Discussion on Papillary carcinoma thyroid - category, types with definitions, other DD for pap ca thyroid along with a whole lot of beautiful cytology pictures - a feast to the eyes
Brainstem
Last part of brain
The medulla oblongata or simply medulla is a long stem-like structure which makes up the lower part of the brainstem.[1] It is anterior and partially inferior to the cerebellum. It is a cone-shaped neuronal mass responsible for autonomic (involuntary) functions, ranging from vomiting to sneezing.[2] The medulla contains the cardiac, respiratory, vomiting and vasomotor centers, and therefore deals with the autonomic functions of breathing, heart rate and blood pressure as well as the sleep wake cycle.
During embryonic development, the medulla oblongata develops from the myelencephalon. The myelencephalon is a secondary vesicle which forms during the maturation of the rhombencephalon, also referred to as the hindbrain.
The bulb is an archaic term for the medulla oblongata.[1] In modern clinical usage, the word bulbar (as in bulbar palsy) is retained for terms that relate to the medulla oblongata, particularly in reference to medical conditions. The word bulbar can refer to the nerves and tracts connected to the medulla, and also by association to those muscles innervated, such as those of the tongue, pharynx and larynx.
Brainstem
Last part of brain
The medulla oblongata or simply medulla is a long stem-like structure which makes up the lower part of the brainstem.[1] It is anterior and partially inferior to the cerebellum. It is a cone-shaped neuronal mass responsible for autonomic (involuntary) functions, ranging from vomiting to sneezing.[2] The medulla contains the cardiac, respiratory, vomiting and vasomotor centers, and therefore deals with the autonomic functions of breathing, heart rate and blood pressure as well as the sleep wake cycle.
During embryonic development, the medulla oblongata develops from the myelencephalon. The myelencephalon is a secondary vesicle which forms during the maturation of the rhombencephalon, also referred to as the hindbrain.
The bulb is an archaic term for the medulla oblongata.[1] In modern clinical usage, the word bulbar (as in bulbar palsy) is retained for terms that relate to the medulla oblongata, particularly in reference to medical conditions. The word bulbar can refer to the nerves and tracts connected to the medulla, and also by association to those muscles innervated, such as those of the tongue, pharynx and larynx.
Includes all the basic concepts about cell - morphology, prokaryotic vs eukaryotic, cell organelles and its functions, methods of division and commonly encountered anomalies.
Includes all the basic concepts about cell - morphology, prokaryotic vs eukaryotic, cell organelles and its functions, methods of division and commonly encountered anomalies.
Similar to Papillary Carcinoma thyroid cytology.pptx (20)
An array of presentation of lymphoma spillover in the peripheral smear and bone marrow. All types of lymphomas are discussed along with a bouquet of HPE pictures
Discussion on types, pathogenesis of hypersensitivity. Referred from Robbins 10th edition. Prepared by a pathology Postgraduate for 2nd year MBBS students
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
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Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
2. CASE HISTORY
A 65 YEAR OLD MALE CAME WITH A COMPLAINT OF SWELLING IN THE
ANTERIOR ASPECT OF NECK FOR PAST 6 MONTHS
NOT ASSOCIATED WITH PAIN
INCREASING IN SIZE RAPIDLY
4. PAST HISTORY
TOTAL THYROIDECTOMY WITH MODIFIED RADICAL NECK DISSECTION
DONE 7 YEARS BACK
PATIENT WAS ON TAB ELTROXIN 100 MCG 1 – 0 – 0 OD
DISCONTINUED SUPPRESSIVE DOSE DUE TO COVID PANDEMIC
27. FOLLICULAR VARIANT
COMPLETELY OR ALMOST COMPLETELY
COMPOSED OF SMALL- TO MEDIUM-
SIZED FOLLICLES LINED BY CELLS WITH
VARIABLE NUCLEAR FEATURES OF PTC.
29. MACROFOLLICULAR VARIANT
>50% OF THE FOLLICLES ARE
ARRANGED AS MACROFOLLICLES
MORE THAN 200 ΜM IN DIAMETER
SUBTLE PTC FEATURES
NO PAPILLAE
NO PSAMOMMA BODIES
ABUNDANT COLLOID
31. ONCOCYTIC VARIANT
• NUCLEAR CHANGES
CHARACTERISTIC OF PTC
• COMPOSED
PREDOMINANTLY OF
ONCOCYTIC CELLS WITH
VARIABLE ARCHITECTURE
• WARTHIN – LIKE VARIANT
• ONCOCYTES
• LYMPHOCYTES
32. TALL CELL VARIANT
• AGGRESSIVE FORM OF PTC
• ELONGATED (“TALL”) TUMOR CELLS
• HEIGHT IS AT LEAST THREE TIMES
THEIR WIDTH
• ABUNDANT DENSE GRANULAR
CYTOPLASM
• TYPICAL NUCLEAR CHANGES OF PTC
33. COLUMNAR CELL VARIANT
• COLUMNAR CELLS
• HYPERCHROMATIC, OVAL, AND
PSEUDOSTRATIFIED NUCLEI
• SUPRANUCLEAR OR SUBNUCLEAR
CYTOPLASMIC VACUOLES
• REMINISCENT OF A COLONIC
ADENOMA OR SECRETORY-TYPE
ENDOMETRIUM
34. SOLID VARIANT
• PRESENCE OF SOLID AREAS THAT LACK PAPILLAE, FOLLICLES, AND COLLOID
STORAGE
• OCCUPY AT LEAST 50% OF THE LESION
• THE NEOPLASTIC CELLS HAVE TYPICAL NUCLEAR FEATURES OF PTC.
35. DIFFUSE SCLEROSING VARIANT
• DIFFUSE INVOLVEMENT OF ONE OR BOTH THYROID
LOBES
• EXTENSIVE LYMPHOVASCULAR INVASION
• NUMEROUS PSAMMOMA BODIES
• SQUAMOUS METAPLASIA
• MARKED LYMPHOCYTIC INFILTRATION
• PROMINENT FIBROSIS
36. CRIBRIFORM MORULAR VARIANT
• CRIBRIFORM AND SOLID ARCHITECTURE
LACKING COLLOID
• TALL AND COLUMNAR OR SPINDLE SHAPED
CELLS & SQUAMOID MORULES
• NUCLEI - HYPERCHROMATIC &
PSEUDOSTRATIFIED
• TYPICAL NUCLEAR FEATURES OF PTC
• NUCLEAR CLEARING CAUSED BY BIOTIN
ACCUMULATION (MORULES)
37. HOBNAIL VARIANT
• LOSS OF CELLULAR POLARITY/COHESIVENESS
• APICALLY PLACED NUCLEI AND BULGING OF THE APICAL CELL
SURFACE
• >30% OF NEOPLASTIC CELLS.
39. HYALINIZING TRABECULAR ADENOMA
• RARE TUMOUR
• FOLLICULAR CELL ORIGIN
• TRABECULAR GROWTH
• MARKED INTRATRABECULAR
HYALINIZATION
• NUCLEAR CHANGES OF PAP CA
40. HURTHLE CELL ATYPIA IN LYMPHOCYTIC
THYROIDITIS
• REACTIVE ATYPIA
• MARKED NUCLEAR
PLEOMORPHISM
• CROWDING & OVERLAPPING
• PALE CHROMATIN
• SMALL NUCLEOLI
• ?ONCYTIC VARIANT OF PAP CA
46. SUSPICIOUS OF MALIGNANCY
• POSITIVE PREDICTIVE VALUE – 60 – 75%
• CELLULAR
• NUCLEI – ENLARGED, ROUND
• POWDER CHROMATIN
• NUCLEAR GROOVES
• SMALL DISTINCT NUCLEOLI
• FOLLICULAR VARIANTS PAP CA PRESENT
AS SOM
47. REFERENCES
• ORELL & STERRETTS FINE NEEDLE ASPIRATION CYTOLOGY 5TH
EDITION
• DIAGNOSTIC CYTOLOGY, PRANAB DEY
• BIBBO M., WILBUR D. COMPREHENSIVE CYTOPATHOLOGY
• THE BETHESDA SYSTEM FOR REPORTING THYROID PATHOLOGY
• ATLAS OF THYROID CYTOPATHOLOGY, SYED Z ALI
• COMMON DIAGNOSTIC PITFALLS IN THYROID CYTOPATHOLOGY
