NJ AIDS Walk 2012
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This document encourages friends to register for the 2012 New Jersey AIDS Walk by forming teams with friends and family. It mentions prizes for the top earner, including a 47" TV. Participating in large numbers and recruiting others makes the event more impactful and fun while supporting lifesaving work for those with HIV/AIDS in New Jersey.
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This document is the winter 2011 issue of the newsletter for the North Jersey Community Research Initiative (NJCRI). NJCRI provides HIV/AIDS services including clinical trials, treatment, care and prevention in Newark, NJ. The issue discusses NJCRI's mission and services, celebrates its 2nd annual fundraiser with a visit from Newark Mayor Corey Booker, announces new programs including a drop-in center and men's group, and highlights client stories and community outreach events.
2010 2nd Annual Meet & Greet Honorees
This document summarizes biographies for several honorees being recognized at NJCRI's 2nd Annual Meet & Greet event. It provides background information on Lisa Mateo, a news reporter being honored; Dr. Robert Fullilove, an educator and HIV/AIDS activist; Dwight Peavy, the executive director of Newark EMA HIV Health Services Planning Council; and Gary Paul Wright, the founder of the African American Office of Gay Concerns. It also recognizes contributions from Henry Iwuala of Kintock Group, Bill Orr as the founder and executive director of NJCRI, client and volunteer Freddie Perry, nurse Ann Sheridan, and Dr. George Perez as NJCRI
NJCRI Staff & Programs
NJCRI is New Jersey’s largest and most comprehensive HIV/AIDS community-based organization. Our mission is “to help people with HIV/AIDS and those at risk for HIV/AIDS.” We conduct state-wide HIV clinical trials, and HIV treatment, care and prevention services in the Greater Newark Area. Populations we serve include youth and adults, men and women, men who have sex with men, people who acquire or who are at risk for HIV through injection drug use, and others.
NJCRI also seeks to address the concerns and disparities of access to health care faced by minority populations. Some of the non-HIV related services we offer include behavioral research, chronic illness management education, street outreach, substance abuse treatment, transportation, food pantry, and technical assistance to other community-based organizations. Approximately 5,000 people avail themselves of our free and confidential services each year.
NJCRI 2nd Annual Meet & Greet Invitation
The New Jersey Community Research Initiative is celebrating its 22nd anniversary on October 7th, 2010 from 6-9 PM at the Aljira: A Center for Contemporary Art in Newark. Tickets cost $60 and can be purchased in advance online or by mailing a check to the provided address. The event will honor community leaders, include hors d'oeuvres, live music, and a silent auction. Lisa Mateo will serve as mistress of ceremonies and Dr. Robert Fullilove will be a special guest.
Volume 2 issue 4 - fall 2010
As a health educator, Liz Kimani educates inmates on health issues like HIV, STDs and Hepatitis C through presentations,
pamphlets, and classes. She encourages testing and safer practices upon release. As a discharge case manager, she connects inmates
to social and medical services for a successful transition. Pamela Bolden-Nmezi provides follow-up case management for at least 6
months after release, evaluating health issues and linking clients to community resources. Antonio Alexander facilitates programs on
healthy relationships and reentry support. Together they work to educate, support, and link incarcerated and recently released individ-
uals to needed health and social services through NJCRI's Project Renew.
Njcri community festival 2010 flyer
Este documento anuncia un festival comunitario que se llevará a cabo el 14 de agosto de 2010 de 10:00 a.m. a 4:00 p.m. en Newark, Nueva Jersey. El festival ofrecerá información sobre servicios de salud disponibles, comida gratis, juegos, música y la aparición de Shrek. Se anima a las familias y amigos a asistir y pasar un buen rato.
Presentation on Syringe Exchange in Newark, New Jersey
New Jersey has high rates of HIV and hepatitis infections among injection drug users. NJCRI's Project Access is a syringe exchange program in Newark that seeks to reduce harm from drug use by providing clean syringes. It has enrolled over 1,300 clients since opening in 2008 without any local, state, or federal funding. Studies show that syringe exchange programs reduce disease transmission and connect clients to treatment and social services without increasing drug use.
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Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
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It is mostly found in the brain, intestines, and blood platelets.
5-HT is utilised to transport messages between nerve cells, is known to be involved in smooth muscle contraction, and adds to overall well-being and pleasure, among other benefits. 5-HT regulates the body's sleep-wake cycles and internal clock by acting as a precursor to melatonin.
It is hypothesised to regulate hunger, emotions, motor, cognitive, and autonomic processes.
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Gastrointestinal Infections
GASTROINTESTINAL INFECTIONS result from the ingestion of pathogens that cause infections at the level of this tract, generally being transmitted by food, water and hands contaminated by microorganisms such as E. coli, Salmonella, Shigella, Vibrio cholerae, Campylobacter, Staphylococcus, Rotavirus among others that are generally contained in feces, thus configuring a FECAL-ORAL type of transmission.
Among the factors that lead to the occurrence of gastrointestinal infections are the hygienic and sanitary deficiencies that characterize our markets and other places where raw or cooked food is sold, poor environmental sanitation in communities, deficiencies in water treatment (or in the process of its plumbing), risky hygienic-sanitary habits (not washing hands after major and/or minor needs), among others.
These are generally consequences (signs and symptoms) resulting from gastrointestinal infections: diarrhea, vomiting, fever and malaise, among others.
The treatment consists of replacing lost liquids and electrolytes (drinking drinking water and other recommended liquids, including consumption of juicy fruits such as papayas, apples, pears, among others that contain water in their composition).
To prevent this, it is necessary to promote health education, improve the hygienic-sanitary conditions of markets and communities in general as a way of promoting, preserving and prolonging PUBLIC HEALTH.
Gastritis and Gastric Health
Gastric Health is one of the most relevant concerns in human health, with gastrointestinal infections being among the main illnesses that affect humans.
Among gastric problems, we have GASTRITIS AND GASTRIC ULCERS as the main public health problems. Gastritis and gastric ulcers normally result from inflammation and corrosion of the walls of the stomach (gastric mucosa) and are generally associated (caused) by the bacterium Helicobacter pylor, which, according to the literature, this bacterium settles on these walls (of the stomach) and starts to release urease that ends up altering the normal pH of the stomach (acid), which leads to inflammation and corrosion of the mucous membranes and consequent gastritis or ulcers, respectively.
In addition to bacterial infections, gastritis and gastric ulcers are associated with several factors, with emphasis on prolonged fasting, chemical substances including drugs, alcohol, foods with strong seasonings including chilli, which ends up causing inflammation of the stomach walls and/or corrosion. of the same, resulting in the appearance of wounds and consequent gastritis or ulcers, respectively.
Among patients with gastritis and/or ulcers, one of the dilemmas is associated with the foods to consume in order to minimize the sensation of pain and discomfort. Gene Expression System-viral gene delivery Mpharm(Pharamaceutics)
Gene therapy can be broadly defined as the transfer of genetic material to cure a disease or at least to improve the clinical status of a patient.
One of the basic concepts of gene therapy is to transform viruses into genetic shuttles, which will deliver the gene of interest into the target cells.
Safe methods have been devised to do this, using several viral and non-viral vectors.
In the future, this technique may allow doctors to treat a disorder by inserting a gene into a patient's cells instead of using drugs or surgery.
The biggest hurdle faced by medical research in gene therapy is the availability of effective gene-carrying vectors that meet all of the following criteria:
Protection of transgene or genetic cargo from degradative action of systemic and endonucleases,
Delivery of genetic material to the target site, i.e., either cell cytoplasm or nucleus,
Low potential of triggering unwanted immune responses or genotoxicity,
Economical and feasible availability for patients .
Viruses are naturally evolved vehicles that efficiently transfer their genes into host cells.
Choice of viral vector is dependent on gene transfer efficiency, capacity to carry foreign genes, toxicity, stability, immune responses towards viral antigens and potential viral recombination.
There are a wide variety of vectors used to deliver DNA or oligo nucleotides into mammalian cells, either in vitro or in vivo.
The most common vector system based on retroviruses, adenoviruses, herpes simplex viruses, adeno associated viruses.
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Academy of Oriental Medicine at Austin
Academy of Oriental Medicine at Austin
Academy of Oriental Medicine at Austin
About AOMA: The Academy of Oriental Medicine at Austin offers a masters-level graduate program in acupuncture and Oriental medicine, preparing its students for careers as skilled, professional practitioners. AOMA is known for its internationally recognized faculty, award-winning student clinical internship program, and herbal medicine program. Since its founding in 1993, AOMA has grown rapidly in size and reputation, drawing students from around the nation and faculty from around the world. AOMA also conducts more than 20,000 patient visits annually in its student and professional clinics. AOMA collaborates with Western healthcare institutions including the Seton Family of Hospitals, and gives back to the community through partnerships with nonprofit organizations and by providing free and reduced price treatments to people who cannot afford them. The Academy of Oriental Medicine at Austin is located at 2700 West Anderson Lane. AOMA also serves patients and retail customers at its south Austin location, 4701 West Gate Blvd. For more information see www.aoma.edu or call 512-492-303434.
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NJ AIDS Walk 2012
- 1. Dear friends, Don’t forget to register to the NJ AIDS Walk 2012. Top Earner Prize ($1,100 or More)!! 47” Vizio Flat Screen TV!! Participating in the New Jersey AIDS Walk 2012 is much more powerful (not to mention, more fun) when you join together with a friend or two…or ten! Or 100! We want YOU to register to walk with us this year and inspire others to walk and fundraise with you! Consider forming a team with your friends, family, and/or co-workers. When you walk, and share your passion by recruiting others to walk, YOU support the lifesaving work of NJCRI, the many other HIV/AIDS organizations in New Jersey and the thousands of men, women, and families who depend on it. Thank you. www.njcri.org http://www.events.org/ejh01/cpage.aspx?e=42399 Join us on Sunday, May 6 in Branch Brook Park, Newark New Jersey.