The document discusses key concepts in Node.js including modules, using Node.js as a web server with HTTP, managing NPM packages, the event loop, event emitters, and streams/pipes. Modules allow code reuse and sharing functionality. Node.js can be used as a web server by creating an HTTP server to handle requests and responses. NPM is used to install, update, search for, and uninstall third-party packages. The event loop handles asynchronous events and callbacks in Node.js. Event emitters emit and handle events. Streams allow reading/writing files and piping data between streams.