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1. Medullary carcinoma
Colloid Nodule

2. Medullary carcinoma
(Malignant)
 Increased cellularity
 Cells
 Individually scattered
 Nests
 Oval to spindle cells
 Increased nuclear to
cytoplasmic ratio
 Eosinophilic cytoplasmic
granules

3.  Amyloid (arrow)
 Finely distributed
chromatin
 Intra-nuclear
inclusions may be
present

4. Colloid Nodule
(Benign)
 Predominantly colloid
 No follicular cells or v.
scanty
 Foam cells/
histeocytes present

5.  Predominantly colloid
 No follicular cells or v.
scanty
 Foam cells/
histeocytes present