1. The document discusses programmatic management of drug-resistant tuberculosis (DR-TB), specifically multi-drug resistant TB (MDR-TB). 2. MDR-TB is defined as TB resistant to both isoniazid and rifampicin, with or without resistance to other drugs. It poses a significant problem as patients who fail treatment have a high risk of death. 3. The epidemiology of MDR-TB in Zambia is described, noting about 1,500 cases annually. Risk factors for development of MDR-TB include poor compliance, physician error, lack of drugs, and failures in TB control programs.