This study focused on manufacturing and characterizing bulk and porous bioglass microspheres of different compositions, including 45S5, 13-93, and S53P4, for use in novel biomedical applications such as delivery of stem cells or growth factors. Microspheres were produced using flame spherodization and were characterized through techniques such as SEM, EDX, and cell culture studies. Preliminary results showed the microspheres supported cell adhesion and proliferation. Further studies will aim to increase the yield of porous microspheres and investigate cell encapsulation within the bioglass microspheres.
A Mathematical Analysis of Blood Flow through Artery with Mild Stenosisijtsrd
Presented herein are the studies of blood flow through artery with mild stenosis. The parameter specified µ and R. It has been observed that the increases the viscosity increase the load capacity. Again it has been observed that increases the value of R decreases the load capacity. Karm Veer Singh | Sushil Kumar | Dr. A. K. Yadav | C. S. Yadav | Dr. S. S. Yadav "A Mathematical Analysis of Blood Flow through Artery with Mild Stenosis" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-5 , August 2020, URL: https://www.ijtsrd.com/papers/ijtsrd31773.pdf Paper Url :https://www.ijtsrd.com/mathemetics/other/31773/a-mathematical-analysis-of-blood-flow-through-artery-with-mild-stenosis/karm-veer-singh
OA15.04. Accelerating the healing of bone fracture using homeopathy: a prospe...home
Results
Faster healing was reported in the homeopathy group by
week 9 following injury, including significant improvement
in fracture line (p < 0.0001), fracture edge
(p<0.0001),>< 0.05) and fracture
union (p< 0.0001) in comparison to placebo. There was
also lower use of analgesics and less self-reported pain
in the homeopathy group.
Conclusion
The study suggests that homoeopathy could enhance
anatomical and functional fracture healing.
Mechanical characterization of different orientation of glass fibre reinforce...eSAT Journals
Abstract The purpose of this study is to evaluation of the mechanical characterisation such as tensile, compression and bending test and to conduct wear test. This study focus on preparation and testing of Polyester resin using glass fibre for different orientation. The Mechanical properties of the polyester changes gradually by changing the layers of fibres and for different orientation of glass fibre the property differs. The laminate is prepared of size 300*300*4mm size and specimens are prepared as per ASTM standard, different layers of glass fibres are one, two and three layers and the orientation of glass fibre is 30o, 60o, and 90o. The glass fibre used is in fabric form. From the results which were obtained we can observed that three layers glass fibre for 90o orientation has improved tensile strength and the compressive strength is found to be more for 600orientation of glass fibre. And the wear rate is also less for three layer of glass fibre for 900 orientations. Keywords: Glass Fibre/Polyesters Composites, Mechanical Characterisation of Polyester, Orientation of Glass Fibre
A Mathematical Analysis of Blood Flow through Artery with Mild Stenosisijtsrd
Presented herein are the studies of blood flow through artery with mild stenosis. The parameter specified µ and R. It has been observed that the increases the viscosity increase the load capacity. Again it has been observed that increases the value of R decreases the load capacity. Karm Veer Singh | Sushil Kumar | Dr. A. K. Yadav | C. S. Yadav | Dr. S. S. Yadav "A Mathematical Analysis of Blood Flow through Artery with Mild Stenosis" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-5 , August 2020, URL: https://www.ijtsrd.com/papers/ijtsrd31773.pdf Paper Url :https://www.ijtsrd.com/mathemetics/other/31773/a-mathematical-analysis-of-blood-flow-through-artery-with-mild-stenosis/karm-veer-singh
OA15.04. Accelerating the healing of bone fracture using homeopathy: a prospe...home
Results
Faster healing was reported in the homeopathy group by
week 9 following injury, including significant improvement
in fracture line (p < 0.0001), fracture edge
(p<0.0001),>< 0.05) and fracture
union (p< 0.0001) in comparison to placebo. There was
also lower use of analgesics and less self-reported pain
in the homeopathy group.
Conclusion
The study suggests that homoeopathy could enhance
anatomical and functional fracture healing.
Mechanical characterization of different orientation of glass fibre reinforce...eSAT Journals
Abstract The purpose of this study is to evaluation of the mechanical characterisation such as tensile, compression and bending test and to conduct wear test. This study focus on preparation and testing of Polyester resin using glass fibre for different orientation. The Mechanical properties of the polyester changes gradually by changing the layers of fibres and for different orientation of glass fibre the property differs. The laminate is prepared of size 300*300*4mm size and specimens are prepared as per ASTM standard, different layers of glass fibres are one, two and three layers and the orientation of glass fibre is 30o, 60o, and 90o. The glass fibre used is in fabric form. From the results which were obtained we can observed that three layers glass fibre for 90o orientation has improved tensile strength and the compressive strength is found to be more for 600orientation of glass fibre. And the wear rate is also less for three layer of glass fibre for 900 orientations. Keywords: Glass Fibre/Polyesters Composites, Mechanical Characterisation of Polyester, Orientation of Glass Fibre
A dental implant (also known as an endosseous implant or fixture) is a surgical component that interfaces with the bone of the jaw or skull to support a dental prosthesis such as a crown, bridge, denture, facial prosthesis or to act as an orthodontic anchor. The basis for modern dental implants is a biologic process called osseointegration where materials, such as titanium, form an intimate bond to bone.
We are going to discuss the four Biomaterials and their Dental Applications, the Advantages and Disadvantages of each Material.
Plenary lecture of the XIV SBPMat Meeting, given by Prof. Paul Ducheyne (University of Pennsylvania, USA) on September 29, 2015, in Rio de Janeiro (Brazil).
K2O - CdO - B2O3 – SiO2glasses containing different concentrations of MnO2 have been prepared. The Physical properties of the glasses are studied from their density. The studies have been analysed in the light of different oxidation states of manganese ion with the aid of the data from optical absorption. The analysis shows that manganese ions exist mainly in Mn2+ state, occupy tetrahedral positions and increase the insulating strength of the glass if MnO2 is present in smaller concentrations.
Synthesis and Elastic Studies of Lead Boro-Tellurite Glass SystemSidek Aziz
Synthesis and Elastic Studies of Lead Boro-Tellurite Glass System presented Seminar Kebangsaan Aplikasi Sains dan Matematik 29-30 October 2013 ata UTHM Johor
A dental implant (also known as an endosseous implant or fixture) is a surgical component that interfaces with the bone of the jaw or skull to support a dental prosthesis such as a crown, bridge, denture, facial prosthesis or to act as an orthodontic anchor. The basis for modern dental implants is a biologic process called osseointegration where materials, such as titanium, form an intimate bond to bone.
We are going to discuss the four Biomaterials and their Dental Applications, the Advantages and Disadvantages of each Material.
Plenary lecture of the XIV SBPMat Meeting, given by Prof. Paul Ducheyne (University of Pennsylvania, USA) on September 29, 2015, in Rio de Janeiro (Brazil).
K2O - CdO - B2O3 – SiO2glasses containing different concentrations of MnO2 have been prepared. The Physical properties of the glasses are studied from their density. The studies have been analysed in the light of different oxidation states of manganese ion with the aid of the data from optical absorption. The analysis shows that manganese ions exist mainly in Mn2+ state, occupy tetrahedral positions and increase the insulating strength of the glass if MnO2 is present in smaller concentrations.
Synthesis and Elastic Studies of Lead Boro-Tellurite Glass SystemSidek Aziz
Synthesis and Elastic Studies of Lead Boro-Tellurite Glass System presented Seminar Kebangsaan Aplikasi Sains dan Matematik 29-30 October 2013 ata UTHM Johor
Abstract
Background: We set out to determine the possibility of radiographically evaluating the degree of marginal bone loss in humans after functional loading of implants at sites of guided bone regeneration (GBR) with autogenous tooth-based bone graft (ATBBG) material (AutoBT®, Korea Tooth Bank, Seoul, Korea).
Materials and Methods: Using ATBBG material, GBR procedures were performed on the extraction sockets with bone defects such as buccal dehiscence and 6 months of healing was allowed. Dental implants were installed and prosthetic procedures were done after another 6 months of healing. Marginal bone levels (MBLs) were radiographically measured following functional loading (mean duration, 10 months; range, 4–18 months) in 10 patients among 19 patients initially enrolled in this study (4 men and 6 women; age range, 39–65 years; mean age, 55.4 years) who maintained follow-up visits after entire surgical and prosthetic procedures.
Results: No significant MBL differences were noted immediately after GBR, implant placement and prosthesis delivery (F=0.245, P>0.05). Changes in the MBLs were not affected by gender.
Conclusion: The ATBBG material is viable for GBR and can yield a stable MBL even after functional loading of implants. The degree of marginal bone loss after loading with ATBBG is stable.
Gelatin-based scaffolds: An intuitive support structure for regenerative therapyAdib Bin Rashid
Advanced regenerative therapy aims to repair pathologically
damaged tissue by cell transplantation in conjunction with
supporting scaffolds. Gelatin-based scaffolds have attracted
much attention in recent years due to their great bio-affinity that
encourages the regeneration of tissues. Nowadays, by
strengthening gelatin-based systems, cutting-edge methods like
3D bioprinting, freeze-drying, microfluidics and gelatin functionalization have shown excellent mimicry of natural tissue. The
fabrication of porous gelatin-based scaffolds for wider tissue
engineering applications including skin, cartilage, bone, liver,
and cardiovascular is reviewed in this work. Additionally, the
crosslinking procedures and the physicochemical characteristics of the gelatin-based scaffolds are also studied. Now, gelatin
is considered one of the highest potential biomaterials for
impending trends in which the gelatin-based scaffolds are used
as a support structure for regenerative therapy.
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
1. Novel Bioglass Microspheres for Biomedical
Applications
Student: Matthew Wadge (emymw@nottingham.ac.uk)
Supervisor: Dr. Ifty Ahmed (ifty.ahmed@nottingham.ac.uk)
Advanced Materials
Research Group
1. Introduction
3. Discussion
Bulk and porous microspheres were successfully manufactured which offer
several advantages over other geometries, for example: minimally invasive
delivery due to their ability to flow easily and the potential to encapsulate
biological components i.e. stem cells[4], drugs, growth factors or other
biological factors.
One of the main issues facing current health care systems is the
increase in bone related disorders such as osteoporosis (loss of bone
tissue), and developing an effective treatment for such conditions.
For over 40 years, Bioglass™ (45S5)[1] has been the quintessential
bioactive glass composition having been used in a broad range of
applications from coatings[2] to scaffolds in tissue engineering[3].
This study focussed on manufacturing and characterising bulk and porous
microspheres (for the first time) from bioglass compositions (to also
include 13-93 & S53P4) as well as Bioglass™ (45S5) for delivery of
biological components (i.e. stem cells and other biological
factors for use in novel biomedical applications).
Acknowledgements
The author would like to acknowledge the help and support given by Dr. Ifty Ahmed & Dr. Laura
Macrì Pellizzeri during this project. In addition, special thanks to the EPSRC for funding this project.
References
[1] Hench L et al, J Mater Sci: Mater Med (2006) 17:967–978
[2] Wilson J, 1985 “Clinical Applications of Bioglass™”, Glass … Current Issues. Springer Netherlands, pp.662-669
[3] Rahaman et al. Acta Biomater. 2011 Jun; 7(6): 2355–2373
[4] Ahmed I et al. Prog Biomater. (2015) 4:1–19
[5] Ylanen H, 2011 “Bioactive Glasses: Materials, Properties and Applications”, Elsevier pp.8-14
[6] Ylanen H et al. Journal of Non-Crystalline Solids 275 (2000) 107-115
[7] http://www.slideshare.net/NationalOsteoporosisSociety/royal-college-of-physicians-conference-2016-
medicine2016 as of 17/08/16
5. Conclusions & Future Studies
• This study has concluded that both bulk and porous microspheres can be
manufactured using 13-93, 45S5 and S53P4 bioactive silicate glass
compositions (Fig. 2, 3 & 5).
• Further studies will aim to increase the yield of porous microspheres for
silicate based glasses.
• Furthermore, additional cell culture studies should be conducted to
investigate cell encapsulation within the Bioglass porous microspheres.
Fig 2. 45S5 Bulk Microspheres Fig 3. S53P4 Porous Microsphere
2. Methods
A flame spherodisation process was used to create bulk and porous
microspheres of size 63-125 µm. Characterisation of spheres included:
Scanning Electron Microscopy (SEM), Energy-dispersive X-ray spectroscopy
(EDX), XRD, SBF Testing, Thermal Analysis (DTA), and Cell culture studies.
Fig 1. Osteoporosis: The Problem[7]
4. Results
Glass Type Composition (wt%)
SiO2 Na2O CaO K2O MgO P2O5
45S5 (Predicted) 45 24.5 24.5 - - 6
45S5 (Actual - EDX) 46.98 21.77 24.84 - - 6.41
13-93 (Predicted) 53 6 20 12 5 4
13-93 (Actual - EDX) 52.98 5.34 22.28 8.87 5.94 4.59
S53P4 (Predicted) 53 23 20 - - 4
S53P4 (Actual - EDX) 53.61 20.84 20.78 - - 4.77
Further EDX analysis of SBF (Simulated Body
Fluid) samples demonstrated formation of a
silicon gel and apatite layer as early as day 3 [6].
(see Figures 6 & 7)
Fig. 3 45S5, 13-93, S53P4 compositions (wt%)
CaPSi
Fig. 7 SBF EDX 45S5 Day 3Fig. 6 SBF EDX 13-93 Day 10
X-ray Diffractometry (XRD) analysis concluded the
amorphous nature of the glasses (Fig. 4).
EDX analysis confirmed the composition of
glasses produced which were concurrent to
literature values[5] (Fig. 3).
In addition, preliminary in vitro cell culture experiments showed that bulk Bioglass
microspheres from all the compositions support cell adhesion as well as cell
proliferation at day 7 (see Figures 8 & 9).
Fig. 8 Representative images of GFP+ hMSCs (human
mesenchymal stem cells) adhered to the bulk bioglass
microspheres at d7
Fig. 9 Assessment of cell proliferation by Presto
Blue assay induced by the microspheres
0
5 0 0 0
1 0 0 0 0
1 5 0 0 0
2 0 0 0 0
2 5 0 0 0
4 5 S 5
1 3 -9 3
S 5 3 P 4
PrestoBlue
(560/590nm)
12h d7
Fig 5. Porous S53P4
Microsphere