The document discusses the goals and challenges of the OpenWorm project, which aims to create a complete multi-scale simulation of the roundworm C. elegans. The simulation would model the worm at various levels, from individual cells and neurons to its whole body and environment. The goals are to better understand the worm and extract general design principles from biological systems that could be applied to modeling the human body. Key challenges include integrating models of the worm's genome, cells, tissues, nervous system, behavior and environment across multiple scales of size and time.
13. Enter the worm: c. elegans I’ve only got 1000 cells in my whole body… please simulate me!
14. A complete simulation of the worm’s brain, body and environment Simulated World Detailed simulation of worm body Detailed simulation of cellular activity
15. The goal: understanding a faithfully simulated organism end to end Extracting mathematical principles from biological systems is necessary if we are going to understand and reconstruct the much larger system of the human.
37. Neuronal model GPU Performance Testing: 302 Hodgkin-Huxley neurons for 140 ms (dt = 0.01ms) Architecture proof of concept using Hodgkin-Huxley neurons ms
51. Cell Body Cell Body Cell Body Cell Body Cell Body Cell Body Cell Body Cell Body Cell Body Cell Body Cell Body Cell Body Quadrant 1 Quadrant 2 Quadrants of muscle cells