The document summarizes key discussions from the 42nd Annual Conference held in Munich on enabling data-intensive science through infrastructure, emphasizing the importance of interoperable data and community-driven initiatives. It highlights the role of the European Commission in shaping policies for better access to scientific information and outlines the H2020 work program aimed at enhancing research infrastructures in Europe. Key challenges identified include high-performance computing, connectivity, and data management for advancing e-infrastructures.