Shot note on ocular drug delivery system

1. IPS SAGE UNIVERSITY,INDORE
OCULAR DRUG DELIVERY
SYSTEM (ODDS)
Submitted To:-
Professor Sunayana Rathore
Institute of pharmacutical
sciences
Submitted by:- Dharmendra Chodhary,
Harsh Patel,
Mayank Choudhary
And Hemant Patel
Class :-B.Pharmacy 7th Semester
4th Year

2. IPS SAGE UNIVERSITY,INDORE
Introduction
Ocular Drug Delivery System (ODDS)
They are specialized dosage form designed to be
instilled into the external surface of eye (topical)
administered inside (intraocular) adjacent (preocular )
to eye.
They novel approch of drug delivery system in which
drug can instilled on the cull de sac cavity of eye is
know as occular drug delivery system.
Note:- cull de sac cavity - the space between eye lids
and eye bolls.
Exmple:- Most commonly-solution, suspension and
ointment

3. IPS SAGE UNIVERSITY,INDORE
Advantage
It provide sustained and controlled drug delivery.
It increase occular bioavalability of drug.
It bypass the protective barrier of eye.
It can esily adminstered by patient himself.

4. IPS SAGE UNIVERSITY,INDORE
Disadvantage
It show poor bioavalability.
It requres preservatives.
It cause interfrance with vision.
The drug solution not stay long time in eye.

5. IPS SAGE UNIVERSITY,INDORE
Intraocular Barriers
01:- Drug Loss Form The Ocular Surface
After instillation,the lacrimal fluid remove instilled drug from
the surface of eye.
02:-Lacrimal Fluid Eye Barrier
The epithelium layer of cornea restrict drug absorption from
the lacrimal fulid in ti eye.

6. IPS SAGE UNIVERSITY,INDORE
03:-Blood occular Barrier
These barriers have two parts; blood-aqueous humor barrier and
blood –retina barrier.
The anterior blood-ocular barrier is composed of the endothelial
cells in the uvea ,this barrier limits the access of hydrophilic drugs
from plasma into the aqueous humor.
Inflammation may disrupt the integrity of this barrier.

7. IPS SAGE UNIVERSITY,INDORE
Method to overcome
The ocular drug delivery system are formulated
with two main objection-
01:-Bioavaiability
02:-Controlled release

8. IPS SAGE UNIVERSITY,INDORE
01:-Viscous Eye Drop:-
-> Pre corneal residence time -Tes
-> Drug loss due to lcrimal dranage - Reduce
By use of saveral sterterges.
Addition of viscosity enhance.

9. IPS SAGE UNIVERSITY,INDORE
02:-Gel
->Provoid Effective Canket between tormulation and corned surface.
Ex. - Pre –formed gel
- Institute forming gel
Both Tes
Bioavaibility se side Effect.
03:-Prodrug
-> They enhance corneal drug permeability by changing the
hydrophilicity or lipophicity of drug.

10. IPS SAGE UNIVERSITY,INDORE