Practical Review about NOAC . Based on Last Guidelines by : Masoud Sajjadi , Fellowship of Interventional Cardiology from Iran Updated May 2021

1. Practical Cardiovascular Review
NOAC
By : Masoud Sajjadi
MD , Fellowship of Interventional Cardiology
Updated May 2021

2. 1. NOAC Practical Guide . EHJ 2015
2. NEJM ( Atlas trial . Compass trial . Augustus trial )
3. ESC Guideline 2016 . AF
5. Braunwald 2018
6. AHA Guideline 2019 . AF
7. ESC Guideline 2019 . PTE
PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

3. 8. AHA Guideline 2019 . CCS
9. American Journal of Hematology 2019
10. Management of Antithrombotic Therapy in AF Patients undergoing
PCI . JACC 2019
11. ESO Guideline 2019
12. ESC Guideline 2020 . AF
13. 2021 European Heart Rhythm Association Practical Guide on the
Use of NOACs in AF
PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

4.  1. Definition
 2. NOAC Mechanism
 3. NOAC vs Warfarin
 4. NOAC Types
 5. NOAC Metabolism
 6. NOAC Indications & Contraindications
 7. NOAC Selection
 8. NOAC Dosage
 9. NOAC Monitoring
10. NOAC & Body weight
PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

5. 11. NOAC In Different Settings
CAD . VTE . AF . LV Thrombus
Thrombocytopenia . HIT
Stroke .CKD .Liver Disease
12. NOAC Switching
13. NOAC & Operation
14. NOAC Reversal
15. NOAC & Bleeding
16. OAC & ICH PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

6. NOAC
Definition
PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

7. NOAC = DOAC
NOAC
New oral anticoagulants or
Novel oral Anticoagulants or
Non-vitamin K antagonist oral anticoagulants
DOAC
Direct oral anticoagulants
PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

8. NOAC
Mechanism
PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

10. NOAC vs Warfarin
PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

12. NOAC Types
PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

13. Dabigatran ( Pradaxa )
PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

14. Rivaroxaban
PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

15. Apixaban
PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

16. Edoxaban Betrixaban
Newer NOACs
PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

17. NOAC
Metabolism
PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

20. NOAC
Indications
&
Contraindications
PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

21.  1. CAD ( SIHD & ACS )
2. VTE ( DVT/PTE )
3. Non-Valvular AF
4. Mild MS + AF
5. LV Thrombus
6. HIT
PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

22.  1. Pregnancy
2. Lactation Period
3. APS
4. CRF
( Dabigatran GFR<30 milt/min - Rivaroxaban < 15mlit/min )
• Apixaban May be Considered In Non-Valvular AF & ESRD – COR IIb ( AHA 2019 )
5. Mechanical Prosthesis or Valve Repair
6. Active Pathological Bleeding or High Bleeding Risk Conditions
7. Chronic Liver Disease ( Child B & C ) or Liver Disease with Coagulopathy
8. Concominat Use of HIV Protease Inhibitors & Azoles
PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

23. NOAC
Selection
PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

27. NOAC Dosage
( EHRA Guideline 2021 )
PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

31. NOAC
Monitoring
PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

32. PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

33. NOAC
&
Body Weight
PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

34. PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

35. NOAC
in
Different Settings
PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

36. NOAC & CAD
PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist
CAD

37. NOAC & CAD

38. PCR Series
Masoud. Sajjadi

39. PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

40. PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

41. PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

42. PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

44. NOAC & VTE
PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist
VTE

45. PCR Series
Masoud. Sajjadi

46. PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

47. PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

48. NOAC & AF
PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist
AF

58. PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist
Antithrombotic Therapy in AF

66. NOAC
&
LV Thrombus
PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist
LV Thrombus

67. PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

68. PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

69. PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

70. PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist
Thrombocytopenia
NOAC & Thrombocytopenia

71. PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

72. NOAC & HIT
PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist
HIT

73. PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

74. PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist
Stroke

78. NOAC & CKD
PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist
CKD

80. NOAC & ESRD . AHA Guideline 2019

81. NOAC
&
Liver Disease
PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist
Liver
Disease

82. NOAC & Liver Disease . EHRA Guideline 2021

83. NOAC
Switching
PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

84. PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

85. PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

86. PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

87. NOAC
&
Operation
PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

94. NOAC
Reversal
PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

95. PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

98. NOAC
&
Bleeding
PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

100. PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

101. PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

102. PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

105. OAC
&
ICH
PCR Series
Masoud. Sajjadi
MD . Interventional Cardiologist

107. OAC & ICH . ESO 2019

110. THANKS FOR
YOUR ATTENTION