disconnection approach

1. Topic:
Disconnection approach and its guidelines
PREPARED BY:
RIMSHA BAKHTAWAR RASHEED
MSC CHEMISTRY
10-5-2021

2. Disconnection approach
• Imaginary breaking of a molecule into its component parts like this is known
as disconnection.
• Disconnection are the reverse of synthesis reaction and for every
disconnection we must have a real and workable reaction in mind for
effecting the corresponding reconnection.

4. EXAMPLE: 1

7. Example
Synthons
Synthetic Equivalents
-

9. 2. Disconnection next to Aromatic ring should not be the priority
Synthons
Synthetic Equivalents

10. Synthons
Synthetic Equivalents
EXAMPLE

11. 3.Disconnect reactive group first
Synthon
Synthetic Equivalents