Auburn Uveal Melanoma Study - 2019 CURE OM Symposium

Melanoma Research Foundation
Melanoma Research FoundationAccount Director at Melanoma Research Foundation
AUBURN UVEAL
MELANOMA POPULATION
John O. Mason, III, M.D.
Retina Consultants of Alabama
UAB Department of Ophthalmology
Director of Retina Service & Ocular Oncology
Fred Kam, M.D.
Auburn University
Medical Director
INCLUSION CRITERIA
• January 1, 1980 to December 31, 2018
• Documented Uveal Melanoma
• Student or Professor at Auburn
• Lived in Auburn
ASPECTS TO THE STUDY
• Participation of Patients
• Geospatial Evaluation
• Environmental Evaluation
• Genetics Evaluation
• Funding
RESPONSIBILITIES WHICH MAY OVERLAP
Dr. Kam:
• Discussions with Geospatial Experts
• Discussions with Alabama Department of Public Health
Dr. Mason:
• Discussions with Genetic Experts in Uveal Melanoma
• Confirmation and Evaluation of All Patients for Inclusion
Into the Study
• Spreadsheet Details Concerning Each Patient
AUBURN UVEAL MELANOMA POPULATION
• 33 Total Possible Candidates for Inclusion (4 Deceased)
• 30 Located and Have Agreed to Participate (3 Deceased and
Family Not Reached)
• All 29 Living Participants Will Participate As Well As Parents
of 1 Deceased Patient
PARTICIPANTS
• 30 Total
• 23/30 Students or Faculty
• 7/30 Lived in Auburn and Spent Time on Campus
DEMOGRAPHICS OF PARTICIPANTS
• 14 Females / 16 Males
• Mean Age at Diagnosis 43 (Range 30 to 71)
• Most Common Dates at Auburn – 1987 to 1992
• 24/30 Were at Auburn from 1983 to 1998
DEMOGRAPHICS AND TREATMENT OF
PARTICIPANTS
• Patients Were Treated by Multiple Ocular Oncologists, The
Most Frequent Being Carol Shields, MD and John Mason, MD
• Metastatic Disease Developed in 6/30
• 8/30 Had Their Eye Removed
• 22/30 Were Treated by Radiation (Plaque or Proton Beam)
• Patients are Currently Living Throughout the United States
NEXT STEPS
• Obtain Additional Funding
• Develop Protocol for Geospatial Testing
• Environmental Testing Would Follow Geospatial Testing
• Develop Protocol for Genetic Testing of Blood and Tissue
Samples
• Obtain Necessary IRB Approval and Consents from Patients
WE WILL TRY TO FIND
ANSWERS…THANK YOU!!!
1 of 10

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Auburn Uveal Melanoma Study - 2019 CURE OM Symposium

  • 1. AUBURN UVEAL MELANOMA POPULATION John O. Mason, III, M.D. Retina Consultants of Alabama UAB Department of Ophthalmology Director of Retina Service & Ocular Oncology Fred Kam, M.D. Auburn University Medical Director
  • 2. INCLUSION CRITERIA • January 1, 1980 to December 31, 2018 • Documented Uveal Melanoma • Student or Professor at Auburn • Lived in Auburn
  • 3. ASPECTS TO THE STUDY • Participation of Patients • Geospatial Evaluation • Environmental Evaluation • Genetics Evaluation • Funding
  • 4. RESPONSIBILITIES WHICH MAY OVERLAP Dr. Kam: • Discussions with Geospatial Experts • Discussions with Alabama Department of Public Health Dr. Mason: • Discussions with Genetic Experts in Uveal Melanoma • Confirmation and Evaluation of All Patients for Inclusion Into the Study • Spreadsheet Details Concerning Each Patient
  • 5. AUBURN UVEAL MELANOMA POPULATION • 33 Total Possible Candidates for Inclusion (4 Deceased) • 30 Located and Have Agreed to Participate (3 Deceased and Family Not Reached) • All 29 Living Participants Will Participate As Well As Parents of 1 Deceased Patient
  • 6. PARTICIPANTS • 30 Total • 23/30 Students or Faculty • 7/30 Lived in Auburn and Spent Time on Campus
  • 7. DEMOGRAPHICS OF PARTICIPANTS • 14 Females / 16 Males • Mean Age at Diagnosis 43 (Range 30 to 71) • Most Common Dates at Auburn – 1987 to 1992 • 24/30 Were at Auburn from 1983 to 1998
  • 8. DEMOGRAPHICS AND TREATMENT OF PARTICIPANTS • Patients Were Treated by Multiple Ocular Oncologists, The Most Frequent Being Carol Shields, MD and John Mason, MD • Metastatic Disease Developed in 6/30 • 8/30 Had Their Eye Removed • 22/30 Were Treated by Radiation (Plaque or Proton Beam) • Patients are Currently Living Throughout the United States
  • 9. NEXT STEPS • Obtain Additional Funding • Develop Protocol for Geospatial Testing • Environmental Testing Would Follow Geospatial Testing • Develop Protocol for Genetic Testing of Blood and Tissue Samples • Obtain Necessary IRB Approval and Consents from Patients
  • 10. WE WILL TRY TO FIND ANSWERS…THANK YOU!!!