International Journal of Computer Science, Engineering and Applications(IJCSEA) is a bi monthly open access peer-reviewed journal that publishes articles which contribute new results in all areas of Computer Science, Engineering and Applications. The journal focuses on all technical and practical aspects of Computer Science. The goal of this journal is to bring together researchers and practitioners from academia and industry to focus on advanced Software Engineering and establishing new collaborations in these areas.
International Journal of Computer Science, Engineering and Applications(IJCSEA) is a bi monthly open access peer-reviewed journal that publishes articles which contribute new results in all areas of Computer Science, Engineering and Applications. The journal focuses on all technical and practical aspects of Computer Science. The goal of this journal is to bring together researchers and practitioners from academia and industry to focus on advanced Software Engineering and establishing new collaborations in these areas.
Call for Papers - Computer Science & Engineering: An International Journal (C...CSEIJJournal
Computer Science & Engineering: An International Journal (CSEIJ) is a bi-monthly open access peer-reviewed journal that publishes articles which contribute new results in all areas of the Computer Science & Computer Engineering. The journal is devoted to the publication of high quality papers on theoretical and practical aspects of computer science and computer Engineering.
Call for Papers - Computer Science & Engineering: An International Journal (C...CSEIJJournal
Computer Science & Engineering: An International Journal (CSEIJ) is a bi-monthly open access peer-reviewed journal that publishes articles which contribute new results in all areas of the Computer Science & Computer Engineering. The journal is devoted to the publication of high quality papers on theoretical and practical aspects of computer science and computer Engineering.
Computer Science & Engineering: An International Journal (CSEIJ) cseij
Computer Science & Engineering: An International Journal (CSEIJ) is a bi-monthly open access peer-reviewed journal that publishes articles which contribute new results in all areas of the Computer Science & Computer Engineering. The journal is devoted to the publication of high quality papers on theoretical and practical aspects of computer science and computer Engineering.
The goal of this journal is to bring together researchers and practitioners from academia and industry to focus on Computer science & Computer Engineering advancements, and establishing new collaborations in these areas. Original research papers, state-of-the-art reviews are invited for publication in all areas of Computer Science & Computer Engineering.
Authors are solicited to contribute to the journal by submitting articles that illustrate research results, projects, surveying works and industrial experiences that describe significant advances in the areas of Computer Science & Engineering.
International Journal of Computer Science, Engineering and Applications(IJCSEA) is a bi monthly open access peer-reviewed journal that publishes articles which contribute new results in all areas of Computer Science, Engineering and Applications. The journal focuses on all technical and practical aspects of Computer Science. The goal of this journal is to bring together researchers and practitioners from academia and industry to focus on advanced Software Engineering and establishing new collaborations in these areas.
Call for Articles - Civil Engineering and Urban Planning: An International Jo...civejjour
Civil Engineering and Urban Planning: An International Journal (CIVEJ) is an open-access, peer-reviewed journal that publishes articles which contribute new results in all areas of the Civil Engineering and Urban Planning. The journal is devoted to the publication of high-quality papers on theoretical and practical aspects of Civil Engineering and Urban Planning. The goal of this journal is to bring together researchers and practitioners from academia and industry to focus on Civil Engineering and Urban Planning advancements, and establishing new collaborations in these areas. Original research papers, state-of-the-art reviews are invited for publication in all areas of Civil Engineering and Urban Planning.
International Journal of Computer Science, Engineering and Applications(IJCSEA) is a bi monthly open access peer-reviewed journal that publishes articles which contribute new results in all areas of Computer Science, Engineering and Applications. The journal focuses on all technical and practical aspects of Computer Science. The goal of this journal is to bring together researchers and practitioners from academia and industry to focus on advanced Software Engineering and establishing new collaborations in these areas.
International Journal of Computer Science, Engineering and Applications(IJCSEA) is a bi monthly open access peer-reviewed journal that publishes articles which contribute new results in all areas of Computer Science, Engineering and Applications. The journal focuses on all technical and practical aspects of Computer Science. The goal of this journal is to bring together researchers and practitioners from academia and industry to focus on advanced Software Engineering and establishing new collaborations in these areas.
Call for Papers - Computer Science & Engineering: An International Journal (C...CSEIJJournal
Computer Science & Engineering: An International Journal (CSEIJ) is a bi-monthly open access peer-reviewed journal that publishes articles which contribute new results in all areas of the Computer Science & Computer Engineering. The journal is devoted to the publication of high quality papers on theoretical and practical aspects of computer science and computer Engineering.
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Computer Science & Engineering: An International Journal (CSEIJ) is a bi-monthly open access peer-reviewed journal that publishes articles which contribute new results in all areas of the Computer Science & Computer Engineering. The journal is devoted to the publication of high quality papers on theoretical and practical aspects of computer science and computer Engineering.
Computer Science & Engineering: An International Journal (CSEIJ) cseij
Computer Science & Engineering: An International Journal (CSEIJ) is a bi-monthly open access peer-reviewed journal that publishes articles which contribute new results in all areas of the Computer Science & Computer Engineering. The journal is devoted to the publication of high quality papers on theoretical and practical aspects of computer science and computer Engineering.
The goal of this journal is to bring together researchers and practitioners from academia and industry to focus on Computer science & Computer Engineering advancements, and establishing new collaborations in these areas. Original research papers, state-of-the-art reviews are invited for publication in all areas of Computer Science & Computer Engineering.
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The AIRCC's International Journal of Computer Science and Information Technology (IJCSIT) is devoted to fields of Computer Science and Information Systems. The IJCSIT is a open access peer-reviewed scientific journal published in electronic form as well as print form. The mission of this journal is to publish original contributions in its field in order to propagate knowledge amongst its readers and to be a reference publication.
Paper Submission - Computer Science & Engineering: An International Journal (...CSEIJJournal
Computer Science & Engineering: An International Journal (CSEIJ) is a bi-monthly open access peer-reviewed journal that publishes articles which contribute new results in all areas of the Computer Science & Computer Engineering. The journal is devoted to the publication of high quality papers on theoretical and practical aspects of computer science and computer Engineering.
International Journal of Computer Science, Engineering and Applications(IJCSEA) is a bi monthly open access peer-reviewed journal that publishes articles which contribute new results in all areas of Computer Science, Engineering and Applications. The journal focuses on all technical and practical aspects of Computer Science. The goal of this journal is to bring together researchers and practitioners from academia and industry to focus on advanced Software Engineering and establishing new collaborations in these areas.
International Journal of Computer Science & Information (IJCSI) is a bi monthly open access peer-reviewed journal that publishes articles which contribute new results in all areas of Computer Science & Information . The journal focuses on all technical and practical aspects of Computer Science & Information . The goal of this journal is to bring together researchers and practitioners from academia and industry to focus on Computer Science & Information and establishing new collaborations in these areas.
International Journal of Computer Science, Engineering and Applications(IJCSEA) is a bi monthly open access peer-reviewed journal that publishes articles which contribute new results in all areas of Computer Science, Engineering and Applications. The journal focuses on all technical and practical aspects of Computer Science. The goal of this journal is to bring together researchers and practitioners from academia and industry to focus on advanced Software Engineering and establishing new collaborations in these areas.
Call for Papers - Computer Science & Engineering: An International Journal (C...CSEIJJournal
Computer Science & Engineering: An International Journal (CSEIJ) is a bi-monthly open access peer-reviewed journal that publishes articles which contribute new results in all areas of the Computer Science & Computer Engineering. The journal is devoted to the publication of high quality papers on theoretical and practical aspects of computer science and computer Engineering.
International Journal of Computational Science and Information Technology (IJ...ijcsity
International Journal of Computational Science and Information Technology (IJCSITY) focuses on Complex systems, information and computation using mathematics and engineering techniques. This is an open access peer-reviewed journal will act as a major forum for the presentation of innovative ideas, approaches, developments, and research projects in the area of Computation theory and applications. It will also serve to facilitate the exchange of information between researchers and industry professionals to discuss the latest issues and advancement in the area of advanced Computation and its applications.
The topics suggested by this journal can be discussed in term of concepts, surveys, state of the art, research, standards, implementations, running experiments, applications, and industrial case studies. Authors are invited to submit complete unpublished papers, which are not under review in any other conference or journal.
34idj3u8ejf8u34je29dju3ju3jeidu3eiffujfruernhufnefcjnfr cj djedojenoujnmeoidjmerif38uj48urj398ej80u4jr8u4jdwediqwdiwemijf34udnurjdiuefrnu34j3etdgfeygvhgcvdekhggwdkgjwygydvjygvsqgxswydgwiutdfewiytg2iytdiytetdiytegyutewgyt bnm hvjyvt gygiyg uyg uyg ku uyg uy gkuygi gu6tfufytiffy uyf uytf uyt fuy tft fyt fuy f yt iytf iytfiy gi gy fuy f y
Computer Science & Engineering: An International Journal (CSEIJ) is a bi-monthly open access peer-reviewed journal that publishes articles which contribute new results in all areas of the Computer Science & Computer Engineering. The journal is devoted to the publication of high quality papers on theoretical and practical aspects of computer science and computer Engineering.
International Journal of Computer Science & Information (IJCSI) is a bi monthly open access peer-reviewed journal that publishes articles which contribute new results in all areas of Computer Science & Information . The journal focuses on all technical and practical aspects of Computer Science & Information . The goal of this journal is to bring together researchers and practitioners from academia and industry to focus on Computer Science & Information and establishing new collaborations in these areas.
Advanced Computing: An International Journal (ACIJ) acijjournal
Advanced Computing: An International Journal (ACIJ) is a bi monthly open access peer-reviewed journal that publishes articles which contribute new results in all areas of the advanced computing. The journal focuses on all technical and practical aspects of high performance computing, green computing, pervasive computing, cloud computing etc. The goal of this journal is to bring together researchers and practitioners from academia and industry to focus on understanding advances in computing and establishing new collaborations in these areas.
Authors are solicited to contribute to the journal by submitting articles that illustrate research results, projects, surveying works and industrial experiences that describe significant advances in the areas of computing.
Advanced Computing: An International Journal (ACIJ)acijjournal
Advanced Computing: An International Journal (ACIJ) is a bi monthly open access peer-reviewed journal that publishes articles which contribute new results in all areas of the advanced computing. The journal focuses on all technical and practical aspects of high performance computing, green computing, pervasive computing, cloud computing etc. The goal of this journal is to bring together researchers and practitioners from academia and industry to focus on understanding advances in computing and establishing new collaborations in these areas.
Advanced Computing: An International Journal (ACIJ)acijjournal
Advanced Computing: An International Journal (ACIJ) is a bi monthly open access peer-reviewed journal that publishes articles which contribute new results in all areas of the advanced computing. The journal focuses on all technical and practical aspects of high performance computing, green computing, pervasive computing, cloud computing etc. The goal of this journal is to bring together researchers and practitioners from academia and industry to focus on understanding advances in computing and establishing new collaborations in these areas.
Journal of Pharmaceutical Research International Certificate of Excellence in Reviewing 2022 Awarded to Assoc. Prof. Tihomir Dovramadjiev Phd Eng 28 January 2022. Certificate No: SDI/HQ/PR/Cert/79878/TIH Journal of Pharmaceutical Research International https://www.journaljpri.com/index.php/JPRI . PUBLONS: https://publons.com/journal/58361/journal-of-pharmaceutical-research-international/ About the Journal Journal of Pharmaceutical Research International (ISSN: 2456-9119) is dedicated to publish high quality papers (Click here for Types of paper) in all areas of pharmaceutical Science including pharmaceutical drugs, community pharmacy, hospital pharmacy, clinical pharmacy, compounding pharmacy, consultant pharmacy, internet pharmacy, veterinary pharmacy, nuclear pharmacy, military pharmacy, pharmacy informatics, pharmaceutics, medicinal chemistry, pharmacognosy, pharmacotherapy, pharmacodynamics, pharmacokinetics, clinical pharmacology, neuropharmacology, psychopharmacology, pharmacogenetics, pharmacogenomics, pharmacoepidemiology, toxicology, theoretical pharmacology, posology, pharmacognosy, behavioral pharmacology, environmental pharmacology, medicine development and safety testing, drug legislation and safety, pharmaceutical microbiology, pharmaceutical molecular biology, pharmaceutical biotechnology. Name: Journal of Pharmaceutical Research International ISSN: 2456-9119 Past name: British Journal of Pharmaceutical Research ISSN: 2231-2919 (past) Frequency: 30 days NLM ID: 101631759 Journal DOI: http://dx.doi.org/10.9734/jpri Peer-review model: Advanced OPEN peer review Index Copernicus: ICV: 100.00 Digital Archiving: Journal Repository (JR), LOCKSS, CLOCKSS ISI MASTER JOURNAL LIST: https://drive.google.com/file/d/14LxT_R4WM3b-kT9JgbLz9gH__ZXvh8X2/view NAAS score (2020): 5.51 Emerging Sources Citation Index: https://drive.google.com/file/d/14LxT_R4WM3b-kT9JgbLz9gH__ZXvh8X2/view
DOI: 10.13140/RG.2.2.33868.28800
https://www.researchgate.net/publication/358173137_Journal_of_Pharmaceutical_Research_International_Certificate_of_Excellence_in_Reviewing_2022_Awarded_to_Assoc_Prof_Tihomir_Dovramadjiev_Phd_Eng_28_January_2022
MDPI REVIEW CONFIRMATION CERTIFICATE 30 December 2021 Assoc. Prof. Tihomir Dovramadjiev PhD Eng.
MDPI (Basel, Switzerland) is a pioneer in scholarly open access publishing and has supported academic communities since 1996.
https://www.mdpi.com/
Journal of Pharmaceutical Research International Certificate of Excellence in Reviewing 2021 Awarded to Assoc. Prof. Tihomir Dovramadjiev Phd Eng 21 December 2021.
Certificate No: SDI/HQ/PR/Cert/79878TIH
Journal of Pharmaceutical Research International https://www.journaljpri.com/index.php/JPRI .
PUBLONS: https://publons.com/journal/58361/journal-of-pharmaceutical-research-international/ About the Journal
Journal of Pharmaceutical Research International (ISSN: 2456-9119) is dedicated to publish high quality papers (Click here for Types of paper) in all areas of pharmaceutical Science including pharmaceutical drugs, community pharmacy, hospital pharmacy, clinical pharmacy, compounding pharmacy, consultant pharmacy, internet pharmacy, veterinary pharmacy, nuclear pharmacy, military pharmacy, pharmacy informatics, pharmaceutics, medicinal chemistry, pharmacognosy, pharmacotherapy, pharmacodynamics, pharmacokinetics, clinical pharmacology, neuropharmacology, psychopharmacology, pharmacogenetics, pharmacogenomics, pharmacoepidemiology, toxicology, theoretical pharmacology, posology, pharmacognosy, behavioral pharmacology, environmental pharmacology, medicine development and safety testing, drug legislation and safety, pharmaceutical microbiology, pharmaceutical molecular biology, pharmaceutical biotechnology.
Name: Journal of Pharmaceutical Research International
ISSN: 2456-9119
Past name: British Journal of Pharmaceutical Research
ISSN: 2231-2919 (past)
Frequency: 30 days
NLM ID: 101631759
Journal DOI: http://dx.doi.org/10.9734/jpri
Peer-review model: Advanced OPEN peer review
Index Copernicus: ICV: 100.00
Digital Archiving: Journal Repository (JR), LOCKSS, CLOCKSS
ISI MASTER JOURNAL LIST: https://drive.google.com/file/d/14LxT_R4WM3b-kT9JgbLz9gH__ZXvh8X2/view
NAAS score (2020): 5.51
Emerging Sources Citation Index: https://drive.google.com/file/d/14LxT_R4WM3b-kT9JgbLz9gH__ZXvh8X2/view
DOI: 10.13140/RG.2.2.11256.57603
https://www.researchgate.net/publication/357222485_Journal_of_Pharmaceutical_Research_International_Certificate_of_Excellence_in_Reviewing_2021_Awarded_to_Assoc_Prof_Tihomir_Dovramadjiev_Phd_Eng_21_December_2021
Official Certificate DATA 2021 - Session Chair Assoc. Prof. Dr. Eng. TIHOMIR DOVRAMADJIEV
INSTICC
10th International Conference on Data Science, Technology and Applications https://www.insticc.org/node/TechnicalProgram/data/2021/personDetails/9d1a4257-3f06-4226-a96e-f70a92d3e33a DATA21-2B: Oral Presentations: Text Analytics Wednesday, July 7th, 2021 09:00 - 11:00 https://www.insticc.org/node/TechnicalProgram/data/2021/personDetails/9d1a4257-3f06-4226-a96e-f70a92d3e33a#timetable-popup-P17969
https://www.researchgate.net/publication/355673124_Official_Certificate_DATA_2021_-_Session_Chair_Assoc_Prof_Dr_Eng_TIHOMIR_DOVRAMADJIEV
DOI: 10.13140/RG.2.2.32494.33602
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The topics suggested by this journal can be discussed in term of concepts, surveys, state of the art, research, standards, implementations, running experiments, applications, and industrial case studies. Authors are invited to submit complete unpublished papers, which are not under review in any other conference or journal.
34idj3u8ejf8u34je29dju3ju3jeidu3eiffujfruernhufnefcjnfr cj djedojenoujnmeoidjmerif38uj48urj398ej80u4jr8u4jdwediqwdiwemijf34udnurjdiuefrnu34j3etdgfeygvhgcvdekhggwdkgjwygydvjygvsqgxswydgwiutdfewiytg2iytdiytetdiytegyutewgyt bnm hvjyvt gygiyg uyg uyg ku uyg uy gkuygi gu6tfufytiffy uyf uytf uyt fuy tft fyt fuy f yt iytf iytfiy gi gy fuy f y
Computer Science & Engineering: An International Journal (CSEIJ) is a bi-monthly open access peer-reviewed journal that publishes articles which contribute new results in all areas of the Computer Science & Computer Engineering. The journal is devoted to the publication of high quality papers on theoretical and practical aspects of computer science and computer Engineering.
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Advanced Computing: An International Journal (ACIJ)acijjournal
Advanced Computing: An International Journal (ACIJ) is a bi monthly open access peer-reviewed journal that publishes articles which contribute new results in all areas of the advanced computing. The journal focuses on all technical and practical aspects of high performance computing, green computing, pervasive computing, cloud computing etc. The goal of this journal is to bring together researchers and practitioners from academia and industry to focus on understanding advances in computing and establishing new collaborations in these areas.
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Journal of Pharmaceutical Research International Certificate of Excellence in Reviewing 2022 Awarded to Assoc. Prof. Tihomir Dovramadjiev Phd Eng 28 January 2022. Certificate No: SDI/HQ/PR/Cert/79878/TIH Journal of Pharmaceutical Research International https://www.journaljpri.com/index.php/JPRI . PUBLONS: https://publons.com/journal/58361/journal-of-pharmaceutical-research-international/ About the Journal Journal of Pharmaceutical Research International (ISSN: 2456-9119) is dedicated to publish high quality papers (Click here for Types of paper) in all areas of pharmaceutical Science including pharmaceutical drugs, community pharmacy, hospital pharmacy, clinical pharmacy, compounding pharmacy, consultant pharmacy, internet pharmacy, veterinary pharmacy, nuclear pharmacy, military pharmacy, pharmacy informatics, pharmaceutics, medicinal chemistry, pharmacognosy, pharmacotherapy, pharmacodynamics, pharmacokinetics, clinical pharmacology, neuropharmacology, psychopharmacology, pharmacogenetics, pharmacogenomics, pharmacoepidemiology, toxicology, theoretical pharmacology, posology, pharmacognosy, behavioral pharmacology, environmental pharmacology, medicine development and safety testing, drug legislation and safety, pharmaceutical microbiology, pharmaceutical molecular biology, pharmaceutical biotechnology. Name: Journal of Pharmaceutical Research International ISSN: 2456-9119 Past name: British Journal of Pharmaceutical Research ISSN: 2231-2919 (past) Frequency: 30 days NLM ID: 101631759 Journal DOI: http://dx.doi.org/10.9734/jpri Peer-review model: Advanced OPEN peer review Index Copernicus: ICV: 100.00 Digital Archiving: Journal Repository (JR), LOCKSS, CLOCKSS ISI MASTER JOURNAL LIST: https://drive.google.com/file/d/14LxT_R4WM3b-kT9JgbLz9gH__ZXvh8X2/view NAAS score (2020): 5.51 Emerging Sources Citation Index: https://drive.google.com/file/d/14LxT_R4WM3b-kT9JgbLz9gH__ZXvh8X2/view
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https://www.researchgate.net/publication/358173137_Journal_of_Pharmaceutical_Research_International_Certificate_of_Excellence_in_Reviewing_2022_Awarded_to_Assoc_Prof_Tihomir_Dovramadjiev_Phd_Eng_28_January_2022
MDPI REVIEW CONFIRMATION CERTIFICATE 30 December 2021 Assoc. Prof. Tihomir Dovramadjiev PhD Eng.
MDPI (Basel, Switzerland) is a pioneer in scholarly open access publishing and has supported academic communities since 1996.
https://www.mdpi.com/
Journal of Pharmaceutical Research International Certificate of Excellence in Reviewing 2021 Awarded to Assoc. Prof. Tihomir Dovramadjiev Phd Eng 21 December 2021.
Certificate No: SDI/HQ/PR/Cert/79878TIH
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PUBLONS: https://publons.com/journal/58361/journal-of-pharmaceutical-research-international/ About the Journal
Journal of Pharmaceutical Research International (ISSN: 2456-9119) is dedicated to publish high quality papers (Click here for Types of paper) in all areas of pharmaceutical Science including pharmaceutical drugs, community pharmacy, hospital pharmacy, clinical pharmacy, compounding pharmacy, consultant pharmacy, internet pharmacy, veterinary pharmacy, nuclear pharmacy, military pharmacy, pharmacy informatics, pharmaceutics, medicinal chemistry, pharmacognosy, pharmacotherapy, pharmacodynamics, pharmacokinetics, clinical pharmacology, neuropharmacology, psychopharmacology, pharmacogenetics, pharmacogenomics, pharmacoepidemiology, toxicology, theoretical pharmacology, posology, pharmacognosy, behavioral pharmacology, environmental pharmacology, medicine development and safety testing, drug legislation and safety, pharmaceutical microbiology, pharmaceutical molecular biology, pharmaceutical biotechnology.
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Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Astronomy Update- Curiosity’s exploration of Mars _ Local Briefs _ leadertele...
MDPI Q1 Flyer Special Issue Editor Assoc Prof Tihomir Dovramadjiev PhD Eng Mathematics and Computer Programming in 2D and 3D Open Source Software
1. CITESCORE
2.2
SCOPUS
IMPACT
FACTOR
2.258
Guest Editor:
Dr. Tihomir Dovramadjiev
Faculty of Shipbuilding,
Technical University of Varna,
9010 Varna, Bulgaria
tihomir.dovramadjiev@ tu-
varna.bg
Deadline for manuscript
submissions:
20 April 2022
Message from the Guest Editor
Mathematics is strongly related to computer programming.
The application of maximum accuracy based on
mathematical principles and functions is a guarantee of
reliability and quality in the development of applications in
2D and 3D open-source computer so ware. The
application in science and practice of open-source
computer software is especially relevant.
This section invites researchers who use the mathematical
functions and computer codes in practice to present, at a
high level, their activities related to:
Applications in 2D and 3D open-source software;
Creation of new 2D and 3D open-source software;
Upgrading of existing 2D and 3D open-source
computer software;
Development of extensions as add-ons, add-ins,
and plug-ins;
Creating scripts;
Creation of two-dimensional and three-
dimensional finished models;
Creating parametric applications for generating 2D
and 3D models based on mathematical values;
Application of mathematical functions and writing
scripts directly in three-dimensional so ware (e.g.,
Blender, FreeCAD and others);
Оthers relevant to the topic.
an Open Access Journal by MDPI
Mathematics and Computer Programming in 2D and 3D Open Source
Software
mdpi.com/si/90181
Special
Issue
2. CITESCORE
2.2
SCOPUS
IMPACT
FACTOR
2.258
Editor-in-Chief Message from the Editor-in-Chief
The journal Mathematics publishes high-quality, refereed
papers that treat both pure and applied mathematics. The
journal highlights articles devoted to the mathematical
treatment of questions arising in physics, chemistry,
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and sociology, particularly those that stress
analytical/algebraic aspects and novel problems and their
solutions. One of the missions of the journal is to serve
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