Mumps is caused by the mumps virus, an RNA virus of the paramyxovirus family. It spreads through respiratory droplets and causes acute benign viral parotitis or mumps of the parotid salivary glands. While antibody response is not sufficient to control infection on its own, cell-mediated immunity plays an important role in symptoms and disease control. Complications can include inflammation of the testes, ovaries or brain. The mumps vaccine is a live attenuated vaccine that is part of the routine MMR vaccine series and provides lifelong immunity against this contagious viral infection.

1. MUMPS
Presented By:
SANDRA SAJU

2. MUMPS VIRUS
 Mumps virus is the cause of acute,
benign viral parotitis.
 RNA virus
(Genus: Rubulavirus of the Paramyxoviridae family)
 Only one serotype is known.
{Hence, lifelong immunity after the infection}

3. Disease Mechanisms
• Cell-mediated immunity is essential for control of infection and responsible for
causing some of the symptoms. Antibody is not sufficient because of virus’s ability
to spread cell to cell.
Spread by respiratory droplets
Replicates in T Lymphocytes
Hematogenous spread
Infection of Parotid gland and Other organs.
Mumps Parotitis

4. Medical microbiology, 7th edition , page no.- 520

5. EPIDEMIOLOGY
I. Virus has large enveloped virion that is easily inactivated by dryness and acid.
II. Contagion period precedes symptoms.
III. Virus may cause asymptomatic shedding.
IV. Host range is limited to humans.
V. Only one serotype exists.
VI. Immunity is lifelong.

6. Symptoms {16-18 days}

8. Transmission
Inhalation / Direct Contact of large-droplet
aerosols.

9. Who Is at Risk?
• Unvaccinated people.
• Immunocompromised people.

10. complications
1.Inflammation of :
 Testicles(Orchitis)
 Ovaries
 Brain (Encephalitis)
2.Temporary or permanent blindness.

11. Geography/Season
• Virus is found worldwide
• Virus is endemic in late winter and early spring.

12. Laboratory diagnosis
 No Laboratory confirmation needed.
 Atypical infection needs laboratory diagnosis.
• Virus isolated from;
Saliva, Urine, Pharynx, Secretions from Stensen duct and CSF.
• Serology: mumps-specific IgM antibody.
• Enzyme-linked immunosorbent assay, Immunofluorescence tests, and
hemagglutination inhibition can be used to detect the mumps virus, antigen, or
antibody

13. Treatment
 No specific Antiviral therapy.
 Antipyretics are administered for fever.
 Bed rest
 And the Diet should be adjusted to patient’s ability to
chew.

14. Modes of Prevention
• Live attenuated vaccine (Jeryl Lynn strain),
Administered as a part of MMR vaccine.
• Keep distance from infected person.

15. Video:

16. References:
• Medical Microbiology, 7th edition, Murray, Rosenthal, Pfaller. [Pages ;519,520]
• http://www.slideshare.net/alanisaad/mumps-5090004
• Video Reference : https://www.youtube.com/watch?v=gZjaCigD4So