2. The Muscular System
Muscles are responsible for all types of
body movement – they contract or
shorten and are the machine of the body
Three basic muscle types are found in the
body
Skeletal muscle
Cardiac muscle
Smooth muscle
3.
4. Function of Muscles
1. Support the
body
2. Allow for
movement by
making bones and
other body parts
move
3. Maintain
constant body
temperature
5. 4. Assist in
movement of
cardiovascular
veins and lymph
5. Protect internal
organs and
stabilize joints
6. Organization of Skeletal Muscle
Muscle
belly
Fascicle:
a bundle of
muscle fibers
Muscle
Fiber:
muscle cell
Sarcomere:
units of
myofibrils
responsible for
the striated
appearance
Myofibrils:
structures
that make
up a muscle
fiber
Myofilament:
protein
filaments that
make up a
sarcomere
Myosin:
thick
filaments
Actin: thin
filaments
7.
8.
9. Coverings of a Skeletal Muscle
Skeletal muscles are
organs
They contain muscle
fibers, nerves, and blood
vessels
Connective tissue
membranes separate each
muscle structure
Fascia – layer of fibrous
tissue that separates
muscles from each other
and from the skin
10. Coverings from largest to smallest
Epimysium –
covers the entire
skeletal muscle
Perimysium –
surrounds a
bundle of muscle
fibers (fascicle)
Endomysium –
surrounds a
single muscle
fiber (cell)
11. Skeletal Muscle Attachments
Epimysium blends into a connective tissue
attachment
Tendon – cord-like structure
Sites of muscle attachment
Bones
Cartilages
Connective tissue coverings
12. Microscopic Anatomy of Muscle Fiber
(muscle cell)
Cells are multinucleate
Nuclei are just beneath the membrane
14. Myofibril
Bundles of myofilaments
Myofibrils are aligned to give distinct bands
Light band = “I band”
Dark band = “A band”
15. Sarcomere
Contractile unit of a muscle fiber
Organization of the sarcomere
Thick filaments = myosin protein
Thin filaments = actin protein
16. Myosin and actin
overlap somewhat
in the sarcomere
Myosin filaments
have heads
(extensions) that
can ‘grab’ onto
actin forming a
crossbridge
17.
18. Skeletal muscles
must be
stimulated by a
nerve (motor
neuron) to
contract
Physiology of Muscle Contraction
19. Step 1: Nerve releases a neurotransmitter
(acetylcholine)
Transmission of Nerve Impulse to
Muscle
20. Step 2: Neurotransmitter causes the
muscle cell membrane gates to open
Step 3: Ions (Na+ & K+) exchange places
causing the sarcoplasmic reticulum to
release Ca2+
Step 4: This release of Ca+ starts the
muscle contraction as the actin filaments
slide past the myosin filaments
21. The Sliding Filament Theory of Muscle
Contraction
Sliding Filament Model - a muscle
contracts when the thin filament in the
muscle fiber slides over the thick filament
Activated by ATP and calcium (Ca+) ions
22. The Sliding Filament Theory of
Muscle Contraction
1) An influx of Ca2+ causes thick myosin
filaments to form crossbridges with the
thin actin filament by exposing the binding
site on actin
23. The Sliding Filament Theory of Muscle
Contraction
2) The crossbridges change shape as it pulls
on filaments which slides towards the center
of the sacromere in the power stroke
The distance between the Z line decreases,
shortening the muscle.
24. 3) The crossbridges detach from the
actin filament when ATP bonds to
myosin head.
25. The Sliding Filament Theory
4) The myosin head gets ready to bond to
actin again using ATP energy
The cycle is repeated on another site of actin
filament using the stored ATP energy
29. Contraction of a Skeletal Muscle
Muscle fiber contraction is “all or none”
Within a skeletal muscle, not all fibers
may be stimulated during the same
interval
Different combinations of muscle fiber
contractions may give differing responses
Graded responses – different degrees of
skeletal muscle shortening
Rapid stimulus = constant contraction or
tetanus
30. Muscle force depends upon the
number of fibers stimulated
More fibers contracting results in
greater muscle tension
Muscles can continue to contract
unless they run out of ATP or
Ca2+
One molecule of ATP supplies
enough energy for one actin and
myosin cross-bridge
31. Energy for Muscle Contraction
Muscles use stored ATP for energy
Bonds of ATP are broken to release energy
Only 4-6 seconds worth of ATP is stored by
muscles
Three ways for muscle to make energy (ATP)
ATP production
for Muscle
Contraction
Creatine
Phosphate
Cellular
Respiration
Fermentation
(Anaerobic
Respiration)
32. 1. Creatine Phosphate
Creatine phosphate is a high-energy
compound and is the fastest way to
make ATP available for muscles
Used for activities lasting < 15
seconds
Anaerobic (no oxygen needed)
Reaction:
Creatine phosphate + ADP ↔ creatine +
ATP
Creatine phosphate is made when a
muscle is at rest
33. 2. Cellular Respiration
Mitochondria use glucose
molecules to make ATP in
the presence of oxygen
Provides most of a muscle’s
ATP
Aerobic (needs oxygen)
Used for activities lasting
hours
Reaction
C6H12O6 + 6O2 6CO2 +
6H2O + ATP energy
1 glucose = 36 ATP
34. 3. Anaerobic Respiration/
Fermentation
Reaction that breaks down
glucose without oxygen
Used for activities lasting
30 – 60 seconds
Anaerobic (no oxygen)
Reaction
Glucose pyruvic acid + 2
ATP lactic acid
Lactic acid is also
produced and causes pain
in the muscle
35. Heavy breathing after exercise is a sign of
oxygen deficiency
A marathon runner is exhausted after crossing
the finish line because they have depleted not
only their oxygen but their glucose as well
It takes up to two days to replace all of the
glucose in the muscles and glycogen in the liver
36. Muscles and Body Movements
Movement is
attained due to a
muscle moving an
attached bone
Muscles are attached
to at least two points
Insertion –
attachment to a
moveable bone
Origin – attachment
to an immovable
bone
37. Types of Ordinary Body Movements
Flexion –
decreases angle of
joint and brings
two bones closer
together
Extension-
increases angle of
joint
38. Rotation- movement of a
bone in longitudinal axis,
shaking head “no”
Abduction – moving
away from the midline
Adduction - moving
toward the midline
Circumduction - cone-
shaped movement,
proximal end doesn’t
move, while distal end
moves in a circle.
39. Types of Muscles
Muscles work in opposing pairs
Ex. Biceps (flexion of arm) and Triceps
(extension of arm)
Prime mover – muscle that does most of
the work
Synergist – muscle that helps a prime mover
in a movement
Antagonist – muscle that opposes or
reverses a prime mover
40. Naming of Skeletal Muscles
Direction of muscle fibers
Example: rectus (straight), orbicularis (circular)
Relative size of the muscle
Example: maximus (largest), minimus
(smallest), longus (long), brevis (short)
Location of the muscle
Example: pectoralis (chest), external (outside),
frontalis (frontal)
Number of origins
Example: triceps (three heads)
41. Location of the muscles origin and
insertion
Example: sterno (on the sternum)
Shape of the muscle
Example: deltoid (triangular)
Action of the muscle
Example: flexor and extensor (flexes or
extends a bone)
42. Affects of Aging on Muscles
1. Muscles that are not used are replaced by
connective tissue then by fat
2. With age comes degeneration of
mitochondria due to exposure to oxygen
and free radicals
3. Changes in the nervous system and
endocrine system also effect structure and
function of muscles
4. Muscles become weaker as we age but
exercise can stimulate muscle build-up
43. She is 86 years young and a body builder.
He is 80, and the oldest Iron man triathlon
participant.
(1.2 mile swim, a 56-mile bike and a 13.1 mile
run = 70.3 miles.)
44. Disorders relating to the Muscular
System
Muscular Dystrophy: inherited, muscle
enlarge due to increased fat and
connective tissue, but fibers degenerate
and atrophy
Duchenne MD: lacking a protein to
maintain the sarcolemma
Myasthemia Gravis: progressive
weakness due to a shortage of
acetylcholine receptors
45. Sprain verses Strain
Strain – overstretching of
a muscle near a joint
Sprain – twisting of a joint
leading to swelling and
injury to ligaments,
tendons, blood vessels and
nerves
46. Myalgia and Tendinitis
Myalgia –
inflammation of
muscle tissue
(arthritis on previous
slide)
Tendinitis –
inflammation of the
tendon due to strain
of repeated activity