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MMP’s and the Role of
Zinc inWound Healing
Dr. MitchellV. Kaminski, Jr.
Board Certified in Nutrition, Surgery andWound Healing
Origin of Zinc – Crab Nebula supernova
Zinc complete electron shell therefore powerful antioxidant
Used by permission ofThe University
ofTexas McDonald Observatory.
Green – Hydrogen (H)
Red – Nitrogen (N)
Reddish - Sulfur (S)
Blue – Oxygen (O)
Violet – Helium (He)
Brown – Polycyclic aromatic Hydrocarbons (C+)
CHO = Carbohydrate & Fat
CHON = Protein
Role of Zinc
• Total Body Content 1500-3000mg
• (IronTBC – 2300-3800mg)
• 300+ Enzyme Reactions
• Epidermal integrity & resistance
• Antioxidant
• Sex hormone, insulin & serotonin
• EU Zincage Study
• Chromosomal RNA/DNA transcription
• Genome stability
• Signal triggering
• MMPs
• Immunity – neutrophils, killer cells, macrophages
Determining a Zinc Deficiency
•Serum zinc vs. functional test
ZincTasteTest (ZTT)
•Zicam oral spray
•Repulsive taste to healthy adult
•Gustin
ZincTasteTest (ZTT)
Zinc Deficiency
•Genetic or acquired
Acrodermatitis Enteropathica (Genetic) Acquired
ZincToxicity
•U.S. Food and Nutrition Board – 40mg/day
•Cancel treatment post 6-weeks
•Our Protocol – 100mg/day (220mg of Zinc Sulfate)
Biofilm
•Complex community of microorganisms
•Characterized by high cell density
•Extracellular polymer matrix
•Physical barrier against antimicrobial
•Facilitates adhesion (tissue & foreign bodies)
•Exopolysaccharide
Necrotic Debris and Biofilm
•MMP9
•Tenacious
•Mechanical Removal
MMPs
•MMPs manufactured by macrophlages and membrane
bound
•15 of 20 MMPs found in wounds – collenganese activity
•MMP9 = DirtyWound
•MMPs digest all proteins in ECS & basement membrane
Extracellular matrix
• Basement membrane
• Proteoglycans
• Heparan sulfate
• Chondroitin sulfate
• Keratan sulfate
• Non-proteoglycan
polysaccharide
• Hyaluronic acid
• Fibers
• Collagen
• Elastin
• Other
• Fibronectin
• Laminin
MMP Inhibitors
•4 tissue families
•TIMP-1,TIMP-2,TIMP-3,TIMP-4
•Common cysteine switch
Conclusion
• Critical to wound healing
• MMPs are zinc dependent
• Serum level unreliable
• Functional test – simple & reliable
• Proposal: Recommended lower limits must be reevaluated
• Current: 70 ug/dL
• Proposed new level be consistent with recovery of normal ZTT

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MMP's and the Role of Zinc in Wound Healing

  • 1. MMP’s and the Role of Zinc inWound Healing Dr. MitchellV. Kaminski, Jr. Board Certified in Nutrition, Surgery andWound Healing
  • 2. Origin of Zinc – Crab Nebula supernova Zinc complete electron shell therefore powerful antioxidant Used by permission ofThe University ofTexas McDonald Observatory. Green – Hydrogen (H) Red – Nitrogen (N) Reddish - Sulfur (S) Blue – Oxygen (O) Violet – Helium (He) Brown – Polycyclic aromatic Hydrocarbons (C+) CHO = Carbohydrate & Fat CHON = Protein
  • 3. Role of Zinc • Total Body Content 1500-3000mg • (IronTBC – 2300-3800mg) • 300+ Enzyme Reactions • Epidermal integrity & resistance • Antioxidant • Sex hormone, insulin & serotonin • EU Zincage Study • Chromosomal RNA/DNA transcription • Genome stability • Signal triggering • MMPs • Immunity – neutrophils, killer cells, macrophages
  • 4. Determining a Zinc Deficiency •Serum zinc vs. functional test
  • 5. ZincTasteTest (ZTT) •Zicam oral spray •Repulsive taste to healthy adult •Gustin
  • 7. Zinc Deficiency •Genetic or acquired Acrodermatitis Enteropathica (Genetic) Acquired
  • 8. ZincToxicity •U.S. Food and Nutrition Board – 40mg/day •Cancel treatment post 6-weeks •Our Protocol – 100mg/day (220mg of Zinc Sulfate)
  • 9.
  • 10. Biofilm •Complex community of microorganisms •Characterized by high cell density •Extracellular polymer matrix •Physical barrier against antimicrobial •Facilitates adhesion (tissue & foreign bodies) •Exopolysaccharide
  • 11. Necrotic Debris and Biofilm •MMP9 •Tenacious •Mechanical Removal
  • 12. MMPs •MMPs manufactured by macrophlages and membrane bound •15 of 20 MMPs found in wounds – collenganese activity •MMP9 = DirtyWound •MMPs digest all proteins in ECS & basement membrane
  • 13. Extracellular matrix • Basement membrane • Proteoglycans • Heparan sulfate • Chondroitin sulfate • Keratan sulfate • Non-proteoglycan polysaccharide • Hyaluronic acid • Fibers • Collagen • Elastin • Other • Fibronectin • Laminin
  • 14. MMP Inhibitors •4 tissue families •TIMP-1,TIMP-2,TIMP-3,TIMP-4 •Common cysteine switch
  • 15. Conclusion • Critical to wound healing • MMPs are zinc dependent • Serum level unreliable • Functional test – simple & reliable • Proposal: Recommended lower limits must be reevaluated • Current: 70 ug/dL • Proposed new level be consistent with recovery of normal ZTT