A clinical information system (CIS) is a technology-based system used at the point of care to support information acquisition, processing, storage and retrieval. It provides a complete electronic health record. Key benefits include easy access to patient data, ability to search and analyze data. Key players who use the CIS include administrators, physicians, nurses and other clinical staff. It is important for all stakeholders to be involved in selection and use. Components of an electronic health record include health information, order management, decision support and administrative functions. Clinical decision support systems can be knowledge-based, providing accurate clinical data, or non-knowledge based, using machine learning from past data. Safety, security, costs and staff education must all be considered for successful