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Melissa, a 12-year-old girl with cystic fibrosis comes to the
primary care office with complaints of increased cough and
productive green sputum over the last week. She also complains
of increasing shortness of breath. She denies sore throat or
nasal congestion. On physical examination her temperature is
101 and she has inspiratory wheezes bilaterally. Negative
lymphadenopathy noted. Posterior pharynx is pink without
exudate. BP 112/72 HR 96 RR 28.
1. In cystic fibrosis, the airway microenvironment favors
bacterial colonization. In a minimum of 150 words explain the
pathophysiological reason for this occurrence.

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