Mr. Carlos Rivera, President & CEO of Vysnova Partners, Inc, provides an overview of OCONUS operations as an Omnibus participant as well as key success points for supporting DoD support functions for programs overseas.
COBRA/Omnibus 4 Industry Day 2016- Contract Life Cycle (CLC) Performance Anal...Ilka T. De León, MBA
Mr. Jeremiah Couch, Acquisition Specialist for Evolution Enterprises Inc., provides a detailed overview of the Omnibus vendor contract life cycle and performance analysis that serves as a tool to both industry and Government participants.
Dr. John Sanders, CAPT USN (retired) and Professor of Medicine Wake Forest School of Medicine- Chief Section on Infectious Diseases, provides an overview of the capabilities Academia can bring to the Omnibus IV community of performers and collaborations with industry and government.
COBRA/Omnibus 4 Industry Day 2016- Contract Life Cycle (CLC) Price-Cost AnalysisIlka T. De León, MBA
Mr. Phillip Borja, Executive Vice President of Contracts and a Senior Acquisition Manager for Evolution Enterprises Inc, provides an overview of Price-Cost Analysis during performance as an Omnibus industry vendor as well as the implications to government participants
Mr. Brian McCarty, Director Air Force Medical Services, Directorate for Research & Acquisitions AF/SG5, provides an overview of their mission and areas of foci to be supported by COBRA & Omnibus 4 vehicles.
COBRA/Omnibus 4 Industry Day 2016- Air Force Clinical Investigation Programs...Ilka T. De León, MBA
Ms. Nereyda Sevilla, Chief Management Official, Air Force Clinical Investigation Program, Office of the Surgeon General, provides an overview of the AF CIP program, its areas of support and foci, and the experience with Omnibus support.
COBRA/Omnibus 4 Industry Day 2016- Contract Life Cycle (CLC) Performance Anal...Ilka T. De León, MBA
Mr. Jeremiah Couch, Acquisition Specialist for Evolution Enterprises Inc., provides a detailed overview of the Omnibus vendor contract life cycle and performance analysis that serves as a tool to both industry and Government participants.
Dr. John Sanders, CAPT USN (retired) and Professor of Medicine Wake Forest School of Medicine- Chief Section on Infectious Diseases, provides an overview of the capabilities Academia can bring to the Omnibus IV community of performers and collaborations with industry and government.
COBRA/Omnibus 4 Industry Day 2016- Contract Life Cycle (CLC) Price-Cost AnalysisIlka T. De León, MBA
Mr. Phillip Borja, Executive Vice President of Contracts and a Senior Acquisition Manager for Evolution Enterprises Inc, provides an overview of Price-Cost Analysis during performance as an Omnibus industry vendor as well as the implications to government participants
Mr. Brian McCarty, Director Air Force Medical Services, Directorate for Research & Acquisitions AF/SG5, provides an overview of their mission and areas of foci to be supported by COBRA & Omnibus 4 vehicles.
COBRA/Omnibus 4 Industry Day 2016- Air Force Clinical Investigation Programs...Ilka T. De León, MBA
Ms. Nereyda Sevilla, Chief Management Official, Air Force Clinical Investigation Program, Office of the Surgeon General, provides an overview of the AF CIP program, its areas of support and foci, and the experience with Omnibus support.
COBRA/Omnibus 4 Industry Day 2016- Navy Marine Corps Public Health Center (NM...Ilka T. De León, MBA
Mr. William Calvert, Deputy Director - Population Health, for the Navy Marine Corps Public Health Center (NMCPHC), provides a Command overview reflecting on his areas of foci and Omnibus participation.
COBRA/Omnibus 4 Industry Day 2016- OMNIBUS IV CONTRACT OVERVIEWIlka T. De León, MBA
Mr. Mike D'Alessandro provides an overview of the timeline and requirements for proposal submission on Omnibus IV the DoD's first $1B medical research and development support vehicle.
Early Payment Discounts: Market Trends and Results at BC Hydro SAP Ariba
When organizations streamline invoice processing, a new opportunity emerges with early payment discounts, and the costs savings can be significant – often greater than the operational savings. In this session, Hackett Group analyst Amy Fong will examine discount management strategies and market trends, and BC Hydro will discuss its early payment discount program and the value that these discounts deliver to the business.
SMART Modular’s Collaboration with Direct Materials Suppliers for Instant Sup...SAP Ariba
As manufacturers become more reliant on their direct materials suppliers, manufacturing and supply chain processes become more iterative and aligned with suppliers. Join this session to hear a leading manufacturer in a highly dynamic industry discuss how to incorporate supplier collaboration in manufacturing plans.
Marketplaces are increasingly important for business-to-business (B2B) buying and selling. But how do you enforce procurement policies without the right access, filters, and control? This must-attend session will teach you how to rationalize your supply chain, simplify nonsourced buying, and augment and replace outdated and overpriced catalogs. The panel will feature experts from the SAP Ariba solution innovation team, AIG, eBay, and HP.
Harnessing the Power of Personal Brand and Executive PresenceSAP Ariba
Join Co- Founder and CEO of Landit, Lisa Skeete Tatum, for a deep dive look into how managing your executive presence through your personal brand, behavior and relationships with colleagues can help leverage your professional growth. Kirsten Allegri Williams, VP of Corporate Marketing at SAP Ariba will assist in facilitating the interactive session and will offer her own insights into the power of a strong personal brand.
Purchasing, Procurement, Vendor, Contract and RFP Process Management with Sha...Optimus BT
Using the Document management, Collaborative and Self service features of SharePoint to implement a turn key procurement management business solution, that will streamline the procurement process, help you comply with regulations, enable you manage contracts, empower self service and participative procurement, aid in informed procurement decisions, in executing an effective procurement strategy and make your procurement function hassle free. Optimus BT is a leader in providing Procurement software and other turnkey solutions using SharePoint.
10 Ways To Improve Your Purchasing DepartmentKeith Taylor
10 ways to improve your purchasing department. Includes tips from a purchasing and materials management professional with over 22 years experience. www.lbsi.com
CohnReznick Technology and Life Sciences OverviewCohnReznick
Fast moving technology and life sciences companies need an accounting firm that can keep pace with their changing financial objectives. CohnReznick can help you make smarter accounting, tax, and business decisions to keep your company moving forward.
Aagami Technology Licensing PresentationAagami, Inc.
Aagami, Inc., is a life sciences consulting firm offering,
· Technology Licensing
· Strategic Consulting
· Market Intelligence
For Global companies in
· Technology Licensing Office of Universities
· Medical Devices & Technology
· Pharma
· Biotech
· Consumer Healthcare
· CROs, CDMOs
In Brief, Aagami Brings:
· Deep Experience of overcoming business and socio-cultural differences of various countries
· Extensive ‘C’ level network nurtured for over 15 years
· Global Deal making skills, honed for decades
· Partners having combined experience of 250+ years
· Supplementing your bandwidth to save time, effort & cost
75+ Bio Pharma clients globally across 125+ assignments have put their trust in Aagami since 2003.
Succession planning is a concept which is not widely understood in South Africa and often confused with Estate Planning.
Succession Planning itself has different meanings depended on circumstances, in a business environment succession planning can be about the transfer of management or the transfer of ownership, whereas in a family it is about the transfer of Value systems
COBRA/Omnibus 4 Industry Day 2016- Navy Marine Corps Public Health Center (NM...Ilka T. De León, MBA
Mr. William Calvert, Deputy Director - Population Health, for the Navy Marine Corps Public Health Center (NMCPHC), provides a Command overview reflecting on his areas of foci and Omnibus participation.
COBRA/Omnibus 4 Industry Day 2016- OMNIBUS IV CONTRACT OVERVIEWIlka T. De León, MBA
Mr. Mike D'Alessandro provides an overview of the timeline and requirements for proposal submission on Omnibus IV the DoD's first $1B medical research and development support vehicle.
Early Payment Discounts: Market Trends and Results at BC Hydro SAP Ariba
When organizations streamline invoice processing, a new opportunity emerges with early payment discounts, and the costs savings can be significant – often greater than the operational savings. In this session, Hackett Group analyst Amy Fong will examine discount management strategies and market trends, and BC Hydro will discuss its early payment discount program and the value that these discounts deliver to the business.
SMART Modular’s Collaboration with Direct Materials Suppliers for Instant Sup...SAP Ariba
As manufacturers become more reliant on their direct materials suppliers, manufacturing and supply chain processes become more iterative and aligned with suppliers. Join this session to hear a leading manufacturer in a highly dynamic industry discuss how to incorporate supplier collaboration in manufacturing plans.
Marketplaces are increasingly important for business-to-business (B2B) buying and selling. But how do you enforce procurement policies without the right access, filters, and control? This must-attend session will teach you how to rationalize your supply chain, simplify nonsourced buying, and augment and replace outdated and overpriced catalogs. The panel will feature experts from the SAP Ariba solution innovation team, AIG, eBay, and HP.
Harnessing the Power of Personal Brand and Executive PresenceSAP Ariba
Join Co- Founder and CEO of Landit, Lisa Skeete Tatum, for a deep dive look into how managing your executive presence through your personal brand, behavior and relationships with colleagues can help leverage your professional growth. Kirsten Allegri Williams, VP of Corporate Marketing at SAP Ariba will assist in facilitating the interactive session and will offer her own insights into the power of a strong personal brand.
Purchasing, Procurement, Vendor, Contract and RFP Process Management with Sha...Optimus BT
Using the Document management, Collaborative and Self service features of SharePoint to implement a turn key procurement management business solution, that will streamline the procurement process, help you comply with regulations, enable you manage contracts, empower self service and participative procurement, aid in informed procurement decisions, in executing an effective procurement strategy and make your procurement function hassle free. Optimus BT is a leader in providing Procurement software and other turnkey solutions using SharePoint.
10 Ways To Improve Your Purchasing DepartmentKeith Taylor
10 ways to improve your purchasing department. Includes tips from a purchasing and materials management professional with over 22 years experience. www.lbsi.com
CohnReznick Technology and Life Sciences OverviewCohnReznick
Fast moving technology and life sciences companies need an accounting firm that can keep pace with their changing financial objectives. CohnReznick can help you make smarter accounting, tax, and business decisions to keep your company moving forward.
Aagami Technology Licensing PresentationAagami, Inc.
Aagami, Inc., is a life sciences consulting firm offering,
· Technology Licensing
· Strategic Consulting
· Market Intelligence
For Global companies in
· Technology Licensing Office of Universities
· Medical Devices & Technology
· Pharma
· Biotech
· Consumer Healthcare
· CROs, CDMOs
In Brief, Aagami Brings:
· Deep Experience of overcoming business and socio-cultural differences of various countries
· Extensive ‘C’ level network nurtured for over 15 years
· Global Deal making skills, honed for decades
· Partners having combined experience of 250+ years
· Supplementing your bandwidth to save time, effort & cost
75+ Bio Pharma clients globally across 125+ assignments have put their trust in Aagami since 2003.
Succession planning is a concept which is not widely understood in South Africa and often confused with Estate Planning.
Succession Planning itself has different meanings depended on circumstances, in a business environment succession planning can be about the transfer of management or the transfer of ownership, whereas in a family it is about the transfer of Value systems
Talent Management on a global scale is much more than simply a local program on a larger scale. Every organisation with global aspirations needs a global talent management strategy.
Use these 6 critical success factors to ensure your program delivers results.
RISE is a winning team of Global Entrepreneurial Professionals with blend of diversified experience in various sectors and a subsidiary of PI Group.
RISE laid the foundation of stepping stone for the prosperity and well being of mankind through self sustained humanitarian aid and development projects with its allies and investors through PI Plateform.
RISE offers vast selection of project & financial management services to its prestigious clients.
RISE are knowledgeable, well-known financial professionals who guide and provide strategies to support with a better and secure financial future.
RISE are focused to create opportunities where our prestigious clients capitalize their resources at par.
RISE are passionate about the growth of your business and helping you to capitalize future with supreme resources .
May ALLAH Almighty escort the team “THE SUCCESS” and make PIs as bonfire of excellence amongst all.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
2. Introduction
Even though it sounds like there are endless of opportunities; running a
business with international operations has many challenges. Especially
if it is a small or mid size businesses, you are taking a bigger risk than
you think. There are many obstacles when going global.
Furthermore supporting DoD-funded OCONUS Life Science Research
and Public Health programs has additional challenges that need to be
considered.
Nonetheless with proper planning and careful execution you can
operate successful programs OCONUS.
3. Common Challenges
• Corporate Leadership – you must invest significant time and energy
• Legal
• Human resources and labor law compliance
• Countries have laws against some type of sales
• Intellectual property rights
• Ability to operate legally
• Banking
• Data privacy laws
• Human Capital Development (Capacity building across all areas)
• Language and Culture - you must develop cultural savvy prior to
entering the country
4. Common Challenges
• Working Across Time Zone – Must be prepared to have 24-hour
management capabilities and customer care
• Currency – Fluctuations can affect your profitability. Could also lead to
compliance problems.
• Product Delivery
• Unexpected high shipping cost
• Negotiating Customs and Import taxes
• Delays in transit
• Currency
5. Other Considerations
• Human Subject Protection rules (HHS, DOD, and Local)
• IRB Support
• Ensuring Contract Compliance
• Ensuring FAR Compliance
6. Key Success Factors
• Find Local Legal support
• Link with Capable Local Partners
• Make sure that you properly vet local partners
• Take advantage of US Department of Commerce programs (Trade Office)
• Research best practices for local operations
7. Key Success Factors
• Develop operation procedures ahead of time
• Develop verifiable processes for any activity that involves funds
• Understand that local staff are in many cases better qualified to do
the work
• Respect your local partner firms
• Have lots of patience
8. About Vysnova Partners
Vysnova Partners Inc. (Vysnova) is a fast growing firm that partners with
government and commercial clients to deliver professional and technical
services on a worldwide basis. We provide a broad range of professional and
institutional support services across multiple areas which include
management consulting, public/global health, research and development,
and Government Operations & Acquisition Support.
Advancing the health and well-being of communities worldwide is at the
core of Vysnova’s mission. Vysnova’s management team has over 30 years of
experience working within and with US Government organizations. Vysnova'
primary focus is on providing subject matter expertise and institutional
support to its clients.
9. About Vysnova Partners
Our staff has carried project activities working with USG, local institutional
partners, NGOs and/or other implementation partners in the United States and
the following countries:
Botswana, Costa Rica, Cuba, Ethiopia, Guatemala, Honduras, Indonesia,
Japan, Kenya, Lesotho, Liberia, Malawi, Mexico, Namibia, Peru, Philippines,
Puerto Rico, Saudi Arabia, Senegal, Tanzania, Tajikistan, Thailand, Rwanda,
Uganda, UAE, Vietnam, Zambia, and Zimbabwe
Our clients include; Department of Defense, US Agency for International
Development, Department of State, Department of Health and Human
Services, and the Veterans Administration.