Node.js is an open source JavaScript runtime environment used to build real-time web applications. The document introduces Node.js, the npm package manager, the Express web application framework, and how to connect a Node.js application to MongoDB. Key points covered include Node.js being single-threaded and event-driven, using npm to install and use packages locally or globally, Express providing features for building web apps and APIs, and using modules like Mongoose to connect a Node app to MongoDB.