Medscape - Selecting Effective Treatment in the Antibiotic-Resistant
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James Atkinson, a PhD from Gloucester, MA, completed an online continuing medical education activity through Medscape titled "Selecting Effective Treatment in the Antibiotic-Resistant Emergency Room Patient". Medscape has designated this educational activity for up to 1 AMA PRA Category 1 Credit and provided Dr. Atkinson with a certificate of completion numbered 14635007.
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The Committee on Transportation and Infrastructure will hold an oversight hearing on the failures of the US Coast Guard's Deepwater Program to comply with contract requirements. The $24 billion, 25-year Deepwater Program is modernizing Coast Guard cutters, patrol boats, airplanes and helicopters. The hearing will focus on an investigation that found the conversion of 110-foot patrol boats to 123-foot patrol boats left eight legacy cutters unseaworthy, in non-compliance with contract requirements. Numerous witnesses from the Coast Guard and contracting companies will testify.
James Atkinson-Summary
The document summarizes issues with TEMPEST compliance on US Coast Guard cutters. It states that the original contract did not specify TEMPEST standards beyond Military Handbook 232A. The cutters did not comply with Handbook 232A requirements for equipment, racks, cables, or power supplies. Certificates falsely claimed compliance. Additionally, the Coast Guard lacked a qualified person to inspect and certify the cutters, so they turned to the Navy for measurements, though the Navy could not certify. Waivers were issued for problems by an acting CTTA who was not fully qualified. The cutters remain a risk to national security, and the Coast Guard has been evasive in responding to questions about TEMPEST issues.
Courtfiling_for_Kaushal_Niroula_in_Pro_Per_Babble_…-3
This motion requests a court order allowing the defendant, Kaushal Niroula, to use a "babble tape" and speaker during visits with his attorneys and investigators at the Indio Jail. The babble tape is an audio file containing over 576 voices designed to mask conversations from any hidden recording devices. It is played through an external speaker to avoid damaging the computer's internal speakers. The motion argues that privileged conversations have been improperly recorded before, so the babble tape is necessary to protect attorney-client privilege during visits.
FullCommitteeTranscript-v2
The House Committee on Transportation and Infrastructure held a hearing on the Coast Guard's Deepwater program. The committee heard testimony from current and former Coast Guard employees and contractors who raised serious concerns about management failures within the Coast Guard that have led to cost overruns, compromised assets and mission capabilities, and rejected early warnings about issues. The chairman commended witnesses who risked their careers to ensure the truth was revealed and hopes this hearing will help improve Coast Guard culture and management of the Deepwater program.
JamesAtkinsonwrittenTestimony
- James Atkinson, president of Granite Island Group, testified before the House Committee on Transportation and Infrastructure about issues with the Coast Guard's Deepwater program.
- Atkinson discovered that ships delivered to the Coast Guard by ICGS, the Deepwater contractor, did not meet TEMPEST standards for protecting classified information and could not be used for classified missions.
- Atkinson provided background on TEMPEST standards and how electromagnetic signals from electronic devices can unintentionally transmit sensitive information if not properly shielded.
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1. Define an electrocardiogram (ECG) and electrocardiography
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3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
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4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
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Cell Therapy Expansion and Challenges in Autoimmune Disease
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
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