Daily minimum nutritional requirements of the critically illRalekeOkoye
Critically ill patients have nutritional needs that are essential in their management. This is a synopsis with specific calculable applications for the daily recommended components of nutrition in critical care.
Appropriate and safe assessment and administration of fuid therapy and nutritional support is of key importance in good surgical practice. It is imperative that the preoperative nutritional state of the patient and the impact of any surgical intervention are taken into account when considering nutritional requirements and the mode of nutrient delivery.
Daily minimum nutritional requirements of the critically illRalekeOkoye
Critically ill patients have nutritional needs that are essential in their management. This is a synopsis with specific calculable applications for the daily recommended components of nutrition in critical care.
Appropriate and safe assessment and administration of fuid therapy and nutritional support is of key importance in good surgical practice. It is imperative that the preoperative nutritional state of the patient and the impact of any surgical intervention are taken into account when considering nutritional requirements and the mode of nutrient delivery.
In the changing scenario of pharmacy practice in India, for successful practice of
Hospital Pharmacy, the students are required to learn various skills like drug distribution,
drug dispensing, manufacturing of parenteral preparations, drug information, patient
counselling, and therapeutic drug monitoring for improved patient care
After this presentation, you should be able to:
Critically evaluate the scientific rationale regarding dietary Na+, P, K+, and fluid restrictions in HD patients, and why these restrictions may be misguided.
Better communicate with HD patients and clinic staff the nuances of these dietary restrictions.
Promote efficacious physical activity programs for hemodialysis patients.
In the changing scenario of pharmacy practice in India, for successful practice of
Hospital Pharmacy, the students are required to learn various skills like drug distribution,
drug dispensing, manufacturing of parenteral preparations, drug information, patient
counselling, and therapeutic drug monitoring for improved patient care
After this presentation, you should be able to:
Critically evaluate the scientific rationale regarding dietary Na+, P, K+, and fluid restrictions in HD patients, and why these restrictions may be misguided.
Better communicate with HD patients and clinic staff the nuances of these dietary restrictions.
Promote efficacious physical activity programs for hemodialysis patients.
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Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
2. • Patients on dialysis are commonly depleted of protein and
energy stores. The degree to which protein and energy depletion
is the result of deficient nutrition or, alternatively, protein and
energy wasting.
• The terminology protein-energy wasting (PEW) syndrome to
describe the loss of body protein mass and fuel reserves in
patients with end-stage kidney disease (ESKD) .
3.
4. Assessment of nutritional status in patients on
hemodialysis:-
• Dietary assessment .
• Physical assessment .
• Laboratory assessment .
5. • Dietary assessment
We question patients monthly about loss of appetite, loss of weight,
weight, or development of gastrointestinal symptoms such as nausea
or vomiting.
We inquire as to psychosocial issues such as access and affordability
of food, ability to prepare meals, and the role of family members in
food preparation
6. • Physical assessment
We measure post dialysis edema-free weight every month. We use the
the weight to calculate the body mass index (BMI) and to monitor for
weight loss.In some patients who cannot achieve post dialysis
euvolemia for a variety of reasons, we monitor the trend of their
weight with simultaneous assessment of interdialytic weight gain and
volume.
Loss of 5 %of non edematous weight within three months or an
unintentional loss of 10 % of nonedematous weight over six months
should be considered an indicator of PEW independently of weight-
for-height measures. A decline in BMI over time may be associated
with increased mortality
7. • Laboratory assessment:-
Serum albumin A serum albumin <3.8 g/dL is a suggested
diagnostic criterion for PEW syndrome.
( not very specific as serum albumin levels may also fall due to non-nutritional factors including
including inflammation, acute or chronic stress, overhydration, urinary or peritoneal losses, and
acidemia)
BUN:-Malnourished patients often show a gradual reduction in BUN. Low
predialysis BUN levels have been associated with increased mortality
( non Specific ).
8. • PNA (protein nitrogen appearance ) :-
The PNA is calculated from the post- and predialysis BUN
concentrations of two consecutive hemodialysis sessions. The rate of
increase in serum urea nitrogen between two consecutive
hemodialysis sessions reflects dietary nitrogen intake.
National guidelines (based on opinion) recommend maintaining a
PNA >1.2 g/kg/day.
10. Causes of PEW (protein energy wasting):-
Decreased intake and anorexia .
Hypercatabolic state.
Insulin resistance.
Metabolic acidosis
The dialysis procedure .
Dietary restrictions .
Medications (such as phosphate
binders, can impair nutrient
absorption.)
11. DIETARY RECOMMENDATIONS TO PREVENT PROTEIN-ENERGY
WASTING
• Kidney Foundation Kidney Disease Outcomes Quality Initiative
(KDOQI) recommends as follow :-
• 1.2 g/kg protein per day; at least 50 percent should be of high biologic
value
• 30 to 35 kcal/kg of calories per day.
• higher than the recommended daily allowance for healthy adults
(which is 0.8 g/kg/day).
• It is important to closely follow metabolic parameters (including urea)
if a high protein diet is prescribed to dialysis patients.
12. If The patient cannot take protein by diet ?
• Nutritional supplement :-
Indications for treatment:-
An unintentional loss of 5 percent of nonedematous weight within three
months or 10 percent of nonedematous weight over six months
Or
An albumin <3.8 g/dL
13. • Oral supplements :-For most patients selected for treatment with
dietary supplements, we use oral supplements.
o formulated specifically for end-stage kidney disease (ESKD)
patients and are low in potassium and dense in nutrients, which
provides adequate calories and protein and minimizes the risk of
hyperkalemia and fluid overload. However, these supplements are
more costly
14. • Intradialytic parenteral nutrition For patients who continue to lose
weight or have very low serum albumin (<3.2 g/dL) despite oral
supplementation and for patients such as those with severe
gastroparesis who may be unable to tolerate oral
supplementation, we use IDPN.
• IDPN is convenient because it is delivered during dialysis and is
likely to be beneficial in some patients