Medscape - Spontaneous Bruising
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James Atkinson, a PhD from Gloucester, MA, completed an online continuing education activity through Medscape titled "Spontaneous Bruising in a 2-Month-Old". Medscape has designated this educational activity for up to 1 AMA PRA Category 1 Credit and has issued Certificate Number 14634066 to document James Atkinson's participation.
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FullCommitteeTranscript-v2
The House Committee on Transportation and Infrastructure held a hearing on the Coast Guard's Deepwater program. The committee heard testimony from current and former Coast Guard employees and contractors who raised serious concerns about management failures within the Coast Guard that have led to cost overruns, compromised assets and mission capabilities, and rejected early warnings about issues. The chairman commended witnesses who risked their careers to ensure the truth was revealed and hopes this hearing will help improve Coast Guard culture and management of the Deepwater program.
JamesAtkinsonwrittenTestimony
- James Atkinson, president of Granite Island Group, testified before the House Committee on Transportation and Infrastructure about issues with the Coast Guard's Deepwater program.
- Atkinson discovered that ships delivered to the Coast Guard by ICGS, the Deepwater contractor, did not meet TEMPEST standards for protecting classified information and could not be used for classified missions.
- Atkinson provided background on TEMPEST standards and how electromagnetic signals from electronic devices can unintentionally transmit sensitive information if not properly shielded.
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This slide consists of all the topics of ketone . This can be used for exam purpose for writing about Diabetic keto acidosis etc . Thank you
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These lecture slides, by Dr Sidra Arshad, offer a simplified look into the mechanisms involved in the regulation of respiration:
Learning objectives:
1. Describe the organisation of respiratory center
2. Describe the nervous control of inspiration and respiratory rhythm
3. Describe the functions of the dorsal and respiratory groups of neurons
4. Describe the influences of the Pneumotaxic and Apneustic centers
5. Explain the role of Hering-Breur inflation reflex in regulation of inspiration
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7. Explain the role of peripheral chemoreceptors in regulation of respiration
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1. Chapter 42, Guyton and Hall Textbook of Medical Physiology, 14th edition
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Cell Therapy Expansion and Challenges in Autoimmune Disease
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
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Medscape - Spontaneous Bruising
- 1. Medscape CME Certificate Page 1 of 1 cme.medscape.com LETTER OF COMPLETION certifies that James Atkinson, PhD 127 Eastern Ave, #291 Gloucester, MA 01930 has participated in the educational activity titled Spontaneous Bruising in a 2-Month-Old on the Internet at http://www.medscape.com , Medscape designates this educational activity for a maximum of AMA PRA Category 1 Credit(s)™. Physicians should only claim credit commensurate with the extent of their participation in the activity. For information on applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board. Certificate Number: 14634066 Cyndi Grimes Director, Continuing Medical Education Medscape Medscape, LLC is the professional education subsidiary of WebMD Health, New York, NY http://cme.medscape.com/activitytracker?view=true&resultId=14634066 9/2/2008