Phospholipid peroxidation and beta-amyloid oxidative stress are the two major factors that lead to Alzheimer's disease according to this review. Isoprostanes play a key role in oxidizing phospholipids in the brain. Experimental results show that lipid peroxidation in the brain from beta-amyloid oxidative stress can potentially damage brain tissue and lead to the development of Alzheimer's disease. The review concludes that these findings are relevant to society's health and advances in medicine for understanding and treating Alzheimer's.