This document provides a guide for healthcare professionals on detecting oral cancer. It details that oral and pharyngeal cancer results in 30,000 new cases and 8,000 deaths annually in the United States, with a 5-year survival rate of 50% if detected early. It describes common warning signs, risk factors, and types of potentially cancerous oral lesions. The guide outlines the process for conducting an oral cancer screening exam, including extraoral and intraoral inspection of tissues and lymph nodes. It emphasizes focusing screening efforts on high risk areas of the tongue, floor of mouth, and lips and educating patients on signs and symptoms of oral cancer.