SpectraCell Laboratories utilizes advanced technology and provides high quality service to physician clients to become a leader in innovative clinical testing that understands its ultimate responsibility is towards patient care. The document then discusses SpectraCell's micronutrient testing which measures the functional levels of vitamins, minerals, and other nutrients within white blood cells to provide a more accurate assessment of an individual's long term nutritional status compared to standard blood tests. This micronutrient testing allows physicians to tailor personalized treatment plans for their patients based on each patient's specific nutritional needs.

1. SpectraCell Laboratories has become the leader in innovative clinical testing by
utilizing the most advanced technology, providing the highest quality service to our
physician clients, and understanding the ultimate responsibility is towards patient care.
COMPREHENSIVE
A N A LY S I S
VITAMINS
50%
MINERALS
AMINO ACIDS
ANTIOXIDANTS of those
FATTY ACIDS taking supplements
METABOLITES will remain de cient.
CARBOHYDRATE
METABOLISM
Call 800.227.LABS (5227) or visit us online at www.SpectraCell.com

3. Micronutrient
Testing
Features and Bene ts
Uses active peripheral lymphocytes instead of serum
Measures the end point of DNA synthesis
Re ects nutrient status over the last 4-8 months
Micronutrient
Measures how micronutrients and antioxidants are actually functioning within the white blood cells
Testing Re ects total metabolic function rather than isolated biochemical pathways
Demonstrates the intracellular func tion of micronutrients simultaneously
Gives physicians the ability to tailor treatment plans to each patient’s speci c requirements rather than to “norms”
Provides a more accurate measurement of long term functional nutritional levels
Are host to cell-mediated immune system
Testing Possesses metabolic pathways common to other cells
Contains nucleus which permits rapi d DNA synthesis and cell growth
Lymphocytes
Measures DNA synthesis and cell growth
Are easily available in large numbers from a standard blood draw
Indicates if nutrients are being absorbed and functioning properly
Knowing nutritional risk factors and treating their causes can contribute to the arrest or prevention of many
Clinical degenerative conditions
Patients derive signi cant bene ts
Applications Measuring and correcting vitamin de ciencies are essential for patients concerned with wellness and anti-aging
Micronutrient testing provides important baseline tests to identify de ciencies
Allows physicians to get more sensitive and accurate nutritional reading
Measuring Functional
Provides long term status, not just an immediate snapshot
Levels Determines if the nutrient is being absorbed and functioning properly on the cellular level
Gives the physicians an overall informative cardiovascular program, not just a lab number
Tests for B6, B12,
Combines Micronutrient testing and HPLC methodology for Homocysteine
Folate & Examines the cellular function of each individual to nd out what is needed to x the homocysteine problem
Homocysteine and reduce risk, cardiovascular disease and stroke
Percentage gives a total antioxidant measurement, not just one or two speci c values
SPECTROX® - Measures ability of cells to withstand attack from free radicals and other oxidative stresses (antioxidant reserve)
Antioxidant Testing Allows for early intervention to correct de ciencies and promote health
Plays role in prevention and clinical treatment of a large variety of disease modalities
No refrigeration or freezing
Easy Sample
Complete test kit and transportation provided
Collection No centrifugation
© 2009 SpectraCell Laboratories Inc. All rights reserved. DOC 305 06.09
Visit us at www.spectracell.com or call us at 800.227.LABS ( 5227) ADVANCED CLINICAL TESTING

4. 123456 Jane Doe
Dr. John Smith
123 Main St
Anytown, USA
SAMPLE

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SAMPLE

6. Jane Doe
SAMPLE

7. Jane Doe
SAMPLE

8. Jane Doe
SAMPLE

9. Jane Doe
Jane Doe
SAMPLE

10. Jane Doe
Jane Doe
SAMPLE

11. Jane Doe
SAMPLE

12. Nutrient Deficiency
Functions Symptoms
NUTRIENT POTENTIAL WHAT IT DOES WHERE IT’S FOUND SYMPTOMS AND PROBLEMS
Antioxidant, regulates oxidation reactions, Wheat germ, liver, eggs, nuts, seeds, Skin, hair, rupturing of red blood cells,
VERY stabilizes cell membrane, immune function, cold - pressed vegetable oils, anemia, bruising, PMS, hot flashes,
VITAMIN E
COMMON protects against cardiovascular disease, dark leafy greens, sweet potatoes, avocados, eczema, psoriasis, cataracts, wound
cataracts, macular degeneration asparagus healing, muscle weakness, sterility
Bones, teeth, helps heart, nerves, muscles, Dairy, wheat/soy flour, molasses, Brewer’s Osteoporosis, osteomalacia, osteoarthritis,
VERY body systems work properly, needs other yeast, Brazil nuts, broccoli, cabbage, dark muscle cramps, irritability, acute anxiety,
CALCIUM
COMMON nutrients to function leafy greens, hazelnuts, oysters, sardines, colon cancer risk
canned salmon
Assists insulin function, increases fertility, Supplementation, Brewer’s yeast, whole Metabolic syndrome, insulin resistance,
CHROMIUM COMMON carbohydrate/fat metabolism, essential for grains, seafood, green beans, broccoli, decreased fertility
fetal growth/development prunes, nuts, potatoes, meat
300 biochemical reactions, muscle/nerve Green vegetables, beans, peas, nuts, Appetite, nausea, vomiting, fatigue cramps,
VERY function, heart rhythm, immune system, seeds, whole unprocessed grains numbness, tingling, seizures, heart spasms,
MAGNESIUM personality changes, heart rhythm
COMMON strong bones, regulates calcium, copper,
zinc, potassium, vitamin D
Antioxidant, works with vitamin E, immune Brewer’s yeast, wheat germ, liver, butter, Destruction to heart/pancreas, sore
function, prostaglandin production cold water fish, shellfish, garlic, whole muscles, fragility of red blood cells,
SELENIUM COMMON
grains, sunflower seeds, Brazil nuts immune system
Supports enzymes, immune system, wound Oysters, red meat, poultry, beans, nuts, Growth retardation, hair loss, diarrhea,
healing, taste/smell, DNA synthesis, normal seafood, whole grains, fortified breakfast impotence, eye & skin lesions, loss of
MOST
ZINC growth & development during pregnancy, cereals, dairy appetite, taste, weight loss, wound healing,
COMMON
childhood and adolescence mental lethargy
Powerful antioxidant, stops oxidation of LDL Oily fish, organ meats, whole grains Congestive heart failure, high blood
cholesterol, energy production, important to pressure, angina, mitral valve prolapse,
CO Q10 COMMON
heart, liver and kidneys fatigue, gingivitis, immune system stroke,
cardiac arrhythmias
Copyright © 2009 SpectraCell Laboratories DOC 303 MicroNutrient
Energy, heart function, oxidize amino acids Red meat, dairy, fish, poultry, tempeh Elevated cholesterol, liver function,
LESS
CARNITINE for energy, metabolize ketones (fermented soybeans), wheat, asparagus, muscle weakness, reduced energy,
COMMON
avocados, peanut butter impaired glucose control
N - ACETYL Glutathione production, lowers Meats, ricotta, cottage cheese, yogurt, Free radical overload, elevated
CYSTEINE (NAC) homocysteine, lipoprotein (a), heal lungs, wheat germ, granola, oat flakes homocysteine, cancer risk, cataracts,
MOST inflammation, decrease muscle fatigue, liver macular degeneration, immune function,
&
COMMON detoxification, immune function toxin elimination
GLUTATHIONE
Energy, blood flow to nerves, glutathione Supplementation, spinach, broccoli, beef, Diabetic neuropathy, reduced muscle mass,
ALPHA LIPOIC
COMMON levels in brain, insulin sensitivity, Brewer’s yeast, some organ meats atherosclerosis, Alzheimer’s, failure to thrive,
ACID
effectiveness of vitamins C, E, antioxidants brain atrophy, high lactic acid
Bone formation, involved in healing process, Oysters, seeds, dark leafy vegetables, Osteoporosis, anemia, baldness, diarrhea,
LESS energy production, hair and skin coloring, organ meats, dried legumes, whole grain general weakness, impaired respiratory
COPPER
COMMON taste sensitivity, stimulates iron absorption, breads, nuts, shellfish, chocolate, soybeans, function, myelopathy, decreased skin
helps metabolize several fatty acids oats, blackstrap molasses pigment, reduced resistance to infection
WWW.SPECTRACELL.COM

13. Nutrient Deficiency
Functions Symptoms
NUTRIENT POTENTIAL WHAT IT DOES WHERE IT’S FOUND SYMPTOMS AND PROBLEMS
Carb. conversion, breaks down fats & Pork, organ meats, whole grain and Heart, age-related cognitive decline,
VERY
VITAMIN B1 protein, digestion, nervous system, skin, hair, enriched cereals, brown rice, wheat germ, Alzheimer’s, fatigue
COMMON eyes, mouth, liver, immune system bran, Brewer’s yeast, blackstrap molasses
Metabolism, carb. conversion, breaks down Brewer’s yeast, almonds, organ meats, Anemia, decreased free radical protection,
VERY
VITAMIN B2 fats & protein, digestion, nervous system, whole grains, wheat germ, mushrooms, soy, cataracts, poor thyroid function, B6
COMMON
skin, hair, eyes, mouth, liver dairy, eggs, green vegetables deficiency, fatigue, elevated homocysteine
Energy, digestion, nervous system, skin, Beets, Brewer’s yeast, meat, poultry, organ Cracking, scaling skin, digestive problems,
LESS
VITAMIN B3 hair, eyes, liver, eliminates toxins, sex/stress meats, fish, seeds, nuts confusion, anxiety, fatigue
COMMON
hormones, improves circulation
Enzyme, protein metabolism, RBC Poultry, tuna, salmon, shrimp, beef liver, Depression, sleep and skin problems,
production, reduces homocysteine, nerve lentils, soybeans, seeds, nuts, avocados, confusion, anxiety, fatigue
VITAMIN B6 COMMON
& muscle cells, DNA/RNA, B12 absorption, bananas, carrots, brown rice, bran, wheat
immune function germ, whole grain flour
Healthy nerve cells, DNA/RNA, red blood Fish, meat, poultry, eggs, milk, Anemia, fatigue, constipation, loss of
VERY cell production, iron function milk products appetite/weight, numbness and tingling in
VITAMIN B12
COMMON the hands and feet, depression, dementia,
poor memory, oral soreness
Carbs, fat, amino acid metabolism (the Salmon, meats, vegetables, grains, legumes, Depression, nervous system, premature
LESS building blocks of protein) lentils, egg yolks, milk, sweet potatoes, graying, hair, skin
BIOTIN seeds, nuts, wheat germ
COMMON
Mental health, infant DNA/RNA, Supplementation, fortified grains, tomato Anemia, immune fuction, fatigue, insomnia,
VERY adolescence & pregnancy, with B12 to juice, green vegetables, black-eyed peas, hair, high homocysteine, cardiovascular
FOLATE
COMMON regulate RBC production, iron function, lentils, beans disease
reduce homocysteine
RBC production, sex and stress-related Meat, vegetables, whole grains, legumes, Stress tolerance, wound healing, skin
Copyright © 2009 SpectraCell Laboratories DOC 303 MicroNutrient
LESS
PANTOTHENATE hormones, immune function, healthy lentils, egg yolks, milk, sweet potatoes, problems, fatigue
COMMON
digestion, helps use other vitamins seeds, nuts, wheat germ, salmon
LESS Eyes, immune function, skin, essential cell Milk, eggs, liver, fortified cereals, orange or Night blindness, immune function, zinc
VITAMIN A
COMMON growth and development green vegetables, fruits deficiency, fat malabsorption
Enzyme activation, second messenger roles Supplemention, broccoli, brussel sprouts, Muscular and nervous irritability, muscle
(transmitting hormonal information), blood cantaloupe, cauliflower, citrus, guava, kiwi, spasms, muscle cramps and tetany, tooth
VITAMIN C COMMON clotting, cell and cell organelle membrane papaya, parsley, peas, potatoes, peppers, decay, periodontal disease, depression,
function, nerve impulse transmission and parsley, rose hips, strawberries and tomatoes possibly hypertension
muscular contraction, tone and irritability
VERY Calcium and phosphorus levels, calcium Sunlight, milk, egg yolks, liver, fish Osteoporosis, calcium absorption, thyroid
VITAMIN D
COMMON absorption, bone mineralization
Aids in the formation of clotting factors and Kale, green tea, turnip greens, spinach, Excessive bleeding, a history of bruising,
LESS bone proteins and the formation of glucose broccoli, lettuce, cabbage, beef liver, appearance of ruptured capillaries or
VITAMIN K
COMMON into glycogen for storage in the liver asparagus, watercress, cheese, oats, peas, menorrhagia (heavy periods)
whole wheat
WWW.SPECTRACELL.COM

14. Do the Prescriptions You Take
Deplete Your Nutritional Status?
SOURCE: DRUG-INDUCED NUTRIENT DEPLETION HANDBOOK, 2ND EDITION
NUTRIENT
DRUG DEFICIENCY POTENTIAL HEALTH PROBLEM
ANTACIDS/ULCER MEDICATIONS Vitamin B12 Anemia, depression, tiredness, weakness, increased cardiovascular risk
Pepcid, Tagamet, Zantac, Prevacid, Folic Acid Birth defects, cervical dysplasia, anemia, heart disease, cancer risk
Prilosec, Magnesium & Aluminum Vitamin D Osteoporosis, muscle weakness, hearing loss
antacids Calcium Osteoporosis, heart and blood pressure irregularities, tooth decay
Iron Anemia, weakness, fatigue, hair loss, brittle nails
Zinc Weak immunity, wound healing, sense of smell/taste, sexual dysfunction
ANTIBIOTICS B Vitamins Short term depletio ects are minimal, but failure to re-inoculate the
Gentomycin, neomycin,streptomycin, Vitamin K GI tract with bene cial bacteria (probiotics) often results in dysbiosis which
cephalosporins, penicillins causes gas, bloating, decreases digestion & absorption of nutrients, and also
may lead to a variety of other health problems.
Tetracyclines Calcium Osteoporosis, heart & blood pressure irregularities, tooth decay
Magnesium Cardiovascular problems, asthma, osteoporosis, cramps, PMS
Iron Slow wound healing, fatigue, anemia
Vitamin B6 Depression, sleep disturbance, increased cardiovascular disease risk
Zinc Weak immunity, wound healing, sense of smell/taste, sexual dysfunction
CHOLESTEROL DRUGS Coenzyme Q10 Various cardiovascular problems, weak immune system, low energy
Lipitor, Crestor, Zocor, and others
ANTI-DEPRESSANTS Coenzyme Q10 Various cardiovascular problems, weak immune system, low energy
Adapin, Aventyl, Elavil, Pamelor, Vitamin B2 Problems with skin, eyes, mucous membranes and nerves
& others
Major Tranquilizers (Thorazine,
Mellaril, Prolixin, Serentil & others)
FEMALE HORMONES Vitamin B6 Depression, sleep disturbance, increased cardiovascular disease risk
Oral Estrogen/Hormone Replacement
Oral Contraceptives Folic Acid Birth defects, cervical dysplasia, anemia, cardiovascular disease
Vitamin B1 Depression, irritability, memory loss, muscle weakness, edema
Vitamin B2 Problems with skin, eyes, mucous membranes and nerves
Vitamin B3 Cracked, scaly skin, swollen tongue, diarrhea
Vitamin B6 Depression, sleep disturbances, increased cardiovascular disease risk
Vitamin B12 Anemia, depression, tiredness, weakness, increased cardiovascular risk
Vitamin C Lowered immune system, easy bruising, poor wound healing
Magnesium Cardiovascular problems, asthma, osteoporosis, cramps, PMS
Selenium Lower immunity, reduced antioxidant protection
Zinc Weak immunity, wound healing, sense of smell/taste, sexual dysfunction
ANTICONVULSANTS Vitamin D Osteoporosis, muscle weakness, hearing loss
Phenobarbital & barbituates Calcium Osteoporosis, heart & blood pressure irregularities, tooth decay
Folic Acid Birth defects, cervical dysplasia, anemia, cardiovascular disease
Dilatin, Tegretol, Mysoline
Biotin Hair loss, depression, cardiac irregularities, dermatitis
Depakane/Depacon
Carnitine Various cardiovascular problems, weak immune system, low energy
Vitamin B12 Anemia, depression, tiredness, weakness, increased cardiovascular risk
Vitamin B1 Depression, irritability, memory loss, muscle weakness, edema
Vitamin K Blood coagulation, skeletal problems
Copper Anemia, fatigue, cardiovascular and connective tissue problems
Selenium Lower immunity, reduced antioxidant protection
Zinc Weak immunity, wound healing, sense of smell/taste, sexual dysfunction
Copyright © 2010 SpectraCell Laboratories DOC 306
Copyright © 2008 SpectraCell Laboratiores, Inc. All Rights Reserved. FIA 306 - 12.08 03.10
ADVANCED CLINICAL TESTING
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15. Do the Prescriptions You Take
Deplete Your Nutritional Status?
SOURCE: DRUG-INDUCED NUTRIENT DEPLETION HANDBOOK, 2ND EDITION
NUTRIENT
DRUG DEFICIENCY POTENTIAL HEALTH PROBLEM
ANTI-INFLAMMATORIES Calcium Osteoporosis, heart and blood pressure irregularities, tooth decay
Corticosteriods: Prednisone, Medrol, Vitamin D Osteoporosis, muscle weakness, hearing loss
Aristocort, Decodron Magnesium Cardiovascular problems, asthma, osteoporosis, cramps, PMS
Zinc Weak immunity, wound healing, sense of smell/taste, sexual dysfunction
Vitamin C Lowered immunity, easy bruising, poor wound healing
Vitamin B6 Depression, sleep disturbances, increased cardiovascular disease risk
Vitamin B12 Anemia, depression, tiredness, weakness, increased cardiovascular risk
Folic Acid Birth defects, cervical dysplasia, anemia, cardiovascular disease
Selenium Lower immunity, reduced antioxidant protection
Chromium Elevated blood sugar, cholesterol & triglycerides, diabetes risk
NSAIDS (Motrin, Aleve, Advil, Anaprox, Folic Acid Birth defects, cervical dysplasia, anemia, cardiovascular disease
Dolobid, Feldene, Naprosyn and others
Aspirin & Salicylates Vitamin C Lowered immune system, easy bruising, poor wound healing
Calcium Osteoporosis, heart & blood pressure irregularities, tooth decay
Folic Acid Birth defects, cervical dysplasia, anemia, cardiovascular disease
Iron Anemia, weakness, fatigue, hair loss, brittle nails
Vitamin B5 fatigue, listlessness, and possible problems with skin, liver and nerves
DIURETICS Calcium Osteoporosis, heart and blood pressure irregularities, tooth decay
Loop Diuretics (Lasix, Bumex, Magnesium Cardiovascular problems, asthma, osteoporosis, cramps, PMS
Edecrin) Vitamin B1 Depression, irritability, memory loss, muscle weakness, edema
Thiazid Diuretics (HCTZ, Enduron, Vitamin B6 Depression, sleep disturbance, increased heart disease risk
Diuril, Lozol, Zaroxolyn, Hygroton Vitamin C Lowered immunity, easy bruising, poor wound healing
and others Zinc Weak immunity, wound healing, sense of smell/taste, sexual dysfunction
Coenzyme Q10 Various cardiovascular problems, weak immune system, low energy
Potassium Irregular heartbeat, muscle weakness, fatigue, edema
Sodium Muscle weakness, dehydration, memory problems, loss of appetite
Potassium Sparing Diuretics Calcium Osteoporosis, heart & blood pressure irregularities, tooth decay
Folic Acid Birth defects, cervical dysplasia, anemia, cardiovascular disease
Zinc Weak immunity, wound healing, sense of smell/taste, sexual dysfunction
CARDIOVASCULAR DRUGS Coenzyme Q10 Various cardiovascular problems, weak immune system, low energy
Antihypertensives (Catapres, Vitamin B6 Depression, sleep disturbance, increased cardiovascular disease risk
Aldomet) Zinc Weak immunity, wound healing, sense of smell/taste, sexual dysfunction
Vitamin B1 Depression, irritability, memory loss, muscle weakness, edema
ACE Inhibitors (Capoten, Vasotec, Zinc Weak immunity, wound healing, sense of smell/taste, sexual dysfunction
Monopril & others)
Bete Blockers (Inderal, Corgard, Coenzyme Q10 Various cardiovascular problems, weak immune system, low energy
Lopressor and others)
DIABETIC DRUGS Coenzyme Q10 Various cardiovascular problems, weak immune system, low energy
Metformin Vitamin B12 Anemia, depression, tiredness, weakness, increased cardiovascular risk
Folic Acid Birth defects, cervical dysplasia, anemia, heart disease, cancer risk
Sulfonylureas (Dymelor, Tolinase, Coenzyme Q10 Various cardiovascular problems, weak immune system, low energy
Micronase/Glynase/DiaBeta)
ANTIVIRAL AGENTS Carnitine Increased blood lipids, abnormal liver function and glucose control
Zidovudine (Retrovir, AZT & other Copper Anemia, fatigue, cardiovascular and connective tissue problems
related drugs) Zinc Weak immunity, wound healing, sense of smell/taste, sexual dysfunction
Vitamin B12 Anemia, depression, tiredness, weakness, increased cardiovascular risk
Foscarnet Calcium Osteoporosis, heart and blood pressure irregularities, tooth decay
Magnesium Cardiovascular problems, asthma, osteoporosis, cramps, PMS
Potassium Irregular heartbeat, muscle© 2007 SpectraCell Laboratiores, Inc. All Rights Reserved.
Copyright
weakness, fatigue, edema
Copyright © 2008 SpectraCell Laboratiores, Inc. All Rights Reserved. FIA 306 - 02.08
Copyright © 2010 SpectraCell Laboratories DOC 306 03.10
Visit usus at www.spectracell.com or call us at 800.227.LABS ( 5227)
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ADVANCED CLINICAL TESTIN G

16. Diagnosis Codes
To prevent denials, when billing third party payors, all requisitions must include all medically necessary ICD-9 diagnosis codes. ICD-9 codes are required by
certain third party payors to confirm the medical necessity of the test(s), and/or profile(s) ordered. The codes listed below are some of the most commonly
received codes for testing performed at SpectraCell Laboratories. These were taken from the 2008 ICD-9 manual issued by AMA. While this list may be
a useful tool, depending upon the nature of your practice, it is not complete. Please refer to the ICD-9 manual for a complete listing. The ultimate responsibility
for correct coding lies with the ordering physician. Please place all medically appropriate ICD-9 codes on the requisition. If ordering for screening purposes,
please provide the appropriate screening ICD-9 codes.
CODE DIAGNOSIS (SYMPTOMS, ILLNESS, INJURY OR COMPLAINT) CODE DIAGNOSIS (SYMPTOMS, ILLNESS, INJURY OR COMPLAINT)
781.0 Abnormal involuntary movements 401.1 Essential hypertension, benign
276.2 Acidosis 401.9 Essential hypertension, unspecified
253.0 Acromegaly and gigantism 345.00 Generalized no convulsive epilepsy
293.0 Acute delirium 240.9 Goiter, unspecified
535.00 Acute gastritis 784.0 Headache
461.1 Acute sinisitis, frontal 786.3 Hemoptysis
436 Acute, but ill-defined, cerebrovascular disease 789.1 Hepatomegaly
288.0 Agranulocytosis 272.4 Hyperlipidemia, other and unspecified
477.9 Allergic rhinitis, cause unspecified 600.00 Hyperplasia of prostate (additional code required to identify urinary
incontinence)
995.3 Allergy, unspecified
621.2 Hypertrophy of uterus
704.00 Alopecia, unspecified
244.9 Hypothyroidism, unspecified
314.01 Attention deficit disorder, with hyperactivity
279.3 Immunity deficiency, unspecified
088.82 Babesiosis
279.10 Immunodeficiency with predominant T-cell defect, unspecified
353.0 Brachial plexus lesions
607.84 Impotence of organic origin
490 Bronchitis, not specified as acute of chronic
075 Infectious mononucleosis
112.85 Candidal enteritis
711.90 Infective arthritis, unspecified
112.9 Candidiasis, of unspecified site
564.1 Irritable bowel syndrome
354.0 Carpal tunnel syndrome
218.9 Leiomyoma of uterus, unspecified
447.4 Celiac artery compression syndrome
088.81 Lyme disease
579.0 Celiac disease
174.9 Malignant neoplasm, of female breast, unspecified
496 Chronic airway obstruction, not elsewhere classified
174.4 Malignant neoplasm of female breast, upper-outer quadrant
780.71 Chronic fatigue syndrome
996.54 Mechanical complication of other specified prosthetic device, implant, and
245.2 Chronic lymphocytic thyroiditis graft, due to breast prosthesis
472.0 Chronic rhinitis 780.93 Memory disturbance, loss or lack
346.00 Classical migraine, without mention of intractable migraine 269.3 Mineral deficiency, unspecified
414.01 Coronary atherosclerosis, of native coronary artery 729.1 Myalgia and myositis, unspecified
255.4 Corticoadrenal insufficiency 269.9 Nutritional deficiency, unspecified
277.00 Cystic Fibrosis
491.21 Obstructive chronic bronchitis, with acute exacerbation
269.1 Deficiency of other vitamins
796.4 Abnormal clinical findings - other
250 Diabetes mellitus
250.0 Diabetes without complications 266.2 B-complex deficiency - other
250.0 O type II or unspecified type, not stated as uncontrolled 780. 79 Malaise and fatigue - other
250.1 1 type I (juvenile type), not stated as uncontrolled 269.8 Nutritional deficiency - other
250.2 2 type II or unspecified type, uncontrolled 277.89 Specified disorders of metabolism - other
250.3 3 type I (juvenile type), uncontrolled 281.1 Vitamin B12 deficiency anemia - other
250.00 Diabetes mellitus without mention of complication 719.44 Pain in joint, hand
250.10 Diabetes with ketocidosis 719.48 Pain in joint, other specified sites Copyright © 2007 SpectraCell Laboratories DOC 309FIA
250.20 Diabetes with hyperosmolarity
786.52 Painful respiration
250.30 Diabetes with other coma
486 Pneumonia, unspecified
250.40 Diabetes with renal manifestations
272.0 Pure hypercholesterolemia
250.50 Diabetes with ophthalmic manifestations
250.60 Diabetes with neurological manifestations 753.0 Renal agenesis and dysgenesis
250.70 Diabetes with peripheral circulatory disorders 786.05 Shortness of breath
250.80 Diabetes with other specified manifestations 780.2 Syncope and collapse
250.90 Diabetes with unspecified complication 786.06 Tachypnea
311 Depressive disorder, not elsewhere classified 985.9 Toxic effect of other metals, unspecified metal
272.9 Disorder of metabolism, unspecified 785.2 Undiagnosed cardiac murmurs
781.1 Disturbances of sensation of smell and taste 266.1 Vitamin B6 deficiency
270.4 Disturbances of sulphur-bearing amino-acid metabolism 269.2 Vitamin deficiency, unspecified
786.09 Dyspnea and respiratory abnormalities, other
782.3 Edema
259.9 Endocrine disorder, unspecified
356.9 ADVANCED CLINICAL TESTING
Visit usHereditary and idiopathic peripheral neuropathy, unspecified
at www.spectracell.com or call us at 800.227.5227

17. SPECTRACELL LABORATORIES
ADVANCED CLINICAL TESTING
Product Tools
VIDEOS
DR. WILDER
LOOP VIDEO
327 309 335 306
Are you spending a Diagnosis Codes Do the Prescriptions You Take
303
fortune on all of these? To prevent denials when billing third party payors, all requisitions must include all medically necessary ICD-9 diagnosis codes. ICD-9 codes are required by
certain third party payors to confirm the medical necessity of the test(s), and/or profile(s) ordered. The codes listed below are some of the most commonly
received codes for testing performed at SpectraCell Laboratories. These were taken from the 2008 ICD-9 manual issued by AMA. While this list may be
If only an apple a day Deplete Your Nutritional Status?
SOURCE: DRUG-INDUCED NUTRIENT DEPLETION HANDBOOK, 2ND EDITION
was really enough.
a useful tool, depending upon the nature of your practice, it is not complete. Please refer to the ICD-9 manual for a complete listing. The ultimate responsibility NUTRIENT
You may not have to.
for correct coding lies with the ordering physician. Please place all medically appropriate ICD-9 codes on the requisition. If ordering for screening purposes, DRUG DEFICIENCY POTENTIAL HEALTH PROBLEM
please provide the appropriate screening ICD-9 codes.
ANTACIDS/ULCER MEDICATIONS Vitamin B12 Anemia, depression, tiredness, weakness, increased cardiovascular risk
CODE DIAGNOSIS (SYMPTOMS, ILLNESS, INJURY OR COMPLAINT) CODE DIAGNOSIS (SYMPTOMS, ILLNESS, INJURY OR COMPLAINT) Pepcid, Tagamet, Zantac, Prevacid, Folic Acid Birth defects, cervical dysplasia, anemia, heart disease, cancer risk
781.0 Abnormal involuntary movements 401.1 Essential hypertension, benign Prilosec, Magnesium & Aluminum Vitamin D Osteoporosis, muscle weakness, hearing loss
276.2 Acidosis 401.9 Essential hypertension, unspecified antacids Calcium Osteoporosis, heart and blood pressure irregularities, tooth decay
253.0 Acromegaly and gigantism 345.00 Generalized no convulsive epilepsy Iron Anemia, weakness, fatigue, hair loss, brittle nails
Ocular Health - Heart Health - 293.0 Acute delirium 240.9 Goiter, unspecified Zinc Weak immunity, wound healing, sense of smell/taste, sexual dysfunction
Good eyesight and prevention of Nutrients that protect the cardiovascular 535.00 Acute gastritis 784.0 Headache
cataracts and macular degeneration system include Vitamin B6, Vitamin B12, 461.1 Acute sinisitis, frontal 786.3 Hemoptysis ANTIBIOTICS B Vitamins Short term depletion affects are minimal, but failure to re-inoculate the NUTRIENT POTENTIAL WHAT IT DOES WHERE IT’S FOUND SYMPTOMS AND PROBLEMS
require adequate levels of Folic Acid, Vitamin E, CoQ10, Calcium, 436 Acute, but ill-defined, cerebrovascular disease 789.1 Hepatomegaly Gentomycin, neomycin,streptomycin, Vitamin K GI tract with beneficial bacteria (probiotics) often results in dysbiosis which
Vitamin E and Vitamin A. Magnesium and Carnitine. 288.0 Agranulocytosis 272.4 Hyperlipidemia, other and unspecified cephalosporins, penicillins causes gas, bloating, decreases digestion & absorption of nutrients, and also Antioxidant, regulates oxidation reactions,
Wheat germ, liver, eggs, nuts, seeds, cold-
Skin, hair, rupturing of red blood cells,
477.9 Allergic rhinitis, cause unspecified 600.00 Hyperplasia of prostate (additional code required to identify urinary may lead to a variety of other health problems. VERY stabilizes cell membrane, immune function, anemia, bruising, PMS, hot flashes,
VITAMIN E pressed vegetable oils, dark leafy greens,
50%
995.3 Allergy, unspecified
621.2
incontinence)
Hypertrophy of uterus
Research has shown that Tetracyclines Calcium Osteoporosis, heart & blood pressure irregularities, tooth decay
COMMON protects against cardiovascular disease,
cataracts, macular degeneration
sweet potatoes, avocados, asparagus
eczema, psoriasis, cataracts, wound
healing, muscle weakness, sterility
Bone Health - 704.00 Alopecia, unspecified
244.9 Hypothyroidism, unspecified
Magnesium Cardiovascular problems, asthma, osteoporosis, cramps, PMS
Cardiovascular Support - Vitamin D, Vitamin B6, Vitamin B12, Folic Acid, 314.01 Attention deficit disorder, with hyperactivity
279.3 Immunity deficiency, unspecified
Iron Slow wound healing, fatigue, anemia Dairy, wheat/soy flour, molasses, Brewer's
Bones, teeth, helps heart, nerves, muscles, Osteoporosis, osteomalacia, osteoarthritis,
Vitamin B2, Vitamin B6, Vitamin B12 and Calcium, Magnesium and Zinc are all nutrients that 088.82 Babesiosis
279.10 Immunodeficiency with predominant T-cell defect, unspecified
Vitamin B6 Depression, sleep disturbance, increased cardiovascular disease risk
CALCIUM
VERY
body systems work properly, needs other
yeast, Brazil nuts, broccoli, cabbage, dark
muscle cramps, irritability, acute anxiety,
Folic Acid are all required for reducing assist in bone remodeling, to ward off osteoporosis 353.0 Brachial plexus lesions
607.84 Impotence of organic origin
Zinc Weak immunity, wound healing, sense of smell/taste, sexual dysfunction COMMON
nutrients to function
leafy greens, hazelnuts, oysters, sardines,
colon cancer risk
and other diseases that weaken the skeletal system. canned salmon
homocysteine levels in the blood and 490 Bronchitis, not specified as acute of chronic
075 Infectious mononucleosis Various cardiovascular problems, weak immune system, low energy
CHOLESTEROL DRUGS Coenzyme Q10
protecting arteries and nerve fibers. 112.85 Candidal enteritis
711.90 Infective arthritis, unspecified Lipitor, Crestor, Zocor, and others Assists insulin function, increased fertility, Supplementation, Brewer’s yeast, whole
112.9 Candidiasis, of unspecified site Metabolic syndrome, insulin resistance,
564.1 Irritable bowel syndrome CHROMIUM COMMON carbohydrate/fat metabolism, essential for grains, seafood, green beans, broccoli,
354.0 Carpal tunnel syndrome decreased fertility
447.4 Celiac artery compression syndrome
218.9 Leiomyoma of uterus, unspecified of those taking multivitamins ANTI-DEPRESSANTS Coenzyme Q10 Various cardiovascular problems, weak immune system, low energy
fetal growth/development prunes, nuts, potatoes, meat
088.81 Lyme disease
579.0 Celiac disease
174.9 Malignant neoplasm, of female breast, unspecified ARE STILL DEFICIENT Adapin, Aventyl, Elavil, Pamelor,
& others
Vitamin B2 Problems with skin, eyes, mucous membranes and nerves 300 biochemical reactions, muscle/nerve Appetite, nausea, vomiting, fatigue , cramps,
VERY function, heart rhythm, immune system, Green vegetables, beans, peas, nuts, numbness, tingling, seizures, heart spasms,
Metabolic Health - 496 Chronic airway obstruction, not elsewhere classified
174.4 Malignant neoplasm of female breast, upper-outer quadrant MAGNESIUM
Vitamin B3, Vitamin B6, Vitamin B12 Vitamin Liver Health - 780.71 Chronic fatigue syndrome
996.54 Mechanical complication of other specified prosthetic device, implant, and
Major Tranquilizers (Thorazine,
Mellaril, Prolixin, Serentil & others)
COMMON strong bones, regulates calcium, copper,
zinc, potassium, vitamin D
seeds, whole unprocessed grains personality changes, heart rhythm
E, Biotin, CoQ10, Chromium, Magnesium and Cysteine and N-Acetyle Cysteine, Selenium, 245.2 Chronic lymphocytic thyroiditis graft, due to breast prosthesis
Zinc all help the body handle daily sugar Vitamin B2 and Vitamin B3 enhance liver 472.0 Chronic rhinitis 780.93 Memory disturbance, loss or lack Brewer's yeast, wheat germ, liver, butter, Destruction to heart/pancreas, sore
FEMALE HORMONES Vitamin B6 Depression, sleep disturbance, increased cardiovascular disease risk Antioxidant, works with vitamin E, immune
load, keeping systems responsive to insulin function and optimize levels of glutathione 346.00 Classical migraine, without mention of intractable migraine 269.3 Mineral deficiency, unspecified
Estrogen/Hormone Replacement SELENIUM COMMON cold water fish, shellfish, garlic, whole muscles, fragility of red blood cells,
function, prostaglandin production
and restoring lost insulin sensitivity. which helps cells fight off toxic challenges. 414.01 Coronary atherosclerosis, of native coronary artery 729.1 Myalgia and myositis, unspecified grains, sunflower seeds, Brazil nuts immune system
255.4 Corticoadrenal insufficiency Oral Contraceptives Folic Acid Birth defects, cervical dysplasia, anemia, cardiovascular disease
269.9 Nutritional deficiency, unspecified
277.00 Cystic Fibrosis Vitamin B1 Depression, irritability, memory loss, muscle weakness, edema Supports enzymes, immune system, wound Growth retardation, hair loss, diarrhea,
491.21 Obstructive chronic bronchitis, with acute exacerbation Oysters, red meat, poultry, beans, nuts,
269.1 Deficiency of other vitamins Vitamin B2 Problems with skin, eyes, mucous membranes and nerves MOST healing, taste/smell, DNA synthesis, normal impotence, eye & skin lesions, loss of
796.4 Abnormal clinical findings - other ZINC seafood, whole grains, fortified breakfast
250 Diabetes mellitus Vitamin B3 Cracked, scaly skin, swollen tongue, diarrhea COMMON growth & development during pregnancy, appetite, taste, weight loss, wound
cereals, dairy
FIND OUT Status -
Antioxidant AVAILABLE AT Joint Support - 250.0 Diabetes without complications 266.2 B-complex deficiency - other
Vitamin B6 Depression, sleep disturbances, increased cardiovascular disease risk childhood, adolescence healing, mental lethargy
Measures the nutrients that help Vitamin E, Alpha-Lipoic Acid and 250.0
250.1
O type II or unspecified type, not stated as uncontrolled
1 type I (juvenile type), not stated as uncontrolled
780. 79
269.8
Malaise and fatigue - other
Nutritional deficiency - other
Ask your doctor today about a simple Vitamin B12 Anemia, depression, tiredness, weakness, increased cardiovascular risk
Congestive heart failure, high blood
Lowered immune system, easy bruising, poor wound healing
B Vitamins all contribute to joint support comprehensive blood test to analyze vitamins,
Vitamin C Powerful antioxidant, stops oxidation of LDL
prevent or repair cellular damage pressure, angina, mitral valve prolapse,
TODAY by oxidation.
250.2 2 type II or unspecified type, uncontrolled 277.89 Specified disorders of metabolism - other Cardiovascular problems, asthma, osteoporosis, cramps, PMS
and controlling inflammation. Magnesium COQ10 COMMON cholesterol, energy production, important to Oily fish, organ meats, whole grains
caused 250.3 3 type I (juvenile type), uncontrolled fatigue, gingivitis, immune system stroke,
minerals and nutrients vital to your well being.
Copyright © 2009 SpectraCell Laboratories DOC 303-01.09
281.1 Vitamin B12 deficiency anemia - other Selenium Lower immunity, reduced antioxidant protection heart, liver and kidneys
250.00 Diabetes mellitus without mention of complication cardiac arrhythmias
719.44 Pain in joint, hand Zinc Weak immunity, wound healing, sense of smell/taste, sexual dysfunction
Copyright © 2009 SpectraCell Laboratories DOC 309-01.09
250.10 Diabetes with ketocidosis
WITH THE Address 250.20 Diabetes with hyperosmolarity
719.48
786.52
Pain in joint, other specified sites
Painful respiration ANTICONVULSANTS Vitamin D Osteoporosis, muscle weakness, hearing loss CARNITINE
LESS Energy, heart function, oxidize amino acids
Red meat, dairy, fish, poultry, tempeh
(fermented soybeans), wheat, asparagus,
Elevated cholesterol, liver function,
muscle weakness, reduced energy,
250.30 Diabetes with other coma COMMON for energy, metabolize ketones
SPECTROX® measures the total
URL MicroNutrient Testing 250.40 Diabetes with renal manifestations
486 Pneumonia, unspecified Phenobarbital & barbituates Calcium Osteoporosis, heart & blood pressure irregularities, tooth decay avocados, peanut butter impaired glucose control
MICRONUTRIENT measuring
antioxidant function of cells by is available now exclusively from SpectraCell
250.50 Diabetes with ophthalmic manifestations
272.0 Pure hypercholesterolemia Folic Acid Birth defects, cervical dysplasia, anemia, cardiovascular disease
Phone/Fax Laboratories. This patented analysis measures
their ability to withstand oxidative stress. Dilatin, Tegretol, Mysoline
753.0 Renal agenesis and dysgenesis Biotin Hair loss, depression, cardiac irregularities, dermatitis N-ACETYL Glutathione production, lowers Free radical overload, elevated
levels of selected vitamins, minerals, antioxidants 250.60 Diabetes with neurological manifestations Depakane/Depacon
Carnitine Various cardiovascular problems, weak immune system, low energy CYSTEINE (NAC) MOST homocysteine, lipoprotein(a), heal lungs, Meats, ricotta, cottage cheese, yogurt, homocysteine, cancer risk, cataracts,
786.05 Shortness of breath
and other essential micronutrients within your 250.70 Diabetes with peripheral circulatory disorders & COMMON inflammation, decrease muscle fatigue, liver wheat germ, granola, oat flakes macular degeneration, immune function,
TEST.
www.SpectraCell.com No Appointment, Doctor's Note or Insurance Necessarycells.
white blood 250.80 Diabetes with other specified manifestations 780.2 Syncope and collapse Vitamin B12
Vitamin B1
Anemia, depression, tiredness, weakness, increased cardiovascular risk
Depression, irritability, memory loss, muscle weakness, edema
GLUTATHIONE detoxification, immune function toxin elimination
250.90 Diabetes with unspecified complication 786.06 Tachypnea
311 Depressive disorder, not elsewhere classified 985.9 Toxic effect of other metals, unspecified metal Vitamin K Blood coagulation, skeletal problems Energy, blood flow to nerves, glutathione Diabetic neuropathy, reduced muscle
Copper Anemia, fatigue, cardiovascular and connective tissue problems ALPHA LIPOIC Supplementation, spinach, broccoli, beef,
272.9 Disorder of metabolism, unspecified 785.2 Undiagnosed cardiac murmurs COMMON levels in brain, insulin sensitivity, mass, atherosclerosis, Alzheimer’s, failure
Selenium Lower immunity, reduced antioxidant protection ACID Brewer's yeast, some organ meats
781.1 Disturbances of sensation of smell and taste 266.1 Vitamin B6 deficiency effectiveness of vitamins C, E, antioxidants to thrive, brain atrophy, high lactic acid
Zinc Weak immunity, wound healing, sense of smell/taste, sexual dysfunction
270.4 Disturbances of sulphur-bearing amino-acid metabolism 269.2 Vitamin deficiency, unspecified
786.09 Dyspnea and respiratory abnormalities, other
782.3
259.9
Edema
Endocrine disorder, unspecified
800.227.LABS (5227) www.SpectraCell.com Copyright © 2008© 2009 SpectraCell Laboratories DOC 306-01.09
Copyright SpectraCell Laboratiores, Inc. All Rights Reserved. FIA 306 - 12.08
ADVANCED CLINICAL TESTING
Visit us at www.spectracell.com or call us at 800.227.LABS (5227) ADVANCED CLINICAL TESTING Visit us atat www.spectracell.com or call us at 800.227.LABS (5227)
Visit us www.spectracell.com or call us at 800.227.5227 ADVANCED CLINICAL TESTING
BROCHURES ARE ALSO AVAILABLE IN SPANISH
body
Understanding Diabetes A CLOSER LOOK AT AR E YO U W
Does your need all of these?
Take Action
a e ct o
L EL
According to the American Diabetes
Association, type 2 diabetes is the most
common form of diabetes. With this type
of diabetes, cells do not receive enough
SpectraCell’s FIA™ picks up nutritional
deficiencies that routine testing does not.
If you are pre-diabetic or already have
331 with the
BALANCE B A LA N C
ED ?
diabetes, functional testing from SpectraCell Find out today able at
insulin. As a result, cells starve for ent Test avail
energy, is right for you, so act now. Ask your MicroNutri
and over time, a glucose buildup in the
blood doctor about SpectraCell’s FIA™ Does yo
stream causes negative effects on a person’s tests ur nutr
eyes, kidneys, nerves or heart.
to find out if you are deficient in any
itional ba
nutrients presented in this brochure
and take action to prevent and lance sta
Today’s fast-paced society has led to quicker, fight diabetes. ck up? FIND OUT
TODAY
Ad dre ss
FIN D OU
higher carbohydrate alternatives as food T TODAY IF YOU’ RE
GETT ING
sources. As a result, there is a greater IF YOU ’RE UR L THE VITA
PILLS IN HAND
threat MINS &
G x
GET TIN
of developing diabetes due to cells becoming
Did You Know... Ph one /Fa Necessary
MINE RALS
THAT
insulin-resistant. THE VIT
AM INS Note or Insurance
's YOUR BODY
tment, Doctor & NEED S.
No Appoin
20.8 million people in the United States, MIN ERA
Micronutrient
s such as niacin, magnesium, or LS THA
T
7% of the population, have diabetes.
calcium, zinc, carnitine, inositol, alpha- YOU R BOD
Y NEE DS.
lipoic acid, as well as vitamins E, B6 An estimated 14.6 million have been
diagnosed.
and D all play an important role in the 6.2 million people (or nearly one-third)
are Balancing yo
prevention and treatment of diabetes. unaware that they already have the disease. ur nutritiona www.Spec
traCell.c
41 million people in the United States, l status om EXECUT
E X E C U T II V E
Ask your doctor today about SpectraCell’s 40 to 74, have pre-diabetes. ages has never be H E A LT H
H E A LT H
VE
FIA™ tests to accurately diagnose your
body’s 10.9 million, or 10.5% of all men aged
en easier. Want to feel young again? AND
AND
exact needs and/or deficiencies. Though WELLNES
years or older, have diabetes although 20
WELLNES S
S
diabetes is a serious disease - with the
treatment - living a longer, healthier
life can be made easier.
right one-third of them do not know it. nearly
STACKED APPLE WE CAN HELP!
9.7 million, or 8.8% of all women aged
years or older, have diabetes although 20
one-third of them do not know it. nearly
The prevalence of diabetes is at least
2
times higher among non-Hispanic Black,to 4
Hispanic/Latino American, American
and Asian Pacific Islander women than Indian,
non-Hispanic white women. among Your Nutritional
Status Matters Ask your do
ctor about
10401 Town Park Drive Houston,
Texas 77072 MicroNutrien
t Testing!
302
For more information call 800.227.LAB www.BeyondWellnesscc.com
S (5227)
or visit us online at www.SpectraCell.com
ADVANCED CLINICAL TESTING
3 PEOPLE W/ VEGGIES
JUMP YOUNG
The LPP Advantage
Standard Cholesterol Testing
rol Testing
Only measuring cholesterol can be misleading.
Choleste is NOT ENOUGH.
Cholesterol has historically been used as the standard
.
ADVAN
Standard
ENOUGH
CED TESTING
indicator for cardiovascular disease, being classified as Approximately 50 percent of people suffering FOR CARDIO
SpectraC
VASCUL
is NOT EN
AR RISK
HDL (good) or LDL (bad). However, it is actually the from heart attacks have shown “normal” Choleste ell’s Lipoprote
50%
lipoprotein particles that carry the cholesterol throughout PLA rol Educ in Parti
cholesterol numbers. NIH – National Heart, RUPTUR QUE ation Prog cle Profi
the body, not the cholesterol within them, that are ram’s (NCEle™ (LPP™)
Blood and Lung Institute, 2001at risk for ES
of people INFLAMM DUE TO identifies
at risk for
responsible for key steps in plaque production and the P) Lipo
ATION protein all
Risk Fact the National
50%
of people
resulting development of cardiovascular disease.
DISEASE HEART DISEASE HDL2b
ors.
HEART d Why is it important to know lipoprotein numbers? Lp(a) RLP
identifie
are not identified by routine testing.
are not testing.
Cardiovascular risk increases with a higher number of low density lipoprotein (LDL) particles, regardless of how much
by routine
cholesterol each lipoprotein particle contains. This is because both a higher number of LDL particles or smaller sized LDL
particles dramatically increase the probability of lipoproteins penetrating the arterial wall, where it can cause serious damage. HDL3
Why measure lipoprotein subgroups? ARTERI
Measuring the lipoprotein subgroups is the only way to evaluate new risk factors, which is crucial for accurate assessment Foam LDL AL LUM
of cardiovascular risk and treatment, according to the National Cholesterol Education Program (NCEP). Build Cells
EN
Plaque
MONOCYT
E CELL
NCEP Emerging Risk Factors
� Small, dense LDL – these atherogenic particles easily penetrate the arterial endothelium causing plaque. LL
Foam CE
� RLP (Remnant Lipoprotein) – very atherogenic lipoprotein that doesn’t need to be oxidized to form plaque. Cell ELIUM
DENSE DAMAGED END
OTH easily oxidize are small dense
� Lp(a) – a prothrombotic small, dense LDL LDL in many d. Lp(a) LDL’s and
of the geneti is prothrombot
� HDL2b – positively correlates with heart health because it is an indicator of how well excess lipids are removed. c variati ic
ARTERI ons.
AL INT
IMA
OXIDIZED
LDL
Visit SpectraCell Laboratories to learn about the
Over 20% of the population has cholesterol-depleted LDL. This is a condition in which a patient’s cholesterol may be
“normal,” but their lipoprotein particle number and hence their actual risk would be much higher than conventional cholesterol MACR
OPHA
tests would indicate. This is Lipoproteinpersons whose triglycerides are high or HDL is low.cardiovascular
especially common in Particle ProfileTM to assess In a cholesterol-depleted risk. GE CELL
ay.
PTM test tod
patient, there can be up to a 40 percent error in risk assessment in a standard lipid panel. Copyright
BROCHURES ARE ALSO ut the LP
© SpectraCell
Laboratorie
s 2008
All Rights
doctor abo
Use LPPTM in your practice for accurate cardiovascular risk assessment. With LPPTM, a physician can begin to treat patients with Reserved
Ask your
atherogenic lipoprotein profiles before overt dyslipidemia becomes apparent.
402 408 412 403
800.227.LABS (5227) Visit us
at www.spe
ctracell.c
w w w. S p e c t r a C e l l . c o m om or call DOC 416
LPP™ 12.08
us at 800.227.
ADVANCED TESTING FOR CARDIOVASCULAR RISK
27)
AVAILABLE IN SPANISH
LABS (5227)
ABS (52
RISK
SCULAR
FOR CARDIOVA
800.227.L r a C e l l . c o m
TESTING ADVANC
ADVANCED ED CLINICA
L TESTING
t
www. S p e c
Copyright © 2008 SpectraCell Laboratories DOC 412-12.08
ADVANCED CLINICAL TESTING
Visit us at www.spectracell.com or call us at 800.227.LABS (5227)
Aspirin Response Test - laboratory test for urinary 11dhTxB2
aspirin Pathways of Thromboxane Production
Are you taking
heart attack?
Low-dose
25% to prevent a
Inflammation aspirin
g?
of patients on
aspirin therapy
.
Is it workin COX-2 COX-1
or no benefit
receive little
Q. Why do I need Q. Do all NSAID’s interfere with aspirin binding? to the
A. Medical studies the Aspirin Respons to interfere with the binding of aspirin
indicate that e Test ? A. To date, only Ibuprofen has been proven
people have been COX-1 enzyme.
platelet which prevents acetylation of the
not
a question of reported to be everyone benefits equally
aspirin “resistant from low
and stroke by aspirin therapy “failure”. Because ” but increasing dose aspirin. In fact
aspirin is known studies indicate that some to take aspirin for heart benefit?
How soon after taking NSAID’s is it safe
helping
doctor to determine stop platelets from Q. that
Points to if you are benefiting sticking together, the to reduce the risk of heart be
it may to Ibuprofen. It is presently recommended
Q. optimally from Aspirin Response attack A. Again this has been addressed only in regard ingesting Ibuprofen before ingesting aspirin or at
consider when What are the your aspirin regimen. Test allows the the individual must wait at least 8 hours
after
A. According to chances that my platelets ingesting Ibuprofen.
interpreting results. receiving the reports in the medical literature,are not respondi least 30 minutes after aspirin ingestion before
desired result. 10% to 40% ng to aspirin?
other factors The fact is that
not detect thisthat may overcome the benefit even if aspirin of patients taking aspirin begun aspirin therapy to test?
How long should I wait after a patient has
5 days for low-dose aspirin therapy to achieve
is were Q.
result. of the aspirin. working on your platelets, not
> 1500 pg/mg ≤ 1500 pg/mg Traditional platelet there According to the literature, it takes up to
If you…
Q. What are the function assaysare A. thromboxane B2 levels.
A. Outcome studies dangers to
me if I am
can maximum reduction in urinary 11-dehydro
w? No Aspirin Effect Aspirin Effect
a higher incidence have demostrated that not benefiting from my
Did you kno to aspirin
drug...
rol lowering a good response. of second heart attacks, patients with aspirin?
Does liver disease affect the results?
take a choleste a poor
strokes or even response to aspirin therapy Q. of thromboxane A2 to
cholesterol. death when compared have A. Yes. Liver disease may prevent the metabolism
not respond you test your Q. Why shouldn’
11-dehydro thromboxane B2.
People who do more likely to die of
to patients with
A. Increasing the t I just take more aspirin?
are three times medication... amount
disease than
those take blood pressure . Aspirin Ensure stomach discomfor of aspirin you take
but there is some t or gastrointestinal may cause an increase in Does renal disease affect the results?
cardiovascular blood pressure Q. of thromboxane A2 to
well to aspirin. you test your Ingested Compliance Only your physician other factor bleeding.
overcoming its More importantly, the
unwanted side
effects such as Yes. Kidney disease may prevent the metabolism
who respond attack... should decide benefit which aspirin A.
cardiovascular prevent a heart Q. if it is safe to may require an may be doing its job 11-dehydro thromboxane B2.
people die of take aspirin to
change your
How often
should I be aspirin dosage. additional medication.
Nearly 2,400 DAY in the United States. A. The optimum tested? an effect on the test?
disease EACH Step 1 individuals losefrequency of testing has not Q. Does the platelet count of the patient have count
Check for Concomitant Ibuprofen or NSAID
addressing a relationship between platelet
ns can test your
usage—this can inhibit effect of aspirin the benefit of
increases in cholestero been
aspirin therapy established. Clinical studies A. To date no studies have been performed to block the
1.1 million America NOW you over time due B2. If there is sufficient aspirin on board
An estimated or recurrent heart t! l. to atheroscle indicate that certain and levels of 11-dehydro thromboxane Platelet count does not necessarily reflect
Aspirin Effec
Q. rotic disease
will have a new Step 2 A.
What does
the Aspirin or COX-1 pathway, then the individual is benefiting. be assumed. More importantly, if the
When an individual’ Response Test can not
attack this year.
Modify Aspirin Dose
(TxA2) which s platelets measure? functional platelets, therefore a correlation platelet turnover, a daily regimen of aspirin
causes more become activated they individual does not have a high percentage
of is
will be fatal. cause formation platelets to become release a
activated and chemical called Thrombox because the effect of aspirin on the platelet
heart attacks should eventually knock out all of the platelets
11-dehydro thrombox of a blood clot.
40% of these Step 3 Check for Elevated Cholesterol- The stick
ane B2 which ART test measures a metabolit together. This may ane A2 the platelet.
dose of this can alter aspirin’s effect from their aspirin
therapy the level is excreted in the urine. e of TxA2 called irreversible and lasts for the lifetime of
that the correct Q. of 11-dehydroTxB2 When an individual
Studies show significantly reduce Is the Aspirin in the urine is is benefiting and what about adding Plavix?
aspirin helps
to A. No. This test Response Test complica very low. Q. How much aspirin should I be recommending the physician may administer doses from 81
Retest aspirin,
Within the guidelines for treatment with
Lower and Control Cholesterol is performed
xane levels. on a random ted? based
to recommend any change in aspirin dose
doctor a thorough A.
thrombo other non-stero history of the other urine sample. It is important
drugs to 325 mg. It is completely up to the physician to a patient’s anti-platelet regimen is strictly
alcohol intake. idal anti-inflammatory drugs. you have taken during that you be able to give Plavix
Step 4 on the individual’s circumstances. Adding studies have
clinical condition of the patient. Certain
Consider underlying condition Note the amount Be the past your
S i.e. Pre-Diabetes/Diabetes and frequency sure to mention any dietary 10 days, especially up to the physician and depends on the
LABORATORIE of aspirin usage. supplements in addition to aspirin in symptomatic patients;
SPECTRACELL TESTING
and
demonstrated an added benefit with Plavix
always demonstrated an added benefit.
however, asymptomatic patients have not
CLINICAL
ADVANCED
ell.com If results remain > 1500 with no aspirin effect
www.S pectraC
(12.08)
- DOC 505 consider changing dose; additional and/or
Laboratories
2008 SpectraCell (5227)
800.227.LABS
Copyright © alternative anti-platelet therapy
Copyright
, Texas 77072
© 2008 SpectraCell
Visit us at Laboratories.
Houston www.spectracell. All Rights Reserved
Park Drive com or call DOC 507
10401 Town
(08.08)
us at 800.227. All Rights Reserved DOC 506 (08.08)
10401 Town Park Drive Houston, Texas 77072 800.227.LABS (5227) www.SpectraCell.com LABS (5227)
Copyright © 2008 SpectraCell Laboratories.
or call us at 800.227.LABS (5227)
Visit us at www.spectracell.com
LABORATORIES
SPECTRACELL TESTING
CLINICAL
ADVANCED
PATIENT HANDOUT PHYSICIAN HANDOUT PATIENT FAQs PHYSICIAN FAQs

18. Client Testimonials
Mark Houston, M.D. M.S., SCH, ABAAM, FACP, FAHA
Internal Medicine
Hypertension Institute – A Cardiovascular Center of Excellence
St. Thomas Medical Center
Nashville, TN
"SpectraCell offers a unique, scientifically-based nutrient evaluation of specific deficiencies that
allows targeted treatment with nutritional supplements. The detection of these abnormalities
allows for a biological, functional and nutritional biochemistry approach for the prevention and
treatment of many diseases for which the basic problem originated with the missing nutrient and
subsequent downstream nutritional dysfunction and illness. Patient and physician recognition of
this valid testing will improve patient compliance, allow for tailored therapy and reduce
numerous diseases”
Seth Baum, M.D.
Cardiologist
VitalRemedy MD
Boca Raton, FL
“As an interventional cardiologist and electrophysiologist dedicated to the advancement of
cardiovascular health, I have come to appreciate the need for individualizing our approach to
patient care. Though it’s important to use large clinical trials as a means of guiding us in an
“evidence based” manner, it has become clear to most of us that these trials too often fall short in
their clinical utility. They frequently fail to address the needs of individual patients, unique and
extraordinarily complex beings who’ve entrusted their health and well being to us, their doctors.
A question often raised by patients and physicians alike relates to the use of antioxidant
supplements such as vitamins C and E, Co Q10, and alpha lipoic acid. Trials evaluating
antioxidants have been mixed, spanning the gamut from very positive to equally negative. Most
of these trials, however, have been neutral. The failure of these studies to solve the antioxidant
puzzle relates to their reliance upon fixed dose supplementation; they neglect the wide range of
individual responses that occur when using antioxidants. They have also ignored the issue of
balancing antioxidants. As antioxidants exist in vivo within a constantly recirculating and
regenerating network, they must be consumed in balance so that an excess of one does not
adversely affect the remaining “players” in what ought to be a harmonious system.
In order to help my patients navigate the tumultuous seas of antioxidant supplementation, I have
relied upon the Spectrox® blood test for the better part of the last decade. By utilizing this test, I
have the ability to supplement patients on an individual, and an “as need” basis. Spectrox®
eliminates the guesswork from supplementation, and permits not only my patients, but me as
well, to feel comfortable that we are “doing the right thing.” Follow up blood tests enable us to
document that any changes we’ve made have had their desired affect. If they haven’t, then it’s
back to the drawing board for another attempt. “
Copyright © 2009 SpectraCell Laboratories DOC 310-01.09
Visit us at www.spectracell.com or call us at 800.227.LABS ( 5227) ADVANCED CLINICAL TESTING

19. Client Testimonials
Rita Ellithorpe, M.D.
Internal Medicine
Tustin Longevity Center
“SpectraCell’s MicroNutrient Testing is a truly valuable diagnostic tool for my practice.”
Michael O'Neal, D.O.
Internal Medicine
Primary Care Team Physician
Toronto Blue Jays
Major League Baseball Club
Chief Executive Officer
CooperativeMed
"SpectraCell’s MicroNutrient Testing allows me to diagnose specific functional deficiencies
and subsequently compound supplements appropriate for the individual needs of my patients."
Diana Schwarzbein, M.D.
Endocrinologist
Endocrinology Institute of Santa Barbara
Santa Barbara, CA
“There are many supplements from vitamins to orthomolecular molecules that can influence a
person's metabolism. As we all know, multiple supplements can be as overwhelming as
prescription drugs and just as costly. Will I recommend zinc, lipoic acid and Co Q-10 to help a
patient recover from adrenal gland burn out, or does the individual make enough lipoic acid and
I need to only recommend zinc and CoQ10? I use the information from SpectraCell’s
MicroNutrient Testing to determine which of these would be the first line choices for that
particular patient and their current situation.
I have found that when my patients are shown their particular data from this blood test, it
motivates them to take their supplements consistently and I am able to put together a supplement
and dietary regimen that targets my patient’s unique deficiencies. Objective data is always helpful.”
Copyright © 2009 SpectraCell Laboratories DOC 310-01.09
Visit us at www.spectracell.com or call us at 800.227.LABS ( 5227) ADVANCED CLINICAL TESTING

20. Ocular Health - Heart Health -
Good eyesight and prevention of Nutrients that protect the cardiovascular
cataracts and macular degeneration system include Vitamin B6, Vitamin B12,
require adequate levels of Folic Acid, Vitamin E, CoQ10, Calcium,
Vitamin E and Vitamin A. Magnesium and Carnitine.
Bone Health -
Cardiovascular Support - Vitamin D, Vitamin B6, Vitamin B12, Folic Acid,
Vitamin B2, Vitamin B6, Vitamin B12 and Calcium, Magnesium and Zinc are all nutrients that
Folic Acid are all required for reducing assist in bone remodeling, to ward off osteoporosis
homocysteine levels in the blood and and other diseases that weaken the skeletal system.
protecting arteries and nerve fibers.
Metabolic Health -
Vitamin B3, Vitamin B6, Vitamin B12 Vitamin Liver Health -
E, Biotin, CoQ10, Chromium, Magnesium and Cysteine and N-Acetyle Cysteine, Selenium,
Zinc all help the body handle daily sugar Vitamin B2 and Vitamin B3 enhance liver
load, keeping systems responsive to insulin function and optimize levels of glutathione
and restoring lost insulin sensitivity. which helps cells fight off toxic challenges.
Antioxidant Status - Joint Support -
Measures the nutrients that help Vitamin E, Alpha-Lipoic Acid and
prevent or repair cellular damage B Vitamins all contribute to joint support
caused by oxidation. and controlling inflammation.
SPECTROX® measures the total MicroNutrient Testing is available
antioxidant function of cells by measuring now exclusively from SpectraCell Laboratories.
their ability to withstand oxidative stress. This patented analysis measures levels of
selected vitamins, minerals, antioxidants and
other essential micronutrients within your
www.SpectraCell.com white blood cells.