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MINOR  HEAD INJURY & MEDIAL TEMPORAL DAMAGE   A PROSPECTIVE CONTROLLED STUDY USING SPECT ,[object Object],[object Object]
[object Object],[object Object],[object Object],Smith DH, Lowenstein DH, Gennarelli DI, McIntosh TK. Persistent memory dysfunction is associated with bilateral hippocampal damage following experimental brain injury. Neurosci Lett 1994;168:151-154
[object Object],[object Object],[object Object],Rempel-Clower NL, Zola SM, Squire LR, Amaral DG. Three cases of enduring memory impairment after bilateral damage limited to the hippocampal formation. J Neurosci 1996;16:5233-5255.
[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[criteria published by the members of the Mild Traumatic brain injury Interdisciplinary Special Interest Group (BISIG)] Kay T, Harrington DE, et al. Definition of mild traumatic brain injury. J Head Trauma Rehabil 1993;8:86
[object Object],Gouvier WD, Cubic B, Jones G, Brantly P, Cutlip Q. Postconcussion symptoms and daily stress in normal and head-injured college populations. Arch Clin Neuropsychol 1992;7:193-211.   POSTCONCUSSION SYNDROME 30 children MTH Group (14) Non MTH group (16) PCSC administered Within 72 hrs & At 3 months PCSC administered Within 72 hrs & At 3 months
[object Object],INVESTIGATION ,[object Object],[object Object],[object Object]
[object Object],30 Children with minor head injury SPECT scan & PCSC administration (within 72 hrs) Medial temporal hypoperfusion (14 children) No Medial temporal hypoperfusion (16 children) 3 months later Repeat SPECT & clinical evaluation (PCSC) 3 months later Repeat SPECT & clinical evaluation (PCSC)
[object Object],[object Object],SPECT
[object Object],ABNORMAL SPECT SCAN
RESULTS 12 children were found to have cognitive dysfunction in the MTH group compared to only two in the control group Relative risk (95% CI)= 6.86(1.84-25.51). P=0.0003
RESULTS
RESULTS
[object Object],[object Object],[object Object]
[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object]

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Minor head injury

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  • 12. RESULTS 12 children were found to have cognitive dysfunction in the MTH group compared to only two in the control group Relative risk (95% CI)= 6.86(1.84-25.51). P=0.0003
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