A study found that a nasal spray containing an artificial form of insulin may improve memory and cognitive abilities in people with mild cognitive impairment or Alzheimer's disease. The study of 60 participants found that those receiving 40 international unit doses of the insulin detemir nasal spray for 21 days showed significantly better short-term memory and processing abilities than those receiving lower doses or a placebo. Specifically, those with the APOE-e4 gene who are at higher risk of Alzheimer's saw greater benefits from the higher dosage, while lower-risk participants saw fewer effects overall. This suggests nasally administered insulin may help treat cognitive decline, building on previous promising trials.

1. Nasal spray may treat
Alzheimer's: Scientists

2. Contd..
A nasal spray that contains a man-made
form of insulin may improve working
memory and other mental capabilities in
adults with mild cognitive impairment
and Alzheimer's, scientists have found.
The study led by researchers at Wake
Forest Baptist Medical Center studied 60
adults diagnosed with amnesic mild
cognitive impairment (MCI) or mild to
moderate Alzheimer's dementia (AD).

3. Contd.
Researchers found that those who received nasallyadministered 40
international unit (IU) doses of insulin detemir, a manufactured form of the
hormone, for 21 days showed significant improvement in their short-term
ability to retain and process verbal and visual information compared with
those who received 20 IU doses or a placebo.
Recipients of 40 IU doses carrying the APOE-e4 gene -known to increase the
risk for Alzheimer's -recorded significantly higher scores than those who
received the lower dosage, while non-carriers across all three groups posted
significantly lower scores.
Previous trials had shown promising effects of nasallyadministered insulin for
adults with AD and MCI, but this study was the first to use insulin detemir.

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