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NURSE - Pediatric Seizures
Illinois Emergency Medical Services for Children
March 2012
Illinois EMSC is a collaborative program between the Illinois Department of Public
Health and Loyola University Health System. Development of this presentation
was supported in part by: Grant 5 H34 MC 00096 from the Department of Health
and Human Services Administration, Maternal and Child Health Bureau
Illinois Emergency Medical
Services for Children (EMSC)
 Illinois EMSC is a collaborative program between the Illinois
Department of Public Health and Loyola University Health
System, aimed at improving pediatric emergency care within our
state.
 Since 1994, The Illinois EMSC Advisory Board and several
committees, organizations and individuals within EMS and
pediatric communities have worked to enhance and integrate:
 Pediatric education
 Practice standards
 Injury prevention
 Data initiatives
2
Illinois EMSC
 The goal of Illinois EMSC is to ensure that
appropriate emergency medical care is
available for ill and injured children at every
point along the continuum of care.
3
This educational activity is being presented
without bias or conflict of interest from the
planners and presenters.
Susan Fuchs MD, FAAP, FACEP
Chair, EMSC Quality Improvement Subcommittee
Children’s Memorial Hospital
Carolynn Zonia, DO, FACOEP, FACEP
Chair, EMSC Facility Recognition Committee
Loyola University Health System
Illinois EMSC Quality Improvement Subcommittee & EMSC Facility Recognition Committee
Paula Atteberry, RN, BSN
Illinois Department of Public Health
Joseph R. Hageman, MD, FAAP
NorthShore University Health
System - Evanston
Cheryl Lovejoy, RN, TNS
Advocate Condell Medical Center
S. Margaret Palk, MD, FAAP
University of Chicago
Comer Children’s Hospital
Herbert Sutherland, DO, FACEP
Central DuPage Hospital
Maureen Bennett, RN, BSN
Loyola University Health System
Sandy Hancock, RN, MS
Saint Alexius Medical Center
Evelyn Lyons, RN, MPH
Illinois Department of Public Health
Parul Patel, MD, MPH, FAAP
Children’s Memorial Hospital
John Underwood, DO, FACEP
Swedish American Hospital
Mark Cichon, DO, FACOEP,
FACEP
Loyola University Health System
Melodie Havlick, RN, BSN, CEN
Rush Copley Memorial Hospital
Patrician Metzler, RN, TNS, SANE-A
Carle Foundation Hospital
Anita Pelka, RN
University of Chicago
Comer Children’s Hospital
LuAnn Vis, RN, MSOD, CPHQ
Loyola University Health System
Kristine Cieslak, MD, FAAP
Children’s Memorial at Central
DuPage Hospital
Kathryn Janies, BA
Illinois EMSC
Michele Moran, RN
Central DuPage Hospital
Anne Porter, PhD, RN, CPHQ
Healthcare Consultant
Jim Wells, RN
Blessing Hospital
Jacqueline Corboy, MD, FAAP
Children’s Memorial Hospital
Cindi LaPorte, RN
Loyola University Health System
Beth Nachtsheim Bolick, RN, MS,
DNP, CPNP-AC, PNP-BC
Rush University
Laura Prestidge, RN, BSN
Illinois EMSC
Leslie Wilkans, RN, BSN
Advocate Good Shepherd Hospital
Don Davidson, MD
Carle Foundation Hospital
Sue Laughlin, RN
Community Memorial Hospital
Andrea Nofsinger, RN, BSN, SANE-A
OSF St. Francis Medical Center
Vanessa Scheidt, RN
Franciscan St. James Health
Beverly Weaver, RN, MS
Northwestern Lake Forest Hospital
Leslie Foster, RN, BSN
OSF St. Anthony Medical Center
Daniel Leonard, MS, MCP
Illinois EMSC
Charles Nozicka, DO, FAAP, FAAEM
Advocate Condell Medical Center
J. Thomas Senko, DO, FAAP
John H. Stroger Jr. Hospital of
Cook County
Special Thanks to:
Jorge Asconapé, MD
Loyola University Health System
Ryan Gagnon, RN
Advocate Christ Medical Center
Jammi Likes, RN, BSN,
NREMT-P
Herrin Hospital
Linnea O’Neill, RN, MPH
Metropolitan Chicago Healthcare
Council
Cathleen Shanahan, RN, BSN, MS
Children’s Memorial Hospital
Eugene Schnitzler, MD
Loyola University Health System
Editors: Christine Kennelly, RN, MS; Sharon M. McCarthy, RN, MS, CPNP
Acknowledgements
4
Purpose
The purpose of this educational module is to
enhance the care of pediatric patients who
present with seizures through appropriate
 Assessment
 Management
 Prevention of complications, and
 Disposition (including patient &
parent/caregiver education)
Suggested Citation: Illinois Emergency Medical Services for Children
(EMSC), NURSE-Pediatric Seizures, March 2012
5
Exclusions
 Management of post traumatic seizures
is beyond the scope of this module and
will not be addressed.
 Neonatal seizures are not addressed in
the body of this module. However,
information can be found in Appendix C.
6
Pediatric Seizures
Few health care problems elicit more distress
than witnessing a child having a seizure. It is
terrifying to many. When the victim is a child,
and the observer is a parent or caregiver, that
terror can become panic.
This module seeks to aid you in minimizing
that distress and maximizing the outcome for
your patient with evidence-based guidelines.
7
Objectives
At the conclusion of this module, you will be
able to:
 Manage the child with a seizure in the prehospital and
Emergency Department (ED) settings
 Identify the distinguishing characteristics between
types of seizures in the pediatric patient
 Explain the rationale for specific diagnostic testing
 Provide educational information related to
care of a child with seizures
NOTE: Hyperlinks are provided throughout the module to offer additional information 8
Table of Contents
1. Introduction and Background
2. Febrile Seizure
3. First Unprovoked Seizure
4. Status Epilepticus
5. References
6. Resources
7. Appendices
 APPENDIX A – EMSC Prehospital Protocols
 APPENDIX B – Sample Emergency Department Guidelines
 APPENDIX C – Neonatal Seizures
9
Introduction
and
Background
Return to Table of Contents
10
 300,000 people have a first seizure
each year
 120,000 are under 18 years of age
 Between 75,000 and 100,000 are under 5
years of age who have experienced a
febrile seizure
 326,000 school aged children through
15 years of age have epilepsy
U.S. Demographics1
11
Incidence in Illinois
 In 2009, 14,400 children aged 0-18 years
were seen in the Emergency Department
as a result of seizures
 Nearly 6,500 required
hospitalization
12
(Source: Illinois Hospital Association. COMPdata. Hospital Discharge database)
Illinois EMSC Statewide
Pediatric Seizure QI Project
In 2010 - 2011, Illinois EMSC conducted a statewide
survey of Emergency Department practice patterns
(including medical record reviews) related to children
presenting with:
 Simple Febrile Seizure (SFS)
 Unprovoked Seizures (UnS), and
 Status Epilepticus (SE)
13
(Source: Illinois EMSC Pediatric Seizures in the Emergency Department Summary Report May 2011)
Pediatric Seizure QI Project (cont.)
Opportunities for improvement:
 Less than half of responding facilities had a
protocol/policy/guideline/clinical pathway that addressed the
clinical management of seizures overall (44%) or clinical
management SE in particular (19%)
 In the prehospital management of pediatric seizures, blood
glucose assessments were documented in only 34% of SFS
patients and slightly over half of UnS/SE patients
 For UnS/SE patients, seizure precautions were either not
taken or not documented in more than 1/3rd of the cases
(Source: Illinois EMSC Pediatric Seizures in the Emergency Department Summary Report May 2011)
14
A Seizure Is:
15
 Abnormal neuronal activity
 A sudden biochemical imbalance at the cell
membrane
 Repeated abnormal electrical discharges
 Seen clinically as changes in motor control,
sensory perception and/or autonomic
function2
Clinical Presentation
Motor Changes
 Parents/caregivers may report seeing:
 Repetitive non-purposeful movements
 Staring
 Lip-smacking
 Falling down without cause
 Stiffening of any or all extremities
 Rhythmic shaking of any or all extremities
16
Seizure activity cannot be interrupted with verbal
or physical stimulation3
Clinical Presentation
Sensory and Autonomic
 Parents/caregivers may report the child is:
 Feeling nauseous
 Feeling odd or peculiar
 Losing control of bowel or bladder
 Feeling numbness, tingling
 Experiencing odd smells or sounds
17
Clinical Presentation
Consciousness
 Consciousness is the usual alertness or
responsiveness the child demonstrates.
 Parents/caregivers may report or you may
observe the child to have:
 Baseline alertness
 Diminished level of consciousness
 Unresponsive and unconscious
18
Clinical Presentation
Events That Mimic Seizures
 Apnea
 Breath Holding
 Dizziness
 Myoclonus
 Pseudoseizures
 Psychogenic
Seizures
 Rigors
 Shuddering
 Syncope
 Tics
 Transient Ischemic
Attacks
19
Seizure Classifications
Generalized Partial
Complex Simple
Involves BOTH hemispheres
of the brain
May have aura No impaired consciousness
Always involves loss of
consciousness
Involves motor* or
autonomic# symptoms
with altered level of
consciousness
Can involve motor,* autonomic#
or somatosensory+ symptoms
Types:
 Tonic or clonic movements
or combination (grand mal)
 Absence (petit mal)
 Myoclonic
 Atonic (e.g., drop attacks)
 Infantile spasms
May generalize May generalize
Types of symptoms:
1) Motor* - head/eye deviation, jerking, stiffening
2) Autonomic# - pupils dilatation, drooling, pallor, change in heart rate or
respiratory rate
3) Somatosensory+ - smells, alteration of perception (déjà vu)
20
Generalized Seizure Classification:
Descriptions1
 Absence - Abrupt lapses of consciousness
lasting a few seconds
 Atonic - Abrupt, unexpected loss of muscle
tone
 Myoclonic - Rapid short contractions of one
or all extremities
21
Febrile Seizure
Return to Table of Contents
22
Febrile Seizure4
Febrile seizures are the most common
seizure disorder in childhood, affecting
2 - 5% of children between the ages of
6 months and 5 years
23
Febrile Seizure5
 Caused by the increase in the core body
temperature greater than 100.4F or 38C
 Threshold of temperature which may trigger
seizures is unique to each individual
 Can occur within the first 24 hours of an
illness
 Can be the first sign of illness in 25 - 50% of
patients
24
Febrile Seizure: Characteristics
 Are benign
 Occurrence: between 6 months to 5 years of
age
 May be either simple or complex type seizure
 Seizure accompanied by fever (before, during
or after) WITHOUT ANY
 Central nervous system infection
 Metabolic disturbance
 History of previous seizure disorder
25
Febrile Seizure: Two Types4
Simple Febrile
 6 months – 5 years of age
 Febrile before, during or after
seizure
 Generalized seizure
lasting less than 15
minutes, and
 Occurs once in a 24-hour
period
Complex Febrile
 6 months – 5 years of age
 Febrile before, during or after
seizure
 Prolonged (lasting more
than 15 minutes),
 Focal seizure, or
 Occurs more than once in
24 hours
26
Febrile Seizure:
Prehospital Assessment
 Assess A,B,C’s
 Assess neurological status (D = Disability using AVPU)
 Obtain seizure history from a dependable witness:
 How long was the seizure?
 What did it look like (movements, eye deviation)?
 History of previous seizures (child and family)?
 Does the child have a current illness/fever?
 Any indications of trauma or abuse?
 Length of postictal phase?
 List current medications
 Include any antipyretics given (time and dose)
27
AVPU
The AVPU scale (Alert, Voice, Pain, Unresponsive) is a system by which
a healthcare professional can measure and record a child’s level of
consciousness. The AVPU scale should be assessed using these identifiable
traits, looking for the best response of each
A Alert – the infant is active, responsive to parents and interacts
appropriately with surroundings; the child is lucid and fully responsive, can
answer questions and see what you're doing.
V Voice – the child or infant is not looking around; responds to your
voice, but may be drowsy, keeps eyes closed and may not speak
coherently, or make sounds.
P Pain – the child or infant is not alert and does not respond to your
voice. Responds to a painful stimulus, e.g., shaking the shoulders or
possibly applying nail bed pressure.
U Unresponsive – the child or infant is unresponsive to any of the
above; unconscious.
28
Febrile Seizure:
Prehospital Management
 Monitor A, B, C, D’s
 Position with C-Spine protection (if trauma)
 Follow seizure and aspiration precautions (per
protocol)
 Physical exam
 Check blood glucose
 If blood glucose < 60, treat as appropriate
Refer to EMSC Seizure protocols (Appendix A) 29
Febrile Seizure:
ED Assessment
 Baseline assessment
 Vital signs (including temperature)
 Assess A, B, C, D’s
 Continue providing and documenting seizure and
aspiration precautions
30
Febrile Seizure:
ED Assessment (cont.)
 Full History
 Obtain seizure history from a dependable witness:
 When did the seizure occur?
 How long was the seizure and what did it look like?
 How was the child acting immediately before the seizure?
 History of previous seizures (child and family)?
 History of developmental delay/recent loss of milestones?
 Does the child have a current illness/fever?
 Any indications of trauma or abuse?
 Length of postictal state?
 Immunization history?
 List current medications
 Include any antipyretics given (time and dose)
31
Febrile Seizure:
ED Management7
 If still seizing, follow Status Epilepticus protocol
 Complete physical exam – to identify the source of
fever
 If child has a prolonged postictal period - consider
administering glucose
 Lab testing - direct toward identifying the source of
fever
 For Simple Febrile Seizures: NO ROUTINE LAB TESTS ARE
NECESSARY
32
Simple Febrile Seizure:
Lumbar Puncture
Evidence-based recommendations from the 2011 AAP
Subcommittee on Febrile Seizures6 are as follows:
“A lumbar puncture should be performed in any child who presents
with a (simple febrile) seizure and a fever and has meningeal signs
and symptoms (e.g., neck stiffness, Kernig and/or Brudzinski
signs) or in any child whose history or examination suggests the
presence of meningitis or intracranial infection.”
Current data does not support routine lumbar
puncture in well-appearing, fully immunized children
who present with a simple febrile seizure.
33
Simple Febrile Seizure:
Lumbar Puncture (cont.)
Additional evidence-based recommendations from the 2011 AAP
Subcommittee on Febrile Seizures6 are as follows:
“In any infant between 6 and 12 months of age who presents with a
(simple febrile) seizure and fever, a lumbar puncture is an option when:
- the child is considered deficient in Haemophilus influenza type b or
Streptococcus pneumoniae immunizations (i.e., has not received
scheduled immunizations as recommended) or
- when the immunization status cannot be determined because of an
increased risk of bacterial meningitis.”
“A lumbar puncture is an option in the child who presents with a (simple
febrile) seizure and fever and is pretreated with antibiotics, because
antibiotic treatment can mask the signs and symptoms of meningitis.”
34
Simple Febrile Seizure:
Diagnostic Testing4,6
EEG CT/MRI
Simple
Febrile
Seizure
Should not be performed
in a neurologically
healthy child.
Results are not predictive of
recurrence or development
of epilepsy
Not indicated
35
There are no current national guidelines addressing
diagnostic testing recommendations for complex
febrile seizures.
Simple Febrile Seizure:
ED Ongoing Management
 Reassess temperature
 Consider giving antipyretic if not
previously administered
 As source of fever is identified, treat
appropriately
36
Simple Febrile Seizure:
Family Education4,6
Here are some frequently asked questions parents/
caregivers may have prior to discharge:
 Is my child brain damaged?
 There is no evidence of impact on learning abilities after
seizure from SFS.
 Will this happen again?
 If child is under 12 months of age at time of first seizure,
recurrence rate is 50%
 If child is greater than 12 months of age at time of first seizure,
recurrence rate is 30%
 Most recurrences occur within 6-12 months of the initial febrile
seizure
37
Simple Febrile Seizure:
Family Education4,6 (cont.)
 Will my child get epilepsy?
 For simple febrile seizures, there is no increased risk
of epilepsy
 Why not treat for possible seizures or fever?
 Anticonvulsants can reduce recurrence. However
potential side effects of medications outweigh the
minor risk of recurrence
 Prophylactic use of antipyretics does not have impact
on recurrence
38
For complex febrile seizures, there is a
slight increase in the risk of epilepsy.
Simple Febrile Seizure:
Family Education7 (cont.)
 Instruct parent/caregivers to prevent injury during a
seizure :
 Position child while seizing in a side-lying
position
 Protect head from injury
 Loosen tight clothing about the neck
 Prevent injury from falls
 Reassure child during event
 Do not place anything in the child’s mouth
39
Simple Febrile Seizure:
Disposition
Prior to discharge home…
 Educate regarding use of:
 Thermometer
 Antipyretics for fever management
 When to contact 9-1-1 or ambulance
 Identify Primary Care Provider for follow-up
appointment and stress importance of follow-up
 Provide developmentally appropriate explanation of
event for child and family members
40
Febrile Seizure:
Test Yourself
1. Simple Febrile Seizures:
A. Indicate an underlying neurological condition
B. Require anticonvulsant medication
C. Occur in children 6 months to 5 years of age
D. Frequently lead to epilepsy
2. Which of the following are
important history questions?
A. Was there trauma ?
B. What did the seizure look like?
C. Medications and herbal supplements?
D. All of the above
3. Diagnostic workup in the ED
is based on suspicions of:
A. Meningitis
B. Trauma
C. Unknown immunization status
D. All of the above
4. Discharge education should
include which of the
following?
A. Teaching about EEG results
B. Importance of antipyretics for fever
C. Importance of follow up MRI
D. Teaching about anticonvulsant
medications
Proceed to next slide for answers
41
Febrile Seizure:
Test Yourself: ANSWER KEY
1. Simple Febrile Seizures:
C. Occur in children 6 months to 5 years of age
2. Which of the following are
important history questions?
D. All of the above
3. Diagnostic workup in the ED
is based on suspicions of:
D. All of the above
4. Discharge education should
include which of the
following?
B. Importance of antipyretics for fever
42
First Unprovoked Seizure
Return to Table of Contents
43
First Unprovoked Seizure8
This is a first seizure that occurs without an immediate
precipitating event. Etiology may be:
 Remote symptomatic (related to a pre-existing brain
abnormality/insult)
 Cryptogenic or idiopathic (no known cause)
Predictors of recurrence include: abnormal EEG,
underlying etiology, and abnormal neurologic exams
 Remote symptomatic – recurrence risk over 2 yrs is above 50%
 Cryptogenic or idiopathic – recurrence risk over 2 yrs is
30-50%
 If first seizure is prolonged, recurrent seizures are more likely to
be prolonged.
44
First Unprovoked Seizure:
Presentation
Parents/caregivers may describe symptoms
consistent with the following:
 Partial seizure
 Generalized onset, tonic-clonic seizure
 Tonic seizure
45
Remember: this is a seizure that occurs
without an immediate precipitating event.
First Unprovoked Seizure:
Prehospital Assessment
 Assess A, B, C, D’s
 Obtain seizure history from a dependable witness:
 How long was the seizure?
 What did it look like (movements, eye deviation)?
 History of previous seizures (child and family)?
 Does the child have a current illness/fever?
 Any indications of trauma or abuse?
 Length of postictal state
 List current medications
 Include any antipyretics given (time and dose)
46
First Unprovoked Seizure:
Prehospital Management
 Monitor A, B, C, D’s
 Position with C-Spine protection (if trauma)
 Follow seizure and aspiration precautions (per protocol)
 Physical assessment
 Check blood glucose
 If blood glucose < 60, treat as appropriate
Refer to EMSC Seizure protocols (Appendix A)
47
First Unprovoked Seizure:
ED Assessment
 Baseline assessment
 Vital signs (including temperature)
 Assess A, B, C, D’s
 Continue providing and documenting seizure and
aspiration precautions
48
First Unprovoked Seizure:
ED Assessment (cont.)
 If still seizing, follow Status Epilepticus protocol
 Full History
 Obtain seizure history from a dependable witness:
 Recent exposures (chemical, industrial)?
 When did the seizure occur?
 How long was the seizure and what did it look like?
 How was the child acting immediately before the seizure?
 History of previous seizures (child and family)?
 History of developmental delay/recent loss of milestones?
 Does the child have a current illness?
 Any indications of trauma or abuse?
 Length of postictal state?
49
First Unprovoked Seizure:
ED Assessment (cont.)
 List current medications
 Include any antipyretics given (time and dose)
 Include anticonvulsants given by prehospital
team (time and dose)
 Physical exam
 Head-to-toe assessment
50
First Unprovoked Seizure:
Diagnostic Testing8
Laboratory tests are based on individual
clinical circumstances and may include:
 CBC with differential
 Blood glucose
 Electrolytes
 Calcium, magnesium, phosphorous
 Urine drug/toxicology screen
 Urine HCG (age dependent)
51
Lumbar puncture is only indicated if there are other
symptoms that suggest a diagnosis of meningitis.
First Unprovoked Seizure:
Diagnostic Testing – MRI8,9
 Outpatient MRI should be considered for:
 Children under 1 year of age
 All children with significant acute cognitive or motor
impairment
 Unexplained abnormalities on neurologic exam
 Seizure of focal onset without generalization
 Abnormal EEG
 Abnormalities on MRI are seen in up to 1/3rd of
children
 However, most abnormalities do not influence immediate
treatment or management (such as need for hospitalization)
52
First Unprovoked Seizure:
Diagnostic Testing - CT Scan8,9
Emergent CT Scan (without contrast) should be
considered for any child who exhibits any of the
following:
 Significant, acute cognitive or motor
impairment
 New focal deficit not quickly resolving
 Not returned to baseline
53
MRI is the modality of choice, if available.
First Unprovoked Seizure:
Diagnostic Testing – EEG8,9
 Obtain on ALL children in whom a nonfebrile
seizure has been diagnosed
 Can be arranged as an outpatient
 Should be interpreted by a neurologist
(preferably pediatric neurologist)
 EEG results will:
 Help predict the risk of recurrence
 Classify the seizure type or epilepsy
syndrome
 Influence the decision to perform additional
neuroimaging studies
54
First Unprovoked Seizure:
ED Management
If child is still actively seizing…
 Refer to Status Epilepticus protocol
When child is stable…
 Consult with Neurologist (or Intensivist)
 For possible medication recommendations
 To determine disposition:
Admit to observe
Transfer (if neurologist is unavailable)
Discharge home
55
First Unprovoked Seizure:
Drug Therapy8,9
 The majority of children who experience an
unprovoked seizure will have few or no
recurrences
 Approximately 10% will go on to have additional
seizures regardless of therapy
 Type of medication if offered depends on:
 Type, frequency and severity of seizures
 Side effects, titration, drug interactions, dosing
forms, cost of drug
 Neurologist preference
56
First Unprovoked Seizure:
Discharge & Family Education
Prior to discharge home…
 Identify Primary Care Provider and Neurologist for
follow-up appointments
 Provide plan for outpatient EEG
 Provide parental support
 Consider rescue medication for home, based on
neurologist recommendation (e.g., rectal
diazepam)
57
First Unprovoked Seizure:
Family Education7
 Instruct parent/caregivers to prevent injury
during a seizure:
 Position child while seizing in a side-lying
position
 Protect head from injury
 Loosen tight clothing about the neck
 Prevent injury from falls
 Reassure child during event
 Do not place anything in the child’s mouth
58
First Unprovoked Seizure:
Family Education (cont.)
 Instruct in use of 9-1-1 or ambulance services
 Provide developmentally appropriate explanation
to child about the seizure event and treatment
 Discourage swimming alone
 No driving a car until cleared by a physician
59
First Unprovoked Seizure:
Family Education (cont.)
Here are some frequently asked questions
parents may have prior to discharge:
 How likely is it that my child will have seizures again?
The risk of recurrence relates to the underlying etiology and EEG
results (normal or abnormal). The majority of children who experience
an unprovoked seizure will have few or no recurrences. Approximately
10% will go on to have additional seizures regardless of therapy.8
 Is there a risk of dying from the seizure if we don’t start
medication today?
Sudden unexpected death is very uncommon (usually related to an
underlying neurologic handicap rather than seizure activity).
There are no studies showing treatment after a first seizure alters the
small risk of sudden death.8
60
First Unprovoked Seizure:
Test Yourself
1. Which of the following is a true statement regarding a First Unprovoked Seizure:
A. Occurs without a precipitating event
B. Is never associated with an underlying neurological condition
C. Always leads to epilepsy
D. Requires immediate initiation of antiepileptic medication
2. Children who have a First Unprovoked Seizure…
A. Have their blood glucose checked by ambulance staff
B. Could proceed to have Status Epilepticus
C. Will require anti-pyretics to prevent seizures
D. A and B
3. All children who have had a First Unprovoked Seizure should have an outpatient EEG.
TRUE FALSE
4. The majority of children who have a First Unprovoked Seizure will have few or no
recurrences.
TRUE FALSE
Proceed to next slide for answers
61
First Unprovoked Seizure:
Test Yourself: ANSWER KEY
1. Which of the following is a true statement regarding a First Unprovoked Seizure:
A. Occurs without a precipitating event
2. Children who have a First Unprovoked Seizure…
D. A and B
3. All children who have had a First Unprovoked Seizure should have an outpatient EEG.
TRUE
4. The majority of children who have a First Unprovoked Seizure will have few or no
recurrences.
TRUE
62
Status Epilepticus
Return to Table of Contents
63
Status Epilepticus:
Definitions10
 Seizures that persist without interruption for
more than 5 minutes
 Two or more sequential seizures without full
recovery of consciousness between seizures
This is a life threatening emergency that
requires immediate treatment.
64
Status Epilepticus10
 Commonly occurs in children with epilepsy (9 -27%
over time)
 Complications from Status Epilepticus result from both
the impact of the convulsive state on the body systems
(such as the cardiac and respiratory systems) and the
neuronal cellular injury which leads to cell death
 Rapid termination of the seizure activity protects
against neuronal injury
65
Status Epilepticus:
Types, Incidence and Description11
66
Type Incidence Description
Remote Symptomatic SE 33%
Status Epilepticus (SE) with no
immediate event but the child had a
previous history of CNS malformation,
traumatic brain injury or chromosomal
disorder
Acute Symptomatic SE 26%
SE with concurrent acute illness (e.g.,
meningitis, encephalitis, hypoxia,
trauma, intoxication)
Febrile SE 22%
SE with a febrile illness but not a
Central Nervous System infection (e.g.,
sinusitis, sepsis, upper respiratory
infection)
Cryptogenic SE 15% SE with no identifiable cause
Status Epilepticus:
Prehospital Assessment
 Assess A, B, C, D‘s
 Obtain seizure history from a dependable
witness:
 When did the seizure begin?
 What did it look like (movements, eye deviation)?
 History of previous seizures (child and family)?
 Does the child have a current illness/fever?
 Any indications of trauma or abuse?
 Emergency Information Form for Children with
Special Needs?
67
Status Epilepticus:
Prehospital Assessment
 List current medications
 Include any antipyretics given (time and dose)
 Do the parents have any anticonvulsant
medications (e.g., rectal diazepam)?
 Have parents given any anticonvulsant
medications (time and dose)?
68
 Assess A, B, C, D’s
 Positioning (with C-Spine protection if trauma)
 Jaw thrust
 Recovery position (side-lying)
 Provide nasal airway, if needed
 Seizure safety precautions (per protocol)
 Aspiration precautions (per protocol)
 Oxygen
 Suction
 Blood glucose testing
 If blood glucose < 60, treat as appropriate
69
Status Epilepticus:
Prehospital Assessment
 If parent/caregiver has rectal diazepam and
has not given it, the parent/caregiver should
be requested to administer it
 Document time and dose
 Follow Pediatric Seizures ALS guideline
(if appropriate)
 Contact Medical Control
REFER TO APPENDIX A for EMSC Seizure Protocols
70
Status Epilepticus:
Prehospital Assessment
Status Epilepticus:
ED Goals of Therapy10,12
Minimize seizure time as much as possible
and provide drug therapy promptly.
 Drug therapy to halt seizure
 With IV/IO access, *LORazepam IV/IO
 If no IV/IO access, start with Diazepam PR
*The Institute for Safe Medication Practices recommends using
Tall Man (mixed case) letters in order to distinguish drugs with
similar sounding names – decreasing the chances of safety errors.
71
Status Epilepticus:
ED Assessment
 Assess A, B, C, D’s
 Full vital signs; check bedside glucose and treat
(per protocol)
 Continue to provide and document seizure and
aspiration precautions (per protocol)
 Review Prehospital History and Treatment
72
Status Epilepticus:
ED Management
 Full History
 Obtain seizure history from a dependable witness:
 How long has the seizure been going on and what did it
look like when it started?
 How was the child acting immediately before the
seizure?
 History of previous seizures (child and family)?
 History of developmental delay/recent loss of
milestones?
 Does the child have a current illness?
 Any indications of trauma or abuse?
 Immunization status
73
Status Epilepticus:
ED Assessment
 Assess E (exposure)
 Current medications?
 When were they last given?
 Recent exposures - chemical, industrial, infectious?
 Was patient recently out of the country?
74
Status Epilepticus:
ED Management – First 5 Minutes12
 Evaluate airway
 Suction, position and provide nasal airway as needed
 Provide 100% oxygen (non-rebreather)
 Establish vascular access
 Draw labs as determined by history (examples:)
 CBC, Electrolytes, Blood glucose, Calcium, Magnesium, Phosphorus
 Toxicology screen, if indicated by history
 Antiepileptic drug level, as indicated
 Administer benzodiazepines
 LORazepam IV/IO 0.1 mg/kg
 No IV access, give either:
 Diazepam PR 0.5 mg/kg (max PR dose = 20 mg) or
 Midazolam IM 0.1 - 0.2 mg/kg
Benzodiazepines may
cause respiratory
and cardiac depression.
REFER TO APPENDIX B for sample guidelines 75
 Reassess A, B, C’s
 Continue supportive airway management
 Suction, position and provide nasal airway as needed
 Provide 100% oxygen (non-rebreather)
 Evaluate results of rapid blood glucose testing
If the seizure activity continues…
 Administer medications (per guidelines)
 Repeat IV LORazepam 0.1 mg/kg
 Administer IV/IM Fosphenytoin 20 mg/kg PE (Phenytoin
equivalents)
REFER TO APPENDIX B for sample guidelines 76
PHENobarbital
is preferred in
neonates.
Status Epilepticus:
ED Management – Next 10 Minutes12
 Having administered 2-3 doses of benzo-
diazepines, and a dose of Fosphenytoin
without halting the seizure, consider the
patient in refractory Status Epilepticus13
 Consult with Neurology and/or Intensivist for
further management recommendations
 If available, evaluate lab results
77
REFER TO APPENDIX B for sample guidelines
Status Epilepticus:
ED Management – Next 15 Minutes12
 If seizure activity persists (after appropriate doses of
benzodiazepines and Fosphenytoin), load with a
second long-acting AED that was not used initially
(e.g., phenobarbital, valproic acid)
 Consider loading with Midazolam IV 0.1 - 0.2 mg/kg
 Manage with continuous EEG monitoring
 Contact PICU/NICU to begin transfer to higher level of care
78
REFER TO APPENDIX B for sample guidelines
It is imperative to stop the seizure activity.
If rapid sequence induction is necessary, use short-acting
paralytics to ensure that ongoing seizure activity is not masked.
Status Epilepticus:
ED Management – Refractory SE
 For a child in Status Epilepticus after 30
minutes of refractory SE, enact plans to
transfer to your PICU/NICU or transport to a
higher level of care
 Continued testing can be arranged in that
setting
 Consider EEG with new onset SE
 Neuroimaging (CT/MRI) if etiology is unknown
REFER TO APPENDIX B for sample guidelines 79
Status Epilepticus:
ED Management – Transfer13
Status Epilepticus:
Disposition
 Discuss child’s progress and advice
regarding admission or transfer based on
patient status and neurology consultation with
parents/caregiver
 Utilize a specialty/critical care transport team
 (If applicable) Explain these events to child in
developmentally appropriate manner
80
Status Epilepticus:
Parent Education
 Provide parents/caregivers information
regarding child’s condition and treatment
plan
 Provide emotional/psychosocial support
 Encourage use of the ACEP/AAP Emergency
Information Form for possible future events
81
Status Epilepticus:
Emergency Information Form
The Emergency Information Form (EIF) for Children With Special
Needs resource was developed by the American College of Emergency
Physicians (ACEP) and the American Academy of Pediatrics (AAP).
 As a standardized medical summary it has
 Information for prehospital and
hospital emergency care personnel
 Updates entered by caregivers
 English and Spanish versions
 24-hour accessibility
 Free, Downloadable, interactive forms are
available at the ACEP and the AAP websites.
82
To be completed by both the child’s medical team and parents/caregivers.
Copies should be kept by parents, as well as on file at the PCP’s office,
subspecialist’s office, local ED, and school nurse’s office.
Status Epilepticus:
Test Yourself
1. You respond to a 9-1-1 call for a 4-year-old child. You find the child on
the floor of the playroom, unresponsive to voice with rhythmic movements
of both the upper and lower extremities. The parents report that the child
has had seizures, starting at age 2. The seizure activity has always lasted
only about 1 minute. The parents called 9-1-1 when the initial seizure
stopped, but the seizure started again with about one minute in between.
They estimate the child has been seizing for about 15 minutes.
Your FIRST response is to:
A. Move the child to the bed
B. Establish vascular access
C. Protect/position the airway
D. Give rectal diazepam
Proceed to next slide for answer
83
Status Epilepticus:
Test Yourself: ANSWER KEY
1. You respond to a 9-1-1 call for a 4-year-old child. You find the child on
the floor of the playroom, unresponsive to voice with rhythmic movements
of both the upper and lower extremities. The parents report that the child
has had seizures, starting at age 2. The seizure activity has always lasted
only about 1 minute. The parents called 9-1-1 when the initial seizure
stopped, but the seizure started again with about one minute in between.
They estimate the child has been seizing for about 15 minutes.
Your FIRST response is to:
C.Protect/position the airway
Proceed to next slide
84
Status Epilepticus:
Test Yourself
2. How quickly should the first benzodiazepine be given after status epilepticus
begins?
A. At 30 minutes
B. At 20 minutes
C. Within 5 minutes
D. After 60 minutes
3. What drugs are used first in status epilepticus?
A. Lorazepam
B. Fosphenytoin
C. Diazepam
D. A and C
4. Who is likely to have status epilepticus?
A. Child with a history of epilepsy
B. Child with encephalitis
C. Child with a traumatic brain injury
D. All of the above Proceed to next slide for answers 85
Status Epilepticus:
Test Yourself: ANSWER KEY
2. How quickly should the first benzodiazepine be given after status epilepticus
begins?
C. Within 5 minutes
3. What drugs are used first in status epilepticus?
D. A and C
4. Who is likely to have status epilepticus?
D. All of the above
86
References
87
Return to Table of Contents
References
1. Epilepsy and Seizure Statistics. (2010). EpilepsyFoundation.org. Retrieved April
21, 2011 from http://www.epilepsyfoundation.org/about/statistics.cfm.
2. Pillow MT, Howes DS, Doctor, SU. Seizures. eMedicine.medscape.com.
Updated Jan 22, 2010.
3. Fisher, PG. First and second seizure: what to do and know. Contemporary
Pediatrics. 2007;24(4):80-89.
4. Steering Committee on Quality Improvement and Management, Subcommittee
on Febrile Seizures. Febrile seizures: clinical practice guideline for the long-term
management of the child with simple febrile seizures. Pediatrics.
2008;121:1281-1286.
5. Freedman SB, Powell EC. Pediatric seizures and their management in the
emergency department. Clin Ped Emerg Med. 2003;4:195-206.
88
References (cont.)
6. Steering Committee on Quality Improvement and Management, Subcommittee
on Febrile Seizures. Neurodiagnostic evaluation of the child with a simple febrile
seizure. Pediatrics. 2011;127;389-394.
7. American Association of Neuroscience Nurses. Care of the patient with
seizures. 2nd ed. Glenview (IL): American Association of Neuroscience Nurses;
(Revised 2009). 23 p.
8. Hirtz D, Berg A, Bettis D, et al. Practice parameter: treatment of the child with a
first unprovoked seizure: report of the Quality Standards Subcommittee of the
American Academy of Neurology and the Practice Committee of the Child
Neurology Society. Neurology. 2003;60:166-175.
9. Hirtz D, Ashwal S, Berg A, et al. Practice parameter: evaluating a first nonfebrile
seizure in children: report of the Quality Standards Subcommittee of the
American Academy of Neurology, the Child Neurology Society, and the
American Epilepsy Society. Neurology. 2000;55:616–623.
89
References (cont.)
10. Millikan D, Rice B, Silbergleit R. Emergency treatment of status epilepticus:
current thinking. Emerg Med Clin North Am. 2009;27(1):101-113.
11. Riviello JJ Jr., Ashwal S, Hirtz D, et al. American Academy of Neurology
Subcommittee, Practice Committee of the Child Neurology Society. Practice
parameter: diagnostic assessment of the child with status epilepticus (an
evidence-based review): report of the Quality Standards Subcommittee of the
American Academy of Neurology and the Practice Committee of the Child
Neurology Society. Neurology. 2006;67(9):1542-50.
12. Goldstein J. Status epilepticus in the pediatric emergency department. Clin Ped
Emerg Med. 2008;9:96-100.
13. Abend NS, Dlugos DJ. Treatment of refractory status epilepticus: literature
review and a proposed protocol. Pediatr Neurol. 2008;38:377-390.
90
Online Resources
American Epilepsy Society
http://www.acep.org/content.aspx?id=26276
American Academy of Neurology Patient Education Materials
http://www.aan.com/go/practice/patient
CDC: Epilepsy
http://www.cdc.gov/Epilepsy/
Citizens United for Research in Epilepsy (CURE)
http://www.cureepilepsy.org/resources/
Epilepsy Foundation: Epilepsy and Seizure Response for Law Enforcement and EMS
(free online training)
http://www.epilepsyfoundation.org/livingwithepilepsy/firstresponders/index.cfm
Epilepsy Therapy Project
http://www.epilepsy.com/epilepsy_therapy_project
91
Return to Table of Contents
Video Resources
Understanding Epilepsy
www.youtube.com/watch?v=MNQlq004FkE
Types of Seizures
www.youtube.com/watch?v=CDccChHrgRA&feature=channel
Understanding Partial Seizures
www.youtube.com/watch?v=e10FSjHvV74&feature=channel
Understanding Generalized Seizures
www.youtube.com/watch?v=w5Jv0SZRwwk&feature=channel
What causes Epilepsy
www.youtube.com/watch?v=6NcqQkKjqTI&feature=fvw
Diagnosing Epilepsy
www.youtube.com/watch?v=HX7L11rhRTw&feature=channel
Seizure Imitators Overview
www.youtube.com/watch?v=J4xJSGpJioI&feature=relmfu 92
Return to Table of Contents
APPENDIX A
EMSC Prehospital Protocols
Return to Table of Contents
93
EMSC Prehospital Protocols
 All Pediatric Seizure care guidelines follow
this sequence:
 Initial Medical Care/Assessment
 Protect the child from Injury
 Vomiting and Aspiration precautions
THE NEXT STEPS DEPEND
ON THE LEVEL OF CARE
OF THE RESPONDER
94
EMSC Prehospital Protocols
Here are examples of prehospital pediatric seizure protocols
 EMERGENCY MEDICAL RESPONDER
CARE GUIDELINE
 BLS CARE GUIDELINE
 ILS CARE GUIDELINE
 ALS CARE GUIDELINE
95
Source: Illinois EMSC Pediatric Prehospital Protocols
APPENDIX B
Sample Emergency Department
Guidelines
Return to Table of Contents
96
Sample ED Status Epilepticus Guidelines
Please give credit to any of the following resources you use
 Children’s Memorial Hospital
Emergency Department Management Guideline
 Advocate Condell Medical Center
Pediatric Emergency Department Clinical Guideline
 University or Chicago Comer Children’s hospital
Pediatric Emergency Department Clinical Guideline: Status
Epilepticus
97
APPENDIX C
Neonatal Seizures
Return to Table of Contents
98
Neonatal Seizures
 Neonatal seizures can be difficult to diagnose
o May consist of very subtle and unusual physical
signs
 Eye deviation, staring episodes, winking
 In neonates, onset of seizure activity is important in
determining etiology
o First 24 - 72 hours of life
 Ischemic hypoxia
 72 hours to 1 week of age
o Familial neonatal seizures
 Metabolic disorders
99
Neonatal Seizures
 Beyond the standard history, ask about the
pregnancy, labor and delivery and maternal risk
factors
 Physical exam should include head circumference
and careful inspection for dysmorphic features and
cutaneous lesions.8
 Consult with a pediatric neurologist to identify
infantile seizure disorders
100
Neonatal Seizures:
Status Epilepticus
 Assess A, B, C’s
 Evaluate and maintain airway
 Provide 100% oxygen
 Establish vascular access
 Obtain rapid glucose
 Administer Medications
 PHENobarbital 20 mg/kg IV
 Repeat up to 40 mg/kg total dose
 Contact Neurology
101
102
THE END

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NURSEpedseizure_slide_set.ppt

  • 1. NURSE - Pediatric Seizures Illinois Emergency Medical Services for Children March 2012 Illinois EMSC is a collaborative program between the Illinois Department of Public Health and Loyola University Health System. Development of this presentation was supported in part by: Grant 5 H34 MC 00096 from the Department of Health and Human Services Administration, Maternal and Child Health Bureau
  • 2. Illinois Emergency Medical Services for Children (EMSC)  Illinois EMSC is a collaborative program between the Illinois Department of Public Health and Loyola University Health System, aimed at improving pediatric emergency care within our state.  Since 1994, The Illinois EMSC Advisory Board and several committees, organizations and individuals within EMS and pediatric communities have worked to enhance and integrate:  Pediatric education  Practice standards  Injury prevention  Data initiatives 2
  • 3. Illinois EMSC  The goal of Illinois EMSC is to ensure that appropriate emergency medical care is available for ill and injured children at every point along the continuum of care. 3 This educational activity is being presented without bias or conflict of interest from the planners and presenters.
  • 4. Susan Fuchs MD, FAAP, FACEP Chair, EMSC Quality Improvement Subcommittee Children’s Memorial Hospital Carolynn Zonia, DO, FACOEP, FACEP Chair, EMSC Facility Recognition Committee Loyola University Health System Illinois EMSC Quality Improvement Subcommittee & EMSC Facility Recognition Committee Paula Atteberry, RN, BSN Illinois Department of Public Health Joseph R. Hageman, MD, FAAP NorthShore University Health System - Evanston Cheryl Lovejoy, RN, TNS Advocate Condell Medical Center S. Margaret Palk, MD, FAAP University of Chicago Comer Children’s Hospital Herbert Sutherland, DO, FACEP Central DuPage Hospital Maureen Bennett, RN, BSN Loyola University Health System Sandy Hancock, RN, MS Saint Alexius Medical Center Evelyn Lyons, RN, MPH Illinois Department of Public Health Parul Patel, MD, MPH, FAAP Children’s Memorial Hospital John Underwood, DO, FACEP Swedish American Hospital Mark Cichon, DO, FACOEP, FACEP Loyola University Health System Melodie Havlick, RN, BSN, CEN Rush Copley Memorial Hospital Patrician Metzler, RN, TNS, SANE-A Carle Foundation Hospital Anita Pelka, RN University of Chicago Comer Children’s Hospital LuAnn Vis, RN, MSOD, CPHQ Loyola University Health System Kristine Cieslak, MD, FAAP Children’s Memorial at Central DuPage Hospital Kathryn Janies, BA Illinois EMSC Michele Moran, RN Central DuPage Hospital Anne Porter, PhD, RN, CPHQ Healthcare Consultant Jim Wells, RN Blessing Hospital Jacqueline Corboy, MD, FAAP Children’s Memorial Hospital Cindi LaPorte, RN Loyola University Health System Beth Nachtsheim Bolick, RN, MS, DNP, CPNP-AC, PNP-BC Rush University Laura Prestidge, RN, BSN Illinois EMSC Leslie Wilkans, RN, BSN Advocate Good Shepherd Hospital Don Davidson, MD Carle Foundation Hospital Sue Laughlin, RN Community Memorial Hospital Andrea Nofsinger, RN, BSN, SANE-A OSF St. Francis Medical Center Vanessa Scheidt, RN Franciscan St. James Health Beverly Weaver, RN, MS Northwestern Lake Forest Hospital Leslie Foster, RN, BSN OSF St. Anthony Medical Center Daniel Leonard, MS, MCP Illinois EMSC Charles Nozicka, DO, FAAP, FAAEM Advocate Condell Medical Center J. Thomas Senko, DO, FAAP John H. Stroger Jr. Hospital of Cook County Special Thanks to: Jorge Asconapé, MD Loyola University Health System Ryan Gagnon, RN Advocate Christ Medical Center Jammi Likes, RN, BSN, NREMT-P Herrin Hospital Linnea O’Neill, RN, MPH Metropolitan Chicago Healthcare Council Cathleen Shanahan, RN, BSN, MS Children’s Memorial Hospital Eugene Schnitzler, MD Loyola University Health System Editors: Christine Kennelly, RN, MS; Sharon M. McCarthy, RN, MS, CPNP Acknowledgements 4
  • 5. Purpose The purpose of this educational module is to enhance the care of pediatric patients who present with seizures through appropriate  Assessment  Management  Prevention of complications, and  Disposition (including patient & parent/caregiver education) Suggested Citation: Illinois Emergency Medical Services for Children (EMSC), NURSE-Pediatric Seizures, March 2012 5
  • 6. Exclusions  Management of post traumatic seizures is beyond the scope of this module and will not be addressed.  Neonatal seizures are not addressed in the body of this module. However, information can be found in Appendix C. 6
  • 7. Pediatric Seizures Few health care problems elicit more distress than witnessing a child having a seizure. It is terrifying to many. When the victim is a child, and the observer is a parent or caregiver, that terror can become panic. This module seeks to aid you in minimizing that distress and maximizing the outcome for your patient with evidence-based guidelines. 7
  • 8. Objectives At the conclusion of this module, you will be able to:  Manage the child with a seizure in the prehospital and Emergency Department (ED) settings  Identify the distinguishing characteristics between types of seizures in the pediatric patient  Explain the rationale for specific diagnostic testing  Provide educational information related to care of a child with seizures NOTE: Hyperlinks are provided throughout the module to offer additional information 8
  • 9. Table of Contents 1. Introduction and Background 2. Febrile Seizure 3. First Unprovoked Seizure 4. Status Epilepticus 5. References 6. Resources 7. Appendices  APPENDIX A – EMSC Prehospital Protocols  APPENDIX B – Sample Emergency Department Guidelines  APPENDIX C – Neonatal Seizures 9
  • 11.  300,000 people have a first seizure each year  120,000 are under 18 years of age  Between 75,000 and 100,000 are under 5 years of age who have experienced a febrile seizure  326,000 school aged children through 15 years of age have epilepsy U.S. Demographics1 11
  • 12. Incidence in Illinois  In 2009, 14,400 children aged 0-18 years were seen in the Emergency Department as a result of seizures  Nearly 6,500 required hospitalization 12 (Source: Illinois Hospital Association. COMPdata. Hospital Discharge database)
  • 13. Illinois EMSC Statewide Pediatric Seizure QI Project In 2010 - 2011, Illinois EMSC conducted a statewide survey of Emergency Department practice patterns (including medical record reviews) related to children presenting with:  Simple Febrile Seizure (SFS)  Unprovoked Seizures (UnS), and  Status Epilepticus (SE) 13 (Source: Illinois EMSC Pediatric Seizures in the Emergency Department Summary Report May 2011)
  • 14. Pediatric Seizure QI Project (cont.) Opportunities for improvement:  Less than half of responding facilities had a protocol/policy/guideline/clinical pathway that addressed the clinical management of seizures overall (44%) or clinical management SE in particular (19%)  In the prehospital management of pediatric seizures, blood glucose assessments were documented in only 34% of SFS patients and slightly over half of UnS/SE patients  For UnS/SE patients, seizure precautions were either not taken or not documented in more than 1/3rd of the cases (Source: Illinois EMSC Pediatric Seizures in the Emergency Department Summary Report May 2011) 14
  • 15. A Seizure Is: 15  Abnormal neuronal activity  A sudden biochemical imbalance at the cell membrane  Repeated abnormal electrical discharges  Seen clinically as changes in motor control, sensory perception and/or autonomic function2
  • 16. Clinical Presentation Motor Changes  Parents/caregivers may report seeing:  Repetitive non-purposeful movements  Staring  Lip-smacking  Falling down without cause  Stiffening of any or all extremities  Rhythmic shaking of any or all extremities 16 Seizure activity cannot be interrupted with verbal or physical stimulation3
  • 17. Clinical Presentation Sensory and Autonomic  Parents/caregivers may report the child is:  Feeling nauseous  Feeling odd or peculiar  Losing control of bowel or bladder  Feeling numbness, tingling  Experiencing odd smells or sounds 17
  • 18. Clinical Presentation Consciousness  Consciousness is the usual alertness or responsiveness the child demonstrates.  Parents/caregivers may report or you may observe the child to have:  Baseline alertness  Diminished level of consciousness  Unresponsive and unconscious 18
  • 19. Clinical Presentation Events That Mimic Seizures  Apnea  Breath Holding  Dizziness  Myoclonus  Pseudoseizures  Psychogenic Seizures  Rigors  Shuddering  Syncope  Tics  Transient Ischemic Attacks 19
  • 20. Seizure Classifications Generalized Partial Complex Simple Involves BOTH hemispheres of the brain May have aura No impaired consciousness Always involves loss of consciousness Involves motor* or autonomic# symptoms with altered level of consciousness Can involve motor,* autonomic# or somatosensory+ symptoms Types:  Tonic or clonic movements or combination (grand mal)  Absence (petit mal)  Myoclonic  Atonic (e.g., drop attacks)  Infantile spasms May generalize May generalize Types of symptoms: 1) Motor* - head/eye deviation, jerking, stiffening 2) Autonomic# - pupils dilatation, drooling, pallor, change in heart rate or respiratory rate 3) Somatosensory+ - smells, alteration of perception (déjà vu) 20
  • 21. Generalized Seizure Classification: Descriptions1  Absence - Abrupt lapses of consciousness lasting a few seconds  Atonic - Abrupt, unexpected loss of muscle tone  Myoclonic - Rapid short contractions of one or all extremities 21
  • 22. Febrile Seizure Return to Table of Contents 22
  • 23. Febrile Seizure4 Febrile seizures are the most common seizure disorder in childhood, affecting 2 - 5% of children between the ages of 6 months and 5 years 23
  • 24. Febrile Seizure5  Caused by the increase in the core body temperature greater than 100.4F or 38C  Threshold of temperature which may trigger seizures is unique to each individual  Can occur within the first 24 hours of an illness  Can be the first sign of illness in 25 - 50% of patients 24
  • 25. Febrile Seizure: Characteristics  Are benign  Occurrence: between 6 months to 5 years of age  May be either simple or complex type seizure  Seizure accompanied by fever (before, during or after) WITHOUT ANY  Central nervous system infection  Metabolic disturbance  History of previous seizure disorder 25
  • 26. Febrile Seizure: Two Types4 Simple Febrile  6 months – 5 years of age  Febrile before, during or after seizure  Generalized seizure lasting less than 15 minutes, and  Occurs once in a 24-hour period Complex Febrile  6 months – 5 years of age  Febrile before, during or after seizure  Prolonged (lasting more than 15 minutes),  Focal seizure, or  Occurs more than once in 24 hours 26
  • 27. Febrile Seizure: Prehospital Assessment  Assess A,B,C’s  Assess neurological status (D = Disability using AVPU)  Obtain seizure history from a dependable witness:  How long was the seizure?  What did it look like (movements, eye deviation)?  History of previous seizures (child and family)?  Does the child have a current illness/fever?  Any indications of trauma or abuse?  Length of postictal phase?  List current medications  Include any antipyretics given (time and dose) 27
  • 28. AVPU The AVPU scale (Alert, Voice, Pain, Unresponsive) is a system by which a healthcare professional can measure and record a child’s level of consciousness. The AVPU scale should be assessed using these identifiable traits, looking for the best response of each A Alert – the infant is active, responsive to parents and interacts appropriately with surroundings; the child is lucid and fully responsive, can answer questions and see what you're doing. V Voice – the child or infant is not looking around; responds to your voice, but may be drowsy, keeps eyes closed and may not speak coherently, or make sounds. P Pain – the child or infant is not alert and does not respond to your voice. Responds to a painful stimulus, e.g., shaking the shoulders or possibly applying nail bed pressure. U Unresponsive – the child or infant is unresponsive to any of the above; unconscious. 28
  • 29. Febrile Seizure: Prehospital Management  Monitor A, B, C, D’s  Position with C-Spine protection (if trauma)  Follow seizure and aspiration precautions (per protocol)  Physical exam  Check blood glucose  If blood glucose < 60, treat as appropriate Refer to EMSC Seizure protocols (Appendix A) 29
  • 30. Febrile Seizure: ED Assessment  Baseline assessment  Vital signs (including temperature)  Assess A, B, C, D’s  Continue providing and documenting seizure and aspiration precautions 30
  • 31. Febrile Seizure: ED Assessment (cont.)  Full History  Obtain seizure history from a dependable witness:  When did the seizure occur?  How long was the seizure and what did it look like?  How was the child acting immediately before the seizure?  History of previous seizures (child and family)?  History of developmental delay/recent loss of milestones?  Does the child have a current illness/fever?  Any indications of trauma or abuse?  Length of postictal state?  Immunization history?  List current medications  Include any antipyretics given (time and dose) 31
  • 32. Febrile Seizure: ED Management7  If still seizing, follow Status Epilepticus protocol  Complete physical exam – to identify the source of fever  If child has a prolonged postictal period - consider administering glucose  Lab testing - direct toward identifying the source of fever  For Simple Febrile Seizures: NO ROUTINE LAB TESTS ARE NECESSARY 32
  • 33. Simple Febrile Seizure: Lumbar Puncture Evidence-based recommendations from the 2011 AAP Subcommittee on Febrile Seizures6 are as follows: “A lumbar puncture should be performed in any child who presents with a (simple febrile) seizure and a fever and has meningeal signs and symptoms (e.g., neck stiffness, Kernig and/or Brudzinski signs) or in any child whose history or examination suggests the presence of meningitis or intracranial infection.” Current data does not support routine lumbar puncture in well-appearing, fully immunized children who present with a simple febrile seizure. 33
  • 34. Simple Febrile Seizure: Lumbar Puncture (cont.) Additional evidence-based recommendations from the 2011 AAP Subcommittee on Febrile Seizures6 are as follows: “In any infant between 6 and 12 months of age who presents with a (simple febrile) seizure and fever, a lumbar puncture is an option when: - the child is considered deficient in Haemophilus influenza type b or Streptococcus pneumoniae immunizations (i.e., has not received scheduled immunizations as recommended) or - when the immunization status cannot be determined because of an increased risk of bacterial meningitis.” “A lumbar puncture is an option in the child who presents with a (simple febrile) seizure and fever and is pretreated with antibiotics, because antibiotic treatment can mask the signs and symptoms of meningitis.” 34
  • 35. Simple Febrile Seizure: Diagnostic Testing4,6 EEG CT/MRI Simple Febrile Seizure Should not be performed in a neurologically healthy child. Results are not predictive of recurrence or development of epilepsy Not indicated 35 There are no current national guidelines addressing diagnostic testing recommendations for complex febrile seizures.
  • 36. Simple Febrile Seizure: ED Ongoing Management  Reassess temperature  Consider giving antipyretic if not previously administered  As source of fever is identified, treat appropriately 36
  • 37. Simple Febrile Seizure: Family Education4,6 Here are some frequently asked questions parents/ caregivers may have prior to discharge:  Is my child brain damaged?  There is no evidence of impact on learning abilities after seizure from SFS.  Will this happen again?  If child is under 12 months of age at time of first seizure, recurrence rate is 50%  If child is greater than 12 months of age at time of first seizure, recurrence rate is 30%  Most recurrences occur within 6-12 months of the initial febrile seizure 37
  • 38. Simple Febrile Seizure: Family Education4,6 (cont.)  Will my child get epilepsy?  For simple febrile seizures, there is no increased risk of epilepsy  Why not treat for possible seizures or fever?  Anticonvulsants can reduce recurrence. However potential side effects of medications outweigh the minor risk of recurrence  Prophylactic use of antipyretics does not have impact on recurrence 38 For complex febrile seizures, there is a slight increase in the risk of epilepsy.
  • 39. Simple Febrile Seizure: Family Education7 (cont.)  Instruct parent/caregivers to prevent injury during a seizure :  Position child while seizing in a side-lying position  Protect head from injury  Loosen tight clothing about the neck  Prevent injury from falls  Reassure child during event  Do not place anything in the child’s mouth 39
  • 40. Simple Febrile Seizure: Disposition Prior to discharge home…  Educate regarding use of:  Thermometer  Antipyretics for fever management  When to contact 9-1-1 or ambulance  Identify Primary Care Provider for follow-up appointment and stress importance of follow-up  Provide developmentally appropriate explanation of event for child and family members 40
  • 41. Febrile Seizure: Test Yourself 1. Simple Febrile Seizures: A. Indicate an underlying neurological condition B. Require anticonvulsant medication C. Occur in children 6 months to 5 years of age D. Frequently lead to epilepsy 2. Which of the following are important history questions? A. Was there trauma ? B. What did the seizure look like? C. Medications and herbal supplements? D. All of the above 3. Diagnostic workup in the ED is based on suspicions of: A. Meningitis B. Trauma C. Unknown immunization status D. All of the above 4. Discharge education should include which of the following? A. Teaching about EEG results B. Importance of antipyretics for fever C. Importance of follow up MRI D. Teaching about anticonvulsant medications Proceed to next slide for answers 41
  • 42. Febrile Seizure: Test Yourself: ANSWER KEY 1. Simple Febrile Seizures: C. Occur in children 6 months to 5 years of age 2. Which of the following are important history questions? D. All of the above 3. Diagnostic workup in the ED is based on suspicions of: D. All of the above 4. Discharge education should include which of the following? B. Importance of antipyretics for fever 42
  • 43. First Unprovoked Seizure Return to Table of Contents 43
  • 44. First Unprovoked Seizure8 This is a first seizure that occurs without an immediate precipitating event. Etiology may be:  Remote symptomatic (related to a pre-existing brain abnormality/insult)  Cryptogenic or idiopathic (no known cause) Predictors of recurrence include: abnormal EEG, underlying etiology, and abnormal neurologic exams  Remote symptomatic – recurrence risk over 2 yrs is above 50%  Cryptogenic or idiopathic – recurrence risk over 2 yrs is 30-50%  If first seizure is prolonged, recurrent seizures are more likely to be prolonged. 44
  • 45. First Unprovoked Seizure: Presentation Parents/caregivers may describe symptoms consistent with the following:  Partial seizure  Generalized onset, tonic-clonic seizure  Tonic seizure 45 Remember: this is a seizure that occurs without an immediate precipitating event.
  • 46. First Unprovoked Seizure: Prehospital Assessment  Assess A, B, C, D’s  Obtain seizure history from a dependable witness:  How long was the seizure?  What did it look like (movements, eye deviation)?  History of previous seizures (child and family)?  Does the child have a current illness/fever?  Any indications of trauma or abuse?  Length of postictal state  List current medications  Include any antipyretics given (time and dose) 46
  • 47. First Unprovoked Seizure: Prehospital Management  Monitor A, B, C, D’s  Position with C-Spine protection (if trauma)  Follow seizure and aspiration precautions (per protocol)  Physical assessment  Check blood glucose  If blood glucose < 60, treat as appropriate Refer to EMSC Seizure protocols (Appendix A) 47
  • 48. First Unprovoked Seizure: ED Assessment  Baseline assessment  Vital signs (including temperature)  Assess A, B, C, D’s  Continue providing and documenting seizure and aspiration precautions 48
  • 49. First Unprovoked Seizure: ED Assessment (cont.)  If still seizing, follow Status Epilepticus protocol  Full History  Obtain seizure history from a dependable witness:  Recent exposures (chemical, industrial)?  When did the seizure occur?  How long was the seizure and what did it look like?  How was the child acting immediately before the seizure?  History of previous seizures (child and family)?  History of developmental delay/recent loss of milestones?  Does the child have a current illness?  Any indications of trauma or abuse?  Length of postictal state? 49
  • 50. First Unprovoked Seizure: ED Assessment (cont.)  List current medications  Include any antipyretics given (time and dose)  Include anticonvulsants given by prehospital team (time and dose)  Physical exam  Head-to-toe assessment 50
  • 51. First Unprovoked Seizure: Diagnostic Testing8 Laboratory tests are based on individual clinical circumstances and may include:  CBC with differential  Blood glucose  Electrolytes  Calcium, magnesium, phosphorous  Urine drug/toxicology screen  Urine HCG (age dependent) 51 Lumbar puncture is only indicated if there are other symptoms that suggest a diagnosis of meningitis.
  • 52. First Unprovoked Seizure: Diagnostic Testing – MRI8,9  Outpatient MRI should be considered for:  Children under 1 year of age  All children with significant acute cognitive or motor impairment  Unexplained abnormalities on neurologic exam  Seizure of focal onset without generalization  Abnormal EEG  Abnormalities on MRI are seen in up to 1/3rd of children  However, most abnormalities do not influence immediate treatment or management (such as need for hospitalization) 52
  • 53. First Unprovoked Seizure: Diagnostic Testing - CT Scan8,9 Emergent CT Scan (without contrast) should be considered for any child who exhibits any of the following:  Significant, acute cognitive or motor impairment  New focal deficit not quickly resolving  Not returned to baseline 53 MRI is the modality of choice, if available.
  • 54. First Unprovoked Seizure: Diagnostic Testing – EEG8,9  Obtain on ALL children in whom a nonfebrile seizure has been diagnosed  Can be arranged as an outpatient  Should be interpreted by a neurologist (preferably pediatric neurologist)  EEG results will:  Help predict the risk of recurrence  Classify the seizure type or epilepsy syndrome  Influence the decision to perform additional neuroimaging studies 54
  • 55. First Unprovoked Seizure: ED Management If child is still actively seizing…  Refer to Status Epilepticus protocol When child is stable…  Consult with Neurologist (or Intensivist)  For possible medication recommendations  To determine disposition: Admit to observe Transfer (if neurologist is unavailable) Discharge home 55
  • 56. First Unprovoked Seizure: Drug Therapy8,9  The majority of children who experience an unprovoked seizure will have few or no recurrences  Approximately 10% will go on to have additional seizures regardless of therapy  Type of medication if offered depends on:  Type, frequency and severity of seizures  Side effects, titration, drug interactions, dosing forms, cost of drug  Neurologist preference 56
  • 57. First Unprovoked Seizure: Discharge & Family Education Prior to discharge home…  Identify Primary Care Provider and Neurologist for follow-up appointments  Provide plan for outpatient EEG  Provide parental support  Consider rescue medication for home, based on neurologist recommendation (e.g., rectal diazepam) 57
  • 58. First Unprovoked Seizure: Family Education7  Instruct parent/caregivers to prevent injury during a seizure:  Position child while seizing in a side-lying position  Protect head from injury  Loosen tight clothing about the neck  Prevent injury from falls  Reassure child during event  Do not place anything in the child’s mouth 58
  • 59. First Unprovoked Seizure: Family Education (cont.)  Instruct in use of 9-1-1 or ambulance services  Provide developmentally appropriate explanation to child about the seizure event and treatment  Discourage swimming alone  No driving a car until cleared by a physician 59
  • 60. First Unprovoked Seizure: Family Education (cont.) Here are some frequently asked questions parents may have prior to discharge:  How likely is it that my child will have seizures again? The risk of recurrence relates to the underlying etiology and EEG results (normal or abnormal). The majority of children who experience an unprovoked seizure will have few or no recurrences. Approximately 10% will go on to have additional seizures regardless of therapy.8  Is there a risk of dying from the seizure if we don’t start medication today? Sudden unexpected death is very uncommon (usually related to an underlying neurologic handicap rather than seizure activity). There are no studies showing treatment after a first seizure alters the small risk of sudden death.8 60
  • 61. First Unprovoked Seizure: Test Yourself 1. Which of the following is a true statement regarding a First Unprovoked Seizure: A. Occurs without a precipitating event B. Is never associated with an underlying neurological condition C. Always leads to epilepsy D. Requires immediate initiation of antiepileptic medication 2. Children who have a First Unprovoked Seizure… A. Have their blood glucose checked by ambulance staff B. Could proceed to have Status Epilepticus C. Will require anti-pyretics to prevent seizures D. A and B 3. All children who have had a First Unprovoked Seizure should have an outpatient EEG. TRUE FALSE 4. The majority of children who have a First Unprovoked Seizure will have few or no recurrences. TRUE FALSE Proceed to next slide for answers 61
  • 62. First Unprovoked Seizure: Test Yourself: ANSWER KEY 1. Which of the following is a true statement regarding a First Unprovoked Seizure: A. Occurs without a precipitating event 2. Children who have a First Unprovoked Seizure… D. A and B 3. All children who have had a First Unprovoked Seizure should have an outpatient EEG. TRUE 4. The majority of children who have a First Unprovoked Seizure will have few or no recurrences. TRUE 62
  • 63. Status Epilepticus Return to Table of Contents 63
  • 64. Status Epilepticus: Definitions10  Seizures that persist without interruption for more than 5 minutes  Two or more sequential seizures without full recovery of consciousness between seizures This is a life threatening emergency that requires immediate treatment. 64
  • 65. Status Epilepticus10  Commonly occurs in children with epilepsy (9 -27% over time)  Complications from Status Epilepticus result from both the impact of the convulsive state on the body systems (such as the cardiac and respiratory systems) and the neuronal cellular injury which leads to cell death  Rapid termination of the seizure activity protects against neuronal injury 65
  • 66. Status Epilepticus: Types, Incidence and Description11 66 Type Incidence Description Remote Symptomatic SE 33% Status Epilepticus (SE) with no immediate event but the child had a previous history of CNS malformation, traumatic brain injury or chromosomal disorder Acute Symptomatic SE 26% SE with concurrent acute illness (e.g., meningitis, encephalitis, hypoxia, trauma, intoxication) Febrile SE 22% SE with a febrile illness but not a Central Nervous System infection (e.g., sinusitis, sepsis, upper respiratory infection) Cryptogenic SE 15% SE with no identifiable cause
  • 67. Status Epilepticus: Prehospital Assessment  Assess A, B, C, D‘s  Obtain seizure history from a dependable witness:  When did the seizure begin?  What did it look like (movements, eye deviation)?  History of previous seizures (child and family)?  Does the child have a current illness/fever?  Any indications of trauma or abuse?  Emergency Information Form for Children with Special Needs? 67
  • 68. Status Epilepticus: Prehospital Assessment  List current medications  Include any antipyretics given (time and dose)  Do the parents have any anticonvulsant medications (e.g., rectal diazepam)?  Have parents given any anticonvulsant medications (time and dose)? 68
  • 69.  Assess A, B, C, D’s  Positioning (with C-Spine protection if trauma)  Jaw thrust  Recovery position (side-lying)  Provide nasal airway, if needed  Seizure safety precautions (per protocol)  Aspiration precautions (per protocol)  Oxygen  Suction  Blood glucose testing  If blood glucose < 60, treat as appropriate 69 Status Epilepticus: Prehospital Assessment
  • 70.  If parent/caregiver has rectal diazepam and has not given it, the parent/caregiver should be requested to administer it  Document time and dose  Follow Pediatric Seizures ALS guideline (if appropriate)  Contact Medical Control REFER TO APPENDIX A for EMSC Seizure Protocols 70 Status Epilepticus: Prehospital Assessment
  • 71. Status Epilepticus: ED Goals of Therapy10,12 Minimize seizure time as much as possible and provide drug therapy promptly.  Drug therapy to halt seizure  With IV/IO access, *LORazepam IV/IO  If no IV/IO access, start with Diazepam PR *The Institute for Safe Medication Practices recommends using Tall Man (mixed case) letters in order to distinguish drugs with similar sounding names – decreasing the chances of safety errors. 71
  • 72. Status Epilepticus: ED Assessment  Assess A, B, C, D’s  Full vital signs; check bedside glucose and treat (per protocol)  Continue to provide and document seizure and aspiration precautions (per protocol)  Review Prehospital History and Treatment 72
  • 73. Status Epilepticus: ED Management  Full History  Obtain seizure history from a dependable witness:  How long has the seizure been going on and what did it look like when it started?  How was the child acting immediately before the seizure?  History of previous seizures (child and family)?  History of developmental delay/recent loss of milestones?  Does the child have a current illness?  Any indications of trauma or abuse?  Immunization status 73
  • 74. Status Epilepticus: ED Assessment  Assess E (exposure)  Current medications?  When were they last given?  Recent exposures - chemical, industrial, infectious?  Was patient recently out of the country? 74
  • 75. Status Epilepticus: ED Management – First 5 Minutes12  Evaluate airway  Suction, position and provide nasal airway as needed  Provide 100% oxygen (non-rebreather)  Establish vascular access  Draw labs as determined by history (examples:)  CBC, Electrolytes, Blood glucose, Calcium, Magnesium, Phosphorus  Toxicology screen, if indicated by history  Antiepileptic drug level, as indicated  Administer benzodiazepines  LORazepam IV/IO 0.1 mg/kg  No IV access, give either:  Diazepam PR 0.5 mg/kg (max PR dose = 20 mg) or  Midazolam IM 0.1 - 0.2 mg/kg Benzodiazepines may cause respiratory and cardiac depression. REFER TO APPENDIX B for sample guidelines 75
  • 76.  Reassess A, B, C’s  Continue supportive airway management  Suction, position and provide nasal airway as needed  Provide 100% oxygen (non-rebreather)  Evaluate results of rapid blood glucose testing If the seizure activity continues…  Administer medications (per guidelines)  Repeat IV LORazepam 0.1 mg/kg  Administer IV/IM Fosphenytoin 20 mg/kg PE (Phenytoin equivalents) REFER TO APPENDIX B for sample guidelines 76 PHENobarbital is preferred in neonates. Status Epilepticus: ED Management – Next 10 Minutes12
  • 77.  Having administered 2-3 doses of benzo- diazepines, and a dose of Fosphenytoin without halting the seizure, consider the patient in refractory Status Epilepticus13  Consult with Neurology and/or Intensivist for further management recommendations  If available, evaluate lab results 77 REFER TO APPENDIX B for sample guidelines Status Epilepticus: ED Management – Next 15 Minutes12
  • 78.  If seizure activity persists (after appropriate doses of benzodiazepines and Fosphenytoin), load with a second long-acting AED that was not used initially (e.g., phenobarbital, valproic acid)  Consider loading with Midazolam IV 0.1 - 0.2 mg/kg  Manage with continuous EEG monitoring  Contact PICU/NICU to begin transfer to higher level of care 78 REFER TO APPENDIX B for sample guidelines It is imperative to stop the seizure activity. If rapid sequence induction is necessary, use short-acting paralytics to ensure that ongoing seizure activity is not masked. Status Epilepticus: ED Management – Refractory SE
  • 79.  For a child in Status Epilepticus after 30 minutes of refractory SE, enact plans to transfer to your PICU/NICU or transport to a higher level of care  Continued testing can be arranged in that setting  Consider EEG with new onset SE  Neuroimaging (CT/MRI) if etiology is unknown REFER TO APPENDIX B for sample guidelines 79 Status Epilepticus: ED Management – Transfer13
  • 80. Status Epilepticus: Disposition  Discuss child’s progress and advice regarding admission or transfer based on patient status and neurology consultation with parents/caregiver  Utilize a specialty/critical care transport team  (If applicable) Explain these events to child in developmentally appropriate manner 80
  • 81. Status Epilepticus: Parent Education  Provide parents/caregivers information regarding child’s condition and treatment plan  Provide emotional/psychosocial support  Encourage use of the ACEP/AAP Emergency Information Form for possible future events 81
  • 82. Status Epilepticus: Emergency Information Form The Emergency Information Form (EIF) for Children With Special Needs resource was developed by the American College of Emergency Physicians (ACEP) and the American Academy of Pediatrics (AAP).  As a standardized medical summary it has  Information for prehospital and hospital emergency care personnel  Updates entered by caregivers  English and Spanish versions  24-hour accessibility  Free, Downloadable, interactive forms are available at the ACEP and the AAP websites. 82 To be completed by both the child’s medical team and parents/caregivers. Copies should be kept by parents, as well as on file at the PCP’s office, subspecialist’s office, local ED, and school nurse’s office.
  • 83. Status Epilepticus: Test Yourself 1. You respond to a 9-1-1 call for a 4-year-old child. You find the child on the floor of the playroom, unresponsive to voice with rhythmic movements of both the upper and lower extremities. The parents report that the child has had seizures, starting at age 2. The seizure activity has always lasted only about 1 minute. The parents called 9-1-1 when the initial seizure stopped, but the seizure started again with about one minute in between. They estimate the child has been seizing for about 15 minutes. Your FIRST response is to: A. Move the child to the bed B. Establish vascular access C. Protect/position the airway D. Give rectal diazepam Proceed to next slide for answer 83
  • 84. Status Epilepticus: Test Yourself: ANSWER KEY 1. You respond to a 9-1-1 call for a 4-year-old child. You find the child on the floor of the playroom, unresponsive to voice with rhythmic movements of both the upper and lower extremities. The parents report that the child has had seizures, starting at age 2. The seizure activity has always lasted only about 1 minute. The parents called 9-1-1 when the initial seizure stopped, but the seizure started again with about one minute in between. They estimate the child has been seizing for about 15 minutes. Your FIRST response is to: C.Protect/position the airway Proceed to next slide 84
  • 85. Status Epilepticus: Test Yourself 2. How quickly should the first benzodiazepine be given after status epilepticus begins? A. At 30 minutes B. At 20 minutes C. Within 5 minutes D. After 60 minutes 3. What drugs are used first in status epilepticus? A. Lorazepam B. Fosphenytoin C. Diazepam D. A and C 4. Who is likely to have status epilepticus? A. Child with a history of epilepsy B. Child with encephalitis C. Child with a traumatic brain injury D. All of the above Proceed to next slide for answers 85
  • 86. Status Epilepticus: Test Yourself: ANSWER KEY 2. How quickly should the first benzodiazepine be given after status epilepticus begins? C. Within 5 minutes 3. What drugs are used first in status epilepticus? D. A and C 4. Who is likely to have status epilepticus? D. All of the above 86
  • 88. References 1. Epilepsy and Seizure Statistics. (2010). EpilepsyFoundation.org. Retrieved April 21, 2011 from http://www.epilepsyfoundation.org/about/statistics.cfm. 2. Pillow MT, Howes DS, Doctor, SU. Seizures. eMedicine.medscape.com. Updated Jan 22, 2010. 3. Fisher, PG. First and second seizure: what to do and know. Contemporary Pediatrics. 2007;24(4):80-89. 4. Steering Committee on Quality Improvement and Management, Subcommittee on Febrile Seizures. Febrile seizures: clinical practice guideline for the long-term management of the child with simple febrile seizures. Pediatrics. 2008;121:1281-1286. 5. Freedman SB, Powell EC. Pediatric seizures and their management in the emergency department. Clin Ped Emerg Med. 2003;4:195-206. 88
  • 89. References (cont.) 6. Steering Committee on Quality Improvement and Management, Subcommittee on Febrile Seizures. Neurodiagnostic evaluation of the child with a simple febrile seizure. Pediatrics. 2011;127;389-394. 7. American Association of Neuroscience Nurses. Care of the patient with seizures. 2nd ed. Glenview (IL): American Association of Neuroscience Nurses; (Revised 2009). 23 p. 8. Hirtz D, Berg A, Bettis D, et al. Practice parameter: treatment of the child with a first unprovoked seizure: report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology. 2003;60:166-175. 9. Hirtz D, Ashwal S, Berg A, et al. Practice parameter: evaluating a first nonfebrile seizure in children: report of the Quality Standards Subcommittee of the American Academy of Neurology, the Child Neurology Society, and the American Epilepsy Society. Neurology. 2000;55:616–623. 89
  • 90. References (cont.) 10. Millikan D, Rice B, Silbergleit R. Emergency treatment of status epilepticus: current thinking. Emerg Med Clin North Am. 2009;27(1):101-113. 11. Riviello JJ Jr., Ashwal S, Hirtz D, et al. American Academy of Neurology Subcommittee, Practice Committee of the Child Neurology Society. Practice parameter: diagnostic assessment of the child with status epilepticus (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology. 2006;67(9):1542-50. 12. Goldstein J. Status epilepticus in the pediatric emergency department. Clin Ped Emerg Med. 2008;9:96-100. 13. Abend NS, Dlugos DJ. Treatment of refractory status epilepticus: literature review and a proposed protocol. Pediatr Neurol. 2008;38:377-390. 90
  • 91. Online Resources American Epilepsy Society http://www.acep.org/content.aspx?id=26276 American Academy of Neurology Patient Education Materials http://www.aan.com/go/practice/patient CDC: Epilepsy http://www.cdc.gov/Epilepsy/ Citizens United for Research in Epilepsy (CURE) http://www.cureepilepsy.org/resources/ Epilepsy Foundation: Epilepsy and Seizure Response for Law Enforcement and EMS (free online training) http://www.epilepsyfoundation.org/livingwithepilepsy/firstresponders/index.cfm Epilepsy Therapy Project http://www.epilepsy.com/epilepsy_therapy_project 91 Return to Table of Contents
  • 92. Video Resources Understanding Epilepsy www.youtube.com/watch?v=MNQlq004FkE Types of Seizures www.youtube.com/watch?v=CDccChHrgRA&feature=channel Understanding Partial Seizures www.youtube.com/watch?v=e10FSjHvV74&feature=channel Understanding Generalized Seizures www.youtube.com/watch?v=w5Jv0SZRwwk&feature=channel What causes Epilepsy www.youtube.com/watch?v=6NcqQkKjqTI&feature=fvw Diagnosing Epilepsy www.youtube.com/watch?v=HX7L11rhRTw&feature=channel Seizure Imitators Overview www.youtube.com/watch?v=J4xJSGpJioI&feature=relmfu 92 Return to Table of Contents
  • 93. APPENDIX A EMSC Prehospital Protocols Return to Table of Contents 93
  • 94. EMSC Prehospital Protocols  All Pediatric Seizure care guidelines follow this sequence:  Initial Medical Care/Assessment  Protect the child from Injury  Vomiting and Aspiration precautions THE NEXT STEPS DEPEND ON THE LEVEL OF CARE OF THE RESPONDER 94
  • 95. EMSC Prehospital Protocols Here are examples of prehospital pediatric seizure protocols  EMERGENCY MEDICAL RESPONDER CARE GUIDELINE  BLS CARE GUIDELINE  ILS CARE GUIDELINE  ALS CARE GUIDELINE 95 Source: Illinois EMSC Pediatric Prehospital Protocols
  • 96. APPENDIX B Sample Emergency Department Guidelines Return to Table of Contents 96
  • 97. Sample ED Status Epilepticus Guidelines Please give credit to any of the following resources you use  Children’s Memorial Hospital Emergency Department Management Guideline  Advocate Condell Medical Center Pediatric Emergency Department Clinical Guideline  University or Chicago Comer Children’s hospital Pediatric Emergency Department Clinical Guideline: Status Epilepticus 97
  • 98. APPENDIX C Neonatal Seizures Return to Table of Contents 98
  • 99. Neonatal Seizures  Neonatal seizures can be difficult to diagnose o May consist of very subtle and unusual physical signs  Eye deviation, staring episodes, winking  In neonates, onset of seizure activity is important in determining etiology o First 24 - 72 hours of life  Ischemic hypoxia  72 hours to 1 week of age o Familial neonatal seizures  Metabolic disorders 99
  • 100. Neonatal Seizures  Beyond the standard history, ask about the pregnancy, labor and delivery and maternal risk factors  Physical exam should include head circumference and careful inspection for dysmorphic features and cutaneous lesions.8  Consult with a pediatric neurologist to identify infantile seizure disorders 100
  • 101. Neonatal Seizures: Status Epilepticus  Assess A, B, C’s  Evaluate and maintain airway  Provide 100% oxygen  Establish vascular access  Obtain rapid glucose  Administer Medications  PHENobarbital 20 mg/kg IV  Repeat up to 40 mg/kg total dose  Contact Neurology 101