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Dr .Anand.M.Tiwari
Head of dept. ICU wanowarie
Critical care medicine,and emergency
physician
Ruby hall clinic
Times of India
 Confirming the presence
of poisonous pesticides
in the midday meal, the
Forensic Science
Laboratory (FSL) said the
contaminated food
contained
monocrotophos, an
organophosphate
insecticide, after experts
examined samples of oil
from the container, food
remains on the platter
and remains of food
items in the utensils.
Pesticide regulations
?
introduction
Organophosphate-diazinon, chlopyriphos, malathion
Carbamate-aldicarb, carbaryl, propoxur
nerve gases (sarin, soman, tabun, VX)
Poisons and medicines are often the same substance
given with different intents.
--Peter Latham (1865)
Reasons---
product mislabeling; label misreading; mistaken
identification of unlabeled chemicals; uninformed
self-medication;
attempted suicide (deliberate self-harm) is the most
common reason for intentional exposure
Tokyo subway incidenceIn the Monday morning rush hour of
March 20, five cult members boarded
different subway trains converging on
central Tokyo.
Four of them each carried two plastic
bags loaded with sarin, and the fifth had
three bags.
At nearly the same moment, they each
dropped the bags to the floor of the jam-
packed train and punctured them with a
specially sharpened umbrella tip. The
cultists then quickly stepped
off the trains as they pulled into the next
station. Getaway drivers were waiting
outside the station for each of them.
10
O .P . Poisoning
Highly lipid soluble
Commonly available poison
Manifestations due to….M, N,CNS actions
“Death due to respiratory failure”
Cholinergic------
SLUDGE-M
Nicotinic--
fasciculation
Central effects
Confusion
Seizures,coma
1-4 DAYS
Fention
Malthion
Diaznion
trichorofan
Management---
Decontamination
atropine
OXIMES
Life support
Ventilator support
FASTHUG
Control of seizures
Oximes
Have
NULL
effect or
possible
harm
Review mcq-
All of the following are signs of acetylcholinesterase
inhibitor toxicity EXCEPT
(A) miosis
(B) salivation
(C) diarrhea
(D) muscle fasciculations
(E) anhydrosis
Match the following
Poisoning Antidote
Paracetamol
OPIOIDS
ASPIRIN(SALICYLATE)
METHANOL
TRICYCLIC ANTIDEPRESSANT
CYANIDE
Amyl nitrate ,sodium nitrite,
Sodium thiosulphite
FAD
BICARBONATES
NALOXONE
NAC
FOMEPIZOLE
EHTANOL
Thank you
Slides available on
 dr.Anand .Tiwari Presentations.
Slide share.net.
dranandtiwari@gmail.com
 In case of help pl contact.=9822545093

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Pesticide Regulations

Editor's Notes

  1. In order for nerve impulses to reach muscles, acetylcholine is released to act as a neurotransmitter at the neuromuscular junction. This allows the nerve impulse to “fire” across the neuromuscular junction. After the acetylcholine has done it’s job, it is critical for it to be deactivated by the enzyme acetylcholinesterase. Otherwise uncontrolled nerve impulses occur. By inhibiting the function of acetylcholinesterase, nerve agents cause various organ systems to be over-stimulated and go “haywire”. The systems most commonly affected include the skeletal muscles, smooth muscles, exocrine glands, and some nerves in both the central nervous system and the ganglia. Once the acetylcholinesterase has been inhibited, the effect cannot be reversed without the medication, Pralidoxime (2-Pam).