New Delhi metallo-beta-lactamase 1 (NDM-1) strains of bacteria can spread easily in medical tourism & medical camps by the physicians, attendants poses a serious threat to the spread of this organism in India & Pakistan due to extensive properties of Metallo -lactamase (MBL) enzymes coding by the bacteria by NDM-1 gene. This gene is meticulously existing in the plasmid of Enterobactereceae members such as Escherichia coli and Kleb-siella pneumoniae result in dramatic antibiotic resistant genes in the bacteria & hydrolyze “various carbapenem anbiots, - lactamase inhibitors”. Therefore, during medical tourism, these bacteria are highly communicable through horizontal gene transfer to spread various diseases in medical torism centres in India—Chennai , Haryana. Inappropriate hand wash, and inappropriate hygiene during the tourism making these bacteria easier to spread through one person to another person Prokaryotes are the simple organisms with simple genome & they have no complex genome. They are very \"responsive\" to external stimuli compared to complex multicellular species as prokaryotes are going to \"change their antigenic variation\" through the phase variation. The genetic integrity include an extra-chromosomal structure called \"plasmid or through conjugate transposon\" & they transfer antibiotic resistant genes through \"horizontal gene transfer\" i.e. transformation, transduction & conjugation as the environmental cues are completely different to their survival habitat. Finally, they acquire stable internal environment to withstand outer invasive environment, as an evolutionary adaptation. However, this type of horizontal gene transfer is not existing in complex multicellular species to \"show slow responsivity\" to changing environmental cues\" as their genetic integrity do not permit to induce changes immediately through \"any process of horizontal gene transfer\". Prokaryotes possess a specific phenomenon of communicating system called quorum sensing when lethal environment developed around them for information passage. Three physiological ways by which bacteria become resistant to antibiotics after they acquire the resistance genes: Chemical transmitters released for communication between bacteria when an antibiotic enters into their habitat so that they change their physiological environment. Synthesis of virulent cell wall synthesis proteins: Lipopolysaccharides and a few enzymatic proteins encoded from antibiotic resistant genes to neutralize or to inactivate antibiotic finally to make harmless to their cell environment.bac Synthesis of virulent M protein: Antibiotic resistant genes are going to synthesize M -protein, a bacterial cell surface protein that can inactivate a variety of antibiotics. Beta-lactamase synthesis: A few bacteria can inactivate antibiotics (methicillin) by synthesizing these enzymes. Solution New Delhi metallo-beta-lactamase 1 (NDM-1) strains of bacteria can spread easily in medical tourism & medical ca.

1. New Delhi metallo-beta-lactamase 1 (NDM-1) strains of bacteria can spread easily in medical
tourism & medical camps by the physicians, attendants poses a serious threat to the spread of this
organism in India & Pakistan due to extensive properties of Metallo -lactamase (MBL) enzymes
coding by the bacteria by NDM-1 gene. This gene is meticulously existing in the plasmid of
Enterobactereceae members such as Escherichia coli and Kleb-siella pneumoniae result in
dramatic antibiotic resistant genes in the bacteria & hydrolyze “various carbapenem anbiots, -
lactamase inhibitors”. Therefore, during medical tourism, these bacteria are highly
communicable through horizontal gene transfer to spread various diseases in medical torism
centres in India—Chennai , Haryana. Inappropriate hand wash, and inappropriate hygiene during
the tourism making these bacteria easier to spread through one person to another person
Prokaryotes are the simple organisms with simple genome & they have no complex genome.
They are very "responsive" to external stimuli compared to complex multicellular species as
prokaryotes are going to "change their antigenic variation" through the phase variation. The
genetic integrity include an extra-chromosomal structure called "plasmid or through conjugate
transposon" & they transfer antibiotic resistant genes through "horizontal gene transfer" i.e.
transformation, transduction & conjugation as the environmental cues are completely different to
their survival habitat. Finally, they acquire stable internal environment to withstand outer
invasive environment, as an evolutionary adaptation. However, this type of horizontal gene
transfer is not existing in complex multicellular species to "show slow responsivity" to
changing environmental cues" as their genetic integrity do not permit to induce changes
immediately through "any process of horizontal gene transfer". Prokaryotes possess a specific
phenomenon of communicating system called quorum sensing when lethal environment
developed around them for information passage.
Three physiological ways by which bacteria become resistant to antibiotics after they acquire the
resistance genes:
Chemical transmitters released for communication between bacteria when an antibiotic enters
into their habitat so that they change their physiological environment.
Synthesis of virulent cell wall synthesis proteins: Lipopolysaccharides and a few enzymatic
proteins encoded from antibiotic resistant genes to neutralize or to inactivate antibiotic finally to
make harmless to their cell environment.bac
Synthesis of virulent M protein: Antibiotic resistant genes are going to synthesize M -protein, a
bacterial cell surface protein that can inactivate a variety of antibiotics.
Beta-lactamase synthesis: A few bacteria can inactivate antibiotics (methicillin) by synthesizing
these enzymes.

2. Solution
New Delhi metallo-beta-lactamase 1 (NDM-1) strains of bacteria can spread easily in medical
tourism & medical camps by the physicians, attendants poses a serious threat to the spread of this
organism in India & Pakistan due to extensive properties of Metallo -lactamase (MBL) enzymes
coding by the bacteria by NDM-1 gene. This gene is meticulously existing in the plasmid of
Enterobactereceae members such as Escherichia coli and Kleb-siella pneumoniae result in
dramatic antibiotic resistant genes in the bacteria & hydrolyze “various carbapenem anbiots, -
lactamase inhibitors”. Therefore, during medical tourism, these bacteria are highly
communicable through horizontal gene transfer to spread various diseases in medical torism
centres in India—Chennai , Haryana. Inappropriate hand wash, and inappropriate hygiene during
the tourism making these bacteria easier to spread through one person to another person
Prokaryotes are the simple organisms with simple genome & they have no complex genome.
They are very "responsive" to external stimuli compared to complex multicellular species as
prokaryotes are going to "change their antigenic variation" through the phase variation. The
genetic integrity include an extra-chromosomal structure called "plasmid or through conjugate
transposon" & they transfer antibiotic resistant genes through "horizontal gene transfer" i.e.
transformation, transduction & conjugation as the environmental cues are completely different to
their survival habitat. Finally, they acquire stable internal environment to withstand outer
invasive environment, as an evolutionary adaptation. However, this type of horizontal gene
transfer is not existing in complex multicellular species to "show slow responsivity" to
changing environmental cues" as their genetic integrity do not permit to induce changes
immediately through "any process of horizontal gene transfer". Prokaryotes possess a specific
phenomenon of communicating system called quorum sensing when lethal environment
developed around them for information passage.
Three physiological ways by which bacteria become resistant to antibiotics after they acquire the
resistance genes:
Chemical transmitters released for communication between bacteria when an antibiotic enters
into their habitat so that they change their physiological environment.
Synthesis of virulent cell wall synthesis proteins: Lipopolysaccharides and a few enzymatic
proteins encoded from antibiotic resistant genes to neutralize or to inactivate antibiotic finally to
make harmless to their cell environment.bac
Synthesis of virulent M protein: Antibiotic resistant genes are going to synthesize M -protein, a
bacterial cell surface protein that can inactivate a variety of antibiotics.

3. Beta-lactamase synthesis: A few bacteria can inactivate antibiotics (methicillin) by synthesizing
these enzymes.