This document provides information on metastasis and lymph node anatomy and surgical procedures related to the neck. It discusses the pathways of metastasis, including lymphatic and hematogenous spread. It describes the triangles and fascial layers of the neck important for surgery. Four types of regional lymphadenectomy procedures are outlined, including their indications and boundaries. Potential complications of radical neck surgery are also summarized.
The midbrain, or mesencephalon (plural: mesencephala or mesencephalons), is the most rostral part of the brainstem and sits above the pons and is adjoined rostrally to the thalamus. During development, the midbrain forms from the middle of three vesicles that arise from the neural tube.
When viewed in cross-section, the midbrain can be divided into three portions:
tectum (posterior)
tegmentum
cerebral peduncles (anterior)
different type of lower limb amputation with indication, peri-operative care, surgical steps, post op care complication and different type of prosthesis
The midbrain, or mesencephalon (plural: mesencephala or mesencephalons), is the most rostral part of the brainstem and sits above the pons and is adjoined rostrally to the thalamus. During development, the midbrain forms from the middle of three vesicles that arise from the neural tube.
When viewed in cross-section, the midbrain can be divided into three portions:
tectum (posterior)
tegmentum
cerebral peduncles (anterior)
different type of lower limb amputation with indication, peri-operative care, surgical steps, post op care complication and different type of prosthesis
NMJ in 2 mins
Comparing NMJ mechanism with bahubali movie
Role of calcium channel blockers in neuromuscular transmission
Synapse,presynaptic & postsynaptic
Depolarisation
Acetylcholine synthesis
Acetylcholine storage and release
Sodium channel structure
Action potential
Postsynaptic receptors
Action of muscle relaxants over postsynaptic receptors
What happens if we given pottasium channel blockers
What is the reason for muscle weakness in preeclamptic patient on Mgso4
Eaton- lambert syndrome
Model of protein mediated membrane fusion and exocytosis
Synaptic cleft
Acetylcholinesterase
Mature receptors and immature receptors
Nicotinic post junctional receptors
Destruction of acetylcholine
Resting membrane potential
Hypocalcemia role in NMJ
Calcium channel types
Synaptophysin
Synaptotagmin
Synaptobrevin
Schwann cells
Anatomy of NMJ
Physiology of NMJ
Morphology of NMJ
Action potential
NMJ in 2 mins
Comparing NMJ mechanism with bahubali movie
Role of calcium channel blockers in neuromuscular transmission
Synapse,presynaptic & postsynaptic
Depolarisation
Acetylcholine synthesis
Acetylcholine storage and release
Sodium channel structure
Action potential
Postsynaptic receptors
Action of muscle relaxants over postsynaptic receptors
What happens if we given pottasium channel blockers
What is the reason for muscle weakness in preeclamptic patient on Mgso4
Eaton- lambert syndrome
Model of protein mediated membrane fusion and exocytosis
Synaptic cleft
Acetylcholinesterase
Mature receptors and immature receptors
Nicotinic post junctional receptors
Destruction of acetylcholine
Resting membrane potential
Hypocalcemia role in NMJ
Calcium channel types
Synaptophysin
Synaptotagmin
Synaptobrevin
Schwann cells
Anatomy of NMJ
Physiology of NMJ
Morphology of NMJ
Action potential
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
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Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
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Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
4. IMMUNOLOGY OF METASTASIS
•
CELLULAR HUMORAL
• T-LYMPHOCYTES (KILLER CELLS) CONNECT WITH TUMOR CELLS AND PROMOTE THEIR REJECTION.
ANOTHER GROUP OF T-LYMPHOCYTES (SUPPRESSORS) STIMULATE THE MULTIPLICATION OF B-
LYMPHOCYTES, WHICH PRODUCE ANTI-TUMOR ANTIBODIES AND, THEREFORE, PROVIDE SPECIFIC
ANTITUMOR IMMUNITY.
6. TOPOGRAPHY OF NECK LYMPHONES.
• KOZLOVA 80 130
• CHIN SUBMANDIBULAR RETROPHARYNGEAL
SUPERFICIAL DEEP CERVICAL
• ALL LYMPH NODES CAN BE INTO THE FOLLOWING METASTATIC ZONES:
- UPPER
- MIDDLE
- LOWER
7. SURGICAL ANATOMY OF THE NECK APPLICABLE TO RADICAL
OPERATIONS ON A REGIONAL LYMPHATIC EQUIPMENT
• ANTERIOR POSTERIOR ANTERIOR
EDGE OF THE TRAPEZIUS MUSCLE
RIGHT LEFT
3
• 1. THE MEDIAL TRIANGLE OF THE NECK IS BOUNDED BY THE MIDLINE OF THE NECK, THE LOWER
EDGE OF THE MANDIBLE AND THE ANTERIOR EDGE OF THE STERNOCLEIDOMASTOID MUSCLE.
WITHIN IT ARE: PAIRED SUBMANDIBULAR TRIANGLE, UNPAIRED CHIN TRIANGLE, SLEEPY TRIANGLE.
• 2. THE LATERAL TRIANGLE OF THE NECK IS FORMED BY THE POSTERIOR EDGE OF THE
STERNOCLEIDOMASTOID MUSCLE, THE ANTERIOR EDGE OF THE TRAPEZIUS MUSCLE, AND THE
UPPER EDGE OF THE CLAVICLE. DIVIDED INTO 2 TRIANGLES: UPPER AND LOWER (CORRESPONDS TO
THE SUPRACLAVICULAR FOSSA).
• 3. THE AREA OF THE STERNOCLEIDOMASTOID MUSCLE CORRESPONDS TO THE BOUNDARIES OF
THIS MUSCLE.
8. FASCIA OF THE NECK (ACCORDING TO
V.N.SHEVKUNENKO).
• 1 FASCIA - SUPERFICIAL FASCIA OF THE NECK, PART OF THE GENERAL SUPERFICIAL FASCIA OF THE BODY. ON THE
NECK, FORMS A SHEATH FOR THE SUBCUTANEOUS MUSCLE.
• 2 SUPERFICIAL LAYER OF THE OWN FASCIA OF THE NECK. FORMS A RECEPTACLE FOR THE STERNOCLEIDOMASTOID
AND TRAPEZIUS MUSCLES AND THE SUBMANDIBULAR SALIVARY GLAND. ATTACHED TO THE LOWER EDGE OF THE
LOWER JAW, CLAVICLE, DELIMITS THE FRONT AND BACK SURFACES OF THE NECK.
• 3 A DEEP LEAF OF THE OWN FASCIA OF THE NECK. COVERS THE MUSCLES BELOW THE HYOID BONE. ON THE MIDLINE
OF THE NECK, 2 AND 3 LEAVES GROW TOGETHER, FORMING A WHITE NECK LINE.
• 4 LEAF - COVERS THE ORGANS OF THE NECK (LARYNX, PHARYNX, ESOPHAGUS, TRACHEA, THYROID GLAND). THE
VISCERAL LEAF OF THIS FASCIA COVERS THE ORGANS OF THE NECK FROM THE OUTSIDE, THE PARIETAL FROM THE
INSIDE, AT THE SAME TIME FORMING THE VAGINA OF THE NEUROVASCULAR BUNDLE OF THE NECK.
• 5 LEAF - PREVERTEBRAL FASCIA. FORMS THE SHEATH OF THE SCALENE MUSCLES AND THE TRUNK OF THE
SYMPATHETIC NERVE.
10. CHARACTERISTIC OF REGIONAL METASTASING
• N0 - NO SIGNS OF METASTATIC LESIONS OF REGIONAL LYMPH NODES.
• N1 - METASTASES IN ONE LYMPH NODE ON THE AFFECTED SIDE UP TO 3 CM OR LESS IN THE
LARGEST DIMENSION.
• N2A - METASTASES IN ONE LYMPH NODE ON THE AFFECTED SIDE UP TO 6 CM IN THE LARGEST
DIMENSION.
• N2B - METASTASES IN SEVERAL LYMPH NODES ON THE AFFECTED SIDE UP TO 6 CM IN THE
LARGEST DIMENSION.
• N2С - METASTASES IN LYMPH NODES ON BOTH SIDES OR ON THE OPPOSITE SIDE UP TO 6 CM IN
GREATEST DIMENSION.
• N3 - LYMPH NODE METASTASIS MORE THAN 6 CM IN GREATEST DIMENSION.
11. CHARACTERISTIC OF REMOTE METASTASING
• M0 - NO SIGNS OF DISTANT METASTASES.
• M1 - THERE ARE DISTANT METASTASES
12. TREATMENT OF REGIONAL METASTASIS
• CURRENTLY, THERE ARE NO UNIFIED APPROACHES TO THE CHOICE OF A METHOD
FOR THE TREATMENT OF REGIONAL METASTASES IN PATIENTS WITH MALIGNANT
NEOPLASMS OF THE MAXILLOFACIAL REGION. ONE OF THE REASONS FOR THIS
SITUATION IS THE DIFFICULTY OF DIAGNOSING METASTASES.
• THERE ARE SUPPORTERS OF RADIATION, SURGICAL AND COMBINED METHODS OF
TREATMENT
13. • MOST SUPPORTERS OF THE COMBINED TREATMENT OF REGIONAL METASTASES
SUGGEST REMOTE GAMMA THERAPY BEFORE SURGERY, INCLUDING THE PRIMARY
FOCUS IN THE IRRADIATION ZONE, AND AFTER A 3-4 WEEK BREAK NECESSARY
FOR THE RADIATION EPIDERMIS TO SUBSIDE, PERFORM LYMPHADENECTOMY IN AN
APPROPRIATE VOLUME. SOME AUTHORS MANAGED TO OBTAIN POSITIVE RESULTS
IN 90% OF PATIENTS.
• THE PROPOSAL TO USE CHEMOTHERAPY IN COMBINATION WITH LOCAL
HYPERTHERMIA HAS NOT GIVEN PROMISING RESULTS. COMPLETE REMISSION OF
METASTASES WAS ACHIEVED ONLY IN 1.3% OF PATIENTS.
• THE MAIN METHOD OF TREATMENT OF REGIONAL METASTASES OF MALIGNANT
TUMORS OF THE MAXILLOFACIAL REGION IS CURRENTLY SURGICAL.
15. INDICATIONS AND CONTRAINDICATIONS FOR
OPERATIONS ON THE REGIONAL LYMPHATIC NECK
APPARATUS.
• IF THE LOCALIZATION OF THE PRIMARY TUMOR IS SUCH THAT THE AREA OF THE LESION DIRECTLY
BORDERS ON THE NECK (PAROTID SALIVARY GLAND, LOWER JAW, FLOOR OF THE MOUTH, TONGUE,
SUBMANDIBULAR SALIVARY GLAND) AND THE PATIENT'S CONDITION ALLOWS, THEN THE
LYMPHATIC APPARATUS IS REMOVED IN THE BLOCK WITH THE PRIMARY FOCUS AT THE SAME TIME.
SEPARATE REMOVAL OF THE PRIMARY FOCUS AND THE REGIONAL LYMPHATIC APPARATUS IS
PERFORMED IN SUCH LOCALIZATIONS AS THE LIP, UPPER JAW, SOFT PALATE.
• A NECESSARY CONDITION FOR PERFORMING RADICAL LYMPHADENECTOMY IS THE CURE OF THE
PRIMARY FOCUS.
• TO REMOVE "IMPACTED" LYMPH NODES DUE TO THE RISK OF COMPLICATIONS SUCH AS BLEEDING
FROM THE COMMON OR INTERNAL CAROTID ARTERIES, TO WHICH SUCH NODES ARE OFTEN FIXED,
AS WELL AS THE HIGH FREQUENCY OF RELAPSES.
• IN THE PRESENCE OF DISTANT METASTASES, REGIONAL LYMPHADENECTOMY DOES NOT PROVIDE A
CURE AND THEREFORE IS MEANINGLESS
17. SUPERIOR CERVICAL EXCISION (HSE).
• INDICATIONS
• THE BOUNDARIES OF THE OPERATING FIELD
• THE VOLUME OF REMOVED TISSUES
• IN CONTRAST TO THE VANACH OPERATION, HSE MANAGES TO REMOVE BIFURCATED LYMPH NODES,
INTO WHICH MALIGNANT TUMORS OF THE MAXILLOFACIAL REGION VERY OFTEN METASTASIZE.
19. THE KRAILLE OPERATION
• INDICATIONS
• THE BOUNDARIES OF THE OPERATING FIELD
• THE VOLUME OF REMOVED TISSUES:
20. GENERAL RULES FOR PERFORMING JREGIONAL
LYMPHADENECTOMY:
• FOR ALL 4 TYPES OF LYMPHADENECTOMY, THE SUBCUTANEOUS MUSCLE OF THE NECK IS INCLUDED
IN THE BLOCK OF REMOVED TISSUES TO REMOVE SUPERFICIAL LYMPH NODES;
• WHEN HSE, FFE, CRAILLE OPERATIONS, THE LOWER POLE OF THE PAROTID SALIVARY GLAND IS
INCLUDED IN THE BLOCK OF REMOVED TISSUES TO FACILITATE ACCESS TO THE UPPER GROUP OF
DEEP CERVICAL LYMPH NODES;
• PERFORMANCE OF ALL TYPES OF LYMPHADENECTOMY PROVIDES FOR THE REMOVAL OF
NECESSARY TISSUES IN A SINGLE BLOCK (BLOCK PRINCIPLE), AND NOT FOR THE EXFOLIATION OF
INDIVIDUAL METASTATIC LYMPH NODES, IN ORDER TO AVOID ABLASTIC DISORDERS;
21. • REMOVAL OF THE TISSUE BLOCK SHOULD BE PERFORMED WITHIN THE BOUNDARIES OF THE
CORRESPONDING FASCIAL SHEATHS (SEE ABOVE), WHICH IS ALSO ONE OF THE PRINCIPLES OF
ABLASTY;
• THE ALLOCATION OF A TISSUE BLOCK ALWAYS GOES FROM BOTTOM TO TOP (FROM THE LOWER
BORDER OF THE FASCIAL SHEATH TO THE UPPER). THE REASON IS THAT THE LYMPH NODES
CLOSEST TO THE PRIMARY TUMOR ARE USUALLY THE FIRST TO BE AFFECTED BY METASTASES. THIS
PRINCE SP ALLOWS TO SOME EXTENT TO REDUCE THE RISK OF SEEDING THE WOUND ON THE
NECK WITH TUMOR CELLS;
• IF A SIMULTANEOUS OPERATION IS PLANNED ON THE PRIMARY TUMOR FOCUS AND THE REGIONAL
LYMPH DRAINAGE PATHWAYS, THEN FOR A SIMILAR REASON, THE SURGICAL INTERVENTION BEGINS
WITH LYMPHADENECTOMY. ONLY AT THE FINAL STAGE OF THE OPERATION, THE PRIMARY TUMOR
IS INCLUDED IN THE TISSUE BLOCK;
• IN ORDER TO AVOID IMPLANTATION METASTASIS DURING THE OPERATION, IT IS NECESSARY TO
CAREFULLY LIGATE THE VESSELS, BECAUSE TUMOR CELLS, WHICH MAY BE IN THEIR LUMEN, ENTER
THE WOUND AND SERVE AS A SOURCE OF TUMOR GROWTH;
• ALL LYMPHADENECTOMIES ARE PERFORMED UNDER ENDOTRACHEAL ANESTHESIA.
22. COMPLICATIONS DURING RADICAL OPERATIONS ON
THE WAYS OF RHEONARY METASTASING
• ALL COMPLICATIONS ARE DIVIDED INTO 2 GROUPS
1. COMPLICATIONS ARISING DURING THE OPERATION.
2. COMPLICATIONS ARISING IN THE POSTOPERATIVE PERIOD. IN EACH GROUP,
COMPLICATIONS OF GENERAL AND LOCAL
23. COMPLICATIONS OF THE 1ST GROUP:
a) DAMAGE TO THE NERVE TRUNKS, MORE OFTEN THE MARGINAL BRANCH OF THE FACIAL NERVE, AS
WELL AS THE HYPOGLOSSAL, LINGUAL, VAGUS NERVES. AS A RESULT, HOARSENESS AND TACHYCARDIA
OCCUR. DAMAGE TO THE PHRENIC NERVE LEADS TO PARALYSIS OF THE CORRESPONDING HALF OF THE
DIAPHRAGM AND, AS A CONSEQUENCE, THE OCCURRENCE OF PNEUMONIA;
b) DAMAGE TO THE THORACIC LYMPHATIC DUCT WHEN PERFORMING LYMPHADENECTOMY ON THE LEFT.
THIS IS FRAUGHT WITH PROLONGED LYMPHORRHEA, THE ADDITION OF SECONDARY INFLAMMATION
TO THE COURSE OF THE WOUND PROCESS, BECAUSE THE LYMPH FLOWING INTO THE WOUND IS
INFECTED. TO PREVENT THIS COMPLICATION, IT IS RECOMMENDED DURING LYMPHADENECTOMY TO
SUTURE NOT ONLY THE BLOOD VESSELS, BUT ALSO THE AREAS OF FATTY TISSUE REMAINING IN THE
WOUND, IN WHICH THE LYMPHATIC VESSELS ARE LOCATED;
24. MEDIASTINAL EMPHYSEMA WITH THE SUBSEQUENT DEVELOPMENT OF PNEUMOTHORAX
AIR EMBOLISM WITH DAMAGE TO LARGE VEINS. TO AVOID THIS, IT IS NECESSARY TO CROSS THE
VENOUS TRUNKS BETWEEN THE TWO CLAMPS AND THEN CAREFULLY LIGATE THEM;
MASSIVE BLEEDING. THE MOST DANGEROUS IS BLEEDING FROM THE INTERNAL AND COMMON
CAROTID ARTERIES. PREVENTION - THE IMPOSITION OF A PROVISIONAL LIGATURE. TO REPLENISH
BLOOD LOSS DURING THE OPERATION, A SINGLE-GROUP BLOOD TRANSFUSION (250-500 ML) IS
NECESSARY.
25. COMPLICATIONS OF THE 2ND GROUP:
a) BREATHING DISORDER (LARYNGOSPASM, LARYNGEAL EDEMA);
a) PNEUMONIA (ASPIRATION);
a) SECONDARY BLEEDING AS A RESULT OF UNRELIABLE VASCULAR LIGATION DURING
SURGERY, INSUFFICIENT HEMOSTASIS, MELTING OF THE VESSEL WALL OR BLOOD
CLOT DUE TO WOUND INFECTION.