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Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Gap Analysis of Insight-Driven 
Personalized Health Services through 
Patient-Controlled Devices 
MIE 2014 Workshop 510 W17 25 
TUESDAY 17:00 - 18:30 
Pei-Yun Sabrina Hsueh, Michael Marschollek, Yardena Peres, Stefan Von Cavallar, 
Fernando Martin Sanchez
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Logistics 
• 17:00-17:15 Opening Remark 
• Key drivers and problems being addressed (Dr, Hsueh, IBM T.J. Watson Research) 
• 17:15-18:10 Presentations 
• Overview of service classes for health-enabling technologies for elderly and a physician’s view 
in relevant applications in the future (Prof. Marschollek, Hanover Medical School). 
• Enablers for successful development of mobile health solution– mobile health solution 
requirements and challenges for scaling up and realizing its full potential (Mr. von Cavallar, 
IBM Research Australia) 
• Enablers for applications in research and potential clinical use – the need for standardised 
reporting guidelines in self-monitoring experiments (Prof. Martin-Sanchez, Melbourne 
Medical School) 
• Business aspects of insight-driven Personalized Health Services through Patient-Controlled 
Devices (Dr. Peres, IBM Research Haifa) 
• Development of Temporal Context-based Feature Abstractions for Enabling Monitoring and 
Managing of Interventions (Dr. Hsueh) 
• 18:10-18:30 Workshop discussion (gap analysis, requirement 
gathering)/audience Q&A 
• 1. Implications and lessons learned from the case studies -- especially the gaps you perceived 
as barriers of entry 
• 2. Requirements for successful redesign of healthcare systems to accommodate patient-generated 
information (with a sub-goal of identifying the areas where such information can 
make most impacts). 
Please leave your email and questions (if any)….
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Pei-Yun (Sabrina) Hsueh, PhD 
Wellness Analytics Lead 
Global Technology Outlook Healthcare Topic co-Lead 
Health Informatics Research Group 
IBM T. J. Watson Research Center 
• Research focus: Insight-driven Healthcare service design via 
wearables and biosensor devices/implants, Patient-generation info, 
Personalization analytics, Patient engagement & Adherence risk 
mitigation
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Elder population and care costs are growing annually, but no reliable 
solutions for early detection and efficacy monitoring 
4 IBM Confidential 
4 
Elderly population expected 
to double by 2030 in US 
Annual per capita healthcare costs 
grows significantly with age 
Early detection and efficacy 
monitoring are key 
Cognitive health is imperiled by the 
lack of reliable solutions 
1 in 3 seniors dies with 
Alzheimer’s or other 
dementia. Up to 72% 
of cases are 
misdiagnosed at the 
PCP level 
In 2013, Alzheimer’s will 
cost US $203 billion. 
This number is 
expected to rise to 
$1.2 trillion by 2050.
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Holistic View of Determinants of Health to Personalized Services 
Endogenous determinant 
(e.g., genetics predisposition) 
Clinical determinant 
(e.g., care flow, care delivery) 
Exogenous determinant 
(e,g, environment, behavioral 
social factors) 
30% 
10% 
60% 
SA Schroder. We can do better - Improving the Health of the Amarican People. NEJM 2007;357:1221-8. 
Cardiovascul 
ar disease 
(73-83%) 
(NHS, NEJM 2000) 
Type II Diabetes 
(58-91%) 
(Finland DPS, NEJM 2001, 2007) 
(US NHS, 2000; CDC DPP, 
2002)(China Da-Qing, 2001) 
Cancer 
(60-69%) 
(HALE, JAMA 2004; 
de lorgeril Arch 
Intern Med, 1998) 
Personalized Medicine 
Personalized Care 
Personalized Prevention and 
Disease Management 
Cardiovascular 
complication (42-57%) 
(UKPDS, US EDIC) 
Eye complication 
(76%), Kidney 
complication (50%), 
Nerve complication 
(60%) 
(UKPDS, US DCCT) 
Huge opportunity space for risk reduction: 
Progress impeded by the lack of granular data capturing tools!
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Technology barriers are lower than ever. 
A whole array of patient-controlled devices are on the rise…. 
fall sensor in a pocket 
adhesive vitals sensor 
6 IBM Confidential 
stretch sensors 
gait analysis in a pocket 
vitals sensor in t-shirt 
insole sensors 
e-textile wireless ECG 
Cardiac monitoring systems 
Requires ultra-low power adaptive 
circuits, non-intrusive form factors 
OpenBCI
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
7 
Wearable/IOT computing is the new mobile 
“Three medical technology stories to watch 
in these areas will be wearable technologies 
for fitness, aging-in-place technologies, and 
real-time monitoring. ” 
—Forbes, “Medical technology stories to 
watch in CES 2014” (Jan 2, 2014) 
“Wearable tech will be as big as the 
smartphone.” 
—Wired, Cover story (Dec 17, 2013) 
• Quantified self (27% of US users) - IDC Report, 2014 
• From IOT to “Internet of Everything” (IOE): 30-50 bn devices in 2020 
- Gartners Report, 2014 
• IoT enabled “Connected Life” market forecast in 2020: Clinical Remote Monitoring 
and Assisted Living to be the 2nd and 3rd largest mkt 
- IDC Report, 2014
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Healthcare is being re-imagined by bringing together high-growth, 
high-value patient generated information and EMR data
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Healthcare becoming both Personal and Collaborative 
The Creative Destruction of Medicine: How Digital Revolution will Create Better 
Healthcare (Eric Topol, 2012) 
(1) What are the implications and lessons? What are the gaps as barriers of entry? 
(2) What are the Requirements for successful redesign of healthcare systems to 
accommodate patient-generated information? What are the areas where such 
information can make most impacts? 
1990 Empirical Medicine 
Intuitive Medicine 
Personalized Service 
Patient-Centric 
Service 
Disease-Centric 
Guideline 
Century of 
behavior change 
Precision Medicine 
Degree of personalization 
Degree of collaboration 
(data dimension) 
Data-Driven 
Evidence
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Workshop Theme 
• 1. Implications and lessons learned from the case 
studies -- especially the gaps you perceived as 
barriers of entry 
• 2. Requirements for successful redesign of 
healthcare systems to accommodate patient-generated 
information (with a sub-goal of identifying 
the areas where such information can make most 
impacts).
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
INTRODUCTION 
• 17:00-17:15 Opening Remark 
• Key drivers and problems being addressed (Dr, Hsueh, IBM T.J. Watson Research) 
• 17:15-18:10 Presentations 
• Overview of service classes for health-enabling technologies for elderly and a physician’s view 
in relevant applications in the future (Prof. Marschollek, Hanover Medical School). 
• Enablers for successful development of mobile health solution– mobile health solution 
requirements and challenges for scaling up and realizing its full potential (Mr. von Cavallar, 
IBM Research Australia) 
• Enablers for applications in research and potential clinical use – the need for standardised 
reporting guidelines in self-monitoring experiments (Prof. Martin-Sanchez, Melbourne 
Medical School) 
• Business aspects of insight-driven Personalized Health Services through Patient-Controlled 
Devices (Dr. Peres, IBM Research Haifa) 
• Development of Temporal Context-based Feature Abstractions for Enabling Monitoring and 
Managing of Interventions (Dr. Hsueh) 
• 18:10-18:30 Workshop discussion (gap analysis, requirement 
gathering)/audience Q&A 
• 1. Implications and lessons learned from the case studies -- especially the gaps you perceived 
as barriers of entry 
• 2. Requirements for successful redesign of healthcare systems to accommodate patient-generated 
information (with a sub-goal of identifying the areas where such information can 
make most impacts).
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Service classes of health-enabling technologies – 
relevant applications in the future 
Michael Marschollek
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Wearables – just nice toys? 
? ? ? ? 
Good medicine and good healthcare 
demand good information
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Wearables – just nice toys? 
more data, (hopefully) more information 
more accurate diagnoses 
early detection of subtle changes, disease onset 
better, targeted treatment 
• Niilo Saranummis‘s 3 ‚P‘s: 
– pervasive technologies 
shall enable semantically interoperable platforms to communicate and store health data 
– personal services 
using sensor technologies for continuously measuring health-related data of an 
individual; to support her or him at specific health problems 
– personalized decision support 
adapted, ‘tuned’ to the individual’s norm, not to averages in populations (not one-size-fits- 
all) 
Saranummi N. IT applications for pervasive, personal, and 
personalized health. IEEE Trans Inf Technol Biomed. 2008; 12: 1-4.
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Haux R et al.. Inform Health Soc Care. 2010 Sep-Dec;35(3- 
4):92-103. PubMed PMID: 21133766.
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Service classes 
• Basic services: 
– Emergency detection and alarm 
– Disease management (chronic diseases) 
– Health status feedback and advice 
• Other services: 
– Communication and social interaction 
– Support for daily life and activities 
– Entertainment, information and communication 
S. Koch et al. Methods Inf Med, 2009. 
Ludwig W et al. Comput Methods Programs Biomed. 2012, 
May;106(2):70-8.
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Example: emergency detection – falls 
• Feldwieser F, Gietzelt M, Goevercin M, Marschollek M, Meis M, Winkelbach S, et al. 
Multimodal sensor-based fall detection within the domestic environment of elderly 
people. Z Gerontol Geriatr. 2014 Aug 12. PubMed PMID: 25112402. 
• Kangas M, Korpelainen R, Vikman I, Nyberg L, Jämsä T. Sensitivity and False Alarm Rate 
of a Fall Sensor in Long-Term Fall Detection in the Elderly. Gerontology. 2014 Aug 13.
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Example: disease management 
• Whole System Demonstrator (WSD) study (UK): 
– Different chronic diseases (e.g. heart failure) 
– ‚Telehealth‘ intervention (oximeters, scales, glucometers, …) 
– Lower mortality and admission rates, higher cost 
– Steventon et al. BMJ 2012; 444:e3874 
• NATARS study (Germany): 
– Geriatric home rehabilitation after mobility-impairing 
fractures 
– Wearable sensor, smart home sensors 
– Marschollek et al. Inform Health Soc Care. 2014 Sep;39(3- 
4):262-71.
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Example: early detection/ diagn., prevention 
• Fall risk assessment/ fall prediction: 
– medium-scale prospective studies, e.g. Greene et al, 2012, 
Gerontology; Marschollek et al, 2012, Meth Inf Med; Gietzelt 
et al, 2014, Inf Health Soc Care 
• Rehabilitation Monitoring/ relapse identification: 
– Steventon et al. BMJ 2012 (WSD study) 
– Marschollek M et al. Inform Health Soc Care. 2014 
– Calliess et al. Sensors, 2014 
• Physical activity promotion (Plischke et al. 2008) 
• Aftercare, paediatric liver TX patients (Marschollek et al. 2013) 
• …
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Epidemiologic perspective: future diseases 
• increase of chronic diseases 
• increase of “age-related deficits” 
• decrease of health professionals 
• application areas: 
– cardiovascular diseases (e.g. congestive heart disease) 
– neuropsychiatric disorders (dementia, uni-/bipolar 
depressive disorders, anxiety disorder) 
– diabetes (and follow-up conditions) 
– musculoskeletal diseases (arthritis and esp. follow-up 
conditions (e.g. post-implant rehabilitation)) 
• but: this is only secondary/ tertiary source: Institute for Hea plthr eMveterincst iaondn E!valuation, 
healthmetricsandevaluation.org
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Gaps and Pitfalls (subjective!) 
• Translating (diagnostic) knowledge into action 
• Lack of integration into health information systems, 
especially on semantic level (modeling) 
– E.g. Marschollek M. Inform Health Soc Care. 2009 
• Psychological: 
– the right not to know 
– trust, security 
• and still: Device interoperability
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
join our IMIA WG: www.wearable-sensors.org
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Stefan von Cavallar Advisory Software Engineer, IBM Research Australia
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
The title of Stefan von Cavallar’s Presentation 
will be: 
Mobile health: Solution requirements and challenges 
for scale-up
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Mobile Health 
Benefits 
•Unprecedented opportunities 
•High growth usage in developing countries = health 
service delivery in regions where otherwise limited 
•Improved access to health services 
•Improved patient communication, ie. Reminders, Care 
plans 
•Monitoring of treatment compliance 
•And MORE… !
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Mobile Health Solution Considerations 
• Health information privacy 
• Health information security 
• Standardization 
• Interoperability 
• Device fragmentation 
• Data fragmentation 
• Geography 
• Budgets $
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Specifically... 
The exchange and collection of data from different 
systems and platforms will be… 
*Essential for users with multiple clinical 
requirements 
*Key to preventing further fragmentation between 
health programs
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
What are we trying to solve? 
Consider this use case: 
•Mother, with daughter 
•Daughter sick for several days with lots of fluid loss 
•They know nearest medical health center is 60Km away, they have no 
transport 
•Both walk to health center, and wait for a further 24 hours until seen due to 
understaffing and high patient numbers 
•Assessment made, treatment given and returned home 
•Mother has no care plan or guidance on next steps 
What happens next?
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
What do we want to do? 
1. Improve health! 
How about the previous use-case becomes: 
• Mother, with daughter 
• Daughter sick for several days with lots of fluid loss 
• They know nearest medical health center is 60Km away, they have no transport 
• Mother uses mobile health credits to send message to a Cognitive Healthcare 
Hub where it is analyzed. Identify open questions to determine severity 
• Message sent back requesting additional information and includes guidance on 
how to gain that information (e.g. how to perform a pinch test) 
• Mother carries out tests and responds. Guidance is given to seek medical 
assistance in the nearest healthcare center. Details for the center are different 
to what the mother knows, its closer (8Km), but in a different direction…
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
• Details of daughters condition are recorded and monitored via the Cognitive 
Healthcare Hub 
• At the health center social worked collect biometric data of waiting patients 
• Information collected and presented to physician for accelerated diagnosis 
• Information fed into Cognitive Healthcare Hub 
• Diagnosis and treatment options presented through the Cognitive Healthcare Hub 
to the healthcare worker. Support diagnosis by checking guidelines, hilight 
treatment options and assemble care plan 
• Daughter is being treated for diarrhea and dehydration 
• The Cognitive Healthcare Hub allows healthcare worker or physician to select a 
recommended care plan that the Hub has personalized for the daughters 
conditions 
• The mother is sent the care plan via wifi 
• Mother and daughter are discharged, complete with a take-home plan for on-going 
treatment 
• At points of time afterwards, the Hub sends out reminders and short enquiries to 
follow up and if necessary request that a health worker check on them
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Solution Requirements 
The solution must engage: 
•A unified data view 
•Health information privacy 
•Health information security 
•Standardized 
•Interoperable 
•Defined device and data structure 
•The users and fulfil their use cases
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Solution Requirements 
• Provide information collecting, learning and sharing infrastructure (ie, 
cognitive healthcare hub) 
• Include historical disease, climate and population data 
• Include continuous disease surveillance and drug consumption data 
• Learn from historical and continuous data 
• Two-way information flow 
• Mobile sensing (eg, occurrence of certain symptoms in a region) and multi-casting 
• Practitioner support (eg, recent weather condition and high number of reported 
infections with same symptoms in the region suggest particular diagnosis) 
• Value proposition 
• Support health workers and the need for diagnosis 
• Provide visibility and forecasting of disease outbreaks and drug demand  supply 
• Enable macro-level priority setting and investment support 
• Monitor the ROI of health investments 
• Provide sustainable infrastructure for data collection and dissemination
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Cognitive Healthcare Hub 
Interface Gateway 
Governments 
Interaction Communication Visualisation 
Mobile Internet Community Radio TV 
Statistics 
Modelling 
Cognitive Computing Analytics 
Machine Learning 
Simulation 
Prediction 
Business Intelligence 
Unified Data View 
Security Access Quality 
Environment Mobile  Social 
Media 
Indigenous 
Knowledge 
Guidelines  
Publications 
Remote 
Sensors 
Registries
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Watson: Question  Answer 
Hospitals 
Deep Thunder: Climate Modeling 
Cognitive Healthcare 
Pharmacies 
Health 
Workers 
Community 
Health 
Centers 
Patients 
Prepare for patient 
increase 
Hub 
Optimized drug distribution 
Support untrained 
Advice for rare conditions 
STEM: Epidemiological Modeling 
Public 
Health 
Boards 
Optimized Resource Allocation
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
GPS Healthcare worker entry Sensors 
Dehydration 
*Healthcare/trained worker only 
Visual 
inspection 
Skin pinch 
timer; App 
Blood viscosity; 
Infra-red sensors; 
camera modified* 
Image analytics on 
lips, eyes; camera; 
MMS 
Community 
General 
questioning 
Tests 
Diagnosis 
Aftercare 
Oral Zinc supplements Rehydration Salts 
Rehydration schedule 
Tracking; how? Reminders 
Local Push 
Treatment 
Calculate therapy 
Public Health 
Water supply analysis 
Pathogen outbreak Pathogen identification 
Individual 
App; 
decision 
tree 
Intravenous fluids
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Challenges for Scale Up 
• Data Fragmentation/Distribution 
• Data inconsistencies 
• Education/Training i.e. Hardware, software 
• Differing working practices 
• Infrastructure, i.e. Easily no data reception 
• Costs, incentives and funding $$$$$ 
• Not everyone has the same level of access to 
technology
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Summary – Implications and lessons learnt 
from this case study 
• Assume nothing… i.e. users with smartphones 
• While countries want the same thing, how they get 
there varies greatly… 
• Technology uptake is not always as easy or advanced 
as one might think 
• Infrastructure is not as mature as required 
• Limited funding/incentives available for adopting 
these technologies/infrastructures 
• Integrating the fragmented data
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Summary – Requirements for successful 
redesign of healthcare systems 
• Everyone to want to contribute 
• Analytics engines using structured and unstructured 
data 
• A system that enables contributors and provides 
tailored data to consumers 
• Data consumption and feedback for improved 
analytics 
• Education and “buy-in”
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Enablers for applications in research and 
potential clinical use: 
Standardised reporting guidelines in self-monitoring 
experiments 
Prof. Martin-Sanchez 
Melbourne Medical School
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
41 
Manager, Mobile Big Data Solutions 
IBM Research - Haifa 
 B.A., M.Sc., Technion – Israel Institute of Technology 
 Senior Researcher, IBM Research – Haifa 
 Focus on leveraging state-of-the-art IT to solve industry 
pain points 
 Mobile, Cloud, Big Data, Analytics 
 Standards  Interoperability 
 HC/Wellness, Retail 
 Prolific EU FP6, FP7 and H2020 research activities 
Yardena Peres
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Research project funded by the 
EU (Nov 2013 - Oct 2016) 
• DAPHNE Consortium: 
– Sensor partners: Evalan, UPM 
– IT partners: IBM Research – Haifa, TreeLogic, Atos, SilverCloud 
– HC partners: Nevet, Bambino Gesu, University of Leeds, IASO 
• DAPHNE Objective: 
– Develop a novel IT platform for delivering personalized guidance 
services for lifestyle management (focused on reducing 
sedentariness) to the citizen/patient by means of: 
• Advanced sensors and mobile phones to acquire and store data on 
lifestyle aspects, behavior and surrounding environment 
• Individual models to monitor health and fitness status 
• Intelligent data processing for the recognition of behavioral trends 
and services for personalized guidance on healthy lifestyle and 
disease prevention 
• Use Case: 
– The system receives clinical parameters from the selected 
sensors, stores health markers, learns personal preferences, and 
generates feedback and recommendations. 
42
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Business aspects of insight-driven Personalized Health 
Services through Patient-Controlled Devices 
• Patient-Controlled Devices are generating large 
amounts of new data 
• This poses several IT challenges 
– Cope with large amounts of varied data while maintaining 
data quality 
– Connect with existing Healthcare Systems (e.g., EHR, HIS) 
– Handle security, privacy and consent management
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Business aspects of insight-driven Personalized Health 
Services through Patient-Controlled Devices 
• Monetize data, e.g. Data as a 
Service (DaaS) Model 
– Patients generate new data 
– IT companies manage it 
– HC providers, Pharma, Payers, 
Retailers, Governments, 
Scientific Research, etc. 
consume it 
– All stakeholders are part of the 
same value-chain
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Development of Temporal Context-based 
Feature Abstractions for Enabling Monitoring 
and Managing of Interventions 
MIE 2014 
Pei-Yun Sabrina Hsueh 
Ke Yu 
Marina Akushevich 
Shweta Shama 
Peter Mooiweer 
Sreeram Ramakrishnan 
IBM GBS BAO/Watson Research
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Technology barriers are lower than ever. 
A whole array of patient-controlled devices are on the rise…. 
fall sensor in a pocket 
adhesive vitals sensor 
46 IBM Confidential 
stretch sensors 
gait analysis in a pocket 
vitals sensor in t-shirt 
insole sensors 
e-textile wireless ECG 
Cardiac monitoring systems 
Requires ultra-low power adaptive 
circuits, non-intrusive form factors 
OpenBCI
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Significant growth in exogenous data poses challenges to existing BigData 
storage and analytics solutions 
Determinants of Health 
Outcomes 
Exogenous 
(Behavior, Socio-economic, 
60 
Environmental, ....) 
% Fitness/WellnessPatient-controlled medical 
devices 
Affinity (digital)Affinity 
(retail) 
Employ 
ment 
Socio-econo 
mic 
databa 
ses 
Data Sources 
Endogenous 
(-omics) 30 
% 
Clinical 
(EMR) 
10 
% 
Exogenous Data Growing Fast 
1240 
PB 
1800 
PB 
6800 
PB 
(annu 
al) 
Episodic; care 
pathways in 
controlled 
settings 
Mostly static 
data, but 
critical for 
personalized 
medicine 
Significant volume 
(every step, heart 
rate, meals,….) and 
variety 
(physiological, 
psychological, 
socio-economic) 
and dynamic 
Data generation ~ 
uncontrolled 
environment 
!
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
A perfect storm awaits….. 
Data Deluge from Patient-generated information
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
49 
Patient generated information are effective for self-management 
and personalized intervention/adaptation 
Increase awareness to self-monitoring 
(Prestwich et al., 09; Burke et al., 05) 
Promoting behavioral change 
(Dietary intake: Burke et al., 05; 
Physical activity: Prestwich et al., 09; Michie et al., 09) 
Triggering reminders to care plans 
(Consolvo et al. 09; Hurling et al., 07) 
Personalizing communication 
messages and education materials 
(Thaler and Sustein, ‘08) 
Nudge: Improving Decisions About Health
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Existing tools lack capabilities to determine appropriate 
metrics most sensitive to individuals 
• Especially true for those require artful interpretation of the 
temporal context of measurement 
– E.g., Hypertension = blood pressure; Diabetes = SMBG; Metabolic 
syndrome = weight, cholesterol level 
• Need new capability to calibrate intra-individual variability 
– E.g., Heart rate variability (HRV) detect abnormal symptoms of 
autonomic nervous system that are correlated with lethal arrhythmias 
– E.g., The variability of B-type natriuretic peptide (BNP)  detect cardiac 
ischemia 
• Barriers: 
– (1) No unifying theoretical models exists for enabling such interpretations 
– (2) The process from feature abstraction to individualized prognosis is 
non-trivial.
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Data-driven Calibration and Personalization Process: 
From Population-based evidence to individualized alerting/adaptatio 
Population Data-driven Insight 
Feature 
Abstraction 
(Candidate feature 
generation) 
Complete feature set 
Feature 
Optimization 
1 
2 
(Optimal set construction) 
Construction of features 
based on variance over 
time 
Analyze and select 
variance features from 
the complete set of 
constructed features 
Optimized Feature subset 
Identify input data 
sources from the optimal 
feature set and configure 
the input of data sources 
Feature 
3 
Population (data 
source configuration) 
Individual Data-driven Personalization 
Individual data captured based on input configuration 
Alert Setting 
(individual-based 
calibration) 
Individual-based alert 
Learning for 
Adaptation 
Slide 51 IBM CONFIDENTIAL 
Monitoring biomarker/patient-generated 
info operational DB 
EHR/PHR 
Repository 
Learn from baseline to understand 
normal variance and use the info to 
determine when to send alerts 
Verify if the selected abstraction is the 
right one for the individual according to 
the KPI. Create time gates events, 
triggers to check if the selected feature 
is the optimal one. 
Individually adapted 
plan (alert and 
intervention) 
4 
5 
Verified feature set for the target individual
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Enabling personalized temporal context interpretation 
by data-driven calibration and personalization 
• Need to streamline the process from population-based feature abstraction 
to individualization 
• Enable more effective monitoring and management of interventions 
Monitoring 
device 
Intra-individual 
variability calibration 
(evidence-based) 
• Service Scenarios: 
Input for monitoring 
feedback generation 
and 
diagnosis/intervention 
– 1. Development of adherence programs for patient self-management 
– 2. Enablement of intervention design for care coordinators/care givers 
– 3. Understanding efficacy for care givers to adapt suggested 
interventions for an individual 
– 4. Evidence-generation for intervention efficacy (population data)
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Summary: Gaps observed in Service Design 
• The lack of reliable means to capture granular patient-generated data in non-clinical 
settings (user’s daily life contexts) 
– Leads to unreliable detection of inflection points, habit formation cycles and assessments of 
treatment efficacy. 
• Need for a framework to integrate analytical insights with feasible service models. 
– Progress impeded by the lack of modular design and data standardization in existing 
healthcare systems 
53 IBM Confidential 
Customer/ 
Patient 
Adherence 
Theme 
#1 
Theme 
#2 
Theme 
#3 
Personalization for 
risk stratification 
(from population to 
individual evidence) 
Personalization for in-context 
recommendation 
(from disease-centric to 
patient-centric) 
Personalization for 
adherence risk 
mitigation 
(from status-insensitive 
to status-sensitive)
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Summary: New requirement of a modular framework to 
accelerate personalized service design 
Technologies to enhance wellness services 
– Guide the identification of customization points in clinical workflow and 
deployment of the Analytics and IM offerings 
– Create new tools and infrastructure for client engagements 
– Explore light-weight approach to connect the components (to prepare for future 
cloud offerings) 
New solutions and services 
– Bring together clients and researchers to understand clinical touch points 
– Demonstrate how to leverage customization points to engage users and possibly 
improve health literacy and outcomes 
Replicable patterns for patient engagement deployment 
– Create ETL procedures to be repeatedly use in other provider settings 
– Explore both hosted and internal deployment possibilities 
Plug-in for other tools 
– Create a recipe from data collection to summarization to customization to 
engagement to outcome measurement 
– Each component can be singled out as a standalone process for other tools
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Gap Analysis of Insight-Driven 
Personalized Health Services through 
Patient-Controlled Devices 
MIE 2014 Workshop 510 W17 25 
TUESDAY 17:00 - 18:30 
Pei-Yun Sabrina Hsueh, Michael Marschollek, Yardena Peres, Stefan Von Cavallar, 
Fernando Martin Sanchez
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Logistics 
• 17:00-17:15 Opening Remark 
• Key drivers and problems being addressed (Dr, Hsueh, IBM T.J. Watson Research) 
• 17:15-18:10 Presentations 
• Overview of service classes for health-enabling technologies for elderly and a physician’s view 
in relevant applications in the future (Prof. Marschollek, Hanover Medical School). 
• Enablers for successful development of mobile health solution– mobile health solution 
requirements and challenges for scaling up and realizing its full potential (Mr. von Cavallar, 
IBM Research Australia) 
• Enablers for applications in research and potential clinical use – the need for standardised 
reporting guidelines in self-monitoring experiments (Prof. Martin-Sanchez, Melbourne 
Medical School) 
• Business aspects of insight-driven Personalized Health Services through Patient-Controlled 
Devices (Dr. Peres, IBM Research Haifa) 
• Development of Temporal Context-based Feature Abstractions for Enabling Monitoring and 
Managing of Interventions (Dr. Hsueh) 
• 18:10-18:30 Workshop discussion (gap analysis, requirement 
gathering)/audience QA 
• 1. Implications and lessons learned from the case studies -- especially the gaps you perceived 
as barriers of entry 
• 2. Requirements for successful redesign of healthcare systems to accommodate patient-generated 
information (with a sub-goal of identifying the areas where such information can 
make most impacts). 
Please leave your email and questions (if any)….
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Workshop Theme 
1. Implications and lessons 
learned from the case 
studies -- especially the 
gaps you perceived as 
barriers of entry 
2. Requirements for 
successful redesign of 
healthcare systems to 
accommodate patient-generated 
information 
(with a sub-goal of 
identifying the areas 
where such information 
can make most impacts). 
• Workflow 
– Knowledge actionable? 
– Integration 
– Lack of modular design 
• User 
– Right not to know, trust, security, 
consent management 
• Data 
– Fragmented, lack of EHR interoperability 
– Beyond big data, uncontrolled env. 
• Device 
– Interoperability, infrastructure 
• Service 
• Resource
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Summary: 
Gap analysis and HC re-design requirement 
• Workflow 
– Lack of integration into health information systems, especially on semantic level (modeling) 
– Lack of modular design of existing healthcare system 
• User 
– Manage the right not to know, trust, security, consent 
– Assume nothing from the start 
– Country/Cultural differences 
• Device 
– Fragmentation ; Lack of interoperability 
– Immature infrastructure 
• Data 
– Fragmented data sources (need to integrate with EHR / HIS) 
– Ecosystem platform (enabling contributors, tailoring data to consumers) 
– Need to create personalization analytics framework (and engine) (data consumption feedback) 
– BigData: large amounts of varied data while maintaining data quality 
– Beyond Bigdata storage and processing, in uncontrolled env. 
– Beyond Bigdata analytics, in uncontrolled env. 
• Service 
– Touchpoint redesign to integrated Clinical/Wellness Service 
• Resource 
– Lack of funding/incentives
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
More questions to think  Suggestions on next 
step? 
• Do provider beliefs and support of these technologies and approaches affect 
patient usage? 
• Will patient interactive reported data improve provider and patient 
communications, reduce risks and increase early interventions? 
• Can adherence to care plans for patients with chronic health conditions be 
increased through technology-mediated techniques? 
• Can analytics based on patient characteristics and adherence behavior be used to 
identify patients at risk for adverse health events, as well as identify “model” 
adherers who are more effective than the average patient at remaining healthy? 
• Can dynamically configured software improve health outcomes for the patient 
and help control costs? 
• How will real time patient reported data shift communications, culture, care 
processes and the patient – provider partnership? 
Consider publishing our summary report in MEDINFO 2015? (any other venue?) 
A follow-up workshop/panel with a more focused theme on the gap and 
requirement perceived as priority?
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Suggestions on next step? 
Traditional Chinese 
Thank You 
Merci 
Grazie 
Gracias 
Obrigado 
Danke 
English 
Japanese 
French 
Russian 
German 
Italian 
Spanish 
Arabic Brazilian Portuguese 
Simplified Chinese 
Hindi 
Tamil 
Thai 
Korean 
Hebrew
Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 
Questions?

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Mie2014 workshop: Gap Analysis of Personalized Health Services through Patient-Controlled Devices

  • 1. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices MIE 2014 Workshop 510 W17 25 TUESDAY 17:00 - 18:30 Pei-Yun Sabrina Hsueh, Michael Marschollek, Yardena Peres, Stefan Von Cavallar, Fernando Martin Sanchez
  • 2. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Logistics • 17:00-17:15 Opening Remark • Key drivers and problems being addressed (Dr, Hsueh, IBM T.J. Watson Research) • 17:15-18:10 Presentations • Overview of service classes for health-enabling technologies for elderly and a physician’s view in relevant applications in the future (Prof. Marschollek, Hanover Medical School). • Enablers for successful development of mobile health solution– mobile health solution requirements and challenges for scaling up and realizing its full potential (Mr. von Cavallar, IBM Research Australia) • Enablers for applications in research and potential clinical use – the need for standardised reporting guidelines in self-monitoring experiments (Prof. Martin-Sanchez, Melbourne Medical School) • Business aspects of insight-driven Personalized Health Services through Patient-Controlled Devices (Dr. Peres, IBM Research Haifa) • Development of Temporal Context-based Feature Abstractions for Enabling Monitoring and Managing of Interventions (Dr. Hsueh) • 18:10-18:30 Workshop discussion (gap analysis, requirement gathering)/audience Q&A • 1. Implications and lessons learned from the case studies -- especially the gaps you perceived as barriers of entry • 2. Requirements for successful redesign of healthcare systems to accommodate patient-generated information (with a sub-goal of identifying the areas where such information can make most impacts). Please leave your email and questions (if any)….
  • 3. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Pei-Yun (Sabrina) Hsueh, PhD Wellness Analytics Lead Global Technology Outlook Healthcare Topic co-Lead Health Informatics Research Group IBM T. J. Watson Research Center • Research focus: Insight-driven Healthcare service design via wearables and biosensor devices/implants, Patient-generation info, Personalization analytics, Patient engagement & Adherence risk mitigation
  • 4. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Elder population and care costs are growing annually, but no reliable solutions for early detection and efficacy monitoring 4 IBM Confidential 4 Elderly population expected to double by 2030 in US Annual per capita healthcare costs grows significantly with age Early detection and efficacy monitoring are key Cognitive health is imperiled by the lack of reliable solutions 1 in 3 seniors dies with Alzheimer’s or other dementia. Up to 72% of cases are misdiagnosed at the PCP level In 2013, Alzheimer’s will cost US $203 billion. This number is expected to rise to $1.2 trillion by 2050.
  • 5. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Holistic View of Determinants of Health to Personalized Services Endogenous determinant (e.g., genetics predisposition) Clinical determinant (e.g., care flow, care delivery) Exogenous determinant (e,g, environment, behavioral social factors) 30% 10% 60% SA Schroder. We can do better - Improving the Health of the Amarican People. NEJM 2007;357:1221-8. Cardiovascul ar disease (73-83%) (NHS, NEJM 2000) Type II Diabetes (58-91%) (Finland DPS, NEJM 2001, 2007) (US NHS, 2000; CDC DPP, 2002)(China Da-Qing, 2001) Cancer (60-69%) (HALE, JAMA 2004; de lorgeril Arch Intern Med, 1998) Personalized Medicine Personalized Care Personalized Prevention and Disease Management Cardiovascular complication (42-57%) (UKPDS, US EDIC) Eye complication (76%), Kidney complication (50%), Nerve complication (60%) (UKPDS, US DCCT) Huge opportunity space for risk reduction: Progress impeded by the lack of granular data capturing tools!
  • 6. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Technology barriers are lower than ever. A whole array of patient-controlled devices are on the rise…. fall sensor in a pocket adhesive vitals sensor 6 IBM Confidential stretch sensors gait analysis in a pocket vitals sensor in t-shirt insole sensors e-textile wireless ECG Cardiac monitoring systems Requires ultra-low power adaptive circuits, non-intrusive form factors OpenBCI
  • 7. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 7 Wearable/IOT computing is the new mobile “Three medical technology stories to watch in these areas will be wearable technologies for fitness, aging-in-place technologies, and real-time monitoring. ” —Forbes, “Medical technology stories to watch in CES 2014” (Jan 2, 2014) “Wearable tech will be as big as the smartphone.” —Wired, Cover story (Dec 17, 2013) • Quantified self (27% of US users) - IDC Report, 2014 • From IOT to “Internet of Everything” (IOE): 30-50 bn devices in 2020 - Gartners Report, 2014 • IoT enabled “Connected Life” market forecast in 2020: Clinical Remote Monitoring and Assisted Living to be the 2nd and 3rd largest mkt - IDC Report, 2014
  • 8. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Healthcare is being re-imagined by bringing together high-growth, high-value patient generated information and EMR data
  • 9. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Healthcare becoming both Personal and Collaborative The Creative Destruction of Medicine: How Digital Revolution will Create Better Healthcare (Eric Topol, 2012) (1) What are the implications and lessons? What are the gaps as barriers of entry? (2) What are the Requirements for successful redesign of healthcare systems to accommodate patient-generated information? What are the areas where such information can make most impacts? 1990 Empirical Medicine Intuitive Medicine Personalized Service Patient-Centric Service Disease-Centric Guideline Century of behavior change Precision Medicine Degree of personalization Degree of collaboration (data dimension) Data-Driven Evidence
  • 10. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Workshop Theme • 1. Implications and lessons learned from the case studies -- especially the gaps you perceived as barriers of entry • 2. Requirements for successful redesign of healthcare systems to accommodate patient-generated information (with a sub-goal of identifying the areas where such information can make most impacts).
  • 11. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices INTRODUCTION • 17:00-17:15 Opening Remark • Key drivers and problems being addressed (Dr, Hsueh, IBM T.J. Watson Research) • 17:15-18:10 Presentations • Overview of service classes for health-enabling technologies for elderly and a physician’s view in relevant applications in the future (Prof. Marschollek, Hanover Medical School). • Enablers for successful development of mobile health solution– mobile health solution requirements and challenges for scaling up and realizing its full potential (Mr. von Cavallar, IBM Research Australia) • Enablers for applications in research and potential clinical use – the need for standardised reporting guidelines in self-monitoring experiments (Prof. Martin-Sanchez, Melbourne Medical School) • Business aspects of insight-driven Personalized Health Services through Patient-Controlled Devices (Dr. Peres, IBM Research Haifa) • Development of Temporal Context-based Feature Abstractions for Enabling Monitoring and Managing of Interventions (Dr. Hsueh) • 18:10-18:30 Workshop discussion (gap analysis, requirement gathering)/audience Q&A • 1. Implications and lessons learned from the case studies -- especially the gaps you perceived as barriers of entry • 2. Requirements for successful redesign of healthcare systems to accommodate patient-generated information (with a sub-goal of identifying the areas where such information can make most impacts).
  • 12. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Service classes of health-enabling technologies – relevant applications in the future Michael Marschollek
  • 13. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Wearables – just nice toys? ? ? ? ? Good medicine and good healthcare demand good information
  • 14. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Wearables – just nice toys? more data, (hopefully) more information more accurate diagnoses early detection of subtle changes, disease onset better, targeted treatment • Niilo Saranummis‘s 3 ‚P‘s: – pervasive technologies shall enable semantically interoperable platforms to communicate and store health data – personal services using sensor technologies for continuously measuring health-related data of an individual; to support her or him at specific health problems – personalized decision support adapted, ‘tuned’ to the individual’s norm, not to averages in populations (not one-size-fits- all) Saranummi N. IT applications for pervasive, personal, and personalized health. IEEE Trans Inf Technol Biomed. 2008; 12: 1-4.
  • 15. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Haux R et al.. Inform Health Soc Care. 2010 Sep-Dec;35(3- 4):92-103. PubMed PMID: 21133766.
  • 16. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Service classes • Basic services: – Emergency detection and alarm – Disease management (chronic diseases) – Health status feedback and advice • Other services: – Communication and social interaction – Support for daily life and activities – Entertainment, information and communication S. Koch et al. Methods Inf Med, 2009. Ludwig W et al. Comput Methods Programs Biomed. 2012, May;106(2):70-8.
  • 17. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Example: emergency detection – falls • Feldwieser F, Gietzelt M, Goevercin M, Marschollek M, Meis M, Winkelbach S, et al. Multimodal sensor-based fall detection within the domestic environment of elderly people. Z Gerontol Geriatr. 2014 Aug 12. PubMed PMID: 25112402. • Kangas M, Korpelainen R, Vikman I, Nyberg L, Jämsä T. Sensitivity and False Alarm Rate of a Fall Sensor in Long-Term Fall Detection in the Elderly. Gerontology. 2014 Aug 13.
  • 18. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Example: disease management • Whole System Demonstrator (WSD) study (UK): – Different chronic diseases (e.g. heart failure) – ‚Telehealth‘ intervention (oximeters, scales, glucometers, …) – Lower mortality and admission rates, higher cost – Steventon et al. BMJ 2012; 444:e3874 • NATARS study (Germany): – Geriatric home rehabilitation after mobility-impairing fractures – Wearable sensor, smart home sensors – Marschollek et al. Inform Health Soc Care. 2014 Sep;39(3- 4):262-71.
  • 19. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Example: early detection/ diagn., prevention • Fall risk assessment/ fall prediction: – medium-scale prospective studies, e.g. Greene et al, 2012, Gerontology; Marschollek et al, 2012, Meth Inf Med; Gietzelt et al, 2014, Inf Health Soc Care • Rehabilitation Monitoring/ relapse identification: – Steventon et al. BMJ 2012 (WSD study) – Marschollek M et al. Inform Health Soc Care. 2014 – Calliess et al. Sensors, 2014 • Physical activity promotion (Plischke et al. 2008) • Aftercare, paediatric liver TX patients (Marschollek et al. 2013) • …
  • 20. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Epidemiologic perspective: future diseases • increase of chronic diseases • increase of “age-related deficits” • decrease of health professionals • application areas: – cardiovascular diseases (e.g. congestive heart disease) – neuropsychiatric disorders (dementia, uni-/bipolar depressive disorders, anxiety disorder) – diabetes (and follow-up conditions) – musculoskeletal diseases (arthritis and esp. follow-up conditions (e.g. post-implant rehabilitation)) • but: this is only secondary/ tertiary source: Institute for Hea plthr eMveterincst iaondn E!valuation, healthmetricsandevaluation.org
  • 21. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Gaps and Pitfalls (subjective!) • Translating (diagnostic) knowledge into action • Lack of integration into health information systems, especially on semantic level (modeling) – E.g. Marschollek M. Inform Health Soc Care. 2009 • Psychological: – the right not to know – trust, security • and still: Device interoperability
  • 22. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices join our IMIA WG: www.wearable-sensors.org
  • 23. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Stefan von Cavallar Advisory Software Engineer, IBM Research Australia
  • 24. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices The title of Stefan von Cavallar’s Presentation will be: Mobile health: Solution requirements and challenges for scale-up
  • 25. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Mobile Health Benefits •Unprecedented opportunities •High growth usage in developing countries = health service delivery in regions where otherwise limited •Improved access to health services •Improved patient communication, ie. Reminders, Care plans •Monitoring of treatment compliance •And MORE… !
  • 26. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Mobile Health Solution Considerations • Health information privacy • Health information security • Standardization • Interoperability • Device fragmentation • Data fragmentation • Geography • Budgets $
  • 27. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Specifically... The exchange and collection of data from different systems and platforms will be… *Essential for users with multiple clinical requirements *Key to preventing further fragmentation between health programs
  • 28. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices What are we trying to solve? Consider this use case: •Mother, with daughter •Daughter sick for several days with lots of fluid loss •They know nearest medical health center is 60Km away, they have no transport •Both walk to health center, and wait for a further 24 hours until seen due to understaffing and high patient numbers •Assessment made, treatment given and returned home •Mother has no care plan or guidance on next steps What happens next?
  • 29. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices What do we want to do? 1. Improve health! How about the previous use-case becomes: • Mother, with daughter • Daughter sick for several days with lots of fluid loss • They know nearest medical health center is 60Km away, they have no transport • Mother uses mobile health credits to send message to a Cognitive Healthcare Hub where it is analyzed. Identify open questions to determine severity • Message sent back requesting additional information and includes guidance on how to gain that information (e.g. how to perform a pinch test) • Mother carries out tests and responds. Guidance is given to seek medical assistance in the nearest healthcare center. Details for the center are different to what the mother knows, its closer (8Km), but in a different direction…
  • 30. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices • Details of daughters condition are recorded and monitored via the Cognitive Healthcare Hub • At the health center social worked collect biometric data of waiting patients • Information collected and presented to physician for accelerated diagnosis • Information fed into Cognitive Healthcare Hub • Diagnosis and treatment options presented through the Cognitive Healthcare Hub to the healthcare worker. Support diagnosis by checking guidelines, hilight treatment options and assemble care plan • Daughter is being treated for diarrhea and dehydration • The Cognitive Healthcare Hub allows healthcare worker or physician to select a recommended care plan that the Hub has personalized for the daughters conditions • The mother is sent the care plan via wifi • Mother and daughter are discharged, complete with a take-home plan for on-going treatment • At points of time afterwards, the Hub sends out reminders and short enquiries to follow up and if necessary request that a health worker check on them
  • 31. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Solution Requirements The solution must engage: •A unified data view •Health information privacy •Health information security •Standardized •Interoperable •Defined device and data structure •The users and fulfil their use cases
  • 32. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Solution Requirements • Provide information collecting, learning and sharing infrastructure (ie, cognitive healthcare hub) • Include historical disease, climate and population data • Include continuous disease surveillance and drug consumption data • Learn from historical and continuous data • Two-way information flow • Mobile sensing (eg, occurrence of certain symptoms in a region) and multi-casting • Practitioner support (eg, recent weather condition and high number of reported infections with same symptoms in the region suggest particular diagnosis) • Value proposition • Support health workers and the need for diagnosis • Provide visibility and forecasting of disease outbreaks and drug demand supply • Enable macro-level priority setting and investment support • Monitor the ROI of health investments • Provide sustainable infrastructure for data collection and dissemination
  • 33. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Cognitive Healthcare Hub Interface Gateway Governments Interaction Communication Visualisation Mobile Internet Community Radio TV Statistics Modelling Cognitive Computing Analytics Machine Learning Simulation Prediction Business Intelligence Unified Data View Security Access Quality Environment Mobile Social Media Indigenous Knowledge Guidelines Publications Remote Sensors Registries
  • 34. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Watson: Question Answer Hospitals Deep Thunder: Climate Modeling Cognitive Healthcare Pharmacies Health Workers Community Health Centers Patients Prepare for patient increase Hub Optimized drug distribution Support untrained Advice for rare conditions STEM: Epidemiological Modeling Public Health Boards Optimized Resource Allocation
  • 35. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices
  • 36. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices GPS Healthcare worker entry Sensors Dehydration *Healthcare/trained worker only Visual inspection Skin pinch timer; App Blood viscosity; Infra-red sensors; camera modified* Image analytics on lips, eyes; camera; MMS Community General questioning Tests Diagnosis Aftercare Oral Zinc supplements Rehydration Salts Rehydration schedule Tracking; how? Reminders Local Push Treatment Calculate therapy Public Health Water supply analysis Pathogen outbreak Pathogen identification Individual App; decision tree Intravenous fluids
  • 37. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Challenges for Scale Up • Data Fragmentation/Distribution • Data inconsistencies • Education/Training i.e. Hardware, software • Differing working practices • Infrastructure, i.e. Easily no data reception • Costs, incentives and funding $$$$$ • Not everyone has the same level of access to technology
  • 38. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Summary – Implications and lessons learnt from this case study • Assume nothing… i.e. users with smartphones • While countries want the same thing, how they get there varies greatly… • Technology uptake is not always as easy or advanced as one might think • Infrastructure is not as mature as required • Limited funding/incentives available for adopting these technologies/infrastructures • Integrating the fragmented data
  • 39. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Summary – Requirements for successful redesign of healthcare systems • Everyone to want to contribute • Analytics engines using structured and unstructured data • A system that enables contributors and provides tailored data to consumers • Data consumption and feedback for improved analytics • Education and “buy-in”
  • 40. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Enablers for applications in research and potential clinical use: Standardised reporting guidelines in self-monitoring experiments Prof. Martin-Sanchez Melbourne Medical School
  • 41. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 41 Manager, Mobile Big Data Solutions IBM Research - Haifa B.A., M.Sc., Technion – Israel Institute of Technology Senior Researcher, IBM Research – Haifa Focus on leveraging state-of-the-art IT to solve industry pain points Mobile, Cloud, Big Data, Analytics Standards Interoperability HC/Wellness, Retail Prolific EU FP6, FP7 and H2020 research activities Yardena Peres
  • 42. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Research project funded by the EU (Nov 2013 - Oct 2016) • DAPHNE Consortium: – Sensor partners: Evalan, UPM – IT partners: IBM Research – Haifa, TreeLogic, Atos, SilverCloud – HC partners: Nevet, Bambino Gesu, University of Leeds, IASO • DAPHNE Objective: – Develop a novel IT platform for delivering personalized guidance services for lifestyle management (focused on reducing sedentariness) to the citizen/patient by means of: • Advanced sensors and mobile phones to acquire and store data on lifestyle aspects, behavior and surrounding environment • Individual models to monitor health and fitness status • Intelligent data processing for the recognition of behavioral trends and services for personalized guidance on healthy lifestyle and disease prevention • Use Case: – The system receives clinical parameters from the selected sensors, stores health markers, learns personal preferences, and generates feedback and recommendations. 42
  • 43. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Business aspects of insight-driven Personalized Health Services through Patient-Controlled Devices • Patient-Controlled Devices are generating large amounts of new data • This poses several IT challenges – Cope with large amounts of varied data while maintaining data quality – Connect with existing Healthcare Systems (e.g., EHR, HIS) – Handle security, privacy and consent management
  • 44. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Business aspects of insight-driven Personalized Health Services through Patient-Controlled Devices • Monetize data, e.g. Data as a Service (DaaS) Model – Patients generate new data – IT companies manage it – HC providers, Pharma, Payers, Retailers, Governments, Scientific Research, etc. consume it – All stakeholders are part of the same value-chain
  • 45. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Development of Temporal Context-based Feature Abstractions for Enabling Monitoring and Managing of Interventions MIE 2014 Pei-Yun Sabrina Hsueh Ke Yu Marina Akushevich Shweta Shama Peter Mooiweer Sreeram Ramakrishnan IBM GBS BAO/Watson Research
  • 46. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Technology barriers are lower than ever. A whole array of patient-controlled devices are on the rise…. fall sensor in a pocket adhesive vitals sensor 46 IBM Confidential stretch sensors gait analysis in a pocket vitals sensor in t-shirt insole sensors e-textile wireless ECG Cardiac monitoring systems Requires ultra-low power adaptive circuits, non-intrusive form factors OpenBCI
  • 47. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Significant growth in exogenous data poses challenges to existing BigData storage and analytics solutions Determinants of Health Outcomes Exogenous (Behavior, Socio-economic, 60 Environmental, ....) % Fitness/WellnessPatient-controlled medical devices Affinity (digital)Affinity (retail) Employ ment Socio-econo mic databa ses Data Sources Endogenous (-omics) 30 % Clinical (EMR) 10 % Exogenous Data Growing Fast 1240 PB 1800 PB 6800 PB (annu al) Episodic; care pathways in controlled settings Mostly static data, but critical for personalized medicine Significant volume (every step, heart rate, meals,….) and variety (physiological, psychological, socio-economic) and dynamic Data generation ~ uncontrolled environment !
  • 48. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices A perfect storm awaits….. Data Deluge from Patient-generated information
  • 49. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices 49 Patient generated information are effective for self-management and personalized intervention/adaptation Increase awareness to self-monitoring (Prestwich et al., 09; Burke et al., 05) Promoting behavioral change (Dietary intake: Burke et al., 05; Physical activity: Prestwich et al., 09; Michie et al., 09) Triggering reminders to care plans (Consolvo et al. 09; Hurling et al., 07) Personalizing communication messages and education materials (Thaler and Sustein, ‘08) Nudge: Improving Decisions About Health
  • 50. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Existing tools lack capabilities to determine appropriate metrics most sensitive to individuals • Especially true for those require artful interpretation of the temporal context of measurement – E.g., Hypertension = blood pressure; Diabetes = SMBG; Metabolic syndrome = weight, cholesterol level • Need new capability to calibrate intra-individual variability – E.g., Heart rate variability (HRV) detect abnormal symptoms of autonomic nervous system that are correlated with lethal arrhythmias – E.g., The variability of B-type natriuretic peptide (BNP)  detect cardiac ischemia • Barriers: – (1) No unifying theoretical models exists for enabling such interpretations – (2) The process from feature abstraction to individualized prognosis is non-trivial.
  • 51. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Data-driven Calibration and Personalization Process: From Population-based evidence to individualized alerting/adaptatio Population Data-driven Insight Feature Abstraction (Candidate feature generation) Complete feature set Feature Optimization 1 2 (Optimal set construction) Construction of features based on variance over time Analyze and select variance features from the complete set of constructed features Optimized Feature subset Identify input data sources from the optimal feature set and configure the input of data sources Feature 3 Population (data source configuration) Individual Data-driven Personalization Individual data captured based on input configuration Alert Setting (individual-based calibration) Individual-based alert Learning for Adaptation Slide 51 IBM CONFIDENTIAL Monitoring biomarker/patient-generated info operational DB EHR/PHR Repository Learn from baseline to understand normal variance and use the info to determine when to send alerts Verify if the selected abstraction is the right one for the individual according to the KPI. Create time gates events, triggers to check if the selected feature is the optimal one. Individually adapted plan (alert and intervention) 4 5 Verified feature set for the target individual
  • 52. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Enabling personalized temporal context interpretation by data-driven calibration and personalization • Need to streamline the process from population-based feature abstraction to individualization • Enable more effective monitoring and management of interventions Monitoring device Intra-individual variability calibration (evidence-based) • Service Scenarios: Input for monitoring feedback generation and diagnosis/intervention – 1. Development of adherence programs for patient self-management – 2. Enablement of intervention design for care coordinators/care givers – 3. Understanding efficacy for care givers to adapt suggested interventions for an individual – 4. Evidence-generation for intervention efficacy (population data)
  • 53. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Summary: Gaps observed in Service Design • The lack of reliable means to capture granular patient-generated data in non-clinical settings (user’s daily life contexts) – Leads to unreliable detection of inflection points, habit formation cycles and assessments of treatment efficacy. • Need for a framework to integrate analytical insights with feasible service models. – Progress impeded by the lack of modular design and data standardization in existing healthcare systems 53 IBM Confidential Customer/ Patient Adherence Theme #1 Theme #2 Theme #3 Personalization for risk stratification (from population to individual evidence) Personalization for in-context recommendation (from disease-centric to patient-centric) Personalization for adherence risk mitigation (from status-insensitive to status-sensitive)
  • 54. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Summary: New requirement of a modular framework to accelerate personalized service design Technologies to enhance wellness services – Guide the identification of customization points in clinical workflow and deployment of the Analytics and IM offerings – Create new tools and infrastructure for client engagements – Explore light-weight approach to connect the components (to prepare for future cloud offerings) New solutions and services – Bring together clients and researchers to understand clinical touch points – Demonstrate how to leverage customization points to engage users and possibly improve health literacy and outcomes Replicable patterns for patient engagement deployment – Create ETL procedures to be repeatedly use in other provider settings – Explore both hosted and internal deployment possibilities Plug-in for other tools – Create a recipe from data collection to summarization to customization to engagement to outcome measurement – Each component can be singled out as a standalone process for other tools
  • 55. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices MIE 2014 Workshop 510 W17 25 TUESDAY 17:00 - 18:30 Pei-Yun Sabrina Hsueh, Michael Marschollek, Yardena Peres, Stefan Von Cavallar, Fernando Martin Sanchez
  • 56. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Logistics • 17:00-17:15 Opening Remark • Key drivers and problems being addressed (Dr, Hsueh, IBM T.J. Watson Research) • 17:15-18:10 Presentations • Overview of service classes for health-enabling technologies for elderly and a physician’s view in relevant applications in the future (Prof. Marschollek, Hanover Medical School). • Enablers for successful development of mobile health solution– mobile health solution requirements and challenges for scaling up and realizing its full potential (Mr. von Cavallar, IBM Research Australia) • Enablers for applications in research and potential clinical use – the need for standardised reporting guidelines in self-monitoring experiments (Prof. Martin-Sanchez, Melbourne Medical School) • Business aspects of insight-driven Personalized Health Services through Patient-Controlled Devices (Dr. Peres, IBM Research Haifa) • Development of Temporal Context-based Feature Abstractions for Enabling Monitoring and Managing of Interventions (Dr. Hsueh) • 18:10-18:30 Workshop discussion (gap analysis, requirement gathering)/audience QA • 1. Implications and lessons learned from the case studies -- especially the gaps you perceived as barriers of entry • 2. Requirements for successful redesign of healthcare systems to accommodate patient-generated information (with a sub-goal of identifying the areas where such information can make most impacts). Please leave your email and questions (if any)….
  • 57. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Workshop Theme 1. Implications and lessons learned from the case studies -- especially the gaps you perceived as barriers of entry 2. Requirements for successful redesign of healthcare systems to accommodate patient-generated information (with a sub-goal of identifying the areas where such information can make most impacts). • Workflow – Knowledge actionable? – Integration – Lack of modular design • User – Right not to know, trust, security, consent management • Data – Fragmented, lack of EHR interoperability – Beyond big data, uncontrolled env. • Device – Interoperability, infrastructure • Service • Resource
  • 58. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Summary: Gap analysis and HC re-design requirement • Workflow – Lack of integration into health information systems, especially on semantic level (modeling) – Lack of modular design of existing healthcare system • User – Manage the right not to know, trust, security, consent – Assume nothing from the start – Country/Cultural differences • Device – Fragmentation ; Lack of interoperability – Immature infrastructure • Data – Fragmented data sources (need to integrate with EHR / HIS) – Ecosystem platform (enabling contributors, tailoring data to consumers) – Need to create personalization analytics framework (and engine) (data consumption feedback) – BigData: large amounts of varied data while maintaining data quality – Beyond Bigdata storage and processing, in uncontrolled env. – Beyond Bigdata analytics, in uncontrolled env. • Service – Touchpoint redesign to integrated Clinical/Wellness Service • Resource – Lack of funding/incentives
  • 59. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices More questions to think Suggestions on next step? • Do provider beliefs and support of these technologies and approaches affect patient usage? • Will patient interactive reported data improve provider and patient communications, reduce risks and increase early interventions? • Can adherence to care plans for patients with chronic health conditions be increased through technology-mediated techniques? • Can analytics based on patient characteristics and adherence behavior be used to identify patients at risk for adverse health events, as well as identify “model” adherers who are more effective than the average patient at remaining healthy? • Can dynamically configured software improve health outcomes for the patient and help control costs? • How will real time patient reported data shift communications, culture, care processes and the patient – provider partnership? Consider publishing our summary report in MEDINFO 2015? (any other venue?) A follow-up workshop/panel with a more focused theme on the gap and requirement perceived as priority?
  • 60. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Suggestions on next step? Traditional Chinese Thank You Merci Grazie Gracias Obrigado Danke English Japanese French Russian German Italian Spanish Arabic Brazilian Portuguese Simplified Chinese Hindi Tamil Thai Korean Hebrew
  • 61. Gap Analysis of Insight-Driven Personalized Health Services through Patient-Controlled Devices Questions?