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Version 1.4 / November 2020 1
Management Protocol
in Hospitals
C VID-19
Ministry of Health and Population, Egypt
Management protocol for COVID-19
Patients
Version 1.4 / November 2020
Management Protocol for
P a t i e n t s
Version 1.4 / November 20202
Version 1.4 / November 2020 3
Table of contents
Item
Page
Number
Triage Protocol
4
Management Protocol
6
Gastrointestinal Manifestations
of COVID-19 15
Anticoagulation of COVID-19
Patients 16
High-Velocity Nasal Insufflation
17
Post-acute COVID Syndrome
18
Prevention and Control of COVID-19 Inside
Health Care Facilities 20
Antibiotics in Covid-19 25
List of Editors 26
Version 1.4 / November 20204
1st
Step: Triage
Case definition + severity assessment
Suspect Case Definition
A) Clinical AND epidemiological criteria: OR: B
Patient with severe acute
respiratory illness (SARI: acute
respiratory infection with history
of fever or measured fever ≥ 38°C
and a cough; onset within last 10
days; requires hospitalization)
-Acute onset of fever and cough OR
-≥ 3 of the followings: fever, cough, sore
throat, coryza, general weakness/fatigue,
headache, myalgia, dyspnea, anorexia/nausea/
vomiting, diarrhea, altered mental status
And 1 of the followings within 14 days of
symptom onset:
Residing or
working in an
area with high
risk of
transmission*
Working in
a healthcare
setting
Residing or
travel to an area
with community
transmission
*Closed residential settings, humanitarian settings such as camp and camp-like settings for displaced persons.
NB: Minimal role for the epidemiological criteria during the period of community spread
Probable Case
A patient who meets clinical criteria AND is a contact of a probable or confirmed case,
or epidemiologically linked to a cluster with at least one confirmed case.
OR
Suspect case with chest imaging showing findings suggestive of COVID-19 disease*
OR
Recent onset of loss of smell or taste in the absence of any other identified cause
OR
Unexplained death in an adult with respiratory distress who was a contact of a probable
or confirmed case or epidemiologically linked to a cluster with at least 1 confirmed case
*Hazy opacities with peripheral and lower lung distribution on chest radiography; multiple bilateral ground
glass opacities with peripheral and lower lung distribution on chest CT; or thickened pleural lines, B lines, or
consolidative patterns on lung ultrasound.
Confirmed Case
A person with laboratory confirmation* of COVID-19 infection, irrespective of clinical signs
and symptoms
*Molecular testing(PCR) with deep nasal swab is the current test of choice for the diagnosis of acute COVID-19
infection
During seasonal flu period, clinical differentiation between influenza and COVID 19 is difficult.
Swab for influenza A &B may help in early differentiation.
Triage Protocol
Version 1.4 / November 2020 5
Severity assessment
Suspected case
-PCR to confirm the diagnosis *
-Assess disease severity
(clinical, lab & imaging)
-Mild symptoms
-Normal imaging
Imaging: +ve
SpO2
≥ 92%
SpO2
< 92%, PaO2
/FiO2
<
300,
respiratory rate > 30
breaths/min, or
lung infiltrates > 50%
Respiratory failure,
septic shock, and/or
multiorgan
dysfunction
Admit to
Intensive care
Admit to
Intermediate Care
Hospitals admission
COVID area
Home isolation &
close follow up
If possible, < 65 years
old & no uncontrolled
comorbidity
Critical illnessSevere
Moderate
Mild Risk Factor
YesNo
In severe and critically ill patients, if-ve 1st
PCR, repeat within 48 hours, negative case is considered after 2 –ve
consecutive RT-PCR results from respiratory samples tested at least 1 day apart.
NB: Unstable patient who don’t meet the suspected criteria should receive 1st
aid therapy in non-COVID area
before referral to general hospital.+ Risk factors include, old age > 60 years, uncontrolled comorbidity as hyperten-
sion, DM, ……. or Social un applicable to home isolation.
All persons with suspected, probable or confirmed COVID-19 should be immediately
isolated to contain the virus transmission.
Triage Protocol
Version 1.4 / November 20206
Time is an important issueTime is an important issue in management of COVID-19. Before day 12( stage of viral
load), Antiviral drug is essential. After day 12, the role of antiviral declines with
augmentation for the role of anti-inflammatory, immune-modulators and Supportive drugs
(stage of hyper-immune state).
Potential antiviral drugs under evaluation for the treatment of COVID-19 include:Potential antiviral drugs under evaluation for the treatment of COVID-19 include:
- Hydroxy ChloroquineHydroxy Chloroquine 400mg/ 12 hours 1st
day followed by 200 mg/12 hours for 6 days,
- IvermectinIvermectin 6 mg (36 mg on day 0 -3-6),
- FavipiravirFavipiravir 1600 twice daily first day then 600 mg twice daily,
- RemdesivirRemdesivir 200 mg IV on day 1, followed by 100 mg IV daily for high risk population for 5
days that could be extended to 10 days if the response is unsatisfactory or
- Lopinavir/RitonavirLopinavir/Ritonavir 200/ 50 mg 2 tablets PO BID
- Monoclonal antibodiesMonoclonal antibodies: early testing in blocking SARS-CoV-2.
- Convalescent plasmaConvalescent plasma: for impending severely ill after counseling the scientific committee
2nd
Step: Management
Home isolation and symptomatic treatmentsymptomatic treatment (eg, antipyretics for fever, adequate nutrition,
appropriate rehydration).
Educate the patientsEducate the patients on signs/symptoms of complications that, if developed, should prompt
pursuit of urgent care.
There are insufficient data to recommend either with or against any antiviral or im-
mune-based therapy in patients with COVID-19 who have mild illness.
Mild illness
All patients with symptomatic COVID-19 and
risk factors for severe disease should be closely
monitored. The clinical course may rapidly
progress in some patients.
Antibiotics are not recommended to prevent
bacterial infection in mild patients. Administer
empiric antibiotics if bacterial
pneumonia/sepsis strongly suspected; re-evaluate
daily.
In non-hospitalized patients, do not initiate
therapeutic anticoagulants or antiplatelet
unless other indications exist.
No harmful effect for administration of vitamin
C or D or Zinc or Lactoferrin within the required
daily dose.
Check Every Patient For Risk
Factors
. Age 65 years
. SpO2 < 92%
. Heart Rate ≥110
. Respiratory Rate ≥ 25 /min.
. Neutrophil / lymphocyte ratio on
CBC ≥ 3.1
. Uncontrolled Comorbidities
. On Immunosuppressive or
chemotherapy drug
. Pregnancy
. Active Malignancy
. Obesity (BM>40)
Management Protocol
Version 1.4 / November 2020 7
All patients with symptomatic COVID-19 and risk factors for severe disease should
be closely monitored. In some patients, the clinical course may rapidly progress.
Flu or COVID-19
IS IT A FLU OR COVID-19?IS IT A FLU OR COVID-19?
SYMPTOM FLU COVID-19
FEVER
FATIGUE
COUGH
SORE THROAT
HEADACHES
RUNNY NOSE
SHORTNESS OF BREATH
BODY ACHES
DIARRHEA AND/OR
VOMITING
ONSET 1-4 days after infection About 5 days after infection but can range
from 2-14 days
LOSS OF TASTE AND/OR
SMELL
RED, SWOLLEN EYES
SKIN RASHES
Version 1.4 / November 20208
Mild Case
Symptomatic case
with lymphopenia or leucopenia
with no radiological signs for pneumonia
1. Age 65
2. Temperature > 38
3. SaO2
≤ 92%
4. Heart Rate ≥ 110
5. Respiratory Rate ≥ 25 /min.
6. Neutrophil / lymphocyte ratio
on CBC ≥ 3.1
7. Uncontrolled Comorbidities
8. Immunosuppressive Drug
9. Pregnancy
10. Active Malignancy
11. On Chemotherapy
12. Obesity (BMI>40)
Check for
Any YESAll No
Age ≥ 65
OR
Age < 65
AND
• Strict Home Isolation (Symptomatic
Treatment)
• Follow and use personal protective guide
equipment
• If any deterioration occurs, back to
hospital
NB: Paracetamol is the preferred antipyretic
If more than 3
symptoms admit
Treatment
- Hydroxychloroquine (400 mg twice in
first day then 200 mg twice for 6 days)
- Zinc 50mg daily
- Acelylcysteine 200 mg t.d.s.
- lactoferrin one sachet twice daily
- Vitamin C 1 gm daily
OR Ivermectin 6 mg (36 mg on day 0
-3-6)
OR Favipiravir 1600 TWICE daily first
day then 600 mg twice daily
+
Version 1.4 / November 2020 9
Anti-virals
Hydroxychloroquine +
Ivermectin or
Lopinavir/Ritonavir
or
Remdesivir for high
risk population with
SaO2 < 92
Immune-modulators
Anti-inflammatory
Anti-coagulation
Steroids
(if patient has severe
dyspnea) RR>24 or CT
scan showing rapid
deterioration
Dexamethasone 6 mg
or its oral equivalent
Prophylactic
anticoagulation if
D-Dimer between
500 -1000
Therapeutic
anti-coagulation if
D-dimer > 1000
Patient has pneumonia manifestations on radiology associated with symptoms &/Or
leucopenia or lymphopenia.
Moderate Case
Anti-virals
anticoagulation if
D-Dimer between
500 -1000
Therapeutic
anti-coagulation if
D-dimer > 1000
Or if severe
hypoxia
Anti-inflammatory
Convalescent
plasma
Steroids
(Dexamethasone 6
mg or methyl
prednisolone (1 mg /
kg /24 hours)
 
Tocilizumab
4-8 mg/kg/day for 2
doses 12 to 24 hours
apart after failure of
steroid therapy to
improve the case for
24 hours
Before day 12
(under clinical trial)
(after scientific
committee
approval)
RR > 30, SaO2 < 92 at room air, PaO2
/FiO2
ratio < 300, Chest radiology showing more than
50% lesion or progressive lesion within 24 to 48 hrs.
Severe cases
Remdesivir
or
Lopinavir/
Ritonavir
Anti-coagulant
Prophylactic
Admit to Intermediate Care
Version 1.4 / November 202010
RR > 30, Sa02 < 92 at room air, PaO2/FiO2 ratio < 300, Chest radiology showing more than
50% lesion or progressive lesion within 24 to 48 hrs. Critically ill if SaO2 <92, or RR>30, or
PaO2/FiO2 ratio < 200 despite Oxygen Therapy.
Critically ill patients
Admit to Intensive care
Anti-virals
Remdesivir
or
Lopinavir/
Ritonavir
Anti-coagulant Anti-inflammatory
Therapeutic
anti-coagulation
Steroids
(Methyl prednisolone 2mg /kg or its
equivalent)
 
Tocilizumab
4-8 mg/kg/day for 2 doses 12 to 24 hours
apart after failure of steroid therapy to
improve the case for 24 hours
Tocilizumab
4-8mg/kg/dose
2 doses
Early Block
the storm
if steroids
failed
Antiviral
Drugs As is In
Severe case
Steroids
Methylpred-
nisolone
1-2 mg/kg/d
Anti-
Coagulation
Enoxaparine
1 mg/kg BID
Prone
Awake or
ventilated
Avoid
Hypoxia
O2/ NIV/
HFNC/IMV
Add
Antibiotics
As per
protocol
1 mg for non
ventilated
and 2 mg for
ventilated
Consider
D-dimer level
as a guide
Improves
V/Q matching
and survival
Don’t wait
too much for
any type of
support Keep
plateau<30
High flow nasal oxygen is an important modality in the early management of critically ill patients.
Version 1.4 / November 2020 11
(HFNC):
Conscious patients with minimal secretions.
Hypoxia SpO2 < 90% on oxygen. Or PaCO2 >40 mmHg provided pH 7.3 and above.
NIV trial shall be short with ABG 30 minutes apart.
Any deterioration in blood gases from baseline or oxygen saturation or consciousness
level shift to IMV.
CPAP gradually increased from 5-10 cmH2O.
Pressure support from 10-15 cm H2O.
HFNC can be alternative to NIV.
Use PPE specially goggles during intubation and avoid bagging.
Indications:
Failed NIV or not available or not practical.
PaO2 < 60 mmhg despite oxygen supplementation.
Progressive   Hypercapnia.
Respiratory acidosis (PH < 7.30).
Progressive or refractory septic shock.
Disturbed consciousness level (GCS ≤ 8) or deterioration in consciousness level from
baseline
Non Invasive Ventilation or High Flow Nasal Cannula
Invasive Mechanical Ventilation:
Version 1.4 / November 202012
COVID-19 PNEUMONIA (type L & type H)
Type L Type H
Type L
Low elastance
Low VA/Q mismatch
Low lung weight
Low recruitability High elastance
High RL shunt
High lung weight
High recruitability
Type H
Non invasive
support
Early intubation Late intubation
HFNC
CPAP
NIV
PEEP (5-10 cmH2O)
Sedation
NMBA
Higher PEEP(10-15
cmH2O)
Prone
(ECMO)
STOP STOP STOP
Lung Damage Progression
(Virus + P-SILI)
Inspiratory effort - edema
Type L and Type H patients are best identified by CT scan and are affected by different
Pathophysiological mechanisms. If CT not available, definition could be used as surrogates:
Respiratory system elastance and recruitability.
Understanding the correct pathophysiology is crucial to establishing the basis for appropriate
treatment.
Version 1.4 / November 2020 13
Plateau
P<30 cmH2
O
Incremental
PEEP
Shift to ARDSNet protocol if neededStep 2:
- ARDSNet protocol:
LOW TV
6-4 ml/kg Driving
P<15 cmH2
O
Initiation of Invasive Mechanical VentilationStep 1:
VCV
TV 8 ml/kg
PEEP 5 cmH2O
Plateau
Pressure
Less than 30
cmH2O
Sat >93
Keep and Watch
Less than 30
Sat<93
Increase PEEP
to 10
More than 30
ARDSnet
protocol
Inspiratory Pause for 1 second
IF PLATEAU ABOVE 30 CMH2O
Version 1.4 / November 202014
Assessment of respiratory support outcomeStep 3:
Improved
Weaning of
respiratory
support
Assess
ABGs, Clinical
Radiological
Stationary
Continue
respiratory
support as
needed
*Criteria for VV ECMO: Age below 55, mechanical ventilation duration
less than 7 days, no comorbidities, preserved conscious level,
PaO2/FiO2 <100 despite prone RESPscore >0.
Expert opinion is needed and depends on availability.
Deteriorating
Criteria for
ECMO*
Start with tidal volume of 6 ml/Kg to keep plateau pressure on volume controlled
ventilation (VCV) below 30 cmH2O, decrease to 4 ml/kg if the plateau remain higher
than 30 allow permissive hypercapnia so long the pH is above 7.3
compensate by increasing respiratory rate up to 30 breath/ minute. Consider heavy
sedation and paralysis. If pressures are high or any evidence of barotrauma shift to
pressure controlled ventilation and be cautious about low tidal volume alarms for
fear of unnoticed endotracheal tube obstruction. Consider ECMO
early if eligible. Increase PEEP gradually if the patient remains hypoxic
according to FIO2 level to keep driving pressure < 15cmH2O. NEVER FORGET
PRONE POSITION.
Version 1.4 / November 2020 15
- Gastrointestinal (GI) symptoms are seen in patients with COVID-19. The preva-
lence could be as high as 50%, but most studies show ranges from 16% to 33%
- Some patients with COVID-19 have presented with isolated GI symptoms that may
precede the development of respiratory symptoms
- It is important to note that medications used for COVID-19 may be associated with
GI symptoms as well.
- Approximately 50% of patients with coronavirus disease 2019 (COVID-19) have
detectable viral RNA in the stool
- Loss of appetite or anorexia is the most commonly reported symptom.
- Diarrhea was the second most common symptom.
- Other digestive manifestations include nausea or vomiting and abdominal pain.
- Dysgeusia has also been reported, often in conjunction with anosmia.
- Currently, management of GI symptoms in patients with COVID-19 is mainly sup-
portive.
- Treatment should be individualized according to the patient’s symptoms, underly-
ing comorbidities and COVID-19–associated complications.
- Oral or intravenous hydration
- The antidiarrheal agent loperamide can be used in an initial dose of 4 mg and with
a maximum daily dose of 16 mg in patients without fever, bloody stools, or risk fac-
tors for C. difficile infection
- Antiemetic drugs can often help relieve symptoms.
Gastrointestinal Manifestations of COVID-19
Gastrointestinal Manifestations
of COVID-19
Version 1.4 / November 202016
Yes No
Anticoagulation in COVID-19 Patients
the patient clinically indicated
for hospitalization
Is he/she critically ill
No Yes
Prophylactic dose
Higher than standard
dose
0.5 mg/kg/m
Therapeutic dose
Consider also therapeutic
anticoagulation for
patients with high
clinical susceptibility
of VTE and those with
Severe hypoxia not
explained by the chest CT
findings
The preferred agents
are LMWH and
Fondaparinux unless
contraindicated
In renal patients, heparin
is the preferred agent.
If the dose of LMWH
exceeds 150 twice daily
use heparin instead.
Anticoagulation in COVID-19
Patients
Version 1.4 / November 2020 17
High Velocity Nasal Insufflation
(Hi-VNI)
•	 Hi-VNI is a first-line therapy for COVID-19 patients who are struggling to
breathe.
•	 Hi-VNI Technology and WOB reduction: The fact that small-bore
cannulas reduce the time required to fully purge the upper airway dead space3 is
significant because as the respiratory rate of a patient in respiratory distress
increases, the time between breaths decreases. By quickly clearing the upper
airway dead space of end-expiratory gas rich in CO2, Hi-VNI Technology helps
patients breathe directly from a fresh gas reservoir and thereby reduces their
WOB.
0
70
60
50
40
30
20
10
10 20 30 40 50 60
HVNI
HFNC
Volumetric Flow (L.min-1
)
Velocity(m.sec-1
)
High-Velocity Nasal Insufflation
Version 1.4 / November 202018
Post- acute COVID syndrome
(long COVID)
Definition & incidence:
In the absence of agreed definition, it may be defined as “patients not
recovering for several weeks or months following the start of symptoms that
were suggestive of COVID, whether patients were tested or not.” It may
extend beyond 3 weeks from the onset of first symptoms up to 3 months,
sometimes occurring after a relatively mild acute illness. If symptoms are
extending beyond 3 months, it is termed Chronic COVID.
In short, “Despite their illness being ‘over,’ they are having a lot of
trouble returning to normal life.” It occurs in around 10% of patients.
Patients can be divided into those who may have serious sequelae (such as
thromboembolic complications) and those with a non-specific clinical pic-
ture, often dominated by fatigue and breathlessness. One last group of
covid-19 patients whose acute illness required intensive care management.
Management:
Specialist referral may be indicated based on clinical finding, for example:
Respiratory: if suspected pulmonary embolism, severe pneumonia.
Cardiology: if suspected myocardi-
al infarction, pericarditis, myocarditis or new heart failure.
Neurology: if suspected neurovascular or acute neurological event.
Pulmonary rehabilitation may be indicated if patient has persistent
breathlessness.
Post-acute COVID syndrome
Version 1.4 / November 2020 19
Medical management:
Symptomatic: treating fever by paracetamol & NSAIDs
Management of co-morbidities including diabetes, hypertension, kidney
diseases & ischemic heart diseases
Listening and empathy
Consider antibiotics for secondary infection
Treat specific complication as indicated
Self-management:
Daily pulse oximetry.
Attention to general health like:
Good diet
Good sleep hygiene
Quitting smoking
Limiting alcohol
limiting caffeine
Rest and relaxation.
Self-pacing and gradual increase exercise.
Set achievable targets.
Post-acute COVID syndrome
Version 1.4 / November 202020
Prevention and Control of Transmission
of COVID-19 inside
Health Care Facilities
Version 1.4 / November 2020 21
General Recommendations for
Prevention and Control of Transmission of COVID-19
inside Health Care Facilities
1-Daily screening of health care workers and patients before entering the
health care facility (HCF) based on clinical signs (fever, respiratory symp-
toms…….).
2- Any health care worker appears/reports to be diseased should be segregated
until proper examination/management.
3- All health care workers are required to wear surgical masks during work
hours (during existence in HCFs).
4- Minimal number of health care workers should be present at the same time
in patient’s units to keep social distancing
5- Restrict unneeded movements between departments.
6- Suspected or confirmed cases should take a separate route from other pa-
tients beginning from the facility entrance (Triage area), and all facility sec-
tions should follow the same separation.
7- Suspected or confirmed cases should be isolated in a well- ventilated isola-
tion room.
8- Standard precaution should be applied :
• Hand hygiene
• Cough etiquette.
• Personal protective equipment.
• Clean and disinfected Environmental surfaces.
• Sterile instrument and devices
• Sharp safety.
• Isolation transmitted precaution.
• Safe injection practices.
General Recommendations
Version 1.4 / November 202022
Recommendations
According To The Type Of Procedure
1) Non Aerosol Generating Procedures (AGPs)
• Standard precautions.
• Isolation precautions taken to prevent the spread of infection by spray and
contact.
• The need to adhere to washing hands before donning personal protective
equipment and immediately upon doffing.
• The necessity to adhere to donning personal protective equipment as
follows:
1- Surgical mask.
2- Protect your eyes by wearing goggles or face shield.
3- Long-sleeve medical gowns (gown) clean, non-sterile or sterile, according to
type of technique.
4- Clean or sterile gloves depending on type of technique.
5- Health care worker are not required to wear protective boots and protective
suits during routine care of cases.
6- Extended use of surgical masks, gowns, eye protectors, and face shields can
be applied while caring for COVID-19 patients in the event of a shortage of
personal 2 protective equipment for the length of the work shift (preferably
not more than six hours).
7- Always remember not to touch the eyes, mouth or nose with contaminated
hands or used gloves (wash your hands or rub using alcohol when touch any
environmental surface).
8- Always clean and disinfect surfaces .
Medical Recommendations
Version 1.4 / November 2020 23
2) Procedures that include (AGPs):
• Tracheal intubation .
• Non-invasive ventilation e.g. BiPAP, CPAP.
• Tracheotomy.
• Cardiopulmonary resuscitation.
• Manual ventilation before intubation or bronchoscopy.
• Sputum induction by using nebulizer hypertonic saline.
The health care workers must adhere to the following:
• Standard precautions.
• Perform procedures inside a well-ventilated room.
• Follow the isolation precautions taken to prevent the spread of infection
through air and contact.
• The need to adhere to washing hands before donning personal protective
equipment and immediately upon doffing them.
Medical Recommendations
Version 1.4 / November 202024
Donning personal protective equipment as follows:
- A high-performance respiratory masks such as N95 or FFP2 or equivalent,
with the need to conduct a tightness test to ensure that there is no leakage.
- Protect your eyes by wearing goggles or face shield.
- Long-sleeve medical gowns (gown) clean, non-sterile or sterile according to
the procedure.
- Clean or sterile gloves depending on type of technique.
- The extended use of a mask, medical gown, eye goggles, or face shield
(Extended use) can be applied while caring for patients with COVID-19 in the
event of a lack of personal protective equipment and for the length of the work
shift (preferably no more than six hours).
- Care must be taken not to touch the eyes, mouth or nose with contaminated
bare hands or using gloves (wash your hands or rub using alcohol when touch
any environmental surface).
- Always clean and disinfect surfaces regularly.
Personal Recommendations
Version 1.4 / November 2020 25
Indications:
- Rapid development of consolidation pattern.
- Development of lobar consolidation.
- Leukocytosis with absolute neutrophilia.
- Reappearance of fever after afebrile days.
- Increased CRP with improved other markers as ferritin.
- Procalcitonin is highly specific.
ANTIBIOTICS IN COVID-19
Low-risk inpatients:
- Combination therapy:
β-lactam (eg, ceftriaxone, or cefotaxime) plus either a macrolide
(eg, azithromycin or clarithromycin) or doxycycline.
- Monotherapy:
Respiratory fluoroquinolone (eg, levofloxacin or moxifloxacin)
High-risk inpatients:
- β-lactam plus a macrolide or fluoroquinolone is recommended.
ANTIBIOTICS IN COVID-19
Version 1.4 / November 202026
Treatment Protocol
Revised By:
NAME AFFILIATION
Hossam Hosny Masoud
Professor of Chest Diseases. Head of
Pulmonary Hypertension Unit, Faculty of
Medicine, Cairo University
Gehan Elassal
Professor of Chest Diseases, faculty of
Medicine , Ain Shams University
Dr. Mohamed Hassany
Fellow of Infectious Diseases and Endemic
Hepatogastroentrology , National Hepatology
and Tropical Medicine Research Institute
Dr. Ahmed Shawky
Professor of Chest Diseases, faculty of
Medicine , Tanta University
Dr. Mohamed Abdel Hakim
Professor of Chest Diseases, faculty of
Medicine , Cairo University
Dr. Samy Zaky
Professor of Hepatogastroentrology and
Infectious Diseases, faculty of Medicine ,
Al Azhar University
Dr. Amin Abdel Baki
Consultant and Head of Hepatology ,
Gastroentrology and Infectious Diseases
Department. National Hepatology and Tropical
Medicine Research Institute
Dr. Akram Abdelbary
Professor of Critical care Medicine , Cairo
University
Chairman elect of ELSO SWAAC chapter
Dr. Ahmed Said
Lecturer of Critical care Medicine , faculty of
Medicine, Cairo University
Dr. Khaled Taema
Assistant Professor of Critical care Medicine ,
faculty of Medicine, Cairo University
Dr. Noha Asem
Minister”s Counselor for Research and Health
Development
Chairman of Research Ethics Committee
MOHP, Lecturer of Public Health , Cairo
University
Version 1.4 / November 2020 27
NAME AFFILIATION
Dr. Ehab Kamal
Minister of Health Assistant for Continuous
Medical Education
General Director of Fever hospitals Directorate
Dr. Wagdy Amin Director General for Chest Diseases , MOHP
Dr. Ehab Attia General Director of IPC Department , MOHP
Dr. Hamdy Ibrahim
Infectious Diseases Consultant , National
Hepatology and Tropical Medicine Research
Institute
Dr. Alaa Eid Head of Preventive Medical Sector MOHP
Treatment Protocol
Revised By:
Version 1.4 / November 202028
Ministry of Health and Population
Egypt / November 2020

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Mohp Egyptian protocol for covid19 november 2020

  • 1. Version 1.4 / November 2020 1 Management Protocol in Hospitals C VID-19 Ministry of Health and Population, Egypt Management protocol for COVID-19 Patients Version 1.4 / November 2020 Management Protocol for P a t i e n t s
  • 2. Version 1.4 / November 20202
  • 3. Version 1.4 / November 2020 3 Table of contents Item Page Number Triage Protocol 4 Management Protocol 6 Gastrointestinal Manifestations of COVID-19 15 Anticoagulation of COVID-19 Patients 16 High-Velocity Nasal Insufflation 17 Post-acute COVID Syndrome 18 Prevention and Control of COVID-19 Inside Health Care Facilities 20 Antibiotics in Covid-19 25 List of Editors 26
  • 4. Version 1.4 / November 20204 1st Step: Triage Case definition + severity assessment Suspect Case Definition A) Clinical AND epidemiological criteria: OR: B Patient with severe acute respiratory illness (SARI: acute respiratory infection with history of fever or measured fever ≥ 38°C and a cough; onset within last 10 days; requires hospitalization) -Acute onset of fever and cough OR -≥ 3 of the followings: fever, cough, sore throat, coryza, general weakness/fatigue, headache, myalgia, dyspnea, anorexia/nausea/ vomiting, diarrhea, altered mental status And 1 of the followings within 14 days of symptom onset: Residing or working in an area with high risk of transmission* Working in a healthcare setting Residing or travel to an area with community transmission *Closed residential settings, humanitarian settings such as camp and camp-like settings for displaced persons. NB: Minimal role for the epidemiological criteria during the period of community spread Probable Case A patient who meets clinical criteria AND is a contact of a probable or confirmed case, or epidemiologically linked to a cluster with at least one confirmed case. OR Suspect case with chest imaging showing findings suggestive of COVID-19 disease* OR Recent onset of loss of smell or taste in the absence of any other identified cause OR Unexplained death in an adult with respiratory distress who was a contact of a probable or confirmed case or epidemiologically linked to a cluster with at least 1 confirmed case *Hazy opacities with peripheral and lower lung distribution on chest radiography; multiple bilateral ground glass opacities with peripheral and lower lung distribution on chest CT; or thickened pleural lines, B lines, or consolidative patterns on lung ultrasound. Confirmed Case A person with laboratory confirmation* of COVID-19 infection, irrespective of clinical signs and symptoms *Molecular testing(PCR) with deep nasal swab is the current test of choice for the diagnosis of acute COVID-19 infection During seasonal flu period, clinical differentiation between influenza and COVID 19 is difficult. Swab for influenza A &B may help in early differentiation. Triage Protocol
  • 5. Version 1.4 / November 2020 5 Severity assessment Suspected case -PCR to confirm the diagnosis * -Assess disease severity (clinical, lab & imaging) -Mild symptoms -Normal imaging Imaging: +ve SpO2 ≥ 92% SpO2 < 92%, PaO2 /FiO2 < 300, respiratory rate > 30 breaths/min, or lung infiltrates > 50% Respiratory failure, septic shock, and/or multiorgan dysfunction Admit to Intensive care Admit to Intermediate Care Hospitals admission COVID area Home isolation & close follow up If possible, < 65 years old & no uncontrolled comorbidity Critical illnessSevere Moderate Mild Risk Factor YesNo In severe and critically ill patients, if-ve 1st PCR, repeat within 48 hours, negative case is considered after 2 –ve consecutive RT-PCR results from respiratory samples tested at least 1 day apart. NB: Unstable patient who don’t meet the suspected criteria should receive 1st aid therapy in non-COVID area before referral to general hospital.+ Risk factors include, old age > 60 years, uncontrolled comorbidity as hyperten- sion, DM, ……. or Social un applicable to home isolation. All persons with suspected, probable or confirmed COVID-19 should be immediately isolated to contain the virus transmission. Triage Protocol
  • 6. Version 1.4 / November 20206 Time is an important issueTime is an important issue in management of COVID-19. Before day 12( stage of viral load), Antiviral drug is essential. After day 12, the role of antiviral declines with augmentation for the role of anti-inflammatory, immune-modulators and Supportive drugs (stage of hyper-immune state). Potential antiviral drugs under evaluation for the treatment of COVID-19 include:Potential antiviral drugs under evaluation for the treatment of COVID-19 include: - Hydroxy ChloroquineHydroxy Chloroquine 400mg/ 12 hours 1st day followed by 200 mg/12 hours for 6 days, - IvermectinIvermectin 6 mg (36 mg on day 0 -3-6), - FavipiravirFavipiravir 1600 twice daily first day then 600 mg twice daily, - RemdesivirRemdesivir 200 mg IV on day 1, followed by 100 mg IV daily for high risk population for 5 days that could be extended to 10 days if the response is unsatisfactory or - Lopinavir/RitonavirLopinavir/Ritonavir 200/ 50 mg 2 tablets PO BID - Monoclonal antibodiesMonoclonal antibodies: early testing in blocking SARS-CoV-2. - Convalescent plasmaConvalescent plasma: for impending severely ill after counseling the scientific committee 2nd Step: Management Home isolation and symptomatic treatmentsymptomatic treatment (eg, antipyretics for fever, adequate nutrition, appropriate rehydration). Educate the patientsEducate the patients on signs/symptoms of complications that, if developed, should prompt pursuit of urgent care. There are insufficient data to recommend either with or against any antiviral or im- mune-based therapy in patients with COVID-19 who have mild illness. Mild illness All patients with symptomatic COVID-19 and risk factors for severe disease should be closely monitored. The clinical course may rapidly progress in some patients. Antibiotics are not recommended to prevent bacterial infection in mild patients. Administer empiric antibiotics if bacterial pneumonia/sepsis strongly suspected; re-evaluate daily. In non-hospitalized patients, do not initiate therapeutic anticoagulants or antiplatelet unless other indications exist. No harmful effect for administration of vitamin C or D or Zinc or Lactoferrin within the required daily dose. Check Every Patient For Risk Factors . Age 65 years . SpO2 < 92% . Heart Rate ≥110 . Respiratory Rate ≥ 25 /min. . Neutrophil / lymphocyte ratio on CBC ≥ 3.1 . Uncontrolled Comorbidities . On Immunosuppressive or chemotherapy drug . Pregnancy . Active Malignancy . Obesity (BM>40) Management Protocol
  • 7. Version 1.4 / November 2020 7 All patients with symptomatic COVID-19 and risk factors for severe disease should be closely monitored. In some patients, the clinical course may rapidly progress. Flu or COVID-19 IS IT A FLU OR COVID-19?IS IT A FLU OR COVID-19? SYMPTOM FLU COVID-19 FEVER FATIGUE COUGH SORE THROAT HEADACHES RUNNY NOSE SHORTNESS OF BREATH BODY ACHES DIARRHEA AND/OR VOMITING ONSET 1-4 days after infection About 5 days after infection but can range from 2-14 days LOSS OF TASTE AND/OR SMELL RED, SWOLLEN EYES SKIN RASHES
  • 8. Version 1.4 / November 20208 Mild Case Symptomatic case with lymphopenia or leucopenia with no radiological signs for pneumonia 1. Age 65 2. Temperature > 38 3. SaO2 ≤ 92% 4. Heart Rate ≥ 110 5. Respiratory Rate ≥ 25 /min. 6. Neutrophil / lymphocyte ratio on CBC ≥ 3.1 7. Uncontrolled Comorbidities 8. Immunosuppressive Drug 9. Pregnancy 10. Active Malignancy 11. On Chemotherapy 12. Obesity (BMI>40) Check for Any YESAll No Age ≥ 65 OR Age < 65 AND • Strict Home Isolation (Symptomatic Treatment) • Follow and use personal protective guide equipment • If any deterioration occurs, back to hospital NB: Paracetamol is the preferred antipyretic If more than 3 symptoms admit Treatment - Hydroxychloroquine (400 mg twice in first day then 200 mg twice for 6 days) - Zinc 50mg daily - Acelylcysteine 200 mg t.d.s. - lactoferrin one sachet twice daily - Vitamin C 1 gm daily OR Ivermectin 6 mg (36 mg on day 0 -3-6) OR Favipiravir 1600 TWICE daily first day then 600 mg twice daily +
  • 9. Version 1.4 / November 2020 9 Anti-virals Hydroxychloroquine + Ivermectin or Lopinavir/Ritonavir or Remdesivir for high risk population with SaO2 < 92 Immune-modulators Anti-inflammatory Anti-coagulation Steroids (if patient has severe dyspnea) RR>24 or CT scan showing rapid deterioration Dexamethasone 6 mg or its oral equivalent Prophylactic anticoagulation if D-Dimer between 500 -1000 Therapeutic anti-coagulation if D-dimer > 1000 Patient has pneumonia manifestations on radiology associated with symptoms &/Or leucopenia or lymphopenia. Moderate Case Anti-virals anticoagulation if D-Dimer between 500 -1000 Therapeutic anti-coagulation if D-dimer > 1000 Or if severe hypoxia Anti-inflammatory Convalescent plasma Steroids (Dexamethasone 6 mg or methyl prednisolone (1 mg / kg /24 hours)   Tocilizumab 4-8 mg/kg/day for 2 doses 12 to 24 hours apart after failure of steroid therapy to improve the case for 24 hours Before day 12 (under clinical trial) (after scientific committee approval) RR > 30, SaO2 < 92 at room air, PaO2 /FiO2 ratio < 300, Chest radiology showing more than 50% lesion or progressive lesion within 24 to 48 hrs. Severe cases Remdesivir or Lopinavir/ Ritonavir Anti-coagulant Prophylactic Admit to Intermediate Care
  • 10. Version 1.4 / November 202010 RR > 30, Sa02 < 92 at room air, PaO2/FiO2 ratio < 300, Chest radiology showing more than 50% lesion or progressive lesion within 24 to 48 hrs. Critically ill if SaO2 <92, or RR>30, or PaO2/FiO2 ratio < 200 despite Oxygen Therapy. Critically ill patients Admit to Intensive care Anti-virals Remdesivir or Lopinavir/ Ritonavir Anti-coagulant Anti-inflammatory Therapeutic anti-coagulation Steroids (Methyl prednisolone 2mg /kg or its equivalent)   Tocilizumab 4-8 mg/kg/day for 2 doses 12 to 24 hours apart after failure of steroid therapy to improve the case for 24 hours Tocilizumab 4-8mg/kg/dose 2 doses Early Block the storm if steroids failed Antiviral Drugs As is In Severe case Steroids Methylpred- nisolone 1-2 mg/kg/d Anti- Coagulation Enoxaparine 1 mg/kg BID Prone Awake or ventilated Avoid Hypoxia O2/ NIV/ HFNC/IMV Add Antibiotics As per protocol 1 mg for non ventilated and 2 mg for ventilated Consider D-dimer level as a guide Improves V/Q matching and survival Don’t wait too much for any type of support Keep plateau<30 High flow nasal oxygen is an important modality in the early management of critically ill patients.
  • 11. Version 1.4 / November 2020 11 (HFNC): Conscious patients with minimal secretions. Hypoxia SpO2 < 90% on oxygen. Or PaCO2 >40 mmHg provided pH 7.3 and above. NIV trial shall be short with ABG 30 minutes apart. Any deterioration in blood gases from baseline or oxygen saturation or consciousness level shift to IMV. CPAP gradually increased from 5-10 cmH2O. Pressure support from 10-15 cm H2O. HFNC can be alternative to NIV. Use PPE specially goggles during intubation and avoid bagging. Indications: Failed NIV or not available or not practical. PaO2 < 60 mmhg despite oxygen supplementation. Progressive   Hypercapnia. Respiratory acidosis (PH < 7.30). Progressive or refractory septic shock. Disturbed consciousness level (GCS ≤ 8) or deterioration in consciousness level from baseline Non Invasive Ventilation or High Flow Nasal Cannula Invasive Mechanical Ventilation:
  • 12. Version 1.4 / November 202012 COVID-19 PNEUMONIA (type L & type H) Type L Type H Type L Low elastance Low VA/Q mismatch Low lung weight Low recruitability High elastance High RL shunt High lung weight High recruitability Type H Non invasive support Early intubation Late intubation HFNC CPAP NIV PEEP (5-10 cmH2O) Sedation NMBA Higher PEEP(10-15 cmH2O) Prone (ECMO) STOP STOP STOP Lung Damage Progression (Virus + P-SILI) Inspiratory effort - edema Type L and Type H patients are best identified by CT scan and are affected by different Pathophysiological mechanisms. If CT not available, definition could be used as surrogates: Respiratory system elastance and recruitability. Understanding the correct pathophysiology is crucial to establishing the basis for appropriate treatment.
  • 13. Version 1.4 / November 2020 13 Plateau P<30 cmH2 O Incremental PEEP Shift to ARDSNet protocol if neededStep 2: - ARDSNet protocol: LOW TV 6-4 ml/kg Driving P<15 cmH2 O Initiation of Invasive Mechanical VentilationStep 1: VCV TV 8 ml/kg PEEP 5 cmH2O Plateau Pressure Less than 30 cmH2O Sat >93 Keep and Watch Less than 30 Sat<93 Increase PEEP to 10 More than 30 ARDSnet protocol Inspiratory Pause for 1 second IF PLATEAU ABOVE 30 CMH2O
  • 14. Version 1.4 / November 202014 Assessment of respiratory support outcomeStep 3: Improved Weaning of respiratory support Assess ABGs, Clinical Radiological Stationary Continue respiratory support as needed *Criteria for VV ECMO: Age below 55, mechanical ventilation duration less than 7 days, no comorbidities, preserved conscious level, PaO2/FiO2 <100 despite prone RESPscore >0. Expert opinion is needed and depends on availability. Deteriorating Criteria for ECMO* Start with tidal volume of 6 ml/Kg to keep plateau pressure on volume controlled ventilation (VCV) below 30 cmH2O, decrease to 4 ml/kg if the plateau remain higher than 30 allow permissive hypercapnia so long the pH is above 7.3 compensate by increasing respiratory rate up to 30 breath/ minute. Consider heavy sedation and paralysis. If pressures are high or any evidence of barotrauma shift to pressure controlled ventilation and be cautious about low tidal volume alarms for fear of unnoticed endotracheal tube obstruction. Consider ECMO early if eligible. Increase PEEP gradually if the patient remains hypoxic according to FIO2 level to keep driving pressure < 15cmH2O. NEVER FORGET PRONE POSITION.
  • 15. Version 1.4 / November 2020 15 - Gastrointestinal (GI) symptoms are seen in patients with COVID-19. The preva- lence could be as high as 50%, but most studies show ranges from 16% to 33% - Some patients with COVID-19 have presented with isolated GI symptoms that may precede the development of respiratory symptoms - It is important to note that medications used for COVID-19 may be associated with GI symptoms as well. - Approximately 50% of patients with coronavirus disease 2019 (COVID-19) have detectable viral RNA in the stool - Loss of appetite or anorexia is the most commonly reported symptom. - Diarrhea was the second most common symptom. - Other digestive manifestations include nausea or vomiting and abdominal pain. - Dysgeusia has also been reported, often in conjunction with anosmia. - Currently, management of GI symptoms in patients with COVID-19 is mainly sup- portive. - Treatment should be individualized according to the patient’s symptoms, underly- ing comorbidities and COVID-19–associated complications. - Oral or intravenous hydration - The antidiarrheal agent loperamide can be used in an initial dose of 4 mg and with a maximum daily dose of 16 mg in patients without fever, bloody stools, or risk fac- tors for C. difficile infection - Antiemetic drugs can often help relieve symptoms. Gastrointestinal Manifestations of COVID-19 Gastrointestinal Manifestations of COVID-19
  • 16. Version 1.4 / November 202016 Yes No Anticoagulation in COVID-19 Patients the patient clinically indicated for hospitalization Is he/she critically ill No Yes Prophylactic dose Higher than standard dose 0.5 mg/kg/m Therapeutic dose Consider also therapeutic anticoagulation for patients with high clinical susceptibility of VTE and those with Severe hypoxia not explained by the chest CT findings The preferred agents are LMWH and Fondaparinux unless contraindicated In renal patients, heparin is the preferred agent. If the dose of LMWH exceeds 150 twice daily use heparin instead. Anticoagulation in COVID-19 Patients
  • 17. Version 1.4 / November 2020 17 High Velocity Nasal Insufflation (Hi-VNI) • Hi-VNI is a first-line therapy for COVID-19 patients who are struggling to breathe. • Hi-VNI Technology and WOB reduction: The fact that small-bore cannulas reduce the time required to fully purge the upper airway dead space3 is significant because as the respiratory rate of a patient in respiratory distress increases, the time between breaths decreases. By quickly clearing the upper airway dead space of end-expiratory gas rich in CO2, Hi-VNI Technology helps patients breathe directly from a fresh gas reservoir and thereby reduces their WOB. 0 70 60 50 40 30 20 10 10 20 30 40 50 60 HVNI HFNC Volumetric Flow (L.min-1 ) Velocity(m.sec-1 ) High-Velocity Nasal Insufflation
  • 18. Version 1.4 / November 202018 Post- acute COVID syndrome (long COVID) Definition & incidence: In the absence of agreed definition, it may be defined as “patients not recovering for several weeks or months following the start of symptoms that were suggestive of COVID, whether patients were tested or not.” It may extend beyond 3 weeks from the onset of first symptoms up to 3 months, sometimes occurring after a relatively mild acute illness. If symptoms are extending beyond 3 months, it is termed Chronic COVID. In short, “Despite their illness being ‘over,’ they are having a lot of trouble returning to normal life.” It occurs in around 10% of patients. Patients can be divided into those who may have serious sequelae (such as thromboembolic complications) and those with a non-specific clinical pic- ture, often dominated by fatigue and breathlessness. One last group of covid-19 patients whose acute illness required intensive care management. Management: Specialist referral may be indicated based on clinical finding, for example: Respiratory: if suspected pulmonary embolism, severe pneumonia. Cardiology: if suspected myocardi- al infarction, pericarditis, myocarditis or new heart failure. Neurology: if suspected neurovascular or acute neurological event. Pulmonary rehabilitation may be indicated if patient has persistent breathlessness. Post-acute COVID syndrome
  • 19. Version 1.4 / November 2020 19 Medical management: Symptomatic: treating fever by paracetamol & NSAIDs Management of co-morbidities including diabetes, hypertension, kidney diseases & ischemic heart diseases Listening and empathy Consider antibiotics for secondary infection Treat specific complication as indicated Self-management: Daily pulse oximetry. Attention to general health like: Good diet Good sleep hygiene Quitting smoking Limiting alcohol limiting caffeine Rest and relaxation. Self-pacing and gradual increase exercise. Set achievable targets. Post-acute COVID syndrome
  • 20. Version 1.4 / November 202020 Prevention and Control of Transmission of COVID-19 inside Health Care Facilities
  • 21. Version 1.4 / November 2020 21 General Recommendations for Prevention and Control of Transmission of COVID-19 inside Health Care Facilities 1-Daily screening of health care workers and patients before entering the health care facility (HCF) based on clinical signs (fever, respiratory symp- toms…….). 2- Any health care worker appears/reports to be diseased should be segregated until proper examination/management. 3- All health care workers are required to wear surgical masks during work hours (during existence in HCFs). 4- Minimal number of health care workers should be present at the same time in patient’s units to keep social distancing 5- Restrict unneeded movements between departments. 6- Suspected or confirmed cases should take a separate route from other pa- tients beginning from the facility entrance (Triage area), and all facility sec- tions should follow the same separation. 7- Suspected or confirmed cases should be isolated in a well- ventilated isola- tion room. 8- Standard precaution should be applied : • Hand hygiene • Cough etiquette. • Personal protective equipment. • Clean and disinfected Environmental surfaces. • Sterile instrument and devices • Sharp safety. • Isolation transmitted precaution. • Safe injection practices. General Recommendations
  • 22. Version 1.4 / November 202022 Recommendations According To The Type Of Procedure 1) Non Aerosol Generating Procedures (AGPs) • Standard precautions. • Isolation precautions taken to prevent the spread of infection by spray and contact. • The need to adhere to washing hands before donning personal protective equipment and immediately upon doffing. • The necessity to adhere to donning personal protective equipment as follows: 1- Surgical mask. 2- Protect your eyes by wearing goggles or face shield. 3- Long-sleeve medical gowns (gown) clean, non-sterile or sterile, according to type of technique. 4- Clean or sterile gloves depending on type of technique. 5- Health care worker are not required to wear protective boots and protective suits during routine care of cases. 6- Extended use of surgical masks, gowns, eye protectors, and face shields can be applied while caring for COVID-19 patients in the event of a shortage of personal 2 protective equipment for the length of the work shift (preferably not more than six hours). 7- Always remember not to touch the eyes, mouth or nose with contaminated hands or used gloves (wash your hands or rub using alcohol when touch any environmental surface). 8- Always clean and disinfect surfaces . Medical Recommendations
  • 23. Version 1.4 / November 2020 23 2) Procedures that include (AGPs): • Tracheal intubation . • Non-invasive ventilation e.g. BiPAP, CPAP. • Tracheotomy. • Cardiopulmonary resuscitation. • Manual ventilation before intubation or bronchoscopy. • Sputum induction by using nebulizer hypertonic saline. The health care workers must adhere to the following: • Standard precautions. • Perform procedures inside a well-ventilated room. • Follow the isolation precautions taken to prevent the spread of infection through air and contact. • The need to adhere to washing hands before donning personal protective equipment and immediately upon doffing them. Medical Recommendations
  • 24. Version 1.4 / November 202024 Donning personal protective equipment as follows: - A high-performance respiratory masks such as N95 or FFP2 or equivalent, with the need to conduct a tightness test to ensure that there is no leakage. - Protect your eyes by wearing goggles or face shield. - Long-sleeve medical gowns (gown) clean, non-sterile or sterile according to the procedure. - Clean or sterile gloves depending on type of technique. - The extended use of a mask, medical gown, eye goggles, or face shield (Extended use) can be applied while caring for patients with COVID-19 in the event of a lack of personal protective equipment and for the length of the work shift (preferably no more than six hours). - Care must be taken not to touch the eyes, mouth or nose with contaminated bare hands or using gloves (wash your hands or rub using alcohol when touch any environmental surface). - Always clean and disinfect surfaces regularly. Personal Recommendations
  • 25. Version 1.4 / November 2020 25 Indications: - Rapid development of consolidation pattern. - Development of lobar consolidation. - Leukocytosis with absolute neutrophilia. - Reappearance of fever after afebrile days. - Increased CRP with improved other markers as ferritin. - Procalcitonin is highly specific. ANTIBIOTICS IN COVID-19 Low-risk inpatients: - Combination therapy: β-lactam (eg, ceftriaxone, or cefotaxime) plus either a macrolide (eg, azithromycin or clarithromycin) or doxycycline. - Monotherapy: Respiratory fluoroquinolone (eg, levofloxacin or moxifloxacin) High-risk inpatients: - β-lactam plus a macrolide or fluoroquinolone is recommended. ANTIBIOTICS IN COVID-19
  • 26. Version 1.4 / November 202026 Treatment Protocol Revised By: NAME AFFILIATION Hossam Hosny Masoud Professor of Chest Diseases. Head of Pulmonary Hypertension Unit, Faculty of Medicine, Cairo University Gehan Elassal Professor of Chest Diseases, faculty of Medicine , Ain Shams University Dr. Mohamed Hassany Fellow of Infectious Diseases and Endemic Hepatogastroentrology , National Hepatology and Tropical Medicine Research Institute Dr. Ahmed Shawky Professor of Chest Diseases, faculty of Medicine , Tanta University Dr. Mohamed Abdel Hakim Professor of Chest Diseases, faculty of Medicine , Cairo University Dr. Samy Zaky Professor of Hepatogastroentrology and Infectious Diseases, faculty of Medicine , Al Azhar University Dr. Amin Abdel Baki Consultant and Head of Hepatology , Gastroentrology and Infectious Diseases Department. National Hepatology and Tropical Medicine Research Institute Dr. Akram Abdelbary Professor of Critical care Medicine , Cairo University Chairman elect of ELSO SWAAC chapter Dr. Ahmed Said Lecturer of Critical care Medicine , faculty of Medicine, Cairo University Dr. Khaled Taema Assistant Professor of Critical care Medicine , faculty of Medicine, Cairo University Dr. Noha Asem Minister”s Counselor for Research and Health Development Chairman of Research Ethics Committee MOHP, Lecturer of Public Health , Cairo University
  • 27. Version 1.4 / November 2020 27 NAME AFFILIATION Dr. Ehab Kamal Minister of Health Assistant for Continuous Medical Education General Director of Fever hospitals Directorate Dr. Wagdy Amin Director General for Chest Diseases , MOHP Dr. Ehab Attia General Director of IPC Department , MOHP Dr. Hamdy Ibrahim Infectious Diseases Consultant , National Hepatology and Tropical Medicine Research Institute Dr. Alaa Eid Head of Preventive Medical Sector MOHP Treatment Protocol Revised By:
  • 28. Version 1.4 / November 202028 Ministry of Health and Population Egypt / November 2020