Novel Tyrosine Kinase Inhibitors for Ovarian Cancer

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Zuleika86

Education Health & Medicine

[object Object],[object Object],[object Object],[object Object],[object Object],Novel Tyrosine Kinase Inhibitors for Ovarian Cancer Experimental Therapeutics Department Dr. Gabriel Lopez-Berestein, MD

Introduction ,[object Object],[object Object],[object Object],[object Object],[object Object]

Focal Adhesion Kinase ,[object Object],[object Object],[object Object],[object Object],[object Object]

Ovarian Cancer Therapy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

New FAK Inhibitors ,[object Object],[object Object],JAK2-10 FAK ATP Binding Pocket

Hypothesis JAK2-10 , inhibitor of JAK, also inhibits FAK activity.

Aim To determine whether JAK2-10 inhibits FAK activation in SKOV3 ovarian cancer cells .

Methods ,[object Object],[object Object],NT Treated 72 -hr ,[object Object],24- hr 48 -hr 24-hr 48-hr 72-hr

[object Object],[object Object],Methods ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],From Molecular Cell Biology by Harvey Lodish et al. Credit: NIAID

- + - + - + 24-hr 48-hr 72-hr Tota l FAK β-Actin Results (-)  untreated (+)  treated 2.5X10 4 cells/mL ,[object Object],- + - + - + 24-hr 48-hr 72-hr pFAK β-Actin 5μM JAK2-10 5μM JAK2-10 SKOV3 Cells

Methods B NT 5 10 μM JAK2-10 ,[object Object],After 72-hr

Results ,[object Object],Dose (μM) % Growth

Conclusions & Ongoing Work ,[object Object],[object Object],[object Object],[object Object],[object Object]

Future Directions ,[object Object],[object Object]

Acknowledgements ,[object Object],[object Object],[object Object]

References ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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