a brief guide on ncni and genmomics

1. NCBI AND
COMPARATIVE
GENOMICS

2. .
Bsc Biotechnology
Sem:-6
Present to:- Kaushal Sir
Group Members
• Avantika Rajpurohit [204]
• Sumaiya Khan[216]
• Shweta Singh[239]
• Swagatika Ray[242]

3. LEN MORE
W
What is NCBI?
• Web Address:- https://www.ncbi.nlm.nih.gov/
• NCBI was established in 1998 as part of national library of
medicines at the national institute of health.
• The NCBI houses a series of databases relevant to
biotechnology and biomedicines and consist important
resources and tools.
• Major databases include GenBank for DNA sequences and
PubMed a bibliographic databases for biomedical literature.
• Major resources includes books, software tools [BLAST],
retrieval system, submission tools and specialize tools.

5. Tools
 Data retrieval tools
 BLAST
• MegaBLAST
• Standard BLAST
 Specialized Tools
• ORF Finder
• e-PCR
Databases
Nucleotide Database
Protein Database
Expression Database
Literature Database
Structure Database
Chemical Database
Other Database
NCBI Databases and
Resources

7. COMPARATIVE GENOMICS
Comparative genomics involves a
comprehensive systematic comparison
of genome sequences.
It begins with computer programs that
identify homologous region within the
genomes under comparison.
Set of homologous sequences are then
grouped with their sequences aligned
at the base-pair level in an attempt to
define whole genome sequence
alignments.

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12. HOW ARE GENOMES COMPARED?
They are compared by their:
 Chromosome level
 Number of genes
 Genome size
 Content (sequence)
 Location (map position)
 Gene order
 Gene cluster
 Translocation

13. Comparative genome sizes of Humans and
other Model organisms

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