1. MEDICAL EMERGENCIES IN PROSTHODONTICS
DR SHUCHI JAIN
MDS 1ST YEAR
DEPARTMENT OF PROSTHODONTICS
2. CONTENT
• Introduction
• The ABCDE
approach
• Common
Emergency Drugs
• Various Types of
Medical
Emergencies
• Prosthodontic
Considerations Of
Different Medical
Emergencies
• Conclusion &
Takeaway Points
2
3. INTRODUCTION
Medical emergencies can and
do occur in the dental setting.
The most common
emergencies reported are –
• Syncope (50%),
• Mild allergic reaction (8%),
• Angina pectoris (8%), and
• Orthostatic hypotension
(8%).
3
4. The medical evaluation of patients considering prosthodontic treatment
is a vital step in treatment planning.
The prosthodontist should be able to assess the inherent risks
associated with the treatment of patients with systemic conditions.
Many factors are associated with evaluating the patient's health status
and risk including the patient's current and past medical and dental
history, current and past use of medications, type of treatment, length of
treatment, invasiveness of treatment, and degree of urgency of
treatment.
4
5. PROCEDURES THAT MAY HELP PREVENT EMERGENCIES
INCLUDE -
Taking a thorough and
accurate medical history.
Taking and recording vital
signs.
5
6. PREPARATION FOR MEDICAL EMERGENCIES IN THE DENTAL
OFFICE
A well-equipped medical
emergency kit,
Automated external defibrillator
(AED) unit,
A portable oxygen tank,
Current cardiopulmonary
resuscitation (CPR) training.
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7. MANAGEMENT OF MEDICAL EMERGENCIES
R - Recognize the signs and symptoms of the emergency and stop all
treatment;
E - Evaluate the patient’s level of consciousness;
P - Place the patient in the appropriate position;
A - Activate the CABs of CPR by checking the circulation, airway, and
breathing;
I - Implement the appropriate emergency protocol for the specific
emergency; and
R - Refer the patient to the appropriate healthcare professional, if
necessary.
7
11. VASOVAGAL SYNCOPE (FAINT)
The ‘simple faint’ is the most common medical emergency to be seen in
dental practice and results in loss of consciousness due to inadequate
cerebral perfusion.
Fainting can be precipitated by pain or emotional stress, changes in
posture, or hypoxia.
Some patients are more prone to fainting than others and it is wise to
treat fainting-prone patients in the supine position.
11
12. CAUSES
CNS
H - Hypoxia/Hypoglycaemia
E - Epilepsy
A - Anxiety
D - Disorder of brain stem
12
CVS
H – Heart attack
E - Embolism
A – Aortic stenosis
R – Arrhythmias
T - Tachycardia
13. FAINTING – SIGNS AND SYMPTOMS
Patient feels faint/lightheaded/dizzy
Pallor
Sweating
Pulse rate slows down
Low blood pressure
Nausea and vomiting
Loss of consciousness
13
14. FAINTING – TREATMENT
Lay the patient in a supine position with feet elevated slightly (10-15º).
A patent airway must be maintained.
Definitive management –
Monitor vital signs
Administer aromatic ammonia
Administration of atropine (0.1g/ml IV)
If recovery is delayed, oxygen should be administered and other causes of
loss of consciousness should be considered.
14
16. HYPERVENTILATION
Hyperventilation is a more common emergency than is often thought.
When hyperventilation persists, it can become extremely distressing to
the patient.
Anxiety is the principal precipitating factor.
16
18. HYPERVENTILATION – TREATMENT
A calm and sympathetic approach from the practitioner is important.
Encourage the patient to rebreathe their own exhaled air to increase the
amount of inhaled carbon dioxide – a paper bag placed over the nose
and mouth allows this.
If no paper bag is handy, the patient’s cupped hands would be a (less
satisfactory) alternative.
Hyperventilation leads to carbon dioxide being ‘washed out’ of the
body producing an alkalosis. If hyperventilation persists, carpal (hand)
and pedal (foot) spasms (tetany) may be seen.
Re-breathing exhaled air increases inspired carbon dioxide levels and
helps to return the situation to normal.
18
19. ASTHMA
Asthma is a potentially life-threatening
condition and should always be taken
seriously.
An attack may be precipitated by exertion,
anxiety, infection, or exposure to an
allergen.
It is important in history to get some idea of
the severity of attacks.
Clues include the precipitating factors,
effectiveness of medication, hospital
admissions due to asthma, and the use of
systemic steroids.
19
20. ASTHMA – SIGNS AND SYMPTOMS
Breathlessness (rapid respiration – more than
25 breaths per minute)
Expiratory wheezing
Use of accessory muscles for respiration
Tachycardia
20
LIFE-THREATENING ASTHMA
Cyanosis or slow respiratory rate (less than 8 breaths per minute)
Bradycardia
Decreased level of consciousness/confusion
21. ASTHMA – TREATMENT
Most attacks will respond to the patient’s inhaler,
usually salbutamol (may need to repeat after 2–3
minutes).
If no rapid response, or features of severe asthma,
call an ambulance.
A medical assessment should be arranged for
patients who require additional doses of
bronchodilator to end an attack.
21
22. A spacer device may need to be used if the patient
has difficulty using the inhaler.
Four to six actuations from the salbutamol inhaler
via a spacer device should be used and repeated
every 10 minutes.
In the British National Formulary, a technique is
described as a ‘homemade’ spacer device.
A hole can be cut out of the base of a paper or
plastic cup. The mouthpiece of the inhaler is
pushed through this. The open end of the cup can
then be applied to the mouth when the inhaler is
activated.
22
23. If the patient is distressed or shows any of the signs of life-threatening
asthma, urgent transport to the hospital should be arranged.
High-flow oxygen should be given whilst awaiting transfer.
If asthma is part of a more generalized anaphylactic reaction, or in
extremis, an intramuscular injection of adrenaline should be given.
All patients, including those who have chronic obstructive pulmonary
disease, should be given high-flow oxygen as even if these patients are
dependent on ‘hypoxic drive’ to stimulate their respiration, they will
come to no harm in the short term.
23
24. CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Chronic obstructive pulmonary disorder (COPD) is a collective term for
lung diseases including chronic bronchitis, emphysema, and chronic
obstructive airway diseases.
COPD patients have breathing problems primarily due to their
constricted airways.
24
25. MANAGEMENT OF COPD
Take proper history of the patient.
The patient’s physician should be consulted for medications and the
status of the diseases.
Provide a stress-free environment during each visit.
Position the patient in an upright position.
Avoid drugs causing respiratory depression like narcotics and sedatives.
Avoid bilateral mandibular block anesthesia.
Avoid ultrasonic instrumentation.
25
26. PROSTHODONTIC CONSIDERATIONS IN COPD
Prosthodontic procedures should not be done until an emergency, i.e.,
in case of active fungal or bacterial respiratory disease.
Use of vasoconstrictors and gingival retraction cord not advised.
When antibiotic therapy is indicated, macrolides (i.e., erythromycin,
azithromycin, and clarithromycin), ciprofloxacin, and clindamycin should
be avoided in patients taking theophylline because of the potential
adverse effect of methylxanthine toxicity.
Acetaminophen and Cox-2 inhibitors can be anti-inflammatory drugs
for these patients since they do not precipitate bronchospasm.
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29. ORAL MANIFESTATIONS OF HYPERTENSION
Oral manifestations of hypertension result not directly due to HTN itself
but occur as a side effect of antihypertensive drugs.
They include –
Xerostomia caused by diuretics,
Lichenoid mucosal lesions, burning mouth, loss of taste sensation
(angiotensin-converting enzyme inhibitors), and
Gingival hyperplasia (calcium channel blockers).
29
30. PROSTHODONTIC CONSIDERATIONS IN HTN
Stress reduction protocol should be followed for anxious patients.
During treatment, abrupt changes in body position should be
discouraged to minimize the risk of orthostatic hypotension.
Although a morning appointment with minimal waiting time is
preferable, lower blood pressure occurs during the daytime rather than
morning. So, afternoon appointments are considered safer.
Local anesthesia with vasoconstrictor should either be avoided or used
in low doses in uncontrolled hypertension cases.
Nonsteroidal anti-inflammatory drugs (NSAIDs) are used only for short
therapy.
30
31. Sharp edges of dentures should be well-trimmed and polished to avoid
trauma.
Utmost care should be provided to avoid soft tissue abrasion during
denture fabrication.
Artificial salivary lubricants can be advised for better post-therapy
results to compensate for the effect of xerostomia.
To reduce gingival bleeding, supragingival margins are advised.
Use of epinephrine for gingival retraction should be carefully
administered.
Resting systolic pressure >180 or diastolic pressure >110 indicates that
all elective procedures should be delayed until blood pressure can be
reduced to a safer level.
31
32. CARDIAC CHEST PAIN
The pain of angina is described as a crushing or band-like tightness of
the chest, which may radiate to the left arm or mandible.
The pain of myocardial infarction (MI) will often be similar to that of
angina but more severe and, unlike angina, will not be relieved by
glyceryl trinitrate (GTN).
In cases of angina, the patient should use their GTN spray, which will
usually remove the symptoms.
Dental treatment may be best left until another day if there is an attack,
according to the practitioner’s discretion.
32
33. CHEST PAIN – POSSIBLE CAUSES
Angina
Myocardial infarction
Pleuritic, e.g. pulmonary embolism
Musculoskeletal
Oesophageal reflux
Hyperventilation
Gall bladder and pancreatic diseases
33
34. MYOCARDIAL INFARCTION – SIGNS AND SYMPTOMS
Severe, crushing chest pain, which
may radiate to the shoulders and
down the arms (particularly the left
arm) and into the mandible.
Shortness of breath.
The skin becomes pale and clammy.
Pulse becomes weak and the patient
may become hypotensive.
Often, there will be nausea and
vomiting.
34
35. MYOCARDIAL INFARCTION – TREATMENT
The practitioner should remain calm and be a reassuring presence.
Call the emergency number.
Most patients will be best managed in the sitting position.
Patients who feel faint should be laid flat.
Give high-flow oxygen (15 L/min).
35
36. Give 300 mg aspirin orally to be chewed (if no allergy) – ensure that
when handing over to the receiving ambulance crew they are made
aware of this as thrombolytic therapy is given by some ambulance
crews.
A patient who has had surgical dental treatment should be highlighted
to the ambulance crew as any significant risk of hemorrhage may affect
the decision to use thrombolytic therapy
If the patient becomes unresponsive, the practitioner should check for
‘signs of life’ (breathing and circulation) and start cardiac pulmonary
resuscitation.
36
37. PROSTHODONTIC MANAGEMENT IN ANGINA PECTORIS
Patients with mild angina (up to one attack per month) can undergo
most nonsurgical dental procedures with normal protocol. Extensive
treatment like implants is postponed or done with nitrous oxide
sedation, and only up to 0.004–0.005 mg of adrenaline is used.
Patients with moderate angina (up to one attack per week) are
prescribed to take a sublingual dose of nitroglycerine prior to extensive
treatment such as implant surgery. Adequate anxiolytic treatment with
oxygen supplementation is recommended.
Patients with unstable angina (daily episodes) are limited to
examination procedures and are advised an absolute contraindication
for elective dental surgery like placement of dental implants.
37
38. DENTAL MANAGEMENT OF MI
Dental management of MI is the same as that of angina pectoris.
Additional considerations include if the patient is under anticoagulants,
the international normalized ratio (INR) should be determined on the
day of treatment, and treatment should be provided within the
recommended limits, i.e., <3.5, with adequate bleeding control for
surgery.
Further hemostasis is mandatory in cases with antiplatelet medications.
38
39. EPILEPTIC SEIZURES
Epilepsy is a disease characterized by an
alteration of awareness, performance,
and mental activities, as well as by
involuntary muscle contractions.
The history will usually reveal the
fact that a patient has epilepsy. A
history should obtain information about
the nature of any seizures, their
frequency, and degree of control.
39
40. EPILEPSY – SIGNS AND SYMPTOMS
The patient may have an ‘aura’ or premonition that a seizure is about to
occur.
Tonic phase – loss of consciousness, the patient becomes rigid and falls
and becomes cyanosed.
Clonic phase – jerking movements of the limbs, tongue may be bitten.
Urinary incontinence, frothing at the mouth.
The seizure often gradually abates after a few minutes but the patient
may remain unconscious and may remain confused after consciousness
has been regained.
Hypoglycemia may present as a fit and should be considered (including
in epileptic patients). Therefore, blood glucose measurement at an early
stage is wise. 40
41. EPILEPSY – TREATMENT OF A FIT
The decision to give medication should be made if seizures are
prolonged with active convulsions for 5 minutes or more (status
epilepticus) or seizures occurring in quick succession. If possible, high-
flow oxygen should be administered.
The possibility of the patient’s airway becoming occluded should be
constantly remembered, and therefore, the airway must be protected.
As far as possible, ensure the safety of the patient and practitioner (do
not attempt to restrain).
41
42. Midazolam is given via the buccal or intra-nasal route (10 mg for
adults). The buccal preparation is marketed as ‘Epistatus’ (10 mg/mL).
For children:
Child 1–5 years-5 mg
Child 5–10 years-7.5 mg
Child more than 10 years-10 mg
In the absence of rapid response to treatment, call an ambulance.
42
43. PROSTHODONTIC CONSIDERATIONS IN EPILEPSY
Prosthodontic treatment can be carried out with the knowledge to
recognize the early signs of a seizure and to take precautions to avoid
such incidents.
For patients who are adequately controlled with medication, can
routinely undergo prosthodontic management.
Patients whose seizure activity does not decrease in intensity following
anticonvulsant treatment may need additional anticonvulsant or
sedative medication, hence there is a need for consultation with a
neurologist before a dental appointment.
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44. DIABETIC EMERGENCIES
Diabetes mellitus (DM) is a metabolic disorder characterized by elevated
plasma glucose levels due to defects in insulin secretion, impaired
function of insulin, or both.
A history of recurrent hypoglycemic episodes and markedly varying
blood glucose levels (from the patient’s measurements) suggest that a
patient attending dental treatment is more likely to develop
hypoglycemia.
It is wise to treat diabetic patients first on any list and ensure that they
have had their normal medication and something to eat before
attending.
44
45. HYPOGLYCAEMIA – SIGNS AND SYMPTOMS
Trembling
Hunger
Headache
Sweating
Slurring of speech
‘Pins and needles’ in lips and tongue
Aggression and/or confusion
Seizures
Unconsciousness
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47. HYPOGLYCAEMIA – TREATMENT
Lie the patient flat (remember A, B, C).
If the patient is conscious, give oral glucose (three lumps of sugar
or 2–4 teaspoons of sugar) or Gluco GelR.
If the patient is unconscious, give 1 mg glucagon intramuscularly
(or subcutaneously).
Get medical help.
47
48. Patients who do not respond to glucagon (a rarity) or those who
have exhausted their supplies of liver glycogen will require 20 mL
of intravenous glucose solution (20–50%) and should be managed
under medical supervision or by the attending ambulance team.
It can take glucagon 5–10 minutes to be effective and the patient’s
airway must be protected at all times.
Once the patient regains consciousness and has an intact gag
reflex, they should be given glucose orally and a high carbohydrate
food.
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49. PROSTHODONTIC CONSIDERATIONS IN DM
Take proper medical history of the patient.
Establish levels of glycemic control early in the treatment process and
query about the diet taken by the patient.
Scheduling the patient's visit preferably in the morning.
Stress reduction protocol should be followed.
Oral hygiene instructions, regular prophylaxis, and monitoring of
periodontal health are advised.
Use of antibiotics is recommended in case of infection.
It is recommended to avoid NSAIDs if the patient is on sulfonylureas.
49
50. In CD:
Always use tissue-friendly material.
Mucostatic impression technique is suggested.
Neutral zone technique is advised.
Denture flanges should be smooth and polished.
Proper oral hygiene instructions should be given along with regular
follow-up visits.
If the patient has less salivation, proper therapy for maintenance of a
wet environment (e.g. water sipping, sugarless gum).
Frequent evaluation of dentures is necessary.
50
51. In RPD:
Maintenance of good oral hygiene must be accomplished first.
All components of RPD should be well adapted to the underlying
tissues.
Utmost oral and prosthesis care instructions should be delivered.
51
52. In FDP:
Avoid traumatization of soft tissues during tooth preparation.
Supragingival finish line is better.
Group function or mutually protected occlusal scheme is regarded as a
better choice for periodontally compromised teeth.
Proper flossing is advised to maintain the oral hygiene.
Hygienic pontic is preferred for the ease of cleansing.
52
53. In implants or implant-supported dentures:
Surgical procedure is started only after adequate control of the diabetic
state.
Pre and post-implant surgery, antimicrobial cover is recommended.
Smoking cessation, proper oral hygiene, and antiseptic mouth rinses are
recommended.
Glucose level should be monitored even after implant placement.
Implant dentistry is not contraindicated in most diabetic patients;
however, their medical care should be controlled post-implant.
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54. ANAPHYLAXIS
Anaphylaxis is a Type I hypersensitivity reaction involving IgE to which
free antigen binds leading to the release of vasoactive peptides and
histamine.
Penicillin and latex are the most likely causes in dentistry.
54
55. ANAPHYLAXIS – SIGNS AND SYMPTOMS
Itchy rash/erythema.
Facial flushing or pallor.
Upper airway (laryngeal) edema and
bronchospasm leading to stridor, wheezing,
and possibly hoarseness.
A respiratory arrest may occur leading to
cardiac arrest.
Vasodilatation leads to low blood pressure
and collapse, which may progress to cardiac
arrest.
55
56. ANAPHYLAXIS – INITIAL TREATMENT
The ABCDE approach should be employed while the diagnosis is being
made.
Administering high-flow oxygen.
Restore blood pressure by lying the patient flat and raising the legs.
56
57. In life-threatening anaphylaxis (hoarseness, stridor, cyanosis, dyspnea,
drowsiness, confusion, or coma), adrenaline should be administered:
Administer 0.5 mL of 1 in 1000 (1mg/ml) adrenaline IM and repeat and
5-minute intervals if no improvement.
The optimum site for injection is the anterolateral mid-third of the
thigh.
Many patients with a history of anaphylactic reactions will carry an
‘EpiPen’, which contains 300 μg of adrenaline.
57
58. CHOKING AND ASPIRATION
Prevention is important through using
rubber dams, instrument chains, mouth
sponges, etc.
Careful suction of the oral cavity and close
observation minimize risk.
If a patient is suspected of having
aspirated a foreign body, they should be
encouraged to cough vigorously in an
attempt to clear the airway and ‘cough up’
the object.
58
59. CHOKING - SIGNS AND SYMPTOMS
General signs of choking -
Attack occurs while eating/misplaced dental instrument/restoration.
Victim may clutch his neck.
Signs of mild airway obstruction -
Response to the question ‘Are you choking?’
Victim speaks and answers ‘YES’.
Signs of severe airway obstruction -
Response to the question ‘Are you choking?’
Victim unable to speak, may respond by nodding.
59
60. MANAGEMENT OF A CHOKING VICTIM
The back blows are delivered by standing to the
victim’s side and slightly behind.
The chest should be supported with one hand and
the victim should lean well forwards so that when
the obstruction is dislodged it is expelled from the
mouth rather than passing further down the
airway.
Up to five sharp blows should be given between
the shoulder blades with the heel of the other
hand.
After each back blow, a check should be made to
see if the obstruction has been relieved.
60
61. If back blows fail, up to five abdominal thrusts
should be given. Stand behind the victim put
both arms around the upper part of their
abdomen, and lean them forward.
The rescuer’s fist should be clenched and
placed between the umbilicus and the lower
end of the sternum.
The clenched fist should be grasped with the
other hand and pulled sharply inwards and
upwards.
This should be repeated up to five times.
The back blows and abdominal thrusts should
be continued cyclically.
61
Heimlich
Thrust
63. LOCAL ANAESTHETIC EMERGENCIES
Allergy to local anaesthetic is rare but should be managed as any other
case of anaphylaxis.
The signs and symptoms of allergy are those of anaphylaxis.
Fainting in association with the injection of local anaesthetic is more
common and can be avoided by administering it while the patient is
supine.
Intravascular injection of local anaesthetic solution can be avoided by
using an aspirating syringe.
63
64. POSSIBLE PROBLEMS WITH LOCAL ANALGESIA
Allergy (rare)
Cardiovascular -
Palpitations
Hypotension
Hypertension
Myocardial infarction
Facial palsy or diplopia -
Provide eye patch.
64
65. MANAGEMENT OF A LOCAL ANAESTHETIC OVERDOSE
Stop the procedure.
Lay the patient flat.
Administer oxygen.
If competent, give intravenous fluids and intravenous anticonvulsants.
Perform basic life support, if needed.
65
66. RECENT ADVANCES IN THE MANAGEMENT OF EMERGENCIES
The most recent advancement is the revised CPR guideline by the
American Heart Association (AHA).
Instead of ABC, now compressions come first only then do airway and
breathing.
Initially, it was believed that the chest compressions should be at least
1-1.5 inches deep but now at least 2-inch deep compressions are
recommended also AHA recommends pushing at least 100
compressions per minute.
66
68. TAKEAWAY POINTS -
Oxygen can be given in any medical emergency except Hyperventilation.
Most important injectable drug – Epinephrine (useful in bronchospasm,
cardiac arrest, and anaphylaxis).
1:1000 (1mg/ml) – IM, SC, SL – Dosage for adults – 0.3mg, children – 0.15mg.
1:10000 (1mg/10ml) – IV – Cardiac arrest.
Nitro glycerine – Sublingually (tablet or spray). Dosage can be repeated
thrice with 5-minute intervals in between. Given in Angina.
Aspirin – Life-saving drug. Given in MI (325mg, chewed for 30 sec and then
swallowed).
Morphine – Severe pain of MI (1-3mg IV or 5 mg IM).
Salbutamol –Drug of choice for bronchospasm (asthma) (2-3 sprays/1-2min).
Atropine – Hypotension + Bradycardia.
Phenylephrine – Hypotension + Tachycardia/Normal heart rate. 68
69. CONCLUSION
As always believed, prevention is the best medicine. Hence, being
prepared for an emergency in a dental clinic is of utmost importance.
Preparation for emergencies involves personal, staff, and office
preparation wherein personal and staff preparation includes an in-depth
knowledge of signs, symptoms, and management of emergencies, basic
life support (BLS) measures, and cardiopulmonary resuscitation (CPR).
Office preparation involves maintaining emergency equipment,
emergency drugs, and backup medical assistance.
Medical consultation should always be considered for appropriate
treatment modifications, wherever required. Systemic evaluation, as well
as physician, consultation, should be an integral part of the
prosthodontic treatment plan.
69
70. REFERENCES
Ghimire, P., Suwal, P., & Basnet, B. B. (2022). Management of Medically
Compromised Prosthodontic Patients. International Journal of Dentistry,
2022. https://doi.org/10.1155/2022/7510578
Resuscitation Council (UK), October 2010.
Epilepsy. National Institute for Health and Clinical Excellence. Clinical
Guideline CG20. October 2004.
Dental Emergencies, First Edition. Edited by Mark Greenwood and Ian
Corbett. C 2012 Blackwell Publishing Ltd. Published 2012 by Blackwell
Publishing Ltd.
Asian Journal of Oral Health and Allied Sciences 2013, Volume 3, Issue 2
Endodontic Considerations in a Medically Compromised Patient: An
Overview Atul Jain et al.
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Examples of medical conditions for which the medical history provides important evidence include, but are not limited to, the following:
• A heart condition—Be alert to a myocardial infarction (MI), congestive heart failure, or cerebrovascular accident (CVA).
• Asthma—Be alert to a possible asthma attack.
• A stroke, frequent headaches, or dizziness—Be alert to a possible CVA.
• Epilepsy—Be alert to a seizure.
Thyroid problems—Be alert to myxedema coma or thyroid storm.
• Diabetes—Be alert to hypoglycemia or diabetic coma.
• Corticosteroid use—Be alert to signs of adrenal insufficiency.
• Allergy—Be alert to an allergic reaction.
• Bleeding disorders—Be alert to bruising, hemorrhage, or hemophilia signs.
Vital signs include -
Pulse,
Respiration,
Blood pressure, and
Temperature.
AEDs can deliver an electric shock to the heart to restore a normal rhythm and save a person’s life.
Accessory muscles of inspiration are - sternocleidomastoid, scalene, pectoralis major and minor, serratus anterior, and latissimus dorsi muscles.
Accessory muscles of expiration are - abdominal muscles (rectus abdominis, transverse abdominis, external and internal oblique), and some muscles of the back (latissimus dorsi, quadratus lumborum, iliocostalis lumborum).
When a person with COPD lies down, the lungs may collapse and compress the airways, reducing the airflow and oxygen levels
By sitting or standing upright, the person can expand the chest cavity and draw more air into the lungs. This can also prevent the accumulation of mucus and secretions in the airways, which can cause infections and inflammation
Methylxanthine toxicity is a condition that occurs when a person or an animal ingests excessive amounts of substances that contain methylxanthines, such as caffeine, theophylline, theobromine, or pentoxifylline. Methylxanthines are stimulants that affect the nervous system, the heart, and the muscles. They can also cause diuresis and increase gastric acid secretion
Orthostatic hypotension is a condition where your blood pressure drops when you stand up after sitting or lying down.
Lidocaine without vasoconstrictor can be used.
LA 1:100000 conc
Pain of MI can be differentiated from angina as –
The pain is more severe in MI,
Lasts longer
And is not relieved by nitro-glycerine.
BP falls below the baseline value in MI where as it increases in angina.
Angina patients comes with past history of chest pain, whereas MI patient has first experience of pain.
Adrenaline is a hormone that stimulates the heart and blood vessels, increasing the heart rate, blood pressure, and oxygen demand of the heart. In people with angina, this can worsen the chest pain and increase the risk of heart attack. Therefore, adrenaline is used in lesser concentration in angina, and only when other treatments are not effective or available
The international normalized ratio (INR) is a standardized number that measures how long it takes for your blood to clot. It is used to monitor the effects of warfarin, a blood thinner that prevents blood clots. The INR is calculated from the prothrombin time (PT), which is a test that measures the clotting time of your blood1
If your INR is too low, you are at risk of developing blood clots. If your INR is too high, you are at risk of bleeding.
If you are not taking blood thinners, the normal INR range is 0.9 to 1.1 for both men and women2
If you are taking blood thinners, such as warfarin, the normal INR range is usually 2 to 3.
Epilepsy is a neurological condition that causes recurrent seizures due to abnormal electrical activity in the brain.
NSAIDs can inhibit the metabolism of sulfonylureas by the liver enzyme CYP2C9, which can increase the blood levels and effects of sulfonylureas. This can lead to hypoglycemia, or low blood sugar, which can cause symptoms such as sweating, shaking, confusion, and loss of consciousness
Tissue friendly material – acrylic resin, porcelain, metal, etc
Group function occlusion is also known as unilateral balanced occlusion. It is seen on the occlusal surface of teeth on one side, when they occlude simultaneously with a smooth uninterrupted glide. The group function on working side distributes the occlusal load1.
Mutually protected occlusion is an occlusal scheme in which the anterior teeth protect the posterior teeth, and vice versa. The anterior teeth protect the posterior teeth by providing for a plane of guidance during excursions, thus allowing the cusps of the posterior teeth to disclude rather than strike one another during lateral or protrusive movements from centric relation. The posterior teeth protect the anterior teeth by providing a stable vertical dimension of occlusion
Hypersensitivity reactions are exaggerated immune responses to harmless substances that cause symptoms such as rash, itching, or anaphylaxis. There are four types of hypersensitivity reactions, depending on the class of antigen that triggers them: type 1 (IgE), type 2 (IgG), type 3 (cell-mediated), and type 4 (T cell).
Here is a brief summary of each type:
Type 1 hypersensitivity causes an immediate response and occurs after a person has exposure to an antigen. The body produces IgE antibodies that bind to mast cells and basophils, which release histamine and other inflammatory mediators. This leads to symptoms such as hives, sneezing, asthma, or anaphylaxis. Common allergens include pollen, dust, food, or animal dander.
Type 2 hypersensitivity involves the binding of IgG and IgM antibodies to antigens on cell surfaces. This activates the complement system and phagocytes, which destroy the target cells. This can result in conditions such as hemolytic anemia, transfusion reactions, or autoimmune diseases.
Type 3 hypersensitivity results from the formation of antigen-antibody complexes that settle on tissues and organs. These complexes trigger the complement system and inflammation, which damage the underlying tissue. Examples of type 3 hypersensitivity include serum sickness, rheumatoid arthritis, or glomerulonephritis.
Type 4 hypersensitivity is mediated by T cells and is a delayed reaction to antigens associated with cells. The T cells release cytokines and recruit macrophages, which cause inflammation and tissue damage. Examples of type 4 hypersensitivity include tuberculin reactions, contact dermatitis, or chronic asthma.
Epinephrine – available in 3 forms – autoinjector (epipen), preloaded syringes (most useful), ampoules.
1:1000 (1mg/ml) – IM, SC, SL – adults – 0.3mg, child – 0.15mg
1:10000 (1mg/10ml) – IV – Cardiac arrest