The study investigated whether decreased activity in the prefrontal cortex (PFC) of obese individuals is an inherent trait or acquired due to obesity. Using an animal model of diet-induced obesity in adult minipigs, the researchers found decreased PFC activity in obese minipigs compared to lean ones. This suggests the abnormal PFC activity is not predetermined but rather depends on nutritional factors. The obese minipigs also showed reduced activity in dopamine-regulating brain areas related to food reward and addiction. The minipig model provides insights into how overeating impacts brain function and metabolism in ways relevant to human obesity.