The document is a publication by Osama Shukir Muhammed Amin, focusing on the MRCP (UK) and MRCP (I) Part I examinations, containing 732 questions across various medical specialties. It emphasizes updates in medicine over the past decade, including topics on COVID-19 and women's health, with each question followed by detailed explanations and references. This is Volume I, with a promise of a subsequent Volume II releasing later in 2022.

2. MRCP(UK) and MRCP(I) Part I
Best of Fives

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4. MRCP(UK) and MRCP(I) Part I
Best of Fives
Volume I
(Cardiovascular Medicine, Respiratory Medicine, Nephrology,
Acid-Base and Electrolytes Disturbances, Urology,
Gastroenterology and Hepatology, Neurology, Stroke Medicine,
Medical Ophthalmology, and Psychiatry)
Osama Shukir Muhammed Amin
MBChB, MD, MRCP, FRCP(Edin), FRCP(Glasg), FRCP(Ire), FRCP(Lond), FACP,
FAHA, FCCP(USA), FRSA
Consultant Neurologist and Director
The Kurdistan Board of Neurology Sulaymaniyah
Formerly, Clinical Associate Professor
International Medical University
Kuala Lumpur, Malaysia
©2022 Osama Shukir Muhammed Amin

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6. Copyright © 2022, Osama Shukir Muhammed Amin.
Copyright Notice:
All rights reserved. No part of this publication may be reproduced or transmitted in
any form or by any means, electronic, mechanical, photocopying, recording, or
otherwise, without prior permission of the copyright owner in writing:
Email: dr.osama.amin@gmail.com
First Edition: 2022.
ISBN: 978-1-4583-4964-4
Disclaimer:
This book was written depending on reliable sources. However, while every effort has
been made to ensure its accuracy, no responsibility for loss, damage, or injury
occasioned on any person acting or refraining from action as a result of information
contained herein can be accepted by the author or publisher.
Published and distributed by Lulu Press, Inc. Northern Carolina, USA.

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Dedication
To my lovely family
Sarah, Awan, and Naz

8. Acknowledgments
I would like to sincerely thank my dear patients; their clinical scenarios were used to
formulate and generate these questions.
Special gratitude goes to my wife, Sarah, for her endless support and encouragement,
and of course, her extreme patience.

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Preface
“Listen to your patient – he is telling you the diagnosis.”, Sir William Osler (b. 1849, d. 1919)
edicine is an ever-changing branch. The COVID-19 global crisis has
reformatted our concepts and perspectives in the understanding of novel
diseases and their treatment, including vaccinations. During the last decade,
there has been a robust revolution in smartphones and the internet access industry, and
accordingly, both have been reflected in the ways how postgraduate trainees get their
information and study.
My previous books, “Get Through MRCP Part I; BOFs” (published by the Royal Society
of Medicine Press in London, 2008), “Mock Papers for MRCPI part I, 2nd Edition”
(published by Lulu Press, Inc., USA, 2016), and “Self-Assessment: 650 BOFs for
MRCP(UK) and MRCP(I) Part I” (published by Lulu Press, Inc., USA, 2017) have
already covered most of the classical examination scenarios and themes. Combined,
they have created a question bank of approximately 1600 questions.
In writing this book, I have tried to focus on the most important updates in medicine
that have been emerging during the past decade; novel diseases, novel investigations,
and newly approved medications. Needless to say, COVID-19 and its SARS-CoV-2,
will be encountered in each chapter, in addition to occupying a unique position in the
chapter on infectious diseases.
The other aspect that I think is very crucial to tackle is women’s health and pregnancy.
Once again, such a topic has been addressed in every chapter. There are no separate
chapters for geriatrics, clinical sciences, and pharmacology (including therapeutics and
toxicology); their questions have been distributed throughout the book’s chapters. Each
answer is followed by an explanation and a reference (source) and/or additional
(further) reading. In this way, you can go there; skim the whole subject if you are
interested to get more information.
I did my best to avoid regurgitated subjects and themes (which have been encompassed by
many books, including mine, during the past 20 years). Although many questions
appear to be difficult and may fit part II examinations, I believe these questions (and
their explanations) will strengthen your background and help you prepare well for the
part II examination. Remember, the goal is to find and fill in the gaps in your knowledge.
Still, after 27 years, I find Sir Davidson’s textbook, “Davidson’s Principles and Practice of
Medicine”, (by Elsevier Health Sciences) to be the best source to build up your solid
foundations. In addition, Medscape (https://emedicine.medscape.com/, by WebMD
LLC.), and StatPearls [Internet] (https://www.ncbi.nlm.nih.gov/books/NBK430685/,
by StatPearls Publishing, Treasure Island) are the best-updated sources of information.
M

10. This is volume I, which assesses the candidates’ knowledge in cardiology, pulmonology,
nephrology (as well as acid-base balance, electrolytes, and urology), gastroenterology
and hepatology, and finally neurology (as well as stroke medicine, medical
ophthalmology, and psychiatry), encompassing 732 bests of fives.
Undoubtedly, if you are well-prepared, you will pass the examination very easily. No
need to panic when you hear your colleagues’ past [bad] experiences. Lack of
preparation is the single most common reason for failure. Remember, practice makes
perfect. Read and self-assess; that’s it!
Volume II will be available in the 2nd half of the year 2022.
Good luck with your career and exams!
OsamaAmin
Osama S. M. Amin
March 2022

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Table of Contents:
Chapter 1: Cardiovascular Medicine
Questions ...........................................................................................................................................1
Answers.........................................................................................................................................25
Chapter 2: Respiratory Medicine
Questions .........................................................................................................................................59
Answers ........................................................................................................................................85
Chapter 3: Nephrology, Acid-Base & Electrolytes Disturbances, & Urology
Questions ...................................................................................................................................... 121
Answers ..................................................................................................................................... 145
Chapter 4: Gastroenterology & Hepatology
Part A Questions ........................................................................................................................ 190
Answers ..................................................................................................................................... 246
Part B Questions ........................................................................................................................ 215
Answers ..................................................................................................................................... 295
Chapter 5: Neurology, Stroke Medicine, Medical Ophthalmology, & Psychiatry
Questions ...................................................................................................................................... 357
Answers ...................................................................................................................................... 413
More Books from the Author ..................................................................................................... 523
About the Author ........................................................................................................................... 525

12. Osama S. M. Amin FRCP MRCP(UK) & MRCP(I) Part II: 200 Cases
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More Books from the Author:
1. MRCP(UK) and MRCP(I) Part II 200, Cases Case Histories, Data Interpretation, &
Photographic Materials (2022):
In writing this book, I tried my best to guide you on how you approach part II written
examinations, how to skim the data, and how to conclude your answer. The subjects I
have chosen apply the rule of “the common is common”. I formulated the scenarios
and their explanation in a way that, I hope, will inform you of the core feature of
decision-making. It’s an art. I have tried to focus on some important updates in
medicine that have been emerging during the past decade; novel diseases, novel
investigations, and newly approved medications. COVID-19 (and its SARS-CoV-2) and
women’s health will be encountered many times. Remember, the goal is to find and fill in the
gaps in your knowledge.
2. Self-Assessment: 650 BOFs for MRCP(UK) and MRCP(I) Part I (2017):
This is the 2nd edition of my previous book, “Self-Assessment for MRCP(UK) part
1”, which was published in 2009. The book has undergone several changes and updates.
The best initial step is to read accredited textbooks. After then, self-assess yourself.
Read this book, chapter after chapter, try to find out your mistakes and gaps in
knowledge, and then re-read what you have missed. In writing this book, I tried my
best to include the commonest examination themes.
3. Mock Papers for MRCPI Part I, 2nd edition (2016):
In this second edition, you will find 3 mock papers. Each one contains 100 questions
in a Best of Five (BOF) format. Self-assess, try to complete each paper within 3 hours,
check out your answers, read the explanation, and re-read accredited medicine
textbooks to fill in the gap in your knowledge. Each question has an “objective”; try to
review what the objective is about. This is the only self-assessment book specifically
written to imitate the MRCPI Part I examination. Each mock paper in the first edition
of this book contained 50 BOFs and 50 MCQs formats.
4. Get Through MRCP Part I: BOFs (2008):
“Get Through MRCP Part 1: BOFs” provides over 600 questions and answers,
allowing the reader to test their knowledge in preparation for the MRCP Part 1
examination. Questions are presented in the style used in the real examination,
and answers are supplemented with useful additional explanatory material to

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help the reader understand why their answer was right, or wrong. The book
offers a useful review of all elements of the syllabus, so the reader can feel fully
prepared when they enter the examination room.

14. Osama S. M. Amin FRCP MRCP(UK) & MRCP(I) Part II: 200 Cases
525
About the Author:
Osama Shukir Muhammed Amin
r. Amin graduated from the Baghdad
University, College of Medicine and
was a valedictorian student in internal
medicine. He got membership diplomas from
the Royal Colleges of Physicians of Ireland and
the UK and then became Board-certified in
neurology. He is a Fellow of the American
College of Physicians (FACP), Fellow of the Royal College of Physicians and Surgeons
of Glasgow (FRCP Glasg), Fellow of the Royal College of Physicians of Edinburgh
(FRCP Edin), Fellow of the Royal College of Physicians of Ireland (FRCPI), Fellow of
the Royal College of Physicians of London (FRCP Lond), and Fellow of the American
Heart Association/American Stroke Association (FAHA). In recognition of his
contribution to ancient history and archaeology, he was elected a Fellow of the Royal
Society of Arts (FRSA) in London. Dr. Amin is a Clinical Associate Professor of
Neurology, Consultant Neurologist, and Director of the Kurdistan Board of
Neurology, Sulaymaniyah. Formerly he was a Clinical Associate Professor at the
International Medical University, Malaysia. He published 67 articles in international
peer-reviewed neurology and internal medicine journals and 7 self-assessment books
for the membership diploma of the Royal Colleges of Physicians of the United
Kingdom and Ireland. In addition, he published more than 30,000 archaeological
illustrations and more than 40 articles in archaeology. He was an associate editor, guest
editor, reviewer in several international peer-reviewed internal medicine and neurology
journals, and former Editor-in-Chief. He is a contributor/team member of “Medical
MasterClass,” the MRCP(UK)’s educational arm of the Royal College of Physicians of
London, UK. Dr. Amin is an international juror for Wiki Science Competition 2017
and 2019, representing the Pan-Arab World, Iran, and Africa. He has contributed quite
a lot to Wikipedia.
D

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