA that indicates undiagnosed prostate cancer. Studies have shown PCMT has 85% sensitivity and 92% negative predictive value, outperforming competitors. PCMT was developed and validated in over 1,700 prostate biopsy samples across 3 stages. A positive PCMT result indicates a need for repeat biopsy, while a negative result allows deferred repeat biopsy for 12-14 months, avoiding unnecessary procedures and their costs and risks. PCMT provides early detection of prostate cancer from existing biopsy samples.
Se describe cómo la retina envía señales por más de una vía en el cerebro. La mayor parte de la información viaja a través del tálamo a la corteza visual y luego a las regiones que llevan a cabo el procesamiento consciente. Sin embargo, algunos datos divergen en el centro motor y el núcleo supraquiasmático, el reloj biológico del cuerpo, lo que permite a ciertos individuos ciegos poseer una habilidad inconsciente para sortear obstáculos.
This study investigated the effects of instrument-assisted cross-fiber massage (IACFM) on the healing of medial collateral ligament (MCL) injuries in rats. Rats received either a short course of 9 IACFM treatments over 3 weeks or a longer course of 30 treatments over 10 weeks, applied to the injured left MCL only. At 4 and 12 weeks, the treated and untreated right MCLs were compared biomechanically and histologically. IACFM accelerated healing at 4 weeks as treated ligaments were stronger, stiffer, and absorbed more energy than untreated ligaments. Histology also showed improved collagen formation with IACFM. However, at 12 weeks there were minimal differences between treated and untreated lig
This document discusses anterior knee pain and the patellofemoral joint. It covers the anatomy and biomechanics of the patellofemoral joint. Various imaging methods for assessing the patellofemoral joint are described, including their limitations. A differential diagnosis of anterior knee pain conditions is provided, along with descriptions of pathologies like patellofemoral pain syndrome, lateral patellar dislocation, and osteochondritis dissecans.
1) Male zebra finches were found to respond differently to calls from their mate versus other females depending on their social context. Specifically, males responded much more to their mate's call when with a mated pair compared to when alone or with other unmated males.
2) Previous studies found male zebra finches did not show mate recognition from female calls. However, the new study found female calls contain identifiable acoustic features allowing for individual recognition.
3) The results suggest social context can influence mate recognition in birds, challenging the view that complex social assessments are unique to primates.
1. The cloacal malformation is a rare birth defect where the urinary, genital, and intestinal tracts converge into a single opening, known as the cloaca.
2. The authors reviewed imaging studies and records of 65 patients with cloacal malformation seen over 20 years to describe the spectrum of abnormalities.
3. Adequate preoperative planning requires precise radiological definition of the abnormal anatomy using imaging studies like cystoscopy, sonography, voiding cystourethrography, and MR imaging to discover coexisting anomalies and plan diversion of the fecal stream.
This summary provides the key details from the document in 3 sentences:
The document discusses several recent scientific studies, including the discovery of two Saturn-sized planets orbiting a star, a clinical trial showing success for a targeted skin cancer drug, and research finding that nets of DNA and proteins in blood vessels help fight infection and provide a scaffold for blood clots. It also summarizes studies on lobster behavior, vision restoration using artificial corneas, tree death in the Amazon, and more. The research highlights cover topics in astronomy, cancer biology, animal behavior, tissue engineering, ecology, and other fields.
1) Researchers used CT scans and finite element modeling to create a highly accurate 3D biomechanical model of the Allosaurus skull.
2) The model showed that forces during feeding were distributed throughout the skull. Bite forces were surprisingly low compared to estimates for Tyrannosaurus rex, indicating Allosaurus had a different feeding strategy of inflicting rapid bites to soft tissues.
3) Contrary to views of its skull being delicate, the analysis found the Allosaurus skull was strongly built to absorb forces from prey impacts and tooth dragging, though its exact adaptations require more study.
PCMT identifies a large-scale deletion in mitochondrial DNA that indicates undiagnosed prostate cancer. Studies have shown PCMT has 85% sensitivity and 92% negative predictive value, outperforming competitors. PCMT was developed and validated in over 1,700 prostate biopsy samples across 3 stages. A positive PCMT result indicates a need for repeat biopsy, while a negative result allows deferred repeat biopsy for 12-14 months, avoiding unnecessary procedures and their costs and risks. PCMT provides early detection of prostate cancer from existing biopsy samples.
Se describe cómo la retina envía señales por más de una vía en el cerebro. La mayor parte de la información viaja a través del tálamo a la corteza visual y luego a las regiones que llevan a cabo el procesamiento consciente. Sin embargo, algunos datos divergen en el centro motor y el núcleo supraquiasmático, el reloj biológico del cuerpo, lo que permite a ciertos individuos ciegos poseer una habilidad inconsciente para sortear obstáculos.
This study investigated the effects of instrument-assisted cross-fiber massage (IACFM) on the healing of medial collateral ligament (MCL) injuries in rats. Rats received either a short course of 9 IACFM treatments over 3 weeks or a longer course of 30 treatments over 10 weeks, applied to the injured left MCL only. At 4 and 12 weeks, the treated and untreated right MCLs were compared biomechanically and histologically. IACFM accelerated healing at 4 weeks as treated ligaments were stronger, stiffer, and absorbed more energy than untreated ligaments. Histology also showed improved collagen formation with IACFM. However, at 12 weeks there were minimal differences between treated and untreated lig
This document discusses anterior knee pain and the patellofemoral joint. It covers the anatomy and biomechanics of the patellofemoral joint. Various imaging methods for assessing the patellofemoral joint are described, including their limitations. A differential diagnosis of anterior knee pain conditions is provided, along with descriptions of pathologies like patellofemoral pain syndrome, lateral patellar dislocation, and osteochondritis dissecans.
1) Male zebra finches were found to respond differently to calls from their mate versus other females depending on their social context. Specifically, males responded much more to their mate's call when with a mated pair compared to when alone or with other unmated males.
2) Previous studies found male zebra finches did not show mate recognition from female calls. However, the new study found female calls contain identifiable acoustic features allowing for individual recognition.
3) The results suggest social context can influence mate recognition in birds, challenging the view that complex social assessments are unique to primates.
1. The cloacal malformation is a rare birth defect where the urinary, genital, and intestinal tracts converge into a single opening, known as the cloaca.
2. The authors reviewed imaging studies and records of 65 patients with cloacal malformation seen over 20 years to describe the spectrum of abnormalities.
3. Adequate preoperative planning requires precise radiological definition of the abnormal anatomy using imaging studies like cystoscopy, sonography, voiding cystourethrography, and MR imaging to discover coexisting anomalies and plan diversion of the fecal stream.
This summary provides the key details from the document in 3 sentences:
The document discusses several recent scientific studies, including the discovery of two Saturn-sized planets orbiting a star, a clinical trial showing success for a targeted skin cancer drug, and research finding that nets of DNA and proteins in blood vessels help fight infection and provide a scaffold for blood clots. It also summarizes studies on lobster behavior, vision restoration using artificial corneas, tree death in the Amazon, and more. The research highlights cover topics in astronomy, cancer biology, animal behavior, tissue engineering, ecology, and other fields.
1) Researchers used CT scans and finite element modeling to create a highly accurate 3D biomechanical model of the Allosaurus skull.
2) The model showed that forces during feeding were distributed throughout the skull. Bite forces were surprisingly low compared to estimates for Tyrannosaurus rex, indicating Allosaurus had a different feeding strategy of inflicting rapid bites to soft tissues.
3) Contrary to views of its skull being delicate, the analysis found the Allosaurus skull was strongly built to absorb forces from prey impacts and tooth dragging, though its exact adaptations require more study.
Evolution is the process of change over generations in a population of organisms. Popular belief prior to Darwin was that species were fixed, but some scientists proposed gradual change to fit environments. Darwin's theory of evolution by natural selection proposed that variation within populations and inheritance of traits with differential survival and reproduction could result in evolution of species over time. Modern synthesis combined Darwin's natural selection with genetics and population thinking.
This document summarizes research analyzing the skeletal remains of Homo floresiensis (LB1) discovered on the Indonesian island of Flores in 2003. Studies of the wrist, shoulder, and skull bones find that LB1 differs significantly from modern humans and Neanderthals in ways that are more similar to early hominins and great apes. This includes features of the trapezoid, capitate, and scaphoid wrist bones, as well as low humeral torsion and short clavicles in the shoulder. Analysis of the skull shows it clusters with archaic Homo species and is distinct from microcephalic humans. Overall, the evidence from multiple bones supports classifying Homo floresiensis as
This document discusses Pavel Pevzner's work on genome rearrangements from an evolutionary and computational perspective. It addresses three main controversies: (1) whether primate, rodent, and carnivore lineages split in a certain order, (2) whether rearrangement hotspots exist in genomes or if rearrangements are random, and (3) debates around the whole genome duplication hypothesis in yeast. The document outlines the arguments on both sides of these controversies and how computational analyses helped resolve, or continue, each debate over time.
This document discusses Pavel Pevzner's research on genome rearrangements from an evolutionary perspective. It explores three main evolutionary controversies: 1) the divergence order of primates, rodents, and carnivores, 2) the existence of rearrangement hotspots in genomes, and 3) whether whole genome duplications occurred in early eukaryotic evolution. For each controversy, the document outlines the opposing views, evidence presented by various studies over time, and how the debates were ultimately resolved (or not resolved in some cases).
This study evaluated the use of real-time ultrasound in diagnosing congenital hip dislocation and dysplasia in infants. The researchers examined 131 hips in 104 patients, finding real-time ultrasound to be reliable and accurate with few false positives or negatives. Ultrasound clearly images cartilaginous structures in the infant hip joint that are poorly visualized on radiographs. The advantages of ultrasound are that it is non-invasive, portable, and does not use radiation. The researchers conclude that ultrasound is a useful adjunct to radiography in diagnosing instability and abnormalities in the infant hip.
This document summarizes an analysis of skeletal remains from three archaeological sites in the San Francisco Bay Area: SFr-7, Ala-342, and Ala-329. The analysis compared dental attrition, vertebral osteophytosis, cranial trauma, and post-cranial trauma between the sites. Differences in dental attrition and vertebral osteophytosis were likely due to differences in diet and environment between coastal and inland sites. Rates of cranial and post-cranial trauma varied between sites and samples, but were inconclusive about levels of interpersonal violence due to small sample sizes and poor provenience of remains. More research is needed to make accurate comparisons between sites over time.
Physical anthropology involves studying human physical variation and evolution through metrics like osteology, anthropometry, and primatology. Cultural anthropology examines human cultures and customs. Together, these fields seek to understand humans and human ancestors through skeletal remains, comparative studies of living primates, and observations of cultural practices.
Our backs are like superheroes, holding us up and helping us move around. But sometimes, even superheroes can get hurt. That’s where slip discs come in.
One health condition that is becoming more common day by day is diabetes.
According to research conducted by the National Family Health Survey of India, diabetic cases show a projection which might increase to 10.4% by 2030.
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
share - Lions, tigers, AI and health misinformation, oh my!.pptxTina Purnat
• Pitfalls and pivots needed to use AI effectively in public health
• Evidence-based strategies to address health misinformation effectively
• Building trust with communities online and offline
• Equipping health professionals to address questions, concerns and health misinformation
• Assessing risk and mitigating harm from adverse health narratives in communities, health workforce and health system
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptxHolistified Wellness
We’re talking about Vedic Meditation, a form of meditation that has been around for at least 5,000 years. Back then, the people who lived in the Indus Valley, now known as India and Pakistan, practised meditation as a fundamental part of daily life. This knowledge that has given us yoga and Ayurveda, was known as Veda, hence the name Vedic. And though there are some written records, the practice has been passed down verbally from generation to generation.
Evolution is the process of change over generations in a population of organisms. Popular belief prior to Darwin was that species were fixed, but some scientists proposed gradual change to fit environments. Darwin's theory of evolution by natural selection proposed that variation within populations and inheritance of traits with differential survival and reproduction could result in evolution of species over time. Modern synthesis combined Darwin's natural selection with genetics and population thinking.
This document summarizes research analyzing the skeletal remains of Homo floresiensis (LB1) discovered on the Indonesian island of Flores in 2003. Studies of the wrist, shoulder, and skull bones find that LB1 differs significantly from modern humans and Neanderthals in ways that are more similar to early hominins and great apes. This includes features of the trapezoid, capitate, and scaphoid wrist bones, as well as low humeral torsion and short clavicles in the shoulder. Analysis of the skull shows it clusters with archaic Homo species and is distinct from microcephalic humans. Overall, the evidence from multiple bones supports classifying Homo floresiensis as
This document discusses Pavel Pevzner's work on genome rearrangements from an evolutionary and computational perspective. It addresses three main controversies: (1) whether primate, rodent, and carnivore lineages split in a certain order, (2) whether rearrangement hotspots exist in genomes or if rearrangements are random, and (3) debates around the whole genome duplication hypothesis in yeast. The document outlines the arguments on both sides of these controversies and how computational analyses helped resolve, or continue, each debate over time.
This document discusses Pavel Pevzner's research on genome rearrangements from an evolutionary perspective. It explores three main evolutionary controversies: 1) the divergence order of primates, rodents, and carnivores, 2) the existence of rearrangement hotspots in genomes, and 3) whether whole genome duplications occurred in early eukaryotic evolution. For each controversy, the document outlines the opposing views, evidence presented by various studies over time, and how the debates were ultimately resolved (or not resolved in some cases).
This study evaluated the use of real-time ultrasound in diagnosing congenital hip dislocation and dysplasia in infants. The researchers examined 131 hips in 104 patients, finding real-time ultrasound to be reliable and accurate with few false positives or negatives. Ultrasound clearly images cartilaginous structures in the infant hip joint that are poorly visualized on radiographs. The advantages of ultrasound are that it is non-invasive, portable, and does not use radiation. The researchers conclude that ultrasound is a useful adjunct to radiography in diagnosing instability and abnormalities in the infant hip.
This document summarizes an analysis of skeletal remains from three archaeological sites in the San Francisco Bay Area: SFr-7, Ala-342, and Ala-329. The analysis compared dental attrition, vertebral osteophytosis, cranial trauma, and post-cranial trauma between the sites. Differences in dental attrition and vertebral osteophytosis were likely due to differences in diet and environment between coastal and inland sites. Rates of cranial and post-cranial trauma varied between sites and samples, but were inconclusive about levels of interpersonal violence due to small sample sizes and poor provenience of remains. More research is needed to make accurate comparisons between sites over time.
Physical anthropology involves studying human physical variation and evolution through metrics like osteology, anthropometry, and primatology. Cultural anthropology examines human cultures and customs. Together, these fields seek to understand humans and human ancestors through skeletal remains, comparative studies of living primates, and observations of cultural practices.
Our backs are like superheroes, holding us up and helping us move around. But sometimes, even superheroes can get hurt. That’s where slip discs come in.
One health condition that is becoming more common day by day is diabetes.
According to research conducted by the National Family Health Survey of India, diabetic cases show a projection which might increase to 10.4% by 2030.
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
share - Lions, tigers, AI and health misinformation, oh my!.pptxTina Purnat
• Pitfalls and pivots needed to use AI effectively in public health
• Evidence-based strategies to address health misinformation effectively
• Building trust with communities online and offline
• Equipping health professionals to address questions, concerns and health misinformation
• Assessing risk and mitigating harm from adverse health narratives in communities, health workforce and health system
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptxHolistified Wellness
We’re talking about Vedic Meditation, a form of meditation that has been around for at least 5,000 years. Back then, the people who lived in the Indus Valley, now known as India and Pakistan, practised meditation as a fundamental part of daily life. This knowledge that has given us yoga and Ayurveda, was known as Veda, hence the name Vedic. And though there are some written records, the practice has been passed down verbally from generation to generation.
Does Over-Masturbation Contribute to Chronic Prostatitis.pptxwalterHu5
In some case, your chronic prostatitis may be related to over-masturbation. Generally, natural medicine Diuretic and Anti-inflammatory Pill can help mee get a cure.
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2. 340 JOHNSON AND BROGDON AJR:139, August 1982
A B
Fig. 1 -Frontal (A) and lateral (B) projections of patella show characteristic dorsal defect (arrows) of patella in typical location. This was an incidental
finding in a 21-year-old white man with mid-shaft fracture of ipsilateral femur.
mace. over a period of observation [2, 4]. In other individuals, as
A fabella was found in 1 28 (1 0%) of 1 304 knees. The our series shows, dorsal defect of the patella may persist
youngest patient with a fabella was 1 4 years; the oldest 83. late into adult life. This is not surprising and is somewhat
When ascertainable, bilaterality was found in 24 (83%) of analogous to the multipartite patella, wherein many individ-
29 individuals. uals start with multiple ossification centers in the patella, but
only a few will demonstrate a multipartite patella as an adult.
Histologic material, in the few cases biopsied [4, 5], has
Discussion not been helpful in elucidating the etiology of dorsal defect
Our findings with respect to multipartite patellae and of the patella, showing primarily nonspecific fibrous tissue
fabellae are consistent with other reports and seem to with no evidence of inflammation or specific reaction.
confirm the validity of our series [6-8]. Thus, in virtually all cases, the dorsal defect of the patella
Our discovery of 1 3 cases of dorsal defect of the patella can be confidently identified and diagnosed in about one of
in 1 349 knees demonstrates an incidence of that lesion in every 1 00 individuals. Ordinarily, no further investigation,
1% of the population. All of the cases tabulated fit the procedure, on treatment will be indicated or necessary.
radiographic description of dorsal defect of the patella, and
no other differential diagnosis was entertained seriously in ACKNOWLEDGMENT
any of them. Three other possible or probable cases were We thank Donald E. Herbert for statistical analysis of some of the
not counted because the defect conceivably could be attnib- data.
uted to degenerative arthritis in two patients and to a brown
tumor of hypempamathymoidism in the other. Contrary to other REFERENCES
published series, we found a predilection of the lesion for
1 . Caffey J. Pediatric x-ray diagnosis, 6th ed. Chicago: Year Book
females (level of significance = 0.05).
Medical, 1972:943
Our experience that three-fourths of the cases of dorsal
2. Keats TE. An atlas of normal roentgen variants, 1 st ed. Chi-
defect of the patella were discovered fortuitously is con-
cago: Year Book Medical, 1973:200
sistent with others. One patient with long-standing com- 3. Goergen TG, Resnick D, Greenway G, Saltzstein SL. Dorsal
plaints refenmable to the right knee underwent a normal defect ofthe patella (DDP): a characteristic radiographic lesion.
arthmoscopy, and the asymptomatic knee was found to con- Radiology 1 979; 1 30 : 333-336
tam an identical lesion. The other two symptomatic patients 4. Haswell DM, Berne AS, Graham CB. The dorsal defect of the
had vague arthnalgias not limited to the affected knee. In patehla. Pediatr Radio! 1 976:4 : 238-242
only one reported case [5] was the defect thought to be 5. Hunter LY, Hensinger RN. Dorsal defect of the patella with
directly related to the patient’s symptoms. cartilagenous involvement: a case report. Clin Orthop
1975;1 10:131 -132
The etiology of dorsal defect of the patella is not known.
6. Ficat AP, Hungerford DS. Disorders ofthe pate!lo-femora! joint.
That it is simply a developmental alteration of the epiphysis
Baltimore: Williams & Wilkins, 1977:56-57
with delayed or failed ossification is the most attractive
7. Smillie IS. Diseases of the knee joint, 2d ed. New York:
possibility. The occurrence of the lesion in that area of the Churchill-Livingston, 1980:49-50
patella most prone to irregularity on multiplicity of ossifica- 8. Friedman AC, Naidich TP. The fabella sign: fabella displace-
tion centers seems to further support this possibility. Some ment in synovial effusion and pophiteal fossa masses. Radiology
dorsal defects have shown evidence of healing or filling-in 1978;127:113-121