The National Pregnancy in Diabetes Audit 2015 report provides the following key information:
- It analyzes data from 155 antenatal diabetes services in England, Wales and the Isle of Man on 3,044 pregnancies in women with diabetes.
- Few women met guidelines for preparation prior to pregnancy, with only 16% of those with Type 1 diabetes and 38% of those with Type 2 diabetes having an HbA1c level below 48 mmol/mol in the first trimester.
- The majority of women did not have contact with an antenatal diabetes team within the first 8 weeks of pregnancy as recommended.
- While some outcomes like stillbirth rates have modestly improved, preterm
This document provides an overview of disorders of carbohydrate metabolism during pregnancy, including gestational diabetes and pre-existing diabetes. It discusses the physiological changes in carbohydrate metabolism during pregnancy, pathogenesis and clinical features of type 1 and type 2 diabetes, effects of diabetes on pregnancy outcomes, management through medical treatment, diet, and obstetric care, and considerations for pre-pregnancy counseling and care during labor and delivery. The goal of management is to achieve near normal blood glucose levels in order to reduce risks of complications for both mother and baby.
Diabetes in pregnancy Dr.Pasham Sharath ChandraPasham sharath
This document discusses diabetes in pregnancy. It provides information on different types of diabetes including type 1, type 2, and gestational diabetes. It notes the risks of diabetes in pregnancy for both the mother and fetus, including complications like miscarriage, pre-eclampsia, and congenital malformations. The document discusses management of pregestational or overt diabetes in pregnancy, including achieving good glycemic control before and during pregnancy through insulin therapy, medical nutrition therapy, glucose monitoring, and lifestyle modifications.
In this interactive lecture Dr. Vicky Guanzon joins me in discussing the updates on the Diagnosis and Treatment of Diabetes in Pregnancy. Delivered at the L'Fischer Hotel in Bacolod City on August 6, 2015.
1) Gestational diabetes occurs in 3-5% of pregnancies and 90% of women with abnormal glucose tolerance have gestational diabetes. Approximately 50% will later develop type 2 diabetes.
2) Gestational diabetes increases risks for both mother and fetus, including preeclampsia for the mother and fetal macrosomia, hypoglycemia and birth trauma for the fetus.
3) Gestational diabetes is managed primarily through diet and exercise, with insulin therapy if needed to control blood glucose levels and minimize complications. Women with gestational diabetes have increased monitoring during and after pregnancy.
diabetes is very common disorder in all age group i.e from infancy to secondary childhood age so intake of good healthy diet is very important for the production of insulin which is needed for body for regular activities
This document discusses diabetes during pregnancy, including pregestational and gestational diabetes. Pregestational diabetes includes type 1 and type 2 diabetes and increases risks for maternal and fetal complications like congenital malformations. Gestational diabetes develops during pregnancy due to insulin resistance and increases risks for the mother and child. Screening and treatment aim to control blood glucose levels and minimize risks.
This document discusses diabetes in pregnancy. It defines gestational diabetes as high blood sugar that develops during pregnancy and usually disappears after giving birth. The document outlines risks of gestational diabetes to both mother and baby, including difficulties during labor, risks of obesity and type 2 diabetes later in life for the baby. It also discusses screening, diagnosis via glucose tolerance tests, and management of gestational diabetes through diet, exercise and possibly medication.
This document discusses gestational diabetes and gestational hypertension. It begins by defining the two conditions and describing their pathophysiology. It then covers screening and diagnosis of gestational diabetes, including risk factors, diagnostic testing guidelines from different organizations, and treatment targets. Treatment involves nutritional therapy, glucose monitoring, and insulin if needed to control blood glucose levels and prevent complications.
This document provides an overview of disorders of carbohydrate metabolism during pregnancy, including gestational diabetes and pre-existing diabetes. It discusses the physiological changes in carbohydrate metabolism during pregnancy, pathogenesis and clinical features of type 1 and type 2 diabetes, effects of diabetes on pregnancy outcomes, management through medical treatment, diet, and obstetric care, and considerations for pre-pregnancy counseling and care during labor and delivery. The goal of management is to achieve near normal blood glucose levels in order to reduce risks of complications for both mother and baby.
Diabetes in pregnancy Dr.Pasham Sharath ChandraPasham sharath
This document discusses diabetes in pregnancy. It provides information on different types of diabetes including type 1, type 2, and gestational diabetes. It notes the risks of diabetes in pregnancy for both the mother and fetus, including complications like miscarriage, pre-eclampsia, and congenital malformations. The document discusses management of pregestational or overt diabetes in pregnancy, including achieving good glycemic control before and during pregnancy through insulin therapy, medical nutrition therapy, glucose monitoring, and lifestyle modifications.
In this interactive lecture Dr. Vicky Guanzon joins me in discussing the updates on the Diagnosis and Treatment of Diabetes in Pregnancy. Delivered at the L'Fischer Hotel in Bacolod City on August 6, 2015.
1) Gestational diabetes occurs in 3-5% of pregnancies and 90% of women with abnormal glucose tolerance have gestational diabetes. Approximately 50% will later develop type 2 diabetes.
2) Gestational diabetes increases risks for both mother and fetus, including preeclampsia for the mother and fetal macrosomia, hypoglycemia and birth trauma for the fetus.
3) Gestational diabetes is managed primarily through diet and exercise, with insulin therapy if needed to control blood glucose levels and minimize complications. Women with gestational diabetes have increased monitoring during and after pregnancy.
diabetes is very common disorder in all age group i.e from infancy to secondary childhood age so intake of good healthy diet is very important for the production of insulin which is needed for body for regular activities
This document discusses diabetes during pregnancy, including pregestational and gestational diabetes. Pregestational diabetes includes type 1 and type 2 diabetes and increases risks for maternal and fetal complications like congenital malformations. Gestational diabetes develops during pregnancy due to insulin resistance and increases risks for the mother and child. Screening and treatment aim to control blood glucose levels and minimize risks.
This document discusses diabetes in pregnancy. It defines gestational diabetes as high blood sugar that develops during pregnancy and usually disappears after giving birth. The document outlines risks of gestational diabetes to both mother and baby, including difficulties during labor, risks of obesity and type 2 diabetes later in life for the baby. It also discusses screening, diagnosis via glucose tolerance tests, and management of gestational diabetes through diet, exercise and possibly medication.
This document discusses gestational diabetes and gestational hypertension. It begins by defining the two conditions and describing their pathophysiology. It then covers screening and diagnosis of gestational diabetes, including risk factors, diagnostic testing guidelines from different organizations, and treatment targets. Treatment involves nutritional therapy, glucose monitoring, and insulin if needed to control blood glucose levels and prevent complications.
1. Tight glycemic control through medical nutrition therapy, exercise, blood glucose monitoring, and potentially insulin is important to manage diabetes in pregnancy.
2. Close fetal surveillance through growth scans and tests are needed to monitor for complications like macrosomia.
3. Delivery timing and type (vaginal vs c-section) depends on maternal and fetal status and risks like macrosomia.
4. Neonatal risks include hypoglycemia, jaundice, and respiratory distress which requires close monitoring after birth.
5. Counseling on future diabetes risk and appropriate contraception is important in postpartum care.
This document discusses diabetes in pregnancy, including gestational diabetes and pre-existing diabetes. It provides details on screening and managing gestational diabetes through medical nutrition therapy, exercise, glucose monitoring, and insulin or oral hypoglycemic agents if needed. It also discusses fetal surveillance, delivery planning, neonatal care, and postpartum management and follow-up. Case examples are presented to illustrate how these guidelines would be applied. The key aspects of managing diabetes in pregnancy are screening, glycemic control through lifestyle and medical interventions, close fetal and maternal monitoring, and delivery planning tailored to each woman's risk factors and disease status.
Diabetes Mellitus & Gestational D iabetes in Pregnancy Lifecare Centre
This document discusses diabetes and gestational diabetes in pregnancy. It covers pre-conception care for women with diabetes, including achieving optimal blood glucose control through diet and medication. It also discusses care during pregnancy such as frequent monitoring and surveillance of the fetus. Complications of uncontrolled diabetes during pregnancy for both mother and baby are outlined. The importance of postpartum care is also mentioned.
This document summarizes diabetes mellitus (DM) and its management during pregnancy. It discusses the different types of DM, including pre-existing type 1 and type 2 DM as well as gestational DM. It outlines the physiological changes in pregnancy that can affect blood sugar levels. Diagnosis and treatment aims to achieve tight glycemic control before and during pregnancy to prevent complications such as fetal macrosomia and neonatal hypoglycemia. Management involves medical nutrition therapy, exercise, insulin therapy, and monitoring throughout pregnancy and the postpartum period. Complications of both maternal DM and infant outcomes are also summarized.
This document discusses gestational diabetes, including its definition, epidemiology, consequences for both mother and fetus, screening recommendations, management, and controversies around diagnostic criteria. Some key points:
- Gestational diabetes is defined as carbohydrate intolerance first recognized during pregnancy and can include undiagnosed preexisting diabetes.
- It affects 2-9% of pregnancies and screening is recommended for at-risk women between 24-28 weeks using a 75g oral glucose tolerance test.
- Risks for the fetus include macrosomia, jaundice, and hypoglycemia. Risks for the mother include preeclampsia, infections, and long-term risk of type 2 diabetes.
Gestational diabetes is a type of diabetes that develops during pregnancy and usually disappears after giving birth. It occurs in 2-10% of pregnancies due to hormonal changes reducing the body's ability to use insulin. While most women have no symptoms, screening tests are done between 24-28 weeks of pregnancy to check blood sugar levels. Eating a healthy diet and exercise can help manage gestational diabetes and reduce risks to both mother and baby like high birth weight or developing diabetes later in life.
Gestational diabetes (GDM) is glucose intolerance first identified during pregnancy. Risk factors include BMI over 30, previous large or diabetic baby, family history of diabetes. GDM is identified through a 75g oral glucose tolerance test. It is associated with risks like large baby, shoulder dystocia, preeclampsia. Treatment like insulin lowers risks. Other types of diabetes may present as GDM and require identification. Mild maternal hyperglycemia increases risks incrementally without a clear threshold.
This document discusses diabetes during pregnancy, including gestational diabetes and prediabetes. It provides statistics on the prevalence of different types of diabetes during pregnancy. Type 2 diabetes in pregnancy has a better prognosis than type 1 diabetes, with fewer complications. The document also discusses risk factors, screening, and management of gestational diabetes and prediabetes during and after pregnancy. It provides guidelines for screening and outlines the one-step and two-step approaches to screening and diagnosing gestational diabetes.
Gestational diabetes occurs in approximately 5% of pregnancies and results in high blood sugar levels during pregnancy. It develops when the placenta produces hormones that prevent the mother's cells from properly using insulin. To manage gestational diabetes, patients must monitor their blood sugar levels, follow a healthy diet with balanced carbohydrate intake, engage in moderate physical activity, and potentially take insulin or other medications. Maintaining blood sugar control is important for the health of both the mother and baby.
Gestational diabetes mellitus (GDM) is a type of diabetes that is first recognized during pregnancy. An oral glucose tolerance test is used to diagnose GDM, with abnormal fasting or post-meal blood glucose levels indicating GDM. Women with GDM are at higher risk of complications during pregnancy like preeclampsia and delivering a large baby, so treatment focuses on maintaining normal blood glucose levels through diet, exercise, and possibly insulin or metformin. After delivery, women with GDM have an increased long-term risk of type 2 diabetes and should undergo screening.
A comprehensive guide to the management of hyperglycaemia in pregnancy aimed at the primary care physician and based on latest evidenced based criteria. Includes information from latest studies such as HAPO study and ACHOIS, and involves guidelines from the IADPSG, ADA, WHO and Malaysia.
1. There are four criteria for diagnosing diabetes: A1C ≥6.5%, FPG ≥126 mg/dL, 2-hr PG ≥200 mg/dL during OGTT, or random PG ≥200 mg/dL.
2. Lowering A1C below 7.0% can reduce microvascular complications and macrovascular disease.
3. Gestational diabetes is diagnosed using a one-step 75g OGTT or two-step 50g GLT and 100g OGTT, with defined plasma glucose thresholds.
This document discusses diabetes in pregnancy. It defines and classifies diabetes in pregnancy as either pregestational or gestational. It recommends screening all pregnant patients for gestational diabetes through risk factors and a 50g oral glucose challenge test between 24-28 weeks of gestation. For those diagnosed with gestational diabetes, it recommends treatment through diet, glucose monitoring, and possible insulin therapy to control blood glucose and minimize risks to the fetus like macrosomia. Close fetal monitoring is also recommended for pregnancies complicated by diabetes.
Diabetes and pregnancy - Endocrine society guidelines 2013Jagjit Khosla
This presentation talks about diabetes mellitus in relation to pregnancy. It classifies diabetes in pregnant pts as overt and gestational diabetes. Then it discusses the various guidelines given by Endocrine Society in 2013 for management of diabetic patients during pregnancy
Gestational Diabetes is a kind of diabetes that only pregnant women get.If a woman get diabetes or high blood sugar when she is pregnant, but she never had it before, then she has gestational diabetes.
Gestational diabetes (GDM) occurs when a woman without diabetes develops high blood sugar levels during pregnancy. It is caused by hormones from the placenta that interfere with the mother's insulin and metabolism. GDM affects approximately 10% of pregnancies and screening involves a glucose challenge test followed by an oral glucose tolerance test if levels are high. Untreated GDM can lead to complications for both mother and baby such as preeclampsia, macrosomia, and jaundice. Treatment focuses on medical nutrition therapy, glucose monitoring, and possibly insulin to control blood sugar and minimize risks.
This document provides information on the classification, screening, diagnosis, treatment, and management of diabetes in pregnancy. It discusses gestational diabetes and pre-gestational diabetes. Guidelines are presented for screening and diagnosing gestational diabetes using oral glucose tolerance tests. The rationale for treating gestational diabetes to reduce risks of complications is explained. Methods for monitoring blood glucose, dietary management, exercise, and insulin treatment regimens are outlined. The document also covers maternal and fetal surveillance during pregnancy, as well as glycemic control during labor and delivery and postpartum follow-up.
Gestational diabetes (GDM) and preexisting diabetes during pregnancy carry risks for both mother and baby. GDM is diagnosed through a two-step screening and testing process involving glucose challenges. Left untreated, GDM can lead to complications like fetal overgrowth and hypoglycemia. Treatment involves lifestyle changes like medical nutrition therapy, exercise and glucose monitoring. If needed, oral medications or insulin may be used to control blood sugar. Close monitoring and control of blood sugar levels during pregnancy and delivery can help reduce risks. After pregnancy, women with GDM have an elevated risk of developing diabetes and require follow up testing.
This document provides an overview of diabetes mellitus in pregnancy. It defines diabetes in pregnancy and gestational diabetes, and discusses their incidence rates. It describes the screening, diagnosis, and management of diabetes in pregnancy. The document outlines the maternal and fetal effects of diabetes during pregnancy and notes increased risks of complications. It emphasizes the importance of glucose monitoring and medical nutrition therapy in managing diabetes in pregnancy.
Gestational diabetes affects 2-3% of pregnancies and is characterized by carbohydrate intolerance that is first diagnosed during pregnancy. It increases the risk of complications for both mother and baby, such as preeclampsia, operative delivery, macrosomia, and neonatal hypoglycemia. Treatment involves diet, exercise, and possibly insulin therapy to maintain normal blood glucose levels and minimize risks. Close monitoring of blood glucose and fetal growth is important throughout the pregnancy and delivery.
Claiming Dignity, book on Reproductive Rights, 2nd editionHRLNIndia
Claiming Dignity, book on Reproductive Rights, 2nd edition
Published by Human Rights Law Network(HRLN), a division of Socio Legal Information Centre(SLIC). For more details about our works, visit us at http://hrln.org
1. Tight glycemic control through medical nutrition therapy, exercise, blood glucose monitoring, and potentially insulin is important to manage diabetes in pregnancy.
2. Close fetal surveillance through growth scans and tests are needed to monitor for complications like macrosomia.
3. Delivery timing and type (vaginal vs c-section) depends on maternal and fetal status and risks like macrosomia.
4. Neonatal risks include hypoglycemia, jaundice, and respiratory distress which requires close monitoring after birth.
5. Counseling on future diabetes risk and appropriate contraception is important in postpartum care.
This document discusses diabetes in pregnancy, including gestational diabetes and pre-existing diabetes. It provides details on screening and managing gestational diabetes through medical nutrition therapy, exercise, glucose monitoring, and insulin or oral hypoglycemic agents if needed. It also discusses fetal surveillance, delivery planning, neonatal care, and postpartum management and follow-up. Case examples are presented to illustrate how these guidelines would be applied. The key aspects of managing diabetes in pregnancy are screening, glycemic control through lifestyle and medical interventions, close fetal and maternal monitoring, and delivery planning tailored to each woman's risk factors and disease status.
Diabetes Mellitus & Gestational D iabetes in Pregnancy Lifecare Centre
This document discusses diabetes and gestational diabetes in pregnancy. It covers pre-conception care for women with diabetes, including achieving optimal blood glucose control through diet and medication. It also discusses care during pregnancy such as frequent monitoring and surveillance of the fetus. Complications of uncontrolled diabetes during pregnancy for both mother and baby are outlined. The importance of postpartum care is also mentioned.
This document summarizes diabetes mellitus (DM) and its management during pregnancy. It discusses the different types of DM, including pre-existing type 1 and type 2 DM as well as gestational DM. It outlines the physiological changes in pregnancy that can affect blood sugar levels. Diagnosis and treatment aims to achieve tight glycemic control before and during pregnancy to prevent complications such as fetal macrosomia and neonatal hypoglycemia. Management involves medical nutrition therapy, exercise, insulin therapy, and monitoring throughout pregnancy and the postpartum period. Complications of both maternal DM and infant outcomes are also summarized.
This document discusses gestational diabetes, including its definition, epidemiology, consequences for both mother and fetus, screening recommendations, management, and controversies around diagnostic criteria. Some key points:
- Gestational diabetes is defined as carbohydrate intolerance first recognized during pregnancy and can include undiagnosed preexisting diabetes.
- It affects 2-9% of pregnancies and screening is recommended for at-risk women between 24-28 weeks using a 75g oral glucose tolerance test.
- Risks for the fetus include macrosomia, jaundice, and hypoglycemia. Risks for the mother include preeclampsia, infections, and long-term risk of type 2 diabetes.
Gestational diabetes is a type of diabetes that develops during pregnancy and usually disappears after giving birth. It occurs in 2-10% of pregnancies due to hormonal changes reducing the body's ability to use insulin. While most women have no symptoms, screening tests are done between 24-28 weeks of pregnancy to check blood sugar levels. Eating a healthy diet and exercise can help manage gestational diabetes and reduce risks to both mother and baby like high birth weight or developing diabetes later in life.
Gestational diabetes (GDM) is glucose intolerance first identified during pregnancy. Risk factors include BMI over 30, previous large or diabetic baby, family history of diabetes. GDM is identified through a 75g oral glucose tolerance test. It is associated with risks like large baby, shoulder dystocia, preeclampsia. Treatment like insulin lowers risks. Other types of diabetes may present as GDM and require identification. Mild maternal hyperglycemia increases risks incrementally without a clear threshold.
This document discusses diabetes during pregnancy, including gestational diabetes and prediabetes. It provides statistics on the prevalence of different types of diabetes during pregnancy. Type 2 diabetes in pregnancy has a better prognosis than type 1 diabetes, with fewer complications. The document also discusses risk factors, screening, and management of gestational diabetes and prediabetes during and after pregnancy. It provides guidelines for screening and outlines the one-step and two-step approaches to screening and diagnosing gestational diabetes.
Gestational diabetes occurs in approximately 5% of pregnancies and results in high blood sugar levels during pregnancy. It develops when the placenta produces hormones that prevent the mother's cells from properly using insulin. To manage gestational diabetes, patients must monitor their blood sugar levels, follow a healthy diet with balanced carbohydrate intake, engage in moderate physical activity, and potentially take insulin or other medications. Maintaining blood sugar control is important for the health of both the mother and baby.
Gestational diabetes mellitus (GDM) is a type of diabetes that is first recognized during pregnancy. An oral glucose tolerance test is used to diagnose GDM, with abnormal fasting or post-meal blood glucose levels indicating GDM. Women with GDM are at higher risk of complications during pregnancy like preeclampsia and delivering a large baby, so treatment focuses on maintaining normal blood glucose levels through diet, exercise, and possibly insulin or metformin. After delivery, women with GDM have an increased long-term risk of type 2 diabetes and should undergo screening.
A comprehensive guide to the management of hyperglycaemia in pregnancy aimed at the primary care physician and based on latest evidenced based criteria. Includes information from latest studies such as HAPO study and ACHOIS, and involves guidelines from the IADPSG, ADA, WHO and Malaysia.
1. There are four criteria for diagnosing diabetes: A1C ≥6.5%, FPG ≥126 mg/dL, 2-hr PG ≥200 mg/dL during OGTT, or random PG ≥200 mg/dL.
2. Lowering A1C below 7.0% can reduce microvascular complications and macrovascular disease.
3. Gestational diabetes is diagnosed using a one-step 75g OGTT or two-step 50g GLT and 100g OGTT, with defined plasma glucose thresholds.
This document discusses diabetes in pregnancy. It defines and classifies diabetes in pregnancy as either pregestational or gestational. It recommends screening all pregnant patients for gestational diabetes through risk factors and a 50g oral glucose challenge test between 24-28 weeks of gestation. For those diagnosed with gestational diabetes, it recommends treatment through diet, glucose monitoring, and possible insulin therapy to control blood glucose and minimize risks to the fetus like macrosomia. Close fetal monitoring is also recommended for pregnancies complicated by diabetes.
Diabetes and pregnancy - Endocrine society guidelines 2013Jagjit Khosla
This presentation talks about diabetes mellitus in relation to pregnancy. It classifies diabetes in pregnant pts as overt and gestational diabetes. Then it discusses the various guidelines given by Endocrine Society in 2013 for management of diabetic patients during pregnancy
Gestational Diabetes is a kind of diabetes that only pregnant women get.If a woman get diabetes or high blood sugar when she is pregnant, but she never had it before, then she has gestational diabetes.
Gestational diabetes (GDM) occurs when a woman without diabetes develops high blood sugar levels during pregnancy. It is caused by hormones from the placenta that interfere with the mother's insulin and metabolism. GDM affects approximately 10% of pregnancies and screening involves a glucose challenge test followed by an oral glucose tolerance test if levels are high. Untreated GDM can lead to complications for both mother and baby such as preeclampsia, macrosomia, and jaundice. Treatment focuses on medical nutrition therapy, glucose monitoring, and possibly insulin to control blood sugar and minimize risks.
This document provides information on the classification, screening, diagnosis, treatment, and management of diabetes in pregnancy. It discusses gestational diabetes and pre-gestational diabetes. Guidelines are presented for screening and diagnosing gestational diabetes using oral glucose tolerance tests. The rationale for treating gestational diabetes to reduce risks of complications is explained. Methods for monitoring blood glucose, dietary management, exercise, and insulin treatment regimens are outlined. The document also covers maternal and fetal surveillance during pregnancy, as well as glycemic control during labor and delivery and postpartum follow-up.
Gestational diabetes (GDM) and preexisting diabetes during pregnancy carry risks for both mother and baby. GDM is diagnosed through a two-step screening and testing process involving glucose challenges. Left untreated, GDM can lead to complications like fetal overgrowth and hypoglycemia. Treatment involves lifestyle changes like medical nutrition therapy, exercise and glucose monitoring. If needed, oral medications or insulin may be used to control blood sugar. Close monitoring and control of blood sugar levels during pregnancy and delivery can help reduce risks. After pregnancy, women with GDM have an elevated risk of developing diabetes and require follow up testing.
This document provides an overview of diabetes mellitus in pregnancy. It defines diabetes in pregnancy and gestational diabetes, and discusses their incidence rates. It describes the screening, diagnosis, and management of diabetes in pregnancy. The document outlines the maternal and fetal effects of diabetes during pregnancy and notes increased risks of complications. It emphasizes the importance of glucose monitoring and medical nutrition therapy in managing diabetes in pregnancy.
Gestational diabetes affects 2-3% of pregnancies and is characterized by carbohydrate intolerance that is first diagnosed during pregnancy. It increases the risk of complications for both mother and baby, such as preeclampsia, operative delivery, macrosomia, and neonatal hypoglycemia. Treatment involves diet, exercise, and possibly insulin therapy to maintain normal blood glucose levels and minimize risks. Close monitoring of blood glucose and fetal growth is important throughout the pregnancy and delivery.
Claiming Dignity, book on Reproductive Rights, 2nd editionHRLNIndia
Claiming Dignity, book on Reproductive Rights, 2nd edition
Published by Human Rights Law Network(HRLN), a division of Socio Legal Information Centre(SLIC). For more details about our works, visit us at http://hrln.org
Hypertension is a common complication of pregnancy that can lead to increased maternal and neonatal morbidity and mortality if not properly managed. It includes conditions like chronic hypertension, pre-eclampsia, and gestational hypertension. Pre-eclampsia affects 5-15% of pregnancies and is characterized by new onset hypertension and proteinuria developing after 20 weeks of gestation. Risk factors include primigravidas, family history, chronic hypertension, and obesity. Treatment involves monitoring, medication to control blood pressure, delivery after 36 weeks gestation, and magnesium sulfate in severe pre-eclampsia to prevent eclampsia. Close antenatal surveillance and multidisciplinary care are important to optimize outcomes.
Treat the Patient: Not the Pregnancy April 2015PASaskatchewan
This document provides information on safely managing common medical conditions during pregnancy and lactation. It discusses medication classification systems and factors affecting drug transfer across the placenta and into breastmilk. Guidelines are presented for treating depression, diabetes, thyroid disorders, infections, pain, nausea, and other issues. Many prescription and over-the-counter drugs are deemed safe to use when necessary, such as most antibiotics, acetaminophen, ranitidine, and antidepressants. Untreated medical conditions pose greater risks than potential side effects of approved medications. Resources for further information and guidance are also referenced.
Breast feeding ppt by Dr. Allah Yar Malikhuraismalik
This document discusses the benefits of breastfeeding for both mothers and infants. It provides information on the composition and types of breastmilk, as well as the advantages it provides through essential nutrients, antibodies, hormones and other factors. The document highlights how breastmilk uniquely meets the needs of infants and supports their development, unlike formula milk. It also outlines recommendations around exclusive breastfeeding for six months and continuing for up to two years. Some risks of breastfeeding and barriers to it are mentioned.
This document discusses abortion, including spontaneous and induced abortion. It covers the pathology, etiology, and factors involved in spontaneous abortion, including fetal factors like chromosomal abnormalities, maternal factors like infections, endocrine issues, nutrition, drug/environmental exposures, and immunological factors such as autoimmune conditions and alloimmune responses. Chromosomal anomalies, especially aneuploidies, account for over half of early spontaneous abortions. Maternal age, diseases, and lifestyle factors can also influence abortion risk.
This document provides guidelines for managing diabetes in pregnancy from preconception to the postnatal period. Key recommendations include:
- Diagnosing gestational diabetes based on specific fasting and post-meal blood glucose levels.
- Providing intensive antenatal care and monitoring for women with diabetes, including regular appointments and blood glucose targets.
- Scheduling induction of labour or caesarean delivery between 37+0 and 38+6 weeks for women with type 1 or 2 diabetes, and delivering women with gestational diabetes by 40+6 weeks.
- Testing women diagnosed with gestational diabetes 6-13 weeks after birth to exclude ongoing diabetes.
- Recurrent pregnancy loss is defined as 3 or more consecutive miscarriages before 20 weeks.
- Genetic causes like chromosomal abnormalities are a major cause and account for around 70% of early miscarriages. Karyotyping of pregnancy tissue can identify chromosomal abnormalities.
- Advanced parental age increases the risk of genetic defects leading to miscarriage due to declining egg/sperm quality. Parental karyotyping may identify balanced translocations in 3-5% of couples.
- A thorough evaluation including genetic, endocrine, anatomical, immunological, and infectious factors can identify a cause in 60% of recurrent pregnancy loss cases.
Presentation covers 3 topics: 1) Definition of infertility with brief review of female reproduction. 2) Discussion of how fertility status is evaluated with a description of some of the tests that are performed. 3) Review of several treatment options. By Dr. Arlene Morales of Fertility Specialists Medical Center (FSMG) http://ivfspecialists.com/
PCOS Treatment Guidelines & Review of Newer Medical Treatment in Infertili...Lifecare Centre
This document discusses the treatment of polycystic ovarian syndrome (PCOS) and infertility. It begins by defining the different PCOS phenotypes and symptoms such as menstrual disorders, high androgen levels, and metabolic syndrome. Lifestyle modifications like weight loss are emphasized as the first treatment approach. For infertility, clomiphene citrate is recommended first, along with metformin. If unsuccessful, gonadotropins or laparoscopic ovarian drilling may be considered. The document then introduces several newer potential treatments using antioxidants like melatonin, N-acetylcysteine, myo-inositol, and vitamin D and chromium supplements, but notes these are not yet approved by treatment guidelines. In summary, lifestyle
This document discusses vaginal bleeding in early pregnancy, which is defined as bleeding before 20 weeks of gestation. It outlines several potential causes of bleeding including abortion, ectopic pregnancy, and molar pregnancy. The differential diagnosis and clinical approach are discussed, including taking a history, examination, and investigations like ultrasound. Management depends on the diagnosis but may include expectant management, medical treatment, or surgical evacuation of the uterus.
This document discusses infertility, including its definition, causes, evaluation, and treatment options. It begins by defining primary and secondary infertility and outlining the requirements for conception. Common causes of infertility for both men and women are then described. The document provides details on evaluating infertility, including medical history, physical exams, lab tests, and procedures like semen analysis and hysterosalpingography. Treatment options are covered, such as ovulation induction, surgery, assisted reproductive technologies like IUI, IVF, and surrogacy. The emotional impact of infertility is also addressed.
O documento discute diabetes gestacional, incluindo causas, sintomas, riscos para a mãe e bebê, tratamento com dieta, exercício e medicação, e fatores de risco como idade, peso e histórico familiar.
This document discusses infertility, including its definition, causes, evaluation, and management. It notes that infertility affects approximately 1 in 7 couples in the UK. Evaluation involves assessing both partners for potential medical causes through history, examination, tests, and procedures. Treatment options range from lifestyle changes to surgery to assisted reproductive technologies (ART) like IVF, depending on the underlying cause. The majority of young couples without known issues will conceive naturally within 2 years.
Infertility affects couples worldwide, with an average incidence of about 15%. Evaluation of both female and male partners is essential to determine the cause, which can be female factors, male factors, or a combination. Treatment options depend on the cause and range from ovulation-inducing drugs, surgery, and assisted reproductive technologies like in vitro fertilization.
clinic database and software management systemMujahed Ahmed
This document describes a study conducted on developing an automated patient record management system for St. Francis Hospital Nsambya. It outlines the background and problems with the current manual system, including duplication of data, inconsistencies, and difficulty analyzing patient medical histories. The objectives are to computerize patient, staff, and drug supplier records to address issues with the manual system. The study involved analyzing the existing system and user requirements to design a new electronic system using databases, PHP, and MySQL. The system was implemented and tested to automate record keeping and improve management of patient information at the hospital.
National Diabetes Inpatient Audit (NaDIA) 2015Laura Fargher
The document is a summary report of the National Diabetes Inpatient Audit (NaDIA) from 2015 in England and Wales. Some key findings from the NaDIA include:
- 38% of patients experienced a diabetes medication error while in hospital. Blood glucose control was often poor, with average "good diabetes days" being only 4.5 out of 7 days.
- Specialist diabetes staffing levels were lower than recommended, with only 36% of patients seeing the diabetes team. Medication errors and poor glucose control suggest staff need more training.
- Foot care has improved but 31% of hospitals still lack a multidisciplinary foot care team, and only 33% of patients received a foot risk assessment.
Preventing type 2 diabetes in england, pop up uni, 2pm, 2 september 2015NHS England
Expo is the most significant annual health and social care event in the calendar, uniting more NHS and care leaders, commissioners, clinicians, voluntary sector partners, innovators and media than any other health and care event.
Expo 15 returned to Manchester and was hosted once again by NHS England. Around 5000 people a day from health and care, the voluntary sector, local government, and industry joined together at Manchester Central Convention Centre for two packed days of speakers, workshops, exhibitions and professional development.
This year, Expo was more relevant and engaging than ever before, happening within the first 100 days of the new Government, and almost 12 months after the publication of the NHS Five Year Forward View. It was also a great opportunity to check on and learn from the progress of Greater Manchester as the area prepares to take over a £6 billion devolved health and social care budget, pledging to integrate hospital, community, primary and social care and vastly improve health and well-being.
More information is available online: www.expo.nhs.uk
The FIGO recommends that gestational diabetes mellitus (GDM) be considered a global health priority. GDM is associated with higher rates of maternal and neonatal morbidity and mortality as well as long term consequences for both mother and child. The FIGO proposes universal testing for GDM during pregnancy, providing the best possible management given available resources in each country, and using the postpartum period to improve health and reduce future risks for both mother and child.
This document summarizes key findings from The NHS Atlas of Variation in Healthcare for People with Diabetes:
- There is significant variation across England in the processes and outcomes of diabetes care provided by Primary Care Trusts (PCTs), with some PCTs performing much better or worse than others.
- Over 60% of people with Type 1 diabetes and almost half of people with Type 2 diabetes did not receive all nine basic care processes for managing their condition.
- Prescribing costs for diabetes treatments have risen 41% since 2005/06 and now account for over 8% of primary care prescribing costs.
- There is up to a 10-fold variation between PCTs in providing recommended
This document provides an introduction to a toolkit for structured education for Type 2 diabetes. It discusses the low uptake of structured education programs despite recommendations and incentives. The toolkit aims to address causes of low uptake and provide guidance to commissioners, providers, and referrers to ensure accessible high-quality structured education. It summarizes the national and local burden of diabetes, costs of complications, and recommends increasing attendance at education to save £1.7 million per CCG annually. Common structured education programs are introduced.
Helen Southwell, Diabetes Commissioning Lead, South Worcestershire CCG,
Dr. Matthew Goodman, Chief Medical Officer, Mapmyhealth
Emma Innes, Matron Diabetes/Senior Lecturer, Worcestershire Acute Hospitals NHS Trust & University of Worcester
‘Think Kidneys': Improving the management of acute kidney injury in the NHS Renal Association
‘Think Kidneys': Improving the management of acute kidney injury in the NHS
Presented by Dr Richard Fluck, National Clinical Director (Renal) – NHS England
This document provides guidance on the diagnosis and management of type 1 diabetes in children, young people, and adults. It includes key recommendations for children and young people regarding management from diagnosis, education, monitoring glycemic control, treatment of diabetic ketoacidosis, and screening for complications. It also highlights the importance of psychosocial support. For adults, it emphasizes the importance of patient-centered care delivered by a multidisciplinary team. It recommends education be offered after diagnosis and repeated annually. The guidance was developed by the National Collaborating Centre for Women's and Children's Health and the National Collaborating Centre for Chronic Conditions.
The document summarizes the achievements of the Nutrition in Older People Programme over the past 4 years. Key points include:
- The programme implemented integrated nutritional care approaches in community settings, screening over 4,600 older people with an average malnutrition prevalence of 20%.
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Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
1. National Pregnancy in Diabetes Audit
Report, 2015
England, Wales and the Isle of Man
21 October 2016
2. The Healthcare Quality Improvement Partnership (HQIP). The National Pregnancy in
Diabetes Audit is commissioned by the Healthcare Quality Improvement Partnership
(HQIP) as part of the National Clinical Audit Programme (NCA). HQIP is led by a
consortium of the Academy of Medical Royal Colleges, the Royal College of Nursing and
National Voices. Its aim is to promote quality improvement, and in particular to increase the
impact that clinical audit has on healthcare quality in England and Wales. HQIP holds the
contract to manage and develop the NCA Programme, comprising more than 30 clinical
audits that cover care provided to people with a wide range of medical, surgical and mental
health conditions. The programme is funded by NHS England, the Welsh Government and,
with some individual audits, also funded by the Health Department of the Scottish
Government, DHSSPS Northern Ireland and the Channel Islands.
NHS Digital is the new trading name for the Health and Social Care Information Centre
(HSCIC). NHS Digital managed the publication of the 2015 annual report.
Diabetes UK is the largest organisation in the UK working for people with diabetes,
funding research, campaigning and helping people live with the condition.
2
Prepared in collaboration with:
The national cardiovascular intelligence network (NCVIN) is a partnership of leading
national cardiovascular organisations which analyses information and data and turns it
into meaningful timely health intelligence for commissioners, policy makers, clinicians
and health professionals to improve services and outcomes.
Supported by:
3. Introduction
• The National Pregnancy in Diabetes (NPID) audit measures
the quality of care and outcomes for women with pre-
gestational diabetes who are pregnant and aims to support
quality improvement.
• Data is collected and submitted by antenatal diabetes services
in England, Wales and the Isle of Man.
• Women consent for their data to be included in the audit.
• The NPID audit is part of the National Diabetes Audit (NDA)
portfolio within the National Clinical (NCA) Audit programme,
commissioned by the Healthcare Quality Improvement
Partnership (HQIP).
• To reduce the burden of data collection for services, NHS
Digital link this data to NDA and Hospital Episode Statistics
(HES)/Patient Episode Database for Wales (PEDW)
information. 3
4. Introduction
The audit seeks to answer three key questions:
• Were women with diabetes adequately prepared for
pregnancy?
• Were appropriate steps taken during pregnancy to minimise
adverse outcomes to the mother?
• Did any adverse outcomes occur?
The 2015 audit report:
• measures against updated NICE guideline NG31
• publishes service level data for the first time
(http://digital.nhs.uk/pubs/npdaudit16)
• does not compare audit data over timea.
a Any service improvements after first report in Oct 2014 will first be seen in the 2016 NPID data collection
(to be published 2017).
1See References section.
4
5. 5
“The NPID audit is the clear benchmark for care and outcomes locally, regionally
and nationally. It is a massive credit to all of the participating units, presents
clearly the huge challenge ahead and provides a firm basis for changes.”
Nick Lewis-Barned, Clinical Lead
“Pregnancy can be stressful at the best of times; adding diabetes into the
equation doesn't exactly make things any easier. Information collected by the
NPID audit is being used to pinpoint what can be done to help women with
diabetes before and throughout their pregnancies. The more data we have, the
more happy and healthy pregnancies we can achieve.”
Melissa, Patient Representative, Advisory Group
“The NPID data enables us to evaluate our project statistically by undertaking
historical comparison, and to identify local variations and action plan accordingly.
Examples are late referral for specialist antenatal care, and low use of pre-
conception folic acid by women with Type 2 diabetes.”
The Eastern Academic Health Science Network Pregnancy & Diabetes Project
6. Measuring against the NICE guideline
The NPID audit measures the quality of care using national standards set out
in NICE guideline NG31, including:
Prior to pregnancy
• use of folic acid supplement prior to pregnancy
• keeping HbA1c below 48 mmol/mol where achievable without causing
problematic hypoglycaemia
• substitution of oral glucose-lowering medications apart from metformin
• suspension of statins and ACE inhibitors/ARBs
During pregnancy
• early first contact with joint diabetes and antenatal clinic
• monitoring HbA1c to assess level of pregnancy risk
• retinal screening
Birth and neonatal care
• elective birth and timing of birth
• keeping babies with their mothers unless clinical need for intensive, high
dependency or special care.
6
1See References section.
7. • In 2015, 3,044 pregnancies in 3,036 women with diabetes
were recorded by 155 antenatal diabetes services.
• 46 per cent (1,386 women) had Type 2 diabetes (over 50 per
cent in some regions, and over 70 per cent among some
ethnic groups). Women with Type 2 diabetes tended to be
older, and more likely to live in areas of social deprivation.
• There is large variation between services/localities in meeting
the NICE guideline recommendations for
– pregnancy preparation
– first contact with the antenatal diabetes team
– minimising admissions to a neonatal unit
Key findings
7
8. Key findings
8
Few women were prepared for pregnancy in the ways
recommended in the NICE guideline:
• Only 16 per cent of women with Type 1 diabetes and 38
per cent of women with Type 2 diabetes had first trimester
HbA1c <48 mmol/mol.
• 46 per cent of women with Type 1 diabetes and 23 per
cent of women with Type 2 diabetes were taking 5mg folic
acid prior to pregnancy.
• Women with Type 1 diabetes from deprived areas were
much less likely to be taking 5mg folic acid or have first
trimester HbA1c < 48 mmol/mol.
9. Key findings
9
The majority of women did not have contact with the antenatal diabetes
team before they were 8 weeks pregnant:
• Only 36 per cent of women with Type 2 diabetes and 55 per cent of
women with Type 1 diabetes had contact in the first 8 weeks of
pregnancy.
Hypoglycaemia during pregnancy:
• Almost 1 in 10 women with Type 1 diabetes had at least one admission to
hospital with recorded hypoglycaemia during their pregnancy.
The majority of births were by caesarean section:
• 66 per cent of women with Type 1 diabetes and 56 per cent of women
with Type 2 diabetes had a birth by caesarean section (elective or
emergency).
10. Key findings
10
There was a modest reduction in adverse pregnancy outcomes:
• The stillbirth rate has reduced significantly since the 2002-03 CEMACH
study2 for women with Type 1 and Type 2 diabetes (10.7 and 10.5 per
1,000 respectively), although it is still higher than in the general population
(4.7 per 1,000 live and stillbirths).
However, preterm delivery and large for gestational age babies were
common and the admission rate to neonatal units was high:
• 40 per cent of singleton births to women with Type 1 diabetes and 22 per
cent of births to women with Type 2 diabetes were preterm (before 37+0
weeks).
• Preterm delivery, babies large for gestational age and admission to a
neonatal unit were more common for women who had HbA1c at 24 weeks+
above 48 mmol/mol.
2 See References section.
11. Recommendations
Diabetes and maternity services
A collaborative approach by diabetes and maternity
services is needed to improve pregnancy outcomes in
women with diabetes by:
• improving preparation for pregnancy:
– promoting access to pregnancy preparation advice
– tailoring approach to offer women the right information at the right time
– informing women about the importance of, and options for, safe
effective contraception
• improving early contact with specialist support:
– creating clear pathways for rapid referral to specialist teams, and
publicising these to primary care and family planning services
• improving achievement of safe glucose control in pregnancy:
– focussing on proactive glucose management in pregnancy 11
12. Recommendations - Core diabetes care services
Primary care, family planning and community teams are
recommended to:
– develop a clear plan for all women with diabetes to ensure
awareness of the value of pregnancy preparation and the
importance of safe effective contraception (including
identification from primary care registers and discussion of
pregnancy as a part of care planning/annual review)
– maintain a clear understanding of how to use referral pathways
for specialist support
Specialist diabetes services are recommended to:
– routinely discuss pregnancy with all appropriate women
– access, where needed, new technologies to support glucose
management
– lead or to identify leadership for quality improvement in antenatal
diabetes care 12
13. Recommendations
Commissioners and Networks
Recommendation
CCGs and LHBs Monitor and improve local performance against
NICE Quality Standard 109 Diabetes in
pregnancy3.
Public Health
Programmes
Work with networks and services to raise
awareness and address inequalities, especially
in Black and Asian populations and deprived
areas.
Patient education
programmes
Include learning about pregnancy explicitly in
diabetes education sessions.
Diabetes and Maternity
Networks
Develop explicit strategies for pregnancy in
diabetes with CCGs, LHBs and Acute Trusts and
coordinate across local health communities.
Diabetes support groups
and charities
Raise awareness of the benefits of pregnancy
preparation.
13
3 See references section.
14. Participation
• 155 services submitted data on pregnancies ending in
2015.
• 10 units submitted data to the audit for the first time.
• 144a of 167 consultant–led maternity units identified in
the RCOG 2013 census4 took part in the audit (86 per
cent).
14
a Difference between 155 services submitting to NPID and 144 from RCOG census due to
non-response to census, services in the NPID audit that provide antenatal care only and
different trust/unit level groupings.
Of the 23 units in the RCOG census not participating in the NPID audit for 2015, 7 have
reported they are collecting data in 2016 and 2 have confirmed they are not eligible for the
NPID audit.
4 See References section
16. Records used in this report
Table 1: Numbers of women, pregnancies and babies, 2015
16
a Diabetes type not specified (39), maturity onset diabetes of the young (MODY) (30) or ‘Other’ diabetes type (18).
b 8 women had two pregnancies recorded.
c 42 twin pregnancies were recorded.
All
diabetes
Type 1
diabetes
Type 2
diabetes Other
Women 3,036 1,563 1,386 87a
Pregnancies b 3,044 1,566 1,391 87
Total pregnancy outcomes c 3,086 1,587 1,409 90
Pregnancies ongoing after 24 weeks 2,866 1,470 1,313 83
Live births after 24 weeks 2,868 1,474 1,313 81
Stillbirths 35 16 14 5
Total infants born after 24 weeks 2,903 1,490 1,327 86
Live births with gestation unknown 4 1 3 0
Live births before 24 weeks 1 1 0 0
Total registered births 2,908 1,492 1,330 86
17. National Pregnancy in Diabetes Audit 2015
Characteristics of women
17
• Diabetes type
• Age
• Duration of diabetes
• BMI
• Ethnicity
• Deprivation
18. Diabetes type by region
18
a Based on location of booking unit (may differ from delivery unit and woman’s residence).
• Overall 46 per cent of pregnancies were in women with Type 2 diabetes.
• Over 50 per cent of pregnancies in London, West Midlands, and Yorkshire
and Humber were in women with Type 2 diabetes.
Figure 2: Mother’s diabetes type for pregnancies by Government Office
Regiona, 2015
0 25 50 75 100
East Midlands
East of England
London
North East
North West (and Isle of Man)
South East
South West
West Midlands
Yorkshire and The Humber
England
Wales
Government
Office Region
Percentage of pregnancies
Type 2 diabetes Type 1 diabetes Other diabetes Diabetes type not known
19. Characteristics
• Women with Type 2 diabetes were older and had higher
Body Mass Index (BMI) than women with Type 1 diabetes.
• Almost 90 per cent of women of asian origin in the audit
and just over 70 per cent of women of black origin in the
audit had Type 2 diabetes, compared with about 30 per
cent of women of white origina.
19
Table 2: Average maternal age, duration of diabetes and Body Mass Index
for pregnancies, 2015
a See supporting information for ethnicity data
b Age at completion of pregnancy.
c Duration of diabetes at start of pregnancy.
Type 1 diabetes Type 2 diabetes
Mean ageb (years) 29.9 33.6
Mean durationc of diabetes (years) 14.9 4.8
Mean Body Mass Index (kg/m2) 26.8 33.3
20. Deprivation
20
• More women with Type 2 diabetes were resident in the
most deprived areas.
Figure 3: Deprivation quintilea,b of mother's area of residence, England and
Wales, 2015
a Deprivation quintile is only available where the woman’s details were recorded in the NDA.
b See the Methodology statement for details of index of multiple deprivation (IMD) method.
17.5 18.6 21.7 21.3 20.9
7.4 11.5
17.0
25.6
38.5
0
10
20
30
40
50
1st quintile
(least deprived)
2nd quintile 3rd quintile 4th quintile 5th quintile
(most deprived)
Percentage
of pregnancies
Deprivation quintile of residence
Type 1 diabetes Type 2 diabetes
21. Characteristics of women - comment
21
• In some areas of England, over half of women in the audit
had Type 2 diabetes.
• The proportion of women with Type 2 diabetes was
extremely high among black and asian ethnic groups.
• Women with Type 2 diabetes were older, more overweight
and more likely to live in deprived areas.
• Initiatives to increase engagement with women with
diabetes prior to pregnancy and offer access to safe,
effective contraception will need to take into account the
different characteristics of women with Type 1 and Type 2
diabetes and how they access health services.
22. National Pregnancy in Diabetes Audit 2015
Were women adequately
prepared for pregnancy?
• HbA1c management
• Folic acid supplement
• Diabetes treatments
• Statins and ACE inhibitors
23. NICE guideline – HbA1c
NICE recommendation (NG31): Explain to women with diabetes who
are planning to become pregnant that establishing good glucose
control before conception and continuing this throughout pregnancy
will reduce the risk of miscarriage, congenital malformation, stillbirth
and neonatal death.
The guideline recommends:
• advising women with diabetes who are planning to become
pregnant to aim to keep their HbA1c level below 48 mmol/mol if this
is achievable without causing problematic hypoglycaemia
• strongly advising women with diabetes whose HbA1c level is above
86 mmol/mol not to get pregnant because of the associated risks
The NPID audit records the first HbA1c measurement in pregnancy
and uses the readings that are in the first trimester as an indication of
HbA1c prior to pregnancy.
23
1See References section.
24. First trimester HbA1c
Women with Type 2 diabetes were much more likely than
women with Type 1 diabetes to have first trimester HbA1c below
48 mmol/mol.
24
Table 3: First trimester HbA1c measurement, 2015
Type 1
diabetes
Type 2
diabetes
Percentage with HbA1c <48 mmol/mol 16.2 38.3
Percentage with HbA1c >=86 mmol/mol 9.6 7.9
Mean HbA1c mmol/mol [standard deviation] 62.7 [16.7] 56.0 [17.4]
25. Which women had first trimester HbA1c <48 mmol/mol?
• Women with Type 2 diabetes and first trimester HbA1c <48
mmol/mol had lower BMI and shorter diabetes duration.
• Those with Type 1 diabetes and first trimester HbA1c <48
mmol/mol had lower BMI and were older.
25
Table 4: Average maternal age, duration of diabetes and BMI for women with
first trimester HbA1c <48 mmol/mol or >=48 mmol/mol, 2015
a Age at completion of pregnancy. b Duration of diabetes at start of pregnancy.
Type 1 diabetes Type 2 diabetes
HbA1c <48 HbA1c >=48 HbA1c <48 HbA1c >=48
Mean age a (years) 31.3 29.8 33.9 33.4
Mean duration b of
diabetes (years) 14.6 15.3 4.2 5.4
Mean Body Mass Index
(kg/m2) 25.7 27.0 31.9 34.0
26. Which women had first trimester HbA1c <48 mmol/mol?
• More than twice as many women with Type 1 diabetes in the
least deprived areas had HbA1c < 48 mmol/mol as in the most
deprived areas.
26
Figure 4: Percentage of pregnancies with first trimester HbA1c < 48 mmol/mol
by deprivation quintilea,b of mother’s residence, England and Wales, 2015
a Deprivation quintile is only available where the woman’s details were recorded in the NDA.
b See the Methodology statement for details of index of multiple deprivation (IMD) method.
24.0
14.6 16.9 17.5
9.9
32.7
43.2 42.1 42.2
34.7
0
25
50
1st quintile
(least deprived)
2nd quintile 3rd quintile 4th quintile 5th quintile
(most deprived)
Percentage of
pregnancies
Deprivation quintile
Type 1 diabetes Type 2 diabetes
27. Local variation in first trimester HbA1c
• The percentage of women achieving first trimester
HbA1c <48 mmol/mol varied greatly between services.
27
Figure 5: Percentage of pregnancies where mother had first trimester HbA1c
<48 mmol/mol, by servicea, 2013 - 2015
a Includes services with at least 10 completed pregnancy records: Type 1 diabetes – 130 services, Type 2 diabetes – 107 services
0
25
50
75
100
Percentage
Services
Lower quartile Median Upper quartile
Type 1 diabetes
0
25
50
75
100
Percentage
Services
Lower quartile Median Upper quartile
Type 2 diabetes
28. NICE guideline – folic acid
• Women with diabetes have an increased risk of having a
pregnancy affected by a neural tube defect.
• NICE recommendation (NG31): Advise women with
diabetes who are planning to become pregnant to take
5mg/day folic acid up to 12 weeks gestation to reduce
this risk.
• The 5mg dose is available on prescription.
28
1See References section.
29. Use of folic acid supplement
• 46.1 per cent of women with Type 1 diabetes were taking
the recommended 5mg dose of folic acid prior to pregnancy,
compared with only 22.5 per cent of women with Type 2
diabetes.
29
Table 5: Use of folic acid supplement prior to pregnancy, 2015
a ‘Not known’ includes women recorded as taking folic acid but with unknown dose.
Type 1 diabetes
(per cent)
Type 2 diabetes
(per cent)
Dose 5mg 46.1 22.5
Dose 400mcg 5.6 11.2
All doses 51.7 33.7
Not taken 39.0 53.0
Not known a 9.3 13.2
30. Which women were taking 5mg folic acid?
• Women with Type 1 diabetes taking 5mg folic acid prior to
pregnancy on average were older and had diabetes for
longer than those not taking any folic acid.
• For women with Type 2 diabetes, there was no difference in
average age or duration of diabetes between the two groups.
30
Table 6: Average maternal age and duration of diabetes for women taking 5mg
folic acid/no folic acid prior to pregnancy, 2015
a Age at completion of pregnancy.
b Duration of diabetes at start of pregnancy.
Type 1 diabetes Type 2 diabetes
5mg None 5mg None
Mean agea (years) 31.6 27.8 33.4 33.8
Mean durationb of diabetes (years) 16.4 13.4 5.1 4.6
31. Which women were taking 5mg folic acid?
• 75 per cent of women with Type 1 diabetes in the least deprived
areas were taking 5mg folic acid, twice as many as in the most
deprived areas.
• Women with Type 2 diabetes were least likely to be taking 5mg folic
acid in the most deprived areas (4th and 5th quintiles).
31
Figure 6: Percentage taking 5mg folic acid supplement prior to pregnancy by
deprivation quintilea,b of mother’s residence, England and Wales, 2015
a Deprivation quintile is only available where the woman’s details were recorded in the NDA.
b See the Methodology statement for details of index of multiple deprivation (IMD) method.
75.1
61.3 54.5 48.9 37.539.6 51.5 43.2
25.6 28.5
0
50
100
1st quintile
(least deprived)
2nd quintile 3rd quintile 4th quintile 5th quintile
(most deprived)
Percentage of
pregnancies
Deprivation quintile
Type 1 diabetes Type 2 diabetes
32. Local variation in use of 5mg folic acid
• The percentage of women taking 5mg folic acid varied
greatly between services.
32
Figure 7: Percentage of pregnancies where mother was taking 5mg folic acid
prior to pregnancy, by servicea, 2013 - 2015
a Includes services with at least 10 completed pregnancy records:
Type 1 diabetes – 130 services, Type 2 diabetes – 107 services
0
25
50
75
100
Percentage
Services
Lower quartile Median Upper quartile
Type 1 diabetes
0
25
50
75
100
Percentage
Services
Lower quartile Median Upper quartile
Type 2 diabetes
33. First trimester HbA1c and folic acid
• Only 13 per cent of women had their first trimester
measurement of HbA1c <48 mmol/mol and were taking 5mg
folic acid.
• The findings of the audit suggest that primary care initiatives
are key to reaching women with Type 2 diabetes to support
pregnancy preparation such as incorporation of pregnancy
planning in group education programmes, consultation prompts
in care and support planning, prompts for pregnancy
information prescriptions embedded into GP IT systems,
working with family planning services, and practice facilitation
to support case finding. This will also help a significant
proportion of women with Type 1 diabetes, although many will
still need pregnancy education and support by specialist teams.
33
34. NICE guideline – medications
NICE recommendations (NG31):
• Women may be advised to use metformin as an adjunct or
alternative to insulin before conception and during
pregnancy, when the likely benefits from improved blood
glucose control outweigh the potential for harm.
• all other oral blood glucose-lowering agents should be
discontinued before pregnancy and insulin substituted.
• ACE inhibitors/ARBs and statins should be discontinued
before pregnancy or as soon as pregnancy is confirmed.
34
1See References section.
35. Diabetes treatment regimen prior to pregnancy
• 8 per cent of women with Type 2 diabetes became
pregnant while taking potentially hazardous glucose
lowering medications.
35
Table 7: Percentage of womena on selected diabetes treatment regimens at
last menstrual period, 2015
a This table excludes pregnancies recorded in the NorDIP survey due to the difference in response
options for this question.
b ‘On insulin’ includes basal bolus insulin regimen, mixed insulin or basal insulin only and insulin pump
therapy.
c ‘Other diabetes medications’ are sulphonylurea or glitinide, gliptin, GLP-1 analogue and pioglitazone,
irrespective of whether the woman was also taking metformin and/or insulin.
d Data quality warning – women with Type 1 diabetes would not be on metformin only.
Type 1 diabetes Type 2 diabetes
On insulin b only 93.4 8.8
On insulin b and metformin only 4.5 10.2
On metformin only 0.9d 52.7
On other diabetes medications c 0.2 8.0
36. Statins and ACE inhibitors/ARBs
• 8.6 per cent of women with Type 2 diabetes were taking
either statins or an ACE inhibitor/ARB or both medications
when they became pregnant.
36
Table 8: Percentage of pregnancies where mother taking statins or ACE
inhibitors/ARBs at last menstrual period, 2015
Type 1
diabetes
Type 2
diabetes
On statins 1.5 5.9
On ACE inhibitor/ARB 1.7 4.5
On at least one of statins/ACE inhibitor/ARB 2.9 8.6
37. Local variation in use of statins/ACE
inhibitors for mothers with Type 2 diabetes
41 services (38 per cent) found at the time of booking 10 per
cent or more of women with Type 2 diabetes were taking
statins and/or an ACE inhibitor at their last menstrual period.
37
Figure 8: Percentage of servicesa reporting <5%, 5-10% or >=10% of
women with Type 2 diabetes on statins and/or ACE inhibitor/ARB at last
menstrual period, 2015
aIncludes 107 services with at least 10 completed pregnancy records for women with Type 2
diabetes.
34.6
27.1
38.3
0
25
50
<5% >=5% and <10% >=10%
Percentage of
services
Percentage of pregnancies
38. Preparation for pregnancy - comment
38
• Few women with diabetes were well prepared for pregnancy.
• Women with Type 2 diabetes were more likely to have HbA1c
<48 mmol/mol than women with Type 1 diabetes (especially
those with shorter diabetes duration). However they had a
low pre-pregnancy use of 5mg folic acid, and appreciable use
of statins and ACE inhibitors/ARB. This suggests that they
were poorly informed/supported in preparation for pregnancy.
• Among women with Type 1 diabetes, women were more likely
to have HbA1c <48 mmol/mol or be taking 5mg folic acid if
they were older, and much less likely to be prepared in either
of these ways if they lived in a deprived area.
39. Preparation for pregnancy - comment
39
• Improving pregnancy preparation will require collaboration
between all sectors of care and women with diabetes.
• For women with Type 2 diabetes, from black and asian
communities, and from areas of social deprivation raising
awareness and pre-pregnancy treatment review should be
priorities.
• For women with Type 1 diabetes pre-pregnancy glucose
control and folic acid use are the priorities.
• The significant variations between services in 5mg folic acid
use, achievement of safer HbA1c levels and medications used
prior to pregnancy suggests a widespread urgent need to
improve practice.
40. National Pregnancy in Diabetes Audit 2015
Care in pregnancy and HbA1c
values
• Timing of first contact with antenatal diabetes team
• HbA1c values in pregnancy
41. NICE guideline
Antenatal care and monitoring HbA1c
NICE recommendations (NG31):
• Offer immediate contact with a joint diabetes and antenatal
clinic to women with diabetes who are pregnant
• Measure HbA1c levels at the booking appointment to
determine the level of risk for the pregnancy
• Consider measuring HbA1c levels in the second and third
trimesters of pregnancy to assess the level of risk for the
pregnancy
• Be aware that level of risk for the pregnancy increases with
an HbA1c level above 48mmol/mol.
41
1See References section.
42. First contact with antenatal diabetes team
Only 54.6 per cent of women with Type 1 diabetes and 36.2
per cent of women with Type 2 diabetes had their first
antenatal diabetes team contact prior to 8 weeks gestation.
42
Figure 9: Gestation (weeks) at first contacta,b with specialist antenatal diabetes
team, 2015
a NICE recommends to offer immediate contact with the antenatal diabetes team – the NPID audit
records the date of first contact with the team during pregnancy.
b Very early appointments are likely to be preconception care appointments already in place.
2.1
52.5
32.2
9.0 2.3 0.8 1.20.9
35.3 36.4
17.3
5.2 2.7 2.2
0
20
40
60
0 to 3 4 to 7 8 to 11 12 to 15 16 to 19 20 to 23 24 and over
Percentage of
pregnancies
Gestation (weeks)
Type 1 diabetes Type 2 diabetes
43. Local variation in timing of first contact with
antenatal diabetes team
The percentage of women having contact in the first 8 weeks
of pregnancy varied greatly between services.
43
Figure 10: Percentage of pregnancies where first contact with antenatal
diabetes team at < 8 weeks gestation by servicea, 2013 - 2015
a Includes services with at least 10 completed pregnancy records:
Type 1 diabetes – 130 services, Type 2 diabetes – 107 services
0
25
50
75
100
Percentage
Services
Lower quartile Median Upper quartile
Type 1 diabetes
0
25
50
75
100
Percentage
Services
Lower quartile Median Upper quartile
Type 2 diabetes
44. HbA1c values in pregnancya
Over 75 per cent of women with Type 2 diabetes, but only 40
per cent of women with Type 1 diabetes had HbA1c below 48
mmol/mol in late pregnancyb.
44
Table 9: HbA1c measurements in first trimester and at 24 weeks+, 2015
Type 1 diabetes Type 2 diabetes
<13
weeks
24
weeks+
<13
weeks
24
weeks+
Percentage with HbA1c <48
mmol/mol 16.2 40.0 38.3 76.0
Mean HbA1c (mmol/mol) 62.7 51.2 56.0 43.2
Standard deviation (mmol/mol) 16.7 11.6 17.4 9.7
a NICE recommends measuring HbA1c at booking, and consider measuring in the second and third
trimesters - the NPID audit records the first and last measurements in pregnancy.
b HbA1c falls physiologically in pregnancy because of changes in iron transport and red cell turnover5.
5 See References section.
45. Care in pregnancy and HbA1c values - comment
45
• Just under half of women with Type 1 diabetes and almost two
thirds with Type 2 diabetes saw the antenatal diabetes team for the
first time when they were 8 weeks pregnant or more.
• Knowing to urgently contact the antenatal diabetes team as soon
as a positive pregnancy test is found should be part of pregnancy
preparation. These figures again suggest poorer levels of
preparation among women with Type 2 diabetes.
• HbA1c levels in later pregnancy remained above 48 mmol/mol for
more than half of women with Type 1 diabetes, and almost a
quarter of women with Type 2 diabetes. Women should receive
more effective support to manage their blood glucose to target
throughout pregnancy to reduce the risks of preterm delivery, large
for gestational age babies and neonatal care unit admissions.
46. National Pregnancy in Diabetes Audit 2015
Were adverse maternal
outcomes minimised during
pregnancy?
• Hospital admissions with hypoglycaemia
• Hospital admissions with DKA (diabetic ketoacidosis)
47. Hypoglycaemia and DKA
47
Table 10: Hospital episodes with diagnosed hypoglycaemiaa during pregnancy,
England and Wales, 2014
Table 11: Hospital episodes with diagnosed DKAa during pregnancy,
England and Wales, 2014
Type 1 diabetes Type 2 diabetes
Number Percentage Number Percentage
At least one admission 124 9.6 25 2.1
No admissions recorded 1,172 90.4 1,144 97.9
Type 1 diabetes Type 2 diabetes
Number Percentage Number Percentage
At least one admission 32 2.5 2 0.2
No admissions recorded 1,264 97.5 1,167 99.8
aSee Data Quality statement.
48. Maternal outcomes during pregnancy - comment
• Hypoglycaemia carries significant risks for pregnant
women, and pregnancies complicated by diabetic
ketoacidosis are associated with increased rates of
perinatal morbidity and mortality6.
• Among women with Type 1 diabetes:
– Almost one in ten had at least one admission to hospital
with hypoglycaemia
– One in 40 had an admission to hospital with DKA
• It should be possible to reduce the risk of these serious
complications that can affect both the mother and their
baby.
486 See References section.
49. National Pregnancy in Diabetes Audit 2015
Timing and mode of birth
• Gestation length
• Onset of labour
• Mode of delivery
50. NICE guideline – timing and mode of birth
NICE recommendations (NG31):
• advise women with no other complications to have an
elective birth by induction of labour, or elective caesarean
section if indicated, between 37+0 and 38+6 weeks of
pregnancya
• consider elective birth before 37+0 weeks if there are
metabolic or any other maternal or fetal complications.
50
a37+0 = 37 weeks and 0 days, 38+6 = 38 weeks and 6 days
1 See References section.
51. Gestation length for singleton births
• The majority of births were between 37+0 and 38+6 weeks.
• 40 per cent of births to women with Type 1 diabetes and 22
per cent of births to women with Type 2 diabetes were
before 37+0 weeks.
51
Figure 11: Gestation at delivery for singleton live births, 2015
0.2 1.9 2.9
9.1
25.6
29.4
26.0
3.4 1.40.7 1.1 2.0 3.8
14.1
24.0
42.1
9.8
2.4
0
25
50
24 to 27 28 to 30 31 to 32 33 to 34 35 to 36 37 38 39 40 and
over
Percentage of
pregnancies
Gestation at delivery
Type 1 diabetes Type 2 diabetes
52. Onset of labour
• Only a small proportion of women had a spontaneous
labour. This may be due to NICE guidance which
recommends advising women to have an elective birth
between 37+0 and 38+6 weeks of pregnancy.
• Women with Type 1 diabetes were more likely to have a
caesarean before labour (45 per cent) than women with
Type 2 diabetes (37 per cent).
52
Table 12: Onset of labour for pregnancies continuing at 24 weeks
gestation, 2014
Type 1 diabetes Type 2 diabetes
Number Percentage Number Percentage
Spontaneous 123 13.2 122 14.6
Induced 384 41.3 404 48.4
Caesarean 423 45.5 308 36.9
53. Method of delivery
Caesarean (either emergency or elective) was the most
common mode of delivery (66 per cent of women with Type 1
diabetes and 56 per cent of women with Type 2 diabetes).
53
Figure 12: Mode of delivery for births at or after 24 weeks gestation,
England and Wales, 2014
32.1 33.8
11.4
1.8
20.8
28.9 27.0
6.4
1.3
36.4
0
10
20
30
40
Elective
caesarean
Emergency
caesarean
Instrumental Other Spontaneous
Percentage Type 1 diabetes Type 2 diabetes
54. Method of delivery where labour induced
42 per cent of women with Type 1 diabetes who had labour
induced before 38+0 weeksa had a caesarean section
compared with only 30 per cent of women with Type 2
diabetes.
54
Figure 13: Mode of delivery for singleton births where labour induced,
England and Wales, 2014
aThe NICE guideline in place during 2014 recommended elective birth after “38 completed weeks”.
42.4
57.6
35.7
64.3
30.1
69.9
34.5
65.5
0
20
40
60
80
Caesarean Vaginal Caesarean Vaginal
Induced before 38 weeks Induced at or after 38 weeks
Percentage Type 1 diabetes Type 2 diabetes
55. • Most births were between 37+0 and 38+6 weeks.
• A substantial minority of births were preterm; 40 per cent of
births to women with Type 1 diabetes were before 37+0 weeks,
compared with 22 per cent of births to women with Type 2
diabetes.
• Almost two thirds of women with Type 1 diabetes and over half
of women with Type 2 diabetes had a caesarean section
(elective or emergency).
• Over 40 per cent of women with Type 1 diabetes who had
labour induced before 38+0 weeks went on to have a caesarean
section, compared with 30 per cent of women with Type 2
diabetes.
55
Timing and mode of birth - comment
56. National Pregnancy in Diabetes Audit 2015
Were adverse fetal/infant
outcomes minimised?
• Pregnancy outcomes
• Stillbirths and neonatal deaths
• Congenital anomalies
• Preterm births
• Birthweights and large for gestational age
• Neonatal unit admissions
57. Pregnancy outcomes
• 98.8 per cent of registered births (live and stillbirths) were
live births.
• In the general England and Wales maternity population,
99.6 per cent of all registered births in 2015 were live
births7.
57
Table 13: Pregnancy outcomes, 2015
Live birth Stillbirth
Termination
of pregnancy Miscarriage b
Type 1 diabetes 1,476 16 15 80
Type 2 diabetes 1,316 14 14 65
Other a 81 5 1 3
a Diabetes type not specified, maturity onset diabetes of the young (MODY) or ‘Other’ diabetes type.
Although the stillbirth rate in this group appears high this should be interpreted with great caution, as
‘Diabetes type not specified’ may include women with Type 1 or Type 2 diabetes, and the small
numbers mean there is a large margin of uncertainty in any estimated rate.
b Early miscarriages (prior to booking) are likely to be under-reported.
7 See References section.
58. Adverse outcomes – stillbirth
• Stillbirth rates for both Type 1 and Type 2 diabetes were
significantly lower than in the 2002-03 CEMACH survey2.
• However they remain higher than the rate of 4.7 per 1,000 in
the 2014 general maternity population7. (The proportion of
older women in the NPID audit may be a contributing factor.)
58
Figure 14: Stillbirth rate (per 1,000 live and stillbirths) with 95 per cent confidence
interval, 2015 compared to CEMACH, 2002- 2003
2,7 See References section.
10.7
25.8
10.5
29.2
0
10
20
30
40
50
Type 1 - NPID Type 1 - CEMACH Type 2 - NPID Type 2 - CEMACH
4.7
(2014 general
population)
59. Adverse outcomes – neonatal death
• There was no change in the neonatal death rate compared
with the CEMACH survey in 2002-032.
• The rate remained higher than in the general population
(2.5 neonatal deaths per 1,000 live births in 2014).
59
Figure 15: Neonatal death rate (per 1,000 live births) with 95 per cent
confidence interval, 2015, compared to CEMACH, 2002- 03
2 See References section.
8.1 9.6 11.4 9.5
0
10
20
30
40
50
Type 1 - NPID Type 1 - CEMACH Type 2 - NPID Type 2 - CEMACH
2.5
(2014 general
population)
60. Adverse outcomes – congenital anomalies
Comparisons with other published rates should be made
cautiously because:
• some anomaly rates exclude certain ‘minor’ anomalies, while
the NPID rate includes any reported anomaly
• NPID data are likely to only include anomalies identified prior to
discharge from hospital, while other sources may include
anomaly notifications some time after birth 60
Table 14: Congenital anomaly rate per 1,000 live and stillbirths, 2015
Type 1 diabetes Type 2 diabetes
Rate per 1,000 a 46.2 34.6
95 per cent confidence interval (36.0, 58.5) (25.3, 46.1)
a Includes live births and terminations at any gestation, stillbirths and miscarriages after 20 weeks.
61. First trimester HbA1c and outcomes
First trimester HbA1c was significantly higher where:
• the pregnancy ended in a miscarriage or
• there was a congenital anomaly.
61
Figure 16: 95 per cent confidence intervals for mean first trimester HbA1c
for selected pregnancy outcomes, 2015
40 50 60 70 80
Anomaly
Miscarriage
Normally formed
stillbirth or neonatal death
Normally formed
and alive at 28 days
Mean first trimester HbA1c (mmol/mol)
Type 1 diabetes Type 2 diabetes
62. Preterm births and HbA1c
Among women who had first trimester HbA1c >=48 mmol/mol,
the preterm birth rate was significantly lower where HbA1c
reduced to <48 mmol/mol by 24 weeks+.
62
Figure 17:Preterm births and HbA1c measurements during pregnancya,b,
2015
a HbA1c measurements in mmol/mol.
b A small number of women not shown on this chart had first trimester HbA1c <48 and HbA1c at 24
weeks+ >=48.
26.4
30.4
48.0
16.2
21.6
35.7
0
25
50
HbA1c before 13 weeks <48 HbA1c before 13 weeks >=48 HbA1c before 13 weeks >=48
HbA1c after 24 weeks <48 HbA1c after 24 weeks <48 HbA1c after 24 weeks >=48
Percentage of
births
Type 1 diabetes Type 2 diabetes
63. Birthweights
• Macrosomia (birthweight 4 kg or more) is a recognised
complication for babies of women with diabetes.
• 18 per cent of babies of women with Type 1 diabetes and
12 per cent of babies of women with Type 2 diabetes had a
birthweight of 4 kg or more.
63
Figure 18: Birthweight distribution for singleton babies, 2015
9.0
14.5
30.1 28.6
12.3
5.5
11.1
21.1
32.1
23.9
9.4
2.4
0
25
50
< 2.5 2.5 to 2.999 3.0 to 3.499 3.5 to 3.999 4.0 to 4.499 4.5 and over
Percentage of
babies
Birthweight (kg)
Type 1 diabetes Type 2 diabetes
64. Birthweight centiles
The number of babies above the 97.7th and 90th birthweight
centiles was much higher than expected for both diabetes
types, based on the range of general population baby weights.
64
Figure 19: Birthweight centilesa for singleton babies, 2015
a Centiles adjust the actual birthweight for maternal ethnicity, height, weight and gestational age at delivery8.
8 See References section.
29.4
46.4
5.2
14.0
23.9
14.0
0
25
50
>=97.7th centile >=90th centile <10th centile
Percentage of
babies
Type 1 diabetes Type 2 diabetes
65. Women who had first trimester HbA1c >=48 mmol/mol were
less likely to have LGA babies (>=90th birthweight centile)
where their HbA1c at 24 weeks+ was below 48 mmol/mol.
65
Large for gestational age (LGA) and HbA1c
Figure 20: Babies large for gestational age and HbA1c during pregnancya,b,
2015
a HbA1c measurements in mmol/mol.
b A small number of women not shown on this chart had first trimester HbA1c <48 and HbA1c at 24 weeks+ >=48.
26.8
34.2
54.9
14.6 19.0
47.4
0
20
40
60
HbA1c before 13 weeks <48 HbA1c before 13 weeks >=48 HbA1c before 13 weeks >=48
HbA1c 24 weeks or later <48 HbA1c 24 weeks or later <48 HbA1c 24 weeks or later >=48
Percentage of
babies
Type 1 diabetes Type 2 diabetes
66. Fetal/infant outcomes - comment
66
• There was a significant reduction in the stillbirth rate for both
diabetes types from the CEMACH survey in 2002-03.
• However, the rates of all serious adverse outcomes
(stillbirth, neonatal death and congenital anomaly) remained
high compared with the background population.
• Women who had a miscarriage or a baby with a congenital
anomaly had higher HbA1c in early pregnancy.
• Large for gestational age (LGA) babies were much more
common than in the general population.
• Women with HbA1c above 48 mmol/mol in early pregnancy
that managed to reduce HbA1c below 48 mmol/mol by 24
weeks were less likely to have a preterm delivery or LGA
baby.
67. NICE guideline – neonatal care
NICE recommendation (NG31): Babies of women with diabetes
should stay with their mothers unless there is a clinical
complication or there are abnormal clinical signs that warrant
admission for intensive or special care.
The guideline lists specific criteria for admission to the
neonatal unit, including if babies have been born:
• before 34 weeks
• between 34 and 36 weeks if dictated clinically
67
1 See References section.
68. Neonatal unit admissions
• The rate of admissions to a neonatal unita was higher among
babies of mothers with Type 1 diabetes.
• For babies born at >=37 weeks, the admission rate was higher
than for full term babies in the general population
(6.1 per cent in 2012 data9).
68
Figure 21: The Percentage of babies admitted to a neonatal unita, 2015
a Neonatal unit includes special care and intensive care.
9 See References section. (General population data not available for preterm births.)
95.1
61.6
28.3
88.8
46.0
14.6
0
25
50
75
100
<34 weeks 34 to 36 weeks 37 weeks and over
Percentage of
babies
Gestational age (weeks)
Type 1 diabetes Type 2 diabetes
69. Neonatal unit admissions – mother and
baby characteristics
Babies born at or after 37 weeks were more likely to be admitted to
a neonatal unita if:
• their mother had HbA1c >=48 mmol/mol at 24 weeks+ gestation or
• they were LGA (>=90th birthweight centile).
69
Figure 22: Percentage of babies born at 37
weeks+ admitted to a neonatal unita by
maternal HbA1c at 24 weeks+, 2015
Figure 23: Percentage of babies born at 37
weeks+ admitted to a neonatal unita that were
large for gestational age (LGA), 2015
a Neonatal unit includes special care and intensive care.
22.7
33.4
12.2
23.6
0
25
50
HbA1c <48 HbA1c>=48 HbA1c <48 HbA1c>=48
Type 1 diabetes Type 2 diabetes
Percentage
25.6
32.1
11.4
25.6
0
25
50
Not LGA LGA Not LGA LGA
Type 1 diabetes Type 2 diabetes
Percentage
70. Local variation in babies born at/after 37 weeks
admitted to neonatal unit
70
Figure 24: The percentage of babies born at/after 37 weeks admitted to a
neonatal unit by servicea, 2013 - 2015
a Includes services with at least 10 completed pregnancy records:
Type 1 diabetes – 130 services, Type 2 diabetes – 107 services.
The percentage of full term babies admitted to a neonatal
unit varied greatly between services.
0
25
50
75
100
Percentage
Services
Lower quartile Median Upper quartile
Type 1 diabetes
0
25
50
75
100
Percentage
Services
Lower quartile Median Upper quartile
Type 2 diabetes
71. Fetal/infant outcomes - comment
71
• Rates of admission to a neonatal unit remained high.
• Admission to the neonatal unit was more likely where
maternal HbA1c was high (>=48 mmol/mol) in late
pregnancy, and/or where the baby was LGA.
• Although some specialist units looking after the highest risk
pregnancies are likely to have a higher rate of admissions
to a neonatal unit, the spread of the data may reflect local
variation in admission policies between similar units.
• Admission to a neonatal unit carries risk as well as reducing
early skin to skin contact and breastfeeding opportunities
and should largely be avoidable.
73. Additional information
The following documents are available from
http://digital.nhs.uk/pubs/npdaudit16
• Supporting data in Excel
• Powerpoint version of this report
• Summary of Key Findings and Recommendations
• Service level 2013-2015 data
• Data Quality Statement
• Methodology
• Glossary
73
74. References
74
1. NICE Diabetes in Pregnancy: Management of diabetes and its complications from pre-conception to the post natal period
https://www.nice.org.uk/Guidance/NG3
2. Confidential Enquiry into Maternal and Child Health: Pregnancy in Women with Type 1 and Type 2 diabetes in 2002-03,
England, Wales and Northern Ireland. London: CEMACH; 2005
http://www.hqip.org.uk/national-programmes/a-z-of-clinical-outcome-review-programmes/cmace-reports/
3 NICE Diabetes in pregnancy Quality Standard QS109
https://www.nice.org.uk/guidance/qs109
4 RCOG Census Report 2013
https://www.rcog.org.uk/globalassets/documents/careers-and-training/census-workforce-planning/census-report-2013.pdf
5.
6.
Worth R, Potter JM, Drury J, Fraser RB, Cullen DR. Glycosylated haemoglobin in normal pregnancy: a longitudinal study
with two independent methods. Diabetologia 1985; 28: 76-9
Sibai BM, Viteri OA. Diabetic ketoacidosis in pregnancy. Obstet Gynecol 2014;123(1):167-78.
7. Office for National Statistics: Births in England and Wales: 2015
http://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/livebirths/bulletins/birthsummarytablesen
glandandwales/2015
8. GROW centile tool: Gardosi J, Francis A. Customised Weight Centile Calculator. GROW v6.7.7.1 (UK), 2015, Gestation
Network, www.gestation.net
9. NHS Digital: NHS Outcomes Framework Indicator 5.5 Admission of full-term babies to neonatal care
http://content.digital.nhs.uk/nhsof
75. Acknowledgements
Development and delivery of the National Pregnancy in
Diabetes (NPID) audit is guided by a multi-professional
advisory group of obstetricians, midwives, diabetes
specialist nurses, diabetologists, public health physicians
and patient representatives, chaired by Dr Nick Lewis-
Barned.
Our thanks to the members of the advisory group and
the analytical team in NHS Digital for the production of
this report.
75