Mesothelioma is a rare cancer that affects the mesothelium tissue lining and is usually caused by exposure to asbestos 20 to 50 years prior. John Doe, age 60, has a history of asbestos exposure and is being followed up for mesothelioma with a CT scan. The scan shows a lobulated pleural thickening in his right lung consistent with mesothelioma. There is no cure for mesothelioma and the prognosis is poor, but treatment options include surgery, radiation, and chemotherapy.