The NHS England Patient Safety Alert aims to standardize early identification of acute kidney injury (AKI) across all healthcare settings. It establishes an algorithm based on international guidelines to systematically detect changes in serum creatinine consistent with AKI. This will generate an AKI stage and rapidly alert clinicians. The goals are to improve AKI detection, management, and outcomes through a consistent detection method, education programs, and prospective data collection to measure impact and drive further improvement. A multi-site study will test the effectiveness of detection/alerting combined with education and clinical bundles.