This document discusses strategies for healthcare organizations to move from optimizing their current performance to achieving higher levels of reliability and performance associated with the "second curve."
The first section outlines two historical curves of innovation in healthcare - the first focusing on standards and best practices, and the second involving new management approaches to achieve reliability levels of 6 sigma or higher.
The rest of the document then discusses three "buckets" or levels that healthcare organizations can progress through: 1) optimizing current performance, 2) preparing to improve by addressing cultural and structural barriers, and 3) distinguishing themselves through new collaborative and system-wide approaches that transcend traditional silos. Key aspects of each bucket are outlined.
Google Recommendations and Implementations Strategiesgbrynza
Â
This group paper was written in my Managing Organizations class with Dr. Chio at the University of Washington Tacoma. This paper describes the recommendations and implementation strategies to be taken when the SWOT Analysis of Google was revealed.
Strategic management final activity ppt (2)Allierskine
Â
This document discusses strategic recommendations for Hyundai Motor Corporation regarding their electric/hybrid vehicle strategic business area (SBA). It analyzes Hyundai's history, environmental turbulence in the auto and electric/hybrid industries, strategic aggressiveness and capability responsiveness frameworks. It identifies strategic capability gaps for Hyundai and discusses possibilities and challenges for expanding in China, including political and cultural risks. It also examines sources of resistance to change at Hyundai and recommends a change management strategy of maintained resistance.
This document discusses the concept of strategic drift, where companies base their development more on past practices than adapting to changes in the external environment. This can lead them to fall out of alignment with their industry over time. Strategic drift occurs through incremental changes that fail to keep pace with the accelerating changes around them. Companies can fall into strategic drift for reasons like relying on familiar strategies, rigid capabilities, strong relationships, and lagged performance effects that make major changes difficult to recognize. The options when strategic drift occurs are transformational change to realign the strategy or potential decline.
Larry Page and Sergey Brin founded Google in 1998 after developing their search technology as PhD students at Stanford University. Google hosts many internet services and products and generates most of its profit from advertising. It processes over one billion search requests and 24 petabytes of user data daily. Google has become a dominant player in the search market but faces threats of declining growth and increasing competition. It aims to become stars in new markets through acquisitions of small companies in rapidly growing sectors, though many acquisitions have struggled or become dogs with low market share in mature industries.
The document provides an overview of Amazon's marketing strategies. It discusses Amazon's history and business model. It then analyzes Amazon's strengths, weaknesses, opportunities, and threats using various frameworks like SWOT analysis, TOWS matrix, BCG matrix, value chain analysis, and PESTLE analysis. Finally, it discusses Amazon's customer relationship management, expansion strategies using different frameworks, e-marketing approach, and corporate social responsibility strategies. The key aspects covered include Amazon's diverse product offerings, focus on customer service, and strategies for global expansion into markets like China and India.
This document provides an overview of IKEA, including its business, vision, mission, strategy, history, and PESTEL analysis. Some key points:
- IKEA is an international home products company that sells ready-to-assemble furniture and home accessories.
- Its vision is to create a better everyday life for many people. Its mission is to offer well-designed, affordable home goods.
- It follows strategies of low prices, quality products, and flat-pack furniture packages for low-cost shipping.
- IKEA has expanded globally since its founding in Sweden in the 1940s. It now has over 400 stores worldwide.
Google Recommendations and Implementations Strategiesgbrynza
Â
This group paper was written in my Managing Organizations class with Dr. Chio at the University of Washington Tacoma. This paper describes the recommendations and implementation strategies to be taken when the SWOT Analysis of Google was revealed.
Strategic management final activity ppt (2)Allierskine
Â
This document discusses strategic recommendations for Hyundai Motor Corporation regarding their electric/hybrid vehicle strategic business area (SBA). It analyzes Hyundai's history, environmental turbulence in the auto and electric/hybrid industries, strategic aggressiveness and capability responsiveness frameworks. It identifies strategic capability gaps for Hyundai and discusses possibilities and challenges for expanding in China, including political and cultural risks. It also examines sources of resistance to change at Hyundai and recommends a change management strategy of maintained resistance.
This document discusses the concept of strategic drift, where companies base their development more on past practices than adapting to changes in the external environment. This can lead them to fall out of alignment with their industry over time. Strategic drift occurs through incremental changes that fail to keep pace with the accelerating changes around them. Companies can fall into strategic drift for reasons like relying on familiar strategies, rigid capabilities, strong relationships, and lagged performance effects that make major changes difficult to recognize. The options when strategic drift occurs are transformational change to realign the strategy or potential decline.
Larry Page and Sergey Brin founded Google in 1998 after developing their search technology as PhD students at Stanford University. Google hosts many internet services and products and generates most of its profit from advertising. It processes over one billion search requests and 24 petabytes of user data daily. Google has become a dominant player in the search market but faces threats of declining growth and increasing competition. It aims to become stars in new markets through acquisitions of small companies in rapidly growing sectors, though many acquisitions have struggled or become dogs with low market share in mature industries.
The document provides an overview of Amazon's marketing strategies. It discusses Amazon's history and business model. It then analyzes Amazon's strengths, weaknesses, opportunities, and threats using various frameworks like SWOT analysis, TOWS matrix, BCG matrix, value chain analysis, and PESTLE analysis. Finally, it discusses Amazon's customer relationship management, expansion strategies using different frameworks, e-marketing approach, and corporate social responsibility strategies. The key aspects covered include Amazon's diverse product offerings, focus on customer service, and strategies for global expansion into markets like China and India.
This document provides an overview of IKEA, including its business, vision, mission, strategy, history, and PESTEL analysis. Some key points:
- IKEA is an international home products company that sells ready-to-assemble furniture and home accessories.
- Its vision is to create a better everyday life for many people. Its mission is to offer well-designed, affordable home goods.
- It follows strategies of low prices, quality products, and flat-pack furniture packages for low-cost shipping.
- IKEA has expanded globally since its founding in Sweden in the 1940s. It now has over 400 stores worldwide.
Keynote (EN): Beyond Budgeting in Practice, at Quality & Excellence Conferenc...Gebhard Borck
Â
The document discusses the need for a new management model beyond traditional budgeting and command-and-control hierarchies. It notes that the world has become more dynamic, complex, and customer-focused, requiring organizations to be more adaptive, decentralized, and responsive. It then outlines principles of the Beyond Budgeting model, which focuses on customer responsibility, devolved leadership, relative targets, transparency, and dynamic processes rather than annual planning and control. Examples are given of companies like Handelsbanken that have successfully implemented aspects of this new model.
Seminar (EN): CFO Forum - Challenges in tough times, Warszaw/Poland, organize...Gebhard Borck
Â
The document discusses the need for organizations to transition from a traditional "command and control" management model designed for efficiency in the industrial age to a new model designed for complexity in today's dynamic knowledge economy. It outlines some of the pitfalls of the traditional hierarchical, centralized model and argues that organizations now need adaptive, decentralized networks and relative, dynamic processes rather than fixed annual planning and budgeting to remain competitive. The document uses examples like Handelsbanken bank to illustrate how radically decentralized models with a focus on customers, autonomy and performance can be very successful.
The document discusses opportunities in the Indian healthcare industry and tertiary healthcare sector specifically. It outlines strengths, weaknesses, opportunities and threats for tertiary healthcare. The main competitors in Delhi are listed along with their number of hospitals, beds, and revenues. The document discusses ethical dilemmas in healthcare and different stages of moral development. It proposes a hybrid business model for the new hospital that incorporates both charity and corporate aspects. Finally, it outlines the basic strategic plan to open a single super specialty neuroscience hospital to address the large demand-supply gap in Delhi.
A Portfolio Strategy - which yield\'s the â Max. Operating Performance per Unit of Enterprise Value with min. expense ratio , lower Beta vs Benchmarks & Competitive liquidity quotient " :: { 9 Templates * 996 Portfolio\'s * 15000 Simulations * 6 Time Zones vs 4 Benchmarks }
The document discusses how business continuity has gone mainstream and provides examples of business continuity in mainstream media. It also addresses how this has impacted expectations from employees and challenges for business continuity programs. The presentation covers various topics related to ensuring business continuity programs adapt and succeed as the discipline becomes more mainstream.
Jean marc saubade-the consumer goods forumECR Community
Â
Jean-Marc Saubade discusses the Consumer Goods Forum update and its focus on the Asia Pacific region. The Consumer Goods Forum was launched in 2009 and brings together retailers and manufacturers to collaborate across the value chain. It has a vision of "Better lives through better business" and a mission to passionately serve shoppers, consumers and communities better, faster with great value and responsibility. The strategic pillars include emerging trends, sustainability, safety and health, operational excellence, knowledge sharing and people development. The climate change work programme has three streams around carbon measurement, deforestation and refrigeration.
The document discusses key aspects of sustainability for global financial services organizations. It highlights that corporate sustainability focuses on creating long-term shareholder value by managing opportunities and risks from sustainability trends. Top-performing financial services firms recognize sustainability as a guiding principle and engage stakeholders. Leaders integrate sustainability into core processes and offer sustainable financial products.
Marcus evans 9th annual commercial translation of regenerative medicine fun...ProteusVenturePartners
Â
This document discusses funding and commercialization strategies for regenerative medicine companies. It notes that while regenerative medicine has made great progress, serious commercialization challenges remain, including developing optimal cells for therapy, manufacturing at scale, addressing regulatory and IP issues, and determining business models. New economic realities require a more capital efficient development model as the "valley of death" between research and commercialization expands. Regenerative medicine translation centers may help enable more efficient technology development and collaborations to address these challenges.
The document provides an overview of a meeting on 6 November 2011 between Lt Gen Green and approximately 125 AFMS Dental Officers. The purpose was to provide updates on the future of the AFMS and Dental Corps. Gen Green discussed strategies to transform deployable capability, build patient-centered care, and invest in education. He also provided updates on initiatives like the electronic health record and open-source technologies. The status of the Dental Corps, performance metrics, and opportunities for development were reviewed. The future of innovation, specialty hospitals, and patient-centered care were also addressed.
The document contains an agenda for Dean Sandler that includes clients, board of directors, strategy meetings, key trends reports, preliminary company valuations, medical reports, training, and visions. It also includes charts, graphs, templates, and presentations. The document provides an overview of Dean Sandler's schedule and materials across various industries including media, financial services, pharmaceuticals, and more.
Jim Martin Final Version Unexpected Consequences Short Version Presentation 1...sixsigmaintegration23
Â
Of the more than forty catastrophic events analyzed in the book, cognitive and organizational failures are associated with approximately 98% of all deaths, property damage, and financial losses. Common causes of these failures include isolated technical failures, isolated project failures, and chronic failures related to issues like food contamination that spanned multiple years.
Jim Martin Final Version Unexpected Consequences Short Version Presentation 1...sixsigmaintegration23
Â
The document discusses unexpected consequences of failures in complex systems. It analyzes over 40 catastrophic events that resulted in over 18 million deaths and $675 billion in damages. Cognitive and organizational failures accounted for about 98% of the consequences. The failures often stemmed from interactions between human decision-making and technological or environmental factors.
This document discusses quality in foresight and forecasting for emerging markets. It begins by providing examples of past forecast failures and outlines several "levels" of future uncertainty. It then discusses various "limits" or challenges with different forecasting approaches, such as relying only on sector experts, overextrapolating trends, and the limitations of quantitative forecasting. It advocates using scenarios to explore multiple plausible futures rather than single point predictions. The document concludes by outlining implications for views of emerging markets like South Africa in 2030, emphasizing the need to plan for unpredictable change, practice high-quality foresight, respect consumer adoption patterns, and understand when we can influence versus must adapt to the future.
The Third Shift: Women Physicians on OverloadiAttain
Â
The unusual stresses of clinical care, administrative tasks and personal life combine to increase burnout among women physicians. There are numerous contextual and personal factors that must be understood to lighten the load and increase their retention in healthcare.
The factors that distinguish highly effective healthcare organizations are discovered through generative internal investigation via Appreciative Inquiry. When the cross section of internal members of the organization are invited to express what happens when extraordinary care is provided, the key strengths are revealed.
The document provides guidance on designing instructional content through various models and frameworks. It discusses:
1. The process of instructional design, which involves creating a thematic structure, selecting an instructional strategy, and integrating them to create learning activities.
2. Models for instructional design including Gagne's "Nine Events of Instruction" and the "4A's of Learning Design" which focus on attracting learners, gaining attention, ensuring availability of content, and driving application.
3. The need for a structured approach when developing technical training, with guidance on how to teach different content types like facts, concepts, processes, and procedures.
4. The "Content Performance Matrix" and focusing
The document discusses strategic planning and visualization through a SOAR framework. It outlines five phases of strategic planning: initiate, inquire, imagine, innovate, and inspire implementation. Each phase involves cycles of assessing strengths, opportunities, aspirations, and results. The document also emphasizes that all elements of an organization must align behind the strategy, including structure, culture, people, measurements, and rewards. A new strategy may require changes to how the organization is structured and decisions are made. Success also requires building the right competencies, focus, and motivation among people. The culture must also support the strategic changes, as culture often resists change but ultimately determines success or failure.
The document discusses Appreciative Inquiry (AI), a strengths-based approach to organizational change and development. It provides an overview of AI, including its key principles and the 5-D cycle of Define, Discover, Dream, Design, and Destiny. Case studies are presented showing how various organizations have used AI to improve performance, build shared visions, and develop strategic plans through collaborative inquiry and storytelling.
This document discusses how transformative learning theory and appreciative inquiry can be combined to promote deep organizational change. It argues that integrating these approaches can provide a theoretical framework for transforming perspectives and behaviors at both the individual and group levels. The summary proposes combining the theories' focus on generating positive visions of change through reflective practices like questioning, storytelling, and exploring strengths to encourage appreciation transformative learning. This integrative process is said to cultivate both individual and collective transformation by challenging assumptions and co-creating exceptional futures through collaborative dialogue and reflection.
Keynote (EN): Beyond Budgeting in Practice, at Quality & Excellence Conferenc...Gebhard Borck
Â
The document discusses the need for a new management model beyond traditional budgeting and command-and-control hierarchies. It notes that the world has become more dynamic, complex, and customer-focused, requiring organizations to be more adaptive, decentralized, and responsive. It then outlines principles of the Beyond Budgeting model, which focuses on customer responsibility, devolved leadership, relative targets, transparency, and dynamic processes rather than annual planning and control. Examples are given of companies like Handelsbanken that have successfully implemented aspects of this new model.
Seminar (EN): CFO Forum - Challenges in tough times, Warszaw/Poland, organize...Gebhard Borck
Â
The document discusses the need for organizations to transition from a traditional "command and control" management model designed for efficiency in the industrial age to a new model designed for complexity in today's dynamic knowledge economy. It outlines some of the pitfalls of the traditional hierarchical, centralized model and argues that organizations now need adaptive, decentralized networks and relative, dynamic processes rather than fixed annual planning and budgeting to remain competitive. The document uses examples like Handelsbanken bank to illustrate how radically decentralized models with a focus on customers, autonomy and performance can be very successful.
The document discusses opportunities in the Indian healthcare industry and tertiary healthcare sector specifically. It outlines strengths, weaknesses, opportunities and threats for tertiary healthcare. The main competitors in Delhi are listed along with their number of hospitals, beds, and revenues. The document discusses ethical dilemmas in healthcare and different stages of moral development. It proposes a hybrid business model for the new hospital that incorporates both charity and corporate aspects. Finally, it outlines the basic strategic plan to open a single super specialty neuroscience hospital to address the large demand-supply gap in Delhi.
A Portfolio Strategy - which yield\'s the â Max. Operating Performance per Unit of Enterprise Value with min. expense ratio , lower Beta vs Benchmarks & Competitive liquidity quotient " :: { 9 Templates * 996 Portfolio\'s * 15000 Simulations * 6 Time Zones vs 4 Benchmarks }
The document discusses how business continuity has gone mainstream and provides examples of business continuity in mainstream media. It also addresses how this has impacted expectations from employees and challenges for business continuity programs. The presentation covers various topics related to ensuring business continuity programs adapt and succeed as the discipline becomes more mainstream.
Jean marc saubade-the consumer goods forumECR Community
Â
Jean-Marc Saubade discusses the Consumer Goods Forum update and its focus on the Asia Pacific region. The Consumer Goods Forum was launched in 2009 and brings together retailers and manufacturers to collaborate across the value chain. It has a vision of "Better lives through better business" and a mission to passionately serve shoppers, consumers and communities better, faster with great value and responsibility. The strategic pillars include emerging trends, sustainability, safety and health, operational excellence, knowledge sharing and people development. The climate change work programme has three streams around carbon measurement, deforestation and refrigeration.
The document discusses key aspects of sustainability for global financial services organizations. It highlights that corporate sustainability focuses on creating long-term shareholder value by managing opportunities and risks from sustainability trends. Top-performing financial services firms recognize sustainability as a guiding principle and engage stakeholders. Leaders integrate sustainability into core processes and offer sustainable financial products.
Marcus evans 9th annual commercial translation of regenerative medicine fun...ProteusVenturePartners
Â
This document discusses funding and commercialization strategies for regenerative medicine companies. It notes that while regenerative medicine has made great progress, serious commercialization challenges remain, including developing optimal cells for therapy, manufacturing at scale, addressing regulatory and IP issues, and determining business models. New economic realities require a more capital efficient development model as the "valley of death" between research and commercialization expands. Regenerative medicine translation centers may help enable more efficient technology development and collaborations to address these challenges.
The document provides an overview of a meeting on 6 November 2011 between Lt Gen Green and approximately 125 AFMS Dental Officers. The purpose was to provide updates on the future of the AFMS and Dental Corps. Gen Green discussed strategies to transform deployable capability, build patient-centered care, and invest in education. He also provided updates on initiatives like the electronic health record and open-source technologies. The status of the Dental Corps, performance metrics, and opportunities for development were reviewed. The future of innovation, specialty hospitals, and patient-centered care were also addressed.
The document contains an agenda for Dean Sandler that includes clients, board of directors, strategy meetings, key trends reports, preliminary company valuations, medical reports, training, and visions. It also includes charts, graphs, templates, and presentations. The document provides an overview of Dean Sandler's schedule and materials across various industries including media, financial services, pharmaceuticals, and more.
Jim Martin Final Version Unexpected Consequences Short Version Presentation 1...sixsigmaintegration23
Â
Of the more than forty catastrophic events analyzed in the book, cognitive and organizational failures are associated with approximately 98% of all deaths, property damage, and financial losses. Common causes of these failures include isolated technical failures, isolated project failures, and chronic failures related to issues like food contamination that spanned multiple years.
Jim Martin Final Version Unexpected Consequences Short Version Presentation 1...sixsigmaintegration23
Â
The document discusses unexpected consequences of failures in complex systems. It analyzes over 40 catastrophic events that resulted in over 18 million deaths and $675 billion in damages. Cognitive and organizational failures accounted for about 98% of the consequences. The failures often stemmed from interactions between human decision-making and technological or environmental factors.
This document discusses quality in foresight and forecasting for emerging markets. It begins by providing examples of past forecast failures and outlines several "levels" of future uncertainty. It then discusses various "limits" or challenges with different forecasting approaches, such as relying only on sector experts, overextrapolating trends, and the limitations of quantitative forecasting. It advocates using scenarios to explore multiple plausible futures rather than single point predictions. The document concludes by outlining implications for views of emerging markets like South Africa in 2030, emphasizing the need to plan for unpredictable change, practice high-quality foresight, respect consumer adoption patterns, and understand when we can influence versus must adapt to the future.
Similar to Moving up the curve: Second curve strategies for change (15)
The Third Shift: Women Physicians on OverloadiAttain
Â
The unusual stresses of clinical care, administrative tasks and personal life combine to increase burnout among women physicians. There are numerous contextual and personal factors that must be understood to lighten the load and increase their retention in healthcare.
The factors that distinguish highly effective healthcare organizations are discovered through generative internal investigation via Appreciative Inquiry. When the cross section of internal members of the organization are invited to express what happens when extraordinary care is provided, the key strengths are revealed.
The document provides guidance on designing instructional content through various models and frameworks. It discusses:
1. The process of instructional design, which involves creating a thematic structure, selecting an instructional strategy, and integrating them to create learning activities.
2. Models for instructional design including Gagne's "Nine Events of Instruction" and the "4A's of Learning Design" which focus on attracting learners, gaining attention, ensuring availability of content, and driving application.
3. The need for a structured approach when developing technical training, with guidance on how to teach different content types like facts, concepts, processes, and procedures.
4. The "Content Performance Matrix" and focusing
The document discusses strategic planning and visualization through a SOAR framework. It outlines five phases of strategic planning: initiate, inquire, imagine, innovate, and inspire implementation. Each phase involves cycles of assessing strengths, opportunities, aspirations, and results. The document also emphasizes that all elements of an organization must align behind the strategy, including structure, culture, people, measurements, and rewards. A new strategy may require changes to how the organization is structured and decisions are made. Success also requires building the right competencies, focus, and motivation among people. The culture must also support the strategic changes, as culture often resists change but ultimately determines success or failure.
The document discusses Appreciative Inquiry (AI), a strengths-based approach to organizational change and development. It provides an overview of AI, including its key principles and the 5-D cycle of Define, Discover, Dream, Design, and Destiny. Case studies are presented showing how various organizations have used AI to improve performance, build shared visions, and develop strategic plans through collaborative inquiry and storytelling.
This document discusses how transformative learning theory and appreciative inquiry can be combined to promote deep organizational change. It argues that integrating these approaches can provide a theoretical framework for transforming perspectives and behaviors at both the individual and group levels. The summary proposes combining the theories' focus on generating positive visions of change through reflective practices like questioning, storytelling, and exploring strengths to encourage appreciation transformative learning. This integrative process is said to cultivate both individual and collective transformation by challenging assumptions and co-creating exceptional futures through collaborative dialogue and reflection.
Can Traditional Chinese Medicine Treat Blocked Fallopian Tubes.pptxFFragrant
Â
There are many traditional Chinese medicine therapies to treat blocked fallopian tubes. And herbal medicine Fuyan Pill is one of the more effective choices.
Storyboard on Acne-Innovative Learning-M. pharm. (2nd sem.) CosmeticsMuskanShingari
Â
Acne is a common skin condition that occurs when hair follicles become clogged with oil and dead skin cells. It typically manifests as pimples, blackheads, or whiteheads, often on the face, chest, shoulders, or back. Acne can range from mild to severe and may cause emotional distress and scarring in some cases.
**Causes:**
1. **Excess Oil Production:** Hormonal changes during adolescence or certain times in adulthood can increase sebum (oil) production, leading to clogged pores.
2. **Clogged Pores:** When dead skin cells and oil block hair follicles, bacteria (usually Propionibacterium acnes) can thrive, causing inflammation and acne lesions.
3. **Hormonal Factors:** Fluctuations in hormone levels, such as during puberty, menstrual cycles, pregnancy, or certain medical conditions, can contribute to acne.
4. **Genetics:** A family history of acne can increase the likelihood of developing the condition.
**Types of Acne:**
- **Whiteheads:** Closed plugged pores.
- **Blackheads:** Open plugged pores with a dark surface.
- **Papules:** Small red, tender bumps.
- **Pustules:** Pimples with pus at their tips.
- **Nodules:** Large, solid, painful lumps beneath the surface.
- **Cysts:** Painful, pus-filled lumps beneath the surface that can cause scarring.
**Treatment:**
Treatment depends on the severity and type of acne but may include:
- **Topical Treatments:** Such as benzoyl peroxide, salicylic acid, or retinoids to reduce bacteria and unclog pores.
- **Oral Medications:** Antibiotics or oral contraceptives for hormonal acne.
- **Procedures:** Such as chemical peels, extraction of comedones, or light therapy for more severe cases.
**Prevention and Management:**
- **Cleanse:** Regularly wash skin with a gentle cleanser.
- **Moisturize:** Use non-comedogenic moisturizers to keep skin hydrated without clogging pores.
- **Avoid Irritants:** Such as harsh cosmetics or excessive scrubbing.
- **Sun Protection:** Use sunscreen to prevent exacerbation of acne scars and inflammation.
Acne treatment can take time, and consistency in skincare routines and treatments is crucial. Consulting a dermatologist can help tailor a treatment plan that suits individual needs and reduces the risk of scarring or long-term skin damage.
Milan J. Anadkat, MD, and Dale V. Reisner discuss generalized pustular psoriasis in this CME activity titled "Supporting Patient-Centered Care in Generalized Pustular Psoriasis: Communications Strategies to Improve Shared Decision-Making." For the full presentation, please visit us at www.peervoice.com/HUM870.
Nutritional deficiency Disorder are problems in india.
It is very important to learn about Indian child's nutritional parameters as well the Disease related to alteration in their Nutrition.
PGx Analysis in VarSeq: A Userâs PerspectiveGolden Helix
Â
Since our release of the PGx capabilities in VarSeq, weâve had a few months to gather some insights from various use cases. Some users approach PGx workflows by means of array genotyping or what seems to be a growing trend of adding the star allele calling to the existing NGS pipeline for whole genome data. Luckily, both approaches are supported with the VarSeq software platform. The genotyping method being used will also dictate what the scope of the tertiary analysis will be. For example, are your PGx reports a standalone pipeline or would your labâs goal be to handle a dual-purpose workflow and report on PGx + Diagnostic findings.
The purpose of this webcast is to:
Discuss and demonstrate the approaches with array and NGS genotyping methods for star allele calling to prep for downstream analysis.
Following genotyping, explore alternative tertiary workflow concepts in VarSeq to handle PGx reporting.
Moreover, we will include insights users will need to consider when validating their PGx workflow for all possible star alleles and options you have for automating your PGx analysis for large number of samples. Please join us for a session dedicated to the application of star allele genotyping and subsequent PGx workflows in our VarSeq software.
Applications of NMR in Protein Structure Prediction.pptxAnagha R Anil
Â
This presentation explores the pivotal role of Nuclear Magnetic Resonance (NMR) spectroscopy in predicting protein structures. It delves into the methodologies, advancements, and applications of NMR in determining the three-dimensional configurations of proteins, which is crucial for understanding their function and interactions.
Storyboard on Skin- Innovative Learning (M-pharm) 2nd sem. (Cosmetics)MuskanShingari
Â
Skin is the largest organ of the human body, serving crucial functions that include protection, sensation, regulation, and synthesis. Structurally, it consists of three main layers: the epidermis, dermis, and hypodermis (subcutaneous layer).
1. **Epidermis**: The outermost layer primarily composed of epithelial cells called keratinocytes. It provides a protective barrier against environmental factors, pathogens, and UV radiation.
2. **Dermis**: Located beneath the epidermis, the dermis contains connective tissue, blood vessels, hair follicles, and sweat glands. It plays a vital role in supporting and nourishing the epidermis, regulating body temperature, and housing sensory receptors for touch, pressure, temperature, and pain.
3. **Hypodermis**: Also known as the subcutaneous layer, it consists of fat and connective tissue that anchors the skin to underlying structures like muscles and bones. It provides insulation, cushioning, and energy storage.
Skin performs essential functions such as regulating body temperature through sweat production and blood flow control, synthesizing vitamin D when exposed to sunlight, and serving as a sensory interface with the external environment.
Maintaining skin health is crucial for overall well-being, involving proper hygiene, hydration, protection from sun exposure, and avoiding harmful substances. Skin conditions and diseases range from minor irritations to chronic disorders, emphasizing the importance of regular care and medical attention when needed.
The biomechanics of running involves the study of the mechanical principles underlying running movements. It includes the analysis of the running gait cycle, which consists of the stance phase (foot contact to push-off) and the swing phase (foot lift-off to next contact). Key aspects include kinematics (joint angles and movements, stride length and frequency) and kinetics (forces involved in running, including ground reaction and muscle forces). Understanding these factors helps in improving running performance, optimizing technique, and preventing injuries.
5. High Reliability in Medicine:
Where Do You Need to Be?
Future Performance
(Second Curve/
6+ Si
Sigma)ď¸
)ď¸
First Curve/
4 sigma
(Craft+Information-
mance
ďą
Age Culture )
ďą (Craft-Age
Perform
(Bifurcation
ďą Culture) curve: 2000s)
ďą
P
Flexner 1910
Time ď° ď° ď° ď° ď° ď° ď° ď° ď° ď° ď° ď°
-
5
7. 2 Historical Curves of Health Care Innovation
(derived from Kuhn, Toffler, Morrison, Merry)
Future Performance
(Second Curve/
6+ Si
Sigma)ď¸
)ď¸
First Curve/
4 sigma
ďŻResilience,
(Transfer/Sustain
mance
ďą 2010
ďŻHuman
Momentum)
ďą (Create and
Perform
(Bifurcation
Factors,
Factors 2000
ďą Build curve: 2012) ďŻ TQM, 1990
ďą Momentum)
P
Circa 1910
Time ď° ď° ď° ď° ď° ď° ď° ď° ď° ď° ď° ď°
-
7
8. High Reliability and The Performance Curve
Safety Culture Safety Operating Sigma Level OperatingÂ
Level Performance Performance Margin
Level Level
Need Chaotic Below Average 0 None or inÂ
Awareness
A deficit
d fi it
Reactive Normal Average 2 2%
Implementing Reliable Good 4 5%
Performer
P f
Proactive Highly Reliable High Performer 6 10%
Generative Ultrasafe Standardâ 7â9 20%
Setter
9. The Healthcare Reform Paradigm Shift:
another View
(From David Bates, MD)
Current Organization Integrated Care
⢠Incented by volume ⢠Incented by value
⢠Focus on acute illness, high margin services ⢠Focus on prevention, care coordination
⢠Focus on individual patient ⢠Focus on population
⢠Fill beds ⢠Prevent unnecessary admissions, readmissions
⢠Payer has more risk
P h ik ⢠Provider has more risk
P id h ik
>>> HIT will be a key tool!
10. The Three Bucket Model
Bucket 1: Optimizing the Bucket 2: Preparing to Bucket 3: Moving Up theÂ
First Curve Move Up the Second Second Curve andÂ
Curve Distinguishing Yourself inÂ
the New Landscape ofÂ
Healthcare
⢠Lean ⢠Coâmanagement ⢠Triâmanagement
⢠St d
Studer ⢠Di l i th t
Dissolving the two siloes
il ⢠3 l
3 column model >>>Â
d l
⢠Emphasis on ⢠Service Line new managementÂ
accountability Organization science
⢠EMR ⢠Collaborative Rounding/ g/ ⢠Strategy LearningÂ
gy g
⢠IHI G.L.I.T.C.H. harvesting System
⢠Root cause analysis/ gap ⢠Safety Culture/ Safety ⢠Resilient System Design
analysis Management System ⢠Systemic Law
⢠PDSA ⢠Relational law
Relational law ⢠Systemic thinking
Systemic thinking
⢠Adaptive Design ⢠Crossâ silo informationÂ
⢠Wholeâsystem Lean (Va. management: beyondÂ
Mason, Thedacare) silos; manage better theÂ
information we have
11. Leading for Change
Bucket 1: Optimizing the Bucket 2: Preparing to Bucket 3: Moving Up theÂ
First Curve Move Up the Second Second Curve andÂ
Curve Distinguishing Yourself inÂ
g g
the New Landscape ofÂ
Healthcare
⢠Focus on data ⢠Widen the lens: focus on both ⢠Use information withÂ
⢠Emphasize problemâsolving
E h i bl l i qualitative and quantitativeÂ
lit ti d tit ti situational awareness, creatingÂ
it ti l ti
⢠Root cause analysis information contextual knowledge
⢠More effective execution of ⢠Precede problemâsolving with ⢠Combine problemâsolving andÂ
established methods (i.e. for problemâfinding problemâfinding with problemâ
preventing central line ⢠Reach out: more information, framing and situationalÂ
infections) wider network, more resilient deployment
(cf. Kim Cameron, FAA) ⢠Add positive deviation, successÂ
⢠Add appreciative inquiry story analysis, and actionÂ
⢠A shift of assumptions on the learning/ ongoingÂ
design criteria for care systemsÂ
design criteria for care systems experimentation
and what performance levelsÂ
are possible and necessaryÂ
(e.g. from % to Sigma thinking)
12. Buckets 1 & 2: Central Line Infections
⢠Bucket 1: Moving from the assumption of âa a
minimal number of inevitable infections that
are inherent in the procedure by just applying
procedureâ
known preventive measures more rigorously
⢠Bucket 2: Achieving 0 infections and in so
infections,
doing, changing our assumptions about
achievable performance
13. 1st Curve Breast Diagnosis
g
Initial Concern
Surgery Consult
OR/OpenBiopsy
OR/O Bi
(Cycle time of process
Biopsy Read
built around practi-
tioners: 1 8 weeks)
1-8 Patient Learns
13
14. Bucket 3: 2nd Curve Breast Diagnosis, Park-
Nicollet H lth S t
Ni ll t Health System, 1995 - P
Presentt
Screening Xray
Immediate Reading
Stereotactic Bi
S i Biopsy
(Cycle time
of process
f Biopsy Read
built around
patients: 2 Patient Learns
hours
possible.) 14
15. Hypothesis: We cannot problem-solve
our way to 2nd Curve High Reliability
Problem Solving âAppreciative Inquiryâ
Problem identified Appreciating/valuing best of âWhat isâ
ď˛ ď˛
Analysis of causes Envisioning âWhat might beâ
ď˛ ď˛
Possible solutions Dialoguing âWhat should be
What beâ
ď˛ ď˛
Action planning Innovating âWhat will beâ
Assumption: Success = Assumption: Success = a
problems solved possibility envisioned/created
âadapted from Bernard Mohr
f
15
16. Creating
g 2 nd Curve Cultures
âChanging how
g g
2nd Curve Vision work is done
changes the
g
Change Processes culture.â
- Jeff Goldsmith, PhD
Change S
Ch Structures
Change Work
2nd Curve Culture
16
17. The Policy Environment:
Affordable Care Act
⢠New insurance rules guaranteeing coverage
⢠High risk
High-risk pool for people with pre existing conditions
pre-existing
⢠Protection for children with pre-existing conditions
⢠Coverage for young adults, to age 26
⢠Small b i
S ll business tax credits
t dit
⢠Preventive care, free for proven services
⢠Early retirees temporary reinsurance
⢠âDoughnut holeâ rebates for Medicare
⢠Annual review of premium increases
⢠Access to care: $ Billions for Community Health Centers
and the National Health Service Corps for low-income
and uninsured
⢠New incentives for providers (ACOs, CMS rewards and
penalties, shared gain provisions)
17
18. âPhysician leadership is essential.
Physician essential
Improving the value of health care is
something only medical teams can do. . .
do
Physicians can lead this change and return
the practice of medicine to its appropriate
focus: enabling health and effective care.â
- Michael Porter, PhD, MBA
18
19. Bucket 3: 2nd Curve Structure
Innovation
Community Memorial Hospital
Menomonee Falls, WI
19
20. A 1917 Design, as of 2012
Board of Trustees
ďŠ
Medical St ff E
M di l Staff Executive
ti Chief Executive
Chi f E ti
Committee Officer
ďŞ
Medical Staff Functions Hospital Functions
(âSilo 1â) (âSilo 2â)
⢠Credentialing ⢠Nursing
⢠Departmental (Peer) ⢠Ancillary
Specialties
Review Departments
⢠Laboratory
⢠Surgical Case Review ⢠Radiology
⢠Blood UR ⢠Physiotherapy
⢠Drug Usage Review ⢠Risk Management
⢠Pharmacy andThe Structure ď° Finance, Planning
2012: ⢠Hierarchy,
Therapeutics ⢠Regulatory Agencies
⢠Medical Records ti
Fragmentation, Communication gaps,
F t C ⢠Etc. ti
i
Misunderstanding, Power Struggles, etc. 20
21. âDoctor, Iâd like you to resign from
this di l t ff f
thi medical staff for reasons of ill
f
health. You make me sick.â
21
22. The Vision
1. Reduce physician time spent in
wasteful Medical Staff activities.
2. Increase the influence of physicians
in the development of service lines
and the redesign of clinical
g f
microsystems.
3.
3 Clinical microsytems that perform
more efficiently and effectively for
both patients and caregivers
22
23. The Starting Point
Board o Trustees
oa d of us ees
Quality Improvement Oversight
Medical Care
Medical Executive Senior Mgt. Team
Committee
Patient/ Operational
Medical Staff
Functions Community Management
Leadership
Caregivers
23
24. COMMUNITY MEMORIAL HOSPITAL
,
Hospital Board
Medical Hospital
Executive Administration
Committee
Management and
Coordination of Care
rative
Practice
Participation
p Management
Collabor
Leadership Patient/
Design
Community
Performance
Improvement
* Specialties provide care in all service lines 24
K:Swp7350(953)miscjanice8.ppt
25. An Emerging Modelâ
Suppliers SCS Innovation StrategyÂ
Payors and Funders
and Funders
Lack of accountability in Hospital  PlanningÂ
Increase  Access to centers ofÂ
Translate Data into practice
excellence
Long  waits for Services inÂ
Increase Access  to Outpatient Care
the community
the community
Lack of community services
Taking a regional
Increase in options for perspective on research
p
â˘Improve Care
community reâintegration
Delivery Increase connections with
Unique challenges forÂ
Unique challenges for Primary care
Primary care
specific populations of care System
â˘Reduce Cost
Need for community
Need to create systems
perspective on care
navigation
â˘Create Jobs
Community services needÂ
Hospitals,Â
p , Expanding Caregiver
Expanding Caregiver
PilotsÂ
to focus on recoveryÂ
and  medical issues Providers, Expand wellness programs
â e.g. Fit for Function
Increase access to CareÂ
Care
rehab for acute chronic conditions
Need for strategic
Collaborations/partnerships
Networks
Lack of awareness ofÂ
Community programs
Increase need for PeerÂ
support â survivor groups
Need to focus on transitions Need to collaborate with
other strategies â i.e. COPD,Â
other strategies i e COPD
Importance of timeliness Diabetes, cardiovascular
of treatment
Increase partnerships with case management
Coordinated Pediatric Care
29. High Reliability in Medicine:
Where Do You Need to Be?
Future Performance
(Second Curve/
6+ Si
Sigma)ď¸
)ď¸
First Curve/
4 sigma
(Craft+Information-
mance
ďą
Age Culture )
ďą (Craft-Age
Perform
(Bifurcation
ďą Culture) curve: 2000s)
ďą
P
Flexner 1910
Time ď° ď° ď° ď° ď° ď° ď° ď° ď° ď° ď° ď°
-
29
31. 2 Historical Curves of Health Care Innovation
(derived from Kuhn, Toffler, Morrison, Merry)
Future Performance
(Second Curve/
6+ Si
Sigma)ď¸
)ď¸
First Curve/
4 sigma
ďŻResilience,
(Transfer/Sustain
mance
ďą 2010
ďŻHuman
Momentum)
ďą (Create and
Perform
(Bifurcation
Factors,
Factors 2000
ďą Build curve: 2012) ďŻ TQM, 1990
ďą Momentum)
P
Circa 1910
Time ď° ď° ď° ď° ď° ď° ď° ď° ď° ď° ď° ď°
-
31
32. Leading for Change
Bucket 1: Optimizing the Bucket 2: Preparing to Bucket 3: Moving Up theÂ
First Curve Move Up the Second Second Curve andÂ
Curve Distinguishing Yourself inÂ
g g
the New Landscape ofÂ
Healthcare
⢠Focus on data ⢠Widen the lens: focus on both ⢠Use information withÂ
⢠Emphasize problemâsolving
E h i bl l i qualitative and quantitativeÂ
lit ti d tit ti situational awareness, creatingÂ
it ti l ti
⢠Root cause analysis information contextual knowledge
⢠More effective execution of ⢠Precede problemâsolving with ⢠Combine problemâsolving andÂ
established methods (i.e. for problemâfinding problemâfinding with problemâ
preventing central line ⢠Reach out: more information, framing and situationalÂ
infections) wider network, more resilient deployment
(cf. Kim Cameron, FAA) ⢠Add positive deviation, successÂ
⢠Add appreciative inquiry story analysis, and actionÂ
⢠A shift of assumptions on the learning/ ongoingÂ
design criteria for care systemsÂ
design criteria for care systems experimentation
and what performance levelsÂ
are possible and necessaryÂ
(e.g. from % to Sigma thinking)
33. Buckets 1 & 2: Central Line Infections
⢠Bucket 1: Moving from the assumption of âa a
minimal number of inevitable infections that
are inherent in the procedure by just applying
procedureâ
known preventive measures more rigorously
⢠Bucket 2: Achieving 0 infections and in so
infections,
doing, changing our assumptions about
achievable performance
34. The Policy Environment:
Affordable Care Act
⢠New insurance rules guaranteeing coverage
⢠High risk
High-risk pool for people with pre existing conditions
pre-existing
⢠Protection for children with pre-existing conditions
⢠Coverage for young adults, to age 26
⢠Small b i
S ll business tax credits
t dit
⢠Preventive care, free for proven services
⢠Early retirees temporary reinsurance
⢠âDoughnut holeâ rebates for Medicare
⢠Annual review of premium increases
⢠Access to care: $ Billions for Community Health Centers
and the National Health Service Corps for low-income
and uninsured
⢠New incentives for providers (ACOs, CMS rewards and
penalties, shared gain provisions)
34