Journal of Pharmaceutical Research International Certificate of Excellence in Reviewing 2022 Awarded to Assoc. Prof. Tihomir Dovramadjiev Phd Eng 28 January 2022

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Journal of Pharmaceutical Research International Certificate of Excellence in Reviewing 2022 Awarded to Assoc. Prof. Tihomir Dovramadjiev Phd Eng 28 January 2022. Certificate No: SDI/HQ/PR/Cert/79878/TIH Journal of Pharmaceutical Research International https://www.journaljpri.com/index.php/JPRI . PUBLONS: https://publons.com/journal/58361/journal-of-pharmaceutical-research-international/ About the Journal Journal of Pharmaceutical Research International (ISSN: 2456-9119) is dedicated to publish high quality papers (Click here for Types of paper) in all areas of pharmaceutical Science including pharmaceutical drugs, community pharmacy, hospital pharmacy, clinical pharmacy, compounding pharmacy, consultant pharmacy, internet pharmacy, veterinary pharmacy, nuclear pharmacy, military pharmacy, pharmacy informatics, pharmaceutics, medicinal chemistry, pharmacognosy, pharmacotherapy, pharmacodynamics, pharmacokinetics, clinical pharmacology, neuropharmacology, psychopharmacology, pharmacogenetics, pharmacogenomics, pharmacoepidemiology, toxicology, theoretical pharmacology, posology, pharmacognosy, behavioral pharmacology, environmental pharmacology, medicine development and safety testing, drug legislation and safety, pharmaceutical microbiology, pharmaceutical molecular biology, pharmaceutical biotechnology. Name: Journal of Pharmaceutical Research International ISSN: 2456-9119 Past name: British Journal of Pharmaceutical Research ISSN: 2231-2919 (past) Frequency: 30 days NLM ID: 101631759 Journal DOI: http://dx.doi.org/10.9734/jpri Peer-review model: Advanced OPEN peer review Index Copernicus: ICV: 100.00 Digital Archiving: Journal Repository (JR), LOCKSS, CLOCKSS ISI MASTER JOURNAL LIST: https://drive.google.com/file/d/14LxT_R4WM3b-kT9JgbLz9gH__ZXvh8X2/view NAAS score (2020): 5.51 Emerging Sources Citation Index: https://drive.google.com/file/d/14LxT_R4WM3b-kT9JgbLz9gH__ZXvh8X2/view DOI: 10.13140/RG.2.2.33868.28800 https://www.researchgate.net/publication/358173137_Journal_of_Pharmaceutical_Research_International_Certificate_of_Excellence_in_Reviewing_2022_Awarded_to_Assoc_Prof_Tihomir_Dovramadjiev_Phd_Eng_28_January_2022

Journal of Pharmaceutical Research International
Tihomir Atanassov Dovramadjiev
Technical University of Varna, Bulgaria
Certificate No: SDI/HQ/PR/Cert/79878/TIH
Date: 28-Jan-2022

MDPI Basel Switzerland CERTIFICATE OF SERVICE 2021 as Guest Editor of Special Issue Mathematics and Computer Programming in 2D and 3D Open Source Software Assoc Prof Tihomir Dovramadjiev PhD Eng MDPI Special Issue "Mathematics and Computer Programming in 2D and 3D Open Source Software" https://www.mdpi.com/journal/mathematics/special_issues/Math_Comput_Program https://www.mdpi.com/journal/mathematics/special_issue_flyer_pdf/Math_Comput_Program/web Journal Rank: JCR - Q1 (Mathematics) / CiteScore - Q1 (General Mathematics) Impact Factor: 2.258 (2020) ; 5-Year Impact Factor: 2.165 (2020) https://www.mdpi.com/journal/mathematics © MDPI (Basel, Switzerland) DOI: 10.13140/RG.2.2.12945.76642 https://www.researchgate.net/publication/357435219_MDPI_Basel_Switzerland_CERTIFICATE_OF_SERVICE_2021_as_Guest_Editor_of_Special_Issue_Mathematics_and_Computer_Programming_in_2D_and_3D_Open_Source_Software_Assoc_Prof_Tihomir_Dovramadjiev_PhD_Eng

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FIDE Master Tihomir Dovramadjiev PhD

MDPI Basel Switzerland CERTIFICATE OF SERVICE 2021 as Topical Advisory Panel Member of Mathematics Assoc. Prof. Tihomir Dovramadjiev PhD Eng. Topical Advisory Panel https://www.mdpi.com/journal/mathematics/topical_advisory_panel Journal Rank: JCR - Q1 (Mathematics) / CiteScore - Q1 (General Mathematics) Impact Factor: 2.258 (2020) ; 5-Year Impact Factor: 2.165 (2020) https://www.mdpi.com/journal/mathematics © MDPI (Basel, Switzerland) DOI: 10.13140/RG.2.2.34756.14727 https://www.researchgate.net/publication/357435114_MDPI_Basel_Switzerland_CERTIFICATE_OF_SERVICE_as_2021_as_Topical_Advisory_Panel_Member_of_Mathematics_Assoc_Prof_Tihomir_Dovramadjiev_PhD_Eng

MDPI Q1 Flyer Special Issue Editor Assoc Prof Tihomir Dovramadjiev PhD Eng Ma...

FIDE Master Tihomir Dovramadjiev PhD

Special Issue Information Dear Colleagues, Mathematics is strongly related to computer programming. The application of maximum accuracy based on mathematical principles and functions is a guarantee of reliability and quality in the development of applications in 2D and 3D open-source computer so ware. The application in science and practice of open-source computer software is especially relevant. This section invites researchers who use the mathematical functions and computer codes in practice to present, at a high level, their activities related to: Applications in 2D and 3D open-source software; Creation of new 2D and 3D open-source software; Upgrading of existing 2D and 3D open-source computer software; Development of extensions as add-ons, add-ins, and plug-ins; Creating scripts; Creation of two-dimensional and three-dimensional finished models; Creating parametric applications for generating 2D and 3D models based on mathematical values; Application of mathematical functions and writing scripts directly in three-dimensional so ware (e.g., Blender, FreeCAD and others). Оthers relevant to the topic. Dr. Tihomir Dovramadjiev Guest Editor MDPI Special Issue "Mathematics and Computer Programming in 2D and 3D Open Source Software" https://www.mdpi.com/journal/mathematics/special_issues/Math_Comput_Program https://www.mdpi.com/journal/mathematics/special_issue_flyer_pdf/Math_Comput_Program/web Journal Rank: JCR - Q1 (Mathematics) / CiteScore - Q1 (General Mathematics) Impact Factor: 2.258 (2020) ; 5-Year Impact Factor: 2.165 (2020) https://www.mdpi.com/journal/mathematics © MDPI (Basel, Switzerland)

MDPI REVIEW CONFIRMATION CERTIFICATE 30 December 2021 Assoc. Prof. Tihomir Do...

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Journal of Pharmaceutical Research International Certificate of Excellence in...

FIDE Master Tihomir Dovramadjiev PhD

Journal of Pharmaceutical Research International Certificate of Excellence in Reviewing 2021 Awarded to Assoc. Prof. Tihomir Dovramadjiev Phd Eng 21 December 2021. Certificate No: SDI/HQ/PR/Cert/79878TIH Journal of Pharmaceutical Research International https://www.journaljpri.com/index.php/JPRI . PUBLONS: https://publons.com/journal/58361/journal-of-pharmaceutical-research-international/ About the Journal Journal of Pharmaceutical Research International (ISSN: 2456-9119) is dedicated to publish high quality papers (Click here for Types of paper) in all areas of pharmaceutical Science including pharmaceutical drugs, community pharmacy, hospital pharmacy, clinical pharmacy, compounding pharmacy, consultant pharmacy, internet pharmacy, veterinary pharmacy, nuclear pharmacy, military pharmacy, pharmacy informatics, pharmaceutics, medicinal chemistry, pharmacognosy, pharmacotherapy, pharmacodynamics, pharmacokinetics, clinical pharmacology, neuropharmacology, psychopharmacology, pharmacogenetics, pharmacogenomics, pharmacoepidemiology, toxicology, theoretical pharmacology, posology, pharmacognosy, behavioral pharmacology, environmental pharmacology, medicine development and safety testing, drug legislation and safety, pharmaceutical microbiology, pharmaceutical molecular biology, pharmaceutical biotechnology. Name: Journal of Pharmaceutical Research International ISSN: 2456-9119 Past name: British Journal of Pharmaceutical Research ISSN: 2231-2919 (past) Frequency: 30 days NLM ID: 101631759 Journal DOI: http://dx.doi.org/10.9734/jpri Peer-review model: Advanced OPEN peer review Index Copernicus: ICV: 100.00 Digital Archiving: Journal Repository (JR), LOCKSS, CLOCKSS ISI MASTER JOURNAL LIST: https://drive.google.com/file/d/14LxT_R4WM3b-kT9JgbLz9gH__ZXvh8X2/view NAAS score (2020): 5.51 Emerging Sources Citation Index: https://drive.google.com/file/d/14LxT_R4WM3b-kT9JgbLz9gH__ZXvh8X2/view DOI: 10.13140/RG.2.2.11256.57603 https://www.researchgate.net/publication/357222485_Journal_of_Pharmaceutical_Research_International_Certificate_of_Excellence_in_Reviewing_2021_Awarded_to_Assoc_Prof_Tihomir_Dovramadjiev_Phd_Eng_21_December_2021

FIDE Master Tihomir Dovramadjiev / Тихомир Доврамаджиев -1 place ChessBase/Pl...

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FIDE Master Tihomir Dovramadjiev / Тихомир Доврамаджиев -1 place ChessBase/Playchess - Germany /1014 tournament 1+0 TD: Gaby Assmann /21.12.2021 http://playserver.chessbase.com/rooms/offtourn1_B.htm ChessBase / Playchess - Germany https://en.chessbase.com/ https://play.chessbase.com/en/ CHESSBASE PLAYCHESS GERMANY FULL RESULTS of FIDE MASTER TIHOMIR DOVRAMADJIEV BULGARIA https://www.slideshare.net/TihomirDovramadjievP/chessbase-playchess-germany-full-result-of-fide-master-tihomir-dovramadjiev-bulgaria Playing nicknames: TigerTAD & Lacetti YouTube Cannel https://www.youtube.com/c/TihomirDovramadjievPhD/about

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FIDE Master Tihomir Dovramadjiev PhD

Chessboxing Sports Illustrated USA 17 October 2005 (page 26) about The 1-st European Chessboxing Champion FIDE Master Tihomir Dovramadjiev Bulgaria. /Date: 1.X.2005 year, Place: Berlin, Germany/. Sports Illustrated USA https://www.si.com/ https://vault.si.com/vault/2005/10/17/the-beat https://vault.si.com/vault/2005/10/17/723919#&gid=ci0258c148e00e26ef&pid=723919---cover-image https://vault.si.com/vault/2005/10/17/723919#&gid=ci0258c148e00e26ef&pid=723919---036---image

Official Certificate DATA 2021 - Session Chair Assoc. Prof. Dr. Eng. TIHOMIR ...

FIDE Master Tihomir Dovramadjiev PhD

Official Certificate DATA 2021 - Session Chair Assoc. Prof. Dr. Eng. TIHOMIR DOVRAMADJIEV INSTICC 10th International Conference on Data Science, Technology and Applications https://www.insticc.org/node/TechnicalProgram/data/2021/personDetails/9d1a4257-3f06-4226-a96e-f70a92d3e33a DATA21-2B: Oral Presentations: Text Analytics Wednesday, July 7th, 2021 09:00 - 11:00 https://www.insticc.org/node/TechnicalProgram/data/2021/personDetails/9d1a4257-3f06-4226-a96e-f70a92d3e33a#timetable-popup-P17969 https://www.researchgate.net/publication/355673124_Official_Certificate_DATA_2021_-_Session_Chair_Assoc_Prof_Dr_Eng_TIHOMIR_DOVRAMADJIEV DOI: 10.13140/RG.2.2.32494.33602

MDPI REVIEW CONFIRMATION CERTIFICATE (24 September 2021) Assoc. Prof. Tihomir Dovramadjiev PhD Eng. Reviewed 6 papers (2021): - MDPI Processes (2) IMPACT FACTOR: 2.847 https://www.mdpi.com/journal/processes - MDPI Applied Science (1) IMPACT FACTOR: 2.679 https://www.mdpi.com/journal/applsci - MDP Machines (1) IMPACT FACTOR: 2.428 https://www.mdpi.com/journal/machines - MDPI Entropy (2) IMPACT FACTOR: 2.524 https://www.mdpi.com/journal/entropy Dr. Shu-Kun Lin, Publisher and President Basel 24 September 2021 MDPI (Basel, Switzerland) is a pioneer in scholarly open access publishing and has supported academic communities since 1996. https://www.mdpi.com/

MDPI REVIEW CONFIRMATION CERTIFICATE 29 July 2021 Assoc. Prof. Tihomir Dovram...

FIDE Master Tihomir Dovramadjiev PhD

MDPI REVIEW CONFIRMATION CERTIFICATE (29 July 2021) Assoc. Prof. Tihomir Dovramadjiev PhD Eng. Reviewed 4 papers (2021; Impact Factor - July 2021): - MDPI Processes (1) IMPACT FACTOR: 2.847 https://www.mdpi.com/journal/processes - MDP Machines (1) IMPACT FACTOR: 2.428 https://www.mdpi.com/journal/machines - MDPI Entropy (2) IMPACT FACTOR: 2.524 https://www.mdpi.com/journal/entropy MDPI (Basel, Switzerland) is a pioneer in scholarly open access publishing and has supported academic communities since 1996. https://www.mdpi.com/

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WORLD CHESS BOXING ORGANIZATION supporting and promoting every sport worldwid...

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Шахбокс - Уикипедия - януари 2021. Chessboxing Wikipedia January 2021 Bulgari...

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CHESSBASE PLAYCHESS GERMANY FULL RESULTS of FIDE MASTER TIHOMIR DOVRAMADJIEV ...

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CHESSBASE PLAYCHESS ГЕРМАНИЯ пълен списък с резултати на ФИДЕ МАЙСТОР ТИХОМИР ДОВРАМАДЖИЕВ БЪЛГАРИЯ CHESSBASE PLAYCHESS GERMANY FULL RESULTS of FIDE MASTER TIHOMIR DOVRAMADJIEV BULGARIA The First European Chess Boxing Champion FIDE Master Tihomir Dovramadjiev Bulgaria Тихомир Атанасов Доврамаджиев - България / ФИДЕ Майстор 2004 Tihomir Atanassov Dovramadjiev - Bulgaria / FIDE Master 2004 Първият Европейски Шампион по Шахбокс 1 Октомври 2005 г., Берлин, Германия The First European Chess Boxing Champion 1 October 2005 year,Berlin, Germany RBB TV https://www.rbb-online.de/fernsehen/ Video Reportage of RBB TV: https://www.youtube.com/watch?v=ynypKbtece https://bg.wikipedia.org/wiki/Тихомир_Тичко https://en.wikipedia.org/wiki/Tihomir_Dovramadjiev https://www.impactio.com/researcher/tihomir-dovramadjiev EUROSPORT https://www.eurosport.com/boxing/world-news/2005/checkmate-meets-ko-ne._sto782958/story.shtml LOS ANGELES TIMES https://www.latimes.com/archives/la-xpm-2005-dec-01-fg-chessboxing1-story.html DIE WELT https://www.welt.de/print-wams/article134145/Ring-frei-fuer-Denker.html CHESSBASE https://de.chessbase.com/post/schwere-kopftreffer

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The Morgan Messenger about the first European Chessboxing Champion Tihomir Ti...

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The Morgan Messenger about the first European Chessboxing Champion Tihomir Titschko Dovramadjiev January 18_ 2006_ Page 14 http://mgm.stparchive.com/Archive/MGM/MGM01182006p14.php Tihomir Dovramadjiev / Тихомир Доврамаджиев RBB TV Berlin 2005. 1st European ChessBoxing Champion. https://www.youtube.com/watch?v=ynypKbtece EUROSPORT https://www.eurosport.com/boxing/world-news/2005/checkmate-meets-ko-ne._sto782958/story.shtml Los Angeles Times https://www.latimes.com/archives/la-xpm-2005-dec-01-fg-chessboxing1-story.html Die WELT https://www.welt.de/print-wams/article134145/Ring-frei-fuer-Denker.html ChessBase Germany https://de.chessbase.com/post/schwere-kopftreffer

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NETHERLANDS Martialask HISTORY OF CHESS BOXING facts and dates

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Martialask Нидерландия Шахбокс исторически събития и дати

FIDE Master Tihomir Dovramadjiev PhD

Tihomir Dovramadjiev - official Wikipedia page September 2020 - English language

FIDE Master Tihomir Dovramadjiev PhD

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Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.

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Introduction: RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression. It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences. dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants. This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes. What are small ncRNAs? micro RNA (miRNA) short interfering RNA (siRNA) Properties of small non-coding RNA: Involved in silencing mRNA transcripts. Called “small” because they are usually only about 21-24 nucleotides long. Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered). Silence an mRNA by base pairing with some sequence on the mRNA. Discovery of siRNA? The first small RNA: In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the development of the worm C. elegans. Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14. Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions. Types of RNAi ( non coding RNA) MiRNA Length (23-25 nt) Trans acting Binds with target MRNA in mismatch Translation inhibition Si RNA Length 21 nt. Cis acting Bind with target Mrna in perfect complementary sequence Piwi-RNA Length ; 25 to 36 nt. Expressed in Germ Cells Regulates trnasposomes activity MECHANISM OF RNAI: First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces. Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands. The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it. THE RISC COMPLEX: RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA Unwinding of double stranded Si RNA by ATP independent Helicase Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA. DICER: endonuclease (RNase Family III) Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC) One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute ARGONAUTE PROTEIN : 1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA 2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity. MiRNA: The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .

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